Advances in Antibiotic-Loaded Nanofibers for the Treatment of Bone Infections: A Review DOI Open Access
Teguh Imanto, Nonni Soraya Sambudi, Khadijah Zai

et al.

Pharmacon Jurnal Farmasi Indonesia, Journal Year: 2024, Volume and Issue: unknown, P. 161 - 175

Published: Dec. 31, 2024

Antibiotic-loaded nanofiber-based drug delivery systems represent a novel approach to treating complex bone infections, particularly osteomyelitis caused by antibiotic-resistant bacteria such as Methicillin-resistant Staphylococcus aureus (MRSA). These offer localized, sustained release, significantly reducing systemic side effects and mitigating the development of antibiotic resistance. This review evaluates advancements in electrospun nanofibers with biodegradable polymers like Poly(lactic-co-glycolic acid) (PLGA) Polycaprolactone (PCL), which ensure controlled release while supporting regeneration. A systematic search using PRISMA guidelines across ScienceDirect ACS Publication databases (2020-2024) identified 42 relevant studies. The inclusion bioactive agents hydroxyapatite was found enhance antibacterial properties accelerate tissue demonstrates that antibiotic-loaded promising, targeted therapeutic alternative conventional treatments, for similar challenging infections. Future research directions will focus on optimizing nanofiber compositions functionalities better meet clinical needs, ensuring more efficient personalized management severe

Language: Английский

Manufacturing and Biological Potential of Saliva‐Loaded Core‐Sheath Pressure‐Spun Polymeric Fibers DOI Creative Commons

Vansh Thukral,

Nanang Qosim, Andre Kurniawan

et al.

Macromolecular Materials and Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

Abstract The rich array of antimicrobial components in saliva offers alternative treatments for drug‐resistant bacteria. One therapeutic challenge associated with the effective delivery salivary is quick degradation proteins outside oral environment. In this study, polyethylene oxide (sheath) and polycaprolactone (core) based fibers are successfully synthesized using pressurized gyration technique. Six different pressure‐spun produced. These created by varying quantity artificial sheath layer. This unique methodology embedding within fiber exhibits enhanced bacterial inhibition against Escherichia coli Staphylococcus aureus 80% 78% efficiency, respectively. study showcases a novel technique promoting wound healing, utilizing core‐sheath fibers, which have tremendous potential because their superior properties, while also aiding process epithelialization. vitro, cytotoxicity test results showed that there no cytotoxic effect on fibroblast cell line. As result, it evaluated produced meshes can be ideal dressing material, considering lack toxic effects high antibacterial activity levels.

Language: Английский

Citations

2
Biomedical Efficacy of Garlic‐Extract‐Loaded Core‐Sheath Plasters for Natural Antimicrobial Wound Care DOI Creative Commons

Hamta Majd,

Merve Gültekinoğlu, Cem Bayram

et al.

Macromolecular Materials and Engineering, Journal Year: 2024, Volume and Issue: 309(9)

Published: April 15, 2024

Abstract This work explores the application of Allium sativum (Garlic) extract, in creation novel polymeric core‐sheath fibers for wound therapy applications. The pressurized gyration (CS PG) technology is utilized to mass‐produce with a polycaprolactone (PCL) core and polyethylene oxide (PEO) sheath, loaded garlic extract. produced maintain structural integrity, long‐term stability provide cell‐friendly surface rapid antibacterial activity. physical properties, morphology, therapeutic delivery, cytotoxicity, thermal chemical PCL, PEO, PEO/Garlic, Core‐Sheath (CS) PEO/PCL PEO/Garlic/PCL are analyzed. Findings show that addition extract greatly increases fibers’ durability, while decreasing their diameter, thus improving cell adhesion proliferation. In‐vitro release tests reveal which has significant action against both Gram‐negative Escherichia coli ( E. ) Gram‐positive Staphylococcus aureus S. bacteria species. Cell viability experiments validate fiber samples' biocompatibility nontoxicity, making them appropriate integrative medicine These structures emphasize potential combining natural agents advanced material technologies develop cost‐effective, sustainable highly effective dressings, offering promising solution growing concerns associated conventional synthetic agents.

Language: Английский

Citations

7
The tailored manufacturing of core (cellulose acetate)-sheath (polyvinylpyrrolidone) polymeric nanofibers for biphasic drug delivery systems using pressure-spinning DOI Creative Commons
Nanang Qosim, Gareth R. Williams, Mohan Edirisinghe

et al.

