Occurrence of phthalate esters in river sediments in areas with different land use patterns DOI
Jun Wang,

Luji Bo,

Lina Li

et al.

The Science of The Total Environment, Journal Year: 2014, Volume and Issue: 500-501, P. 113 - 119

Published: Sept. 15, 2014

Language: Английский

Current concepts in neuroendocrine disruption DOI
Martha León‐Olea, Christopher J. Martyniuk,

Edward F. Orlando

et al.

General and Comparative Endocrinology, Journal Year: 2014, Volume and Issue: 203, P. 158 - 173

Published: Feb. 13, 2014

Language: Английский

Citations

129
Phthalate acid esters (PAEs) accumulation in coastal sediments from regions with different land use configuration along the Persian Gulf DOI
Hossein Arfaeinia, Mehdi Fazlzadeh,

Farhad Taghizadeh

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2018, Volume and Issue: 169, P. 496 - 506

Published: Nov. 22, 2018

Language: Английский

Citations

125
Thyroid Endocrine Disruption in Zebrafish Larvae after Exposure to Mono-(2-Ethylhexyl) Phthalate (MEHP) DOI Creative Commons

Wenhui Zhai,

Zhigang Huang, Li Chen

et al.

PLoS ONE, Journal Year: 2014, Volume and Issue: 9(3), P. e92465 - e92465

Published: March 21, 2014

Phthalates are extensively used as plasticizers in a variety of daily-life products, resulting widespread distribution aquatic environments. However, limited information is available on the endocrine disrupting effects phthalates organisms. The aim present study was to examine whether exposure mono-(2-ethylhexyl) phthalate (MEHP), hydrolytic metabolite di-(2-ethylhexyl) (DEHP) disrupts thyroid system fish. In this study, zebrafish (Danio rerio) embryos were exposed different concentrations MEHP (1.6, 8, 40, and 200 μg/L) from 2 h post-fertilization (hpf) 168 hpf. whole-body content hormone transcription genes involved hypothalamic-pituitary-thyroid (HPT) axis examined. Treatment with significantly decreased T4 contents increased T3 contents, indicating disruption. upregulation related metabolism (Dio2 UGT1ab) might be responsible for contents. Elevated gene Dio1 also observed which assist degrade Exposure induced development (Nkx2.1 Pax8) synthesis (TSHβ, NIS TG). encoding proteins TH transport (transthyretin, TTR) transcriptionally down-regulated after MEHP. Overall, these results demonstrate that acute alters hormones embryos/larvae changes HPT axis, thus exerting toxicity.

Language: Английский

Citations

117
Degradation of Di(2-Ethylhexyl) Phthalate by a Novel Gordonia alkanivorans Strain YC-RL2 DOI

Ruth Nahurira,

Lei Ren,

Jinlong Song

et al.

Current Microbiology, Journal Year: 2017, Volume and Issue: 74(3), P. 309 - 319

Published: Jan. 12, 2017

Language: Английский

Citations

110
The Effects of Disturbance on Hypothalamus-Pituitary-Thyroid (HPT) Axis in Zebrafish Larvae after Exposure to DEHP DOI Creative Commons
Pan‐Pan Jia,

Yanbo Ma,

Chunjiao Lu

et al.

PLoS ONE, Journal Year: 2016, Volume and Issue: 11(5), P. e0155762 - e0155762

Published: May 25, 2016

Di-(2-ethylhexyl) phthalate (DEHP) has the potential to disrupt thyroid endocrine system, but underlying mechanism is unknown. In this study, zebrafish (Danio rerio) embryos were exposed different concentrations of DEHP (0, 40, 100, 200, 400 μg/L) from 2 168 hours post fertilization (hpf). Thyroid hormones (THs) levels and transcriptional profiling key genes related hypothalamus-pituitary-thyroid (HPT) axis examined. The result whole-body thyroxine (T4) triiodothyronine (T3) indicated that hormone homeostasis was disrupted by in larvae. After exposure DEHP, mRNA expressions stimulating (tshβ) corticotrophin releasing (crh) increased a concentration dependent manner, respectively. expression level involved development (nkx2.1 pax8) synthesis (sodium/iodide symporter, nis, thyroglobulin, tg) also measured. transcripts nkx2.1 tg significantly after exposure, while those nis pax8 had no significant change. Down-regulation uridinediphosphate-glucuronosyl-transferase (ugt1ab) up-regulation thyronine deiodinase (dio2) might change THs levels. addition, transcript transthyretin (ttr) up-regulated, receptors (trα trβ) remained unchanged. All results demonstrated altered larvae changed HPT axis, proving induced toxicity potentially affected synthesis, regulation action hormones.

