Toxic Effects of Di-2-ethylhexyl Phthalate: An Overview

BioMed Research International, Journal Year: 2018, Volume and Issue: 2018, P. 1 - 10

Published: Jan. 1, 2018

Di-2-ethylhexyl phthalate (DEHP) is extensively used as a plasticizer in many products, especially medical devices, furniture materials, cosmetics, and personal care products. DEHP noncovalently bound to plastics, therefore, it will leach out of these products after repeated use, heating, and/or cleaning the Due overuse enters pollutes environment through release from industrial settings plastic waste disposal sites. can enter body inhalation, ingestion, dermal contact on daily basis, which has raised some concerns about its safety potential effects human health. The main aim this review give an overview endocrine, testicular, ovarian, neural, hepatotoxic, cardiotoxic animal models humans vitro vivo.

Language: Английский

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Hazards of phthalates (PAEs) exposure: A review of aquatic animal toxicology studies

The Science of The Total Environment, Journal Year: 2021, Volume and Issue: 771, P. 145418 - 145418

Published: Jan. 27, 2021

Language: Английский

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Nanotoxicity of different sizes of graphene (G) and graphene oxide (GO) in vitro and in vivo

Environmental Pollution, Journal Year: 2019, Volume and Issue: 247, P. 595 - 606

Published: Jan. 25, 2019

Language: Английский

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Exposure to mercuric chloride induces developmental damage, oxidative stress and immunotoxicity in zebrafish embryos-larvae

Aquatic Toxicology, Journal Year: 2016, Volume and Issue: 181, P. 76 - 85

Published: Nov. 2, 2016

Language: Английский

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Bisphenols as Environmental Triggers of Thyroid Dysfunction: Clues and Evidence

International Journal of Environmental Research and Public Health, Journal Year: 2020, Volume and Issue: 17(8), P. 2654 - 2654

Published: April 13, 2020

Bisphenols (BPs), and especially bisphenol A (BPA), are known endocrine disruptors (EDCs), capable of interfering with estrogen androgen activities, as well being suspected other health outcomes. Given the crucial role thyroid hormones increasing incidence carcinoma in last few decades, this review analyzes effects BPS on thyroid, considering original research vitro, vivo, humans published from January 2000 to October 2019. Both vitro vivo studies reported ability BPs disrupt function through multiple mechanisms. The antagonism receptors (TRs), which affects TR-mediated transcriptional activity, direct action gene expression at pituitary level, competitive binding transport proteins, induction toxicity several cell lines likely main mechanisms leading dysfunction. In humans, results more contradictory, though some evidence suggests potential risk nodules. standardized methodology toxicological prospective epidemiological individual exposure assessments warranted evaluate pathophysiology resulting damage establish temporal relationship between markers long-term effects.

Language: Английский

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Developmental toxicity of glyphosate on embryo-larval zebrafish (Danio rerio)

Ecotoxicology and Environmental Safety, Journal Year: 2022, Volume and Issue: 236, P. 113493 - 113493

Published: April 6, 2022

Glyphosate (GLY) induces developmental toxicity in fish, but research on the mechanism is limited. In this study, zebrafish embryos were exposed for 120 hpf to 0.7, 7, and 35 mg L-1 GLY. The results show that GLY treatment induced including premature hatching, reduced heartbeats, pericardial yolk sac oedema, swim bladder deficiency, shortened body length, which was possibly due a significantly decreased triiodothyronine (T3)/thyroxine (T4) ratio abnormal expression patterns of hypothalamic-pituitary-thyroid (HPT) (crh, tshβ, tr α, β, t ) growth hormone/insulin-like factor (GH/IGF) axis-related genes (gh, ghrα, ghrβ, igf1, igf1rα, igf1rβ) larvae addition, exposure altered levels SOD CAT, increased ROS, promoted malondialdehyde (MDA) content, endoplasmic reticulum (ER) stress signalling pathway factors (perk, eif2α, gadd34, atf4, ire1α, xbp1, atf6, hspa5, chop), suggesting oxidative injury ER larvae. Further showed with higher concentration upregulated iNOS, IL-1β, TNF-α while inhibiting IL-10 TGF-β, causes an inflammatory reaction we also found apoptosis larvae, determined by acridine orange staining p53, caspase-3, -8, -9. Taken together, our demonstrate T3/T4 ratio, disturbed HPT GH/IGF genes, stress, reactions, This investigation contributes improved understanding fish.

Language: Английский

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Association of phthalate exposure with thyroid function during pregnancy

Environment International, Journal Year: 2021, Volume and Issue: 157, P. 106795 - 106795

Published: Aug. 4, 2021

The extent of thyroid disruptive effects phthalates during pregnancy remains unclear.To investigate the association maternal urinary with markers system early pregnancy.Urinary concentrations phthalate metabolites and serum stimulating hormone (TSH), free total thyroxine (FT4 TT4) triiodothyronine (FT3 TT3) were measured in pregnant women Swedish Environmental Longitudinal, Mother child, Asthma allergy study (2007-ongoing), a population-based prospective cohort.In 1,996 included women, higher di-ethyl-hexyl (DEHP) associated lower FT4 (β [SE] for molar sum: -0.13 [0.06], P = 0.03) TSH/FT4 ratio (0.003 [0.001], 0.03). Higher di-iso-nonyl (DINP) TT4 0.93 [0.44], as well TT4/FT4 TT4/TT3 ratios. both dibutyl butyl-benzyl (DBP BBzP) T4/T3 (free total) FT4/TT4 FT3/TT3 A diisononyl cyclohexane dicarboxylate (DINCH) metabolite concentration was TT3.These results translate from experimental studies suggesting that exposure to may interfere pregnancy. This is also true compounds have been introduced replace known phthalates. Further should take into account human evidence better potential underlying mechanisms disruption by

Language: Английский

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Fish toxicity testing for identification of thyroid disrupting chemicals

Environmental Pollution, Journal Year: 2021, Volume and Issue: 284, P. 117374 - 117374

Published: May 18, 2021

Identification of thyroid disrupting chemicals (TDCs), one the most studied types endocrine disruptors (EDs), is required according to EU regulations on industrial chemicals, pesticides, and biocides. Following that requirement, use fish as a unique non-mammalian model species for identification EDs may be warranted. This study summarized evaluated effects TDCs sensitive endpoints including hormones, related gene expression, immunostaining follicles, eye size pigmentation, swim bladder inflation well secondary sex characteristics, ratio, growth reproduction. Changes in reflect balanced outcome different processes cascade. Thyroid also altered by non-thyroid molecular or pathways non-specific factors such general toxicity, development, stress, nutrient, environmental like temperature pH. Defining chemical specific important TDCs. Application AOP (adverse pathway) concept could helpful defining critical events needed testing fish.

Language: Английский

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Comparison of developmental toxicity induced by PFOA, HFPO-DA, and HFPO-TA in zebrafish embryos

Chemosphere, Journal Year: 2022, Volume and Issue: 311, P. 136999 - 136999

Published: Oct. 25, 2022

Language: Английский

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Phthalates released from microplastics can't be ignored: Sources, fate, ecological risks, and human exposure risks

TrAC Trends in Analytical Chemistry, Journal Year: 2024, Volume and Issue: 179, P. 117870 - 117870

Published: July 18, 2024

Language: Английский

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