Materials & Design, Journal Year: 2025, Volume and Issue: unknown, P. 113939 - 113939

Published: April 1, 2025

Language: Английский

Citations

0
Electrospun Ibuprofen-Loaded Blend PCL/PEO Fibers for Topical Drug Delivery Applications DOI Open Access

Diala Bani Mustafa,

Tsuyoshi Sakai, Osamu Satō

et al.

Polymers, Journal Year: 2024, Volume and Issue: 16(13), P. 1934 - 1934

Published: July 6, 2024

Electrospun drug-eluting fibers have demonstrated potentials in topical drug delivery applications, where releases can be modulated by polymer fiber compositions. In this study, blend of polycaprolactone (PCL) and polyethylene oxide (PEO) at various compositions were electrospun from 10 wt% solutions to encapsulate a model ibuprofen (IBP). The results showed that the average solution viscosities determined electrospinning parameters resulting diameters. Increasing PEO contents PCL/PEO decreased elastic moduli, tensile strength, fracture strains, IBP exhibited plasticizing effect fibers. promoted surface wettability vitro release suggested transition gradual fast when increasing up 120 min. viability using MTT assays compatible with MEF-3T3 fibroblasts. conclusion, our explained scientific correlations between properties physicomechanical These fibers, having ability modulate release, are suitable for applications.

Language: Английский

Citations

2
Electrospun PCL/Alginate/Nanoclay Nerve Conduit with Olfactory Ectomesenchymal Stem Cells for Nerve Regeneration DOI
Ghazaleh Larijani, Maryam Poostchi, Farzaneh Faridghiasi

et al.

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 7(11), P. 7522 - 7534

Published: Oct. 17, 2024

Biocompatible and biodegradable nerve growth conduits (NGCs) provide a promising alternative to conventional grafting for peripheral regeneration. Incorporating nanoclay (NC) has been shown increase the hydrophilicity flexibility of polymeric scaffolds. In present study, poly caprolactone-alginate (PCL-ALG) with varying percentages NC (0.1%, 0.2%, 0.5%) were fabricated using electrospinning technique. The conduit containing 0.5% showed greater in elongation (33%) porosity, reaching 95% lowest contact angle (10°). For vitro, human olfactory ectomesenchymal stem cells (OE-MSCs) used as favorable choice neuronal differentiation owing origin from neural crest. viability proliferation OE-MSCs maintained after 5 days on scaffolds NC, confirmed by MTT assay, cell adhesion analysis, live/dead staining. Furthermore, impact PCL-ALG-NC paracrine activity was studied period 7 days. Our results indicated that OE-MSCs, when cocultured PC12 NGC, have capability release factor levels up 1392.83 pg/mL. summary, electrospun PCL-ALG an optimal dosage (0.5%) seeded shows outcomes NGC scaffold

Language: Английский

Citations

2
Advances in Antibiotic-Loaded Nanofibers for the Treatment of Bone Infections: A Review DOI Open Access
Teguh Imanto, Nonni Soraya Sambudi, Khadijah Zai

et al.

Pharmacon Jurnal Farmasi Indonesia, Journal Year: 2024, Volume and Issue: unknown, P. 161 - 175

Published: Dec. 31, 2024

Antibiotic-loaded nanofiber-based drug delivery systems represent a novel approach to treating complex bone infections, particularly osteomyelitis caused by antibiotic-resistant bacteria such as Methicillin-resistant Staphylococcus aureus (MRSA). These offer localized, sustained release, significantly reducing systemic side effects and mitigating the development of antibiotic resistance. This review evaluates advancements in electrospun nanofibers with biodegradable polymers like Poly(lactic-co-glycolic acid) (PLGA) Polycaprolactone (PCL), which ensure controlled release while supporting regeneration. A systematic search using PRISMA guidelines across ScienceDirect ACS Publication databases (2020-2024) identified 42 relevant studies. The inclusion bioactive agents hydroxyapatite was found enhance antibacterial properties accelerate tissue demonstrates that antibiotic-loaded promising, targeted therapeutic alternative conventional treatments, for similar challenging infections. Future research directions will focus on optimizing nanofiber compositions functionalities better meet clinical needs, ensuring more efficient personalized management severe

Language: Английский

Citations

0