Language: Английский

Citations

101
Zebrafish: A Versatile Animal Model for Fertility Research DOI Creative Commons

Jing Ying Hoo,

Yatinesh Kumari, Mohd. Farooq Shaikh

et al.

BioMed Research International, Journal Year: 2016, Volume and Issue: 2016, P. 1 - 20

Published: Jan. 1, 2016

The utilization of zebrafish in biomedical research is very common the world nowadays. Today, it has emerged as a favored vertebrate organism for science reproduction. There significant growth amount numbers scientific literature pertaining to discoveries reproductive sciences zebrafish. It implied importance this particular field research. In essence, current available covered from specific brain region or neurons zebrafish, which are responsible regulation, until gonadal level animal. and findings have proven that small animal sharing close/similar system with mammals. More interestingly, behavioral characteristics along establishment courtship behavior categorization laid an even stronger foundation firmer reason on suitability sciences. view immense development sciences, review aimed at compiling describing proximate close similarity regulation human factors contributing infertility, showing its versatility potential usage fertility

Language: Английский

Citations

97
Probabilistic assessment of risks of diethylhexyl phthalate (DEHP) in surface waters of China on reproduction of fish DOI
Na Liu,

Yeyao Wang,

Qi Yang

et al.

Environmental Pollution, Journal Year: 2016, Volume and Issue: 213, P. 482 - 488

Published: March 10, 2016

Language: Английский

Citations

95
The degradation of phthalate esters in marine sediments by persulfate over iron–cerium oxide catalyst DOI
Cheng‐Di Dong, Chin‐Pao Huang, Thanh-Binh Nguyen

et al.

The Science of The Total Environment, Journal Year: 2019, Volume and Issue: 696, P. 133973 - 133973

Published: Aug. 19, 2019

Language: Английский

Citations

85
Effects of biodegradable plastic film mulching on soil microbial communities in two agroecosystems DOI Creative Commons
Sreejata Bandopadhyay, Henry Y. Sintim, Jennifer M. DeBruyn

et al.

PeerJ, Journal Year: 2020, Volume and Issue: 8, P. e9015 - e9015

Published: April 20, 2020

Plastic mulch films are used globally in crop production but incur considerable disposal and environmental pollution issues. Biodegradable plastic (BDMs), an alternative to polyethylene (PE)-based films, designed be tilled into the soil where they expected mineralized carbon dioxide, water microbial biomass. However, insufficient research regarding impacts of repeated incorporation BDMs on communities has partly contributed limited adoption BDMs. In this study, we evaluated effects BDM community structure function over two years geographical locations: Knoxville, TN, Mount Vernon, WA, USA. Treatments included four (three commercially available one experimental film), a biodegradable cellulose paper mulch, non-biodegradable PE no plot. Bacterial determined using 16S rRNA gene amplicon sequencing revealed significant differences by location season. Differences bacterial treatment were not for any season either location, except Fall 2015 WA observed between no-mulch plots. Extracellular enzyme assays characterize functionally, revealing sampling both TN minimal treatments. Overall, had comparable influences films.

Language: Английский

Citations

82
Review of endocrine disruptors on male and female reproductive systems DOI

Hyekyoung Hannah You,

Gwonhwa Song

Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology, Journal Year: 2021, Volume and Issue: 244, P. 109002 - 109002

Published: Feb. 21, 2021

Language: Английский

Citations

56