International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(7), P. 3767 - 3767
Published: March 28, 2024
Ultraviolet
radiation
(UVR)
has
various
effects
on
human
cells
and
tissues,
which
can
lead
to
a
variety
of
skin
diseases
cause
inconvenience
people’s
lives.
Among
them,
solar
dermatitis
is
one
the
important
risk
factors
for
malignant
melanoma,
so
prevention
treatment
very
necessary.
Additionally,
liquiritin
(LQ)
anti-inflammatory
effects.
In
this
study,
we
aimed
evaluate
pro-wound
healing
carbomer
gel
cold
paste
(LQ-CG-CP)
in
vitro
vivo.
The
results
MTT
experiments
showed
no
cytotoxicity
LQ
at
concentrations
40
μg/mL
below
cell
damage
UVB
irradiation
doses
above
60
mJ/cm2.
Moreover,
promote
migration.
ELISA
also
that
inhibited
elevation
inflammatory
tumor
necrosis
factor-α
(TNF-α),
interleukin-1β
(IL-1β),
interleukin-6
(IL-6)
after
irradiation.
mouse
model
dermatitis,
2%
LQ-CG-CP
best
therapeutic
efficacy
wound
relief
itching
compared
MEIBAO
moist
burn
moisturizer
(MEBO).
What
more,
histopathological
examination
show
promotes
re-epithelialization,
shrinks
wounds,
collagen
production,
thus
promoting
healing.
Simultaneously,
reduced
TNF-α,
IL-1β,
IL-6
expression.
addition,
was
not
observed
changes
blood
biochemical
abnormalities
mice.
Overall,
great
potential
dermatitis.
Journal of Food Biochemistry,
Journal Year:
2025,
Volume and Issue:
2025(1)
Published: Jan. 1, 2025
Nonalcoholic
fatty
liver
disease
(NAFLD)
has
become
a
global
pandemic,
imposing
significant
socioeconomic
burden.
Hepatic
steatosis
is
key
pathological
event
in
NAFLD.
However,
there
still
lack
of
effective
drugs
for
NAFLD
treatment.
Liquiritin
(LIQ),
derived
from
licorice
root,
exhibits
antioxidative
and
anti‐inflammatory
properties,
making
it
valuable
managing
various
conditions
such
as
dermatological
disorders,
respiratory
ailments,
gastritis.
Here,
we
investigated
the
impact
underlying
mechanisms
LIQ
on
hepatic
mouse
primary
hepatocytes
(MPHs).
Our
study
found
that
significantly
decreased
palmitic
acid
(PA)‐induced
lipid
accumulation
MPHs.
Additionally,
remarkably
increased
mRNA
expression
Cpt1a,
PPAR
α
,
Ehhadh,
Cyp4a10,
Acox1,
suggesting
achieves
its
lipid‐lowering
effect
by
regulating
mitochondria‐mediated
β‐oxidation.
Furthermore,
regulatory
mitochondrial
oxidative
phosphorylation
(OXPHOS)
process
was
confirmed
Seahorse
analysis.
Mechanistically,
bioinformatics
analysis
predicted
VEGFA
crucial
target
mediating
beneficial
effects
against
PA‐induced
Notably,
treatment
with
purified
protein
partially
counteracted
properties
LIQ.
our
data
showed
promoted
degradation
through
ubiquitin–proteasome
pathway.
Therefore,
findings
not
only
confirm
MPHs
but
also
identify
potential
target.
These
results
highlight
therapeutic
promise
introduce
novel
treating
steatosis.
ACS Omega,
Journal Year:
2025,
Volume and Issue:
10(7), P. 7112 - 7119
Published: Feb. 16, 2025
Two
new
crystalline
compounds,
named
[LG·H2O]n
(1;
LG
=
liquiritigenin)
and
[LQ·C2H5OH·H2O]n
(2;
LQ
liquiritin),
have
been
synthesized
structurally
characterized
by
single-crystal
powder
X-ray
diffraction,
thermogravimetric
analyses
(TGA),
nuclear
magnetic
resonance
(NMR),
high-resolution
mass
spectrometry
(HR-MS),
infrared
spectra
(IR).
1
2
crystallize
in
space
groups
Pna21
P212121,
respectively.
In
the
structure
of
1,
liquiritigenin
water
molecules
are
connected
hydrogen
bonds
for
construction
a
novel
3,5-connected
network
topology
with
point
symbol
(63)(67·83),
which
each
molecule
acts
as
5-connected
3-connected
node,
Both
reduce
amyloid-β-induced
toxicity
Caenorhabditis
elegans
(CL4176
strain)
improving
expression
level
SOD.
Gene
studies
RT-qPCR
indicate
upregulation
skn-1
sod-3
while
downregulation
daf-16
hsf-1
C.
elegans.
Molecular
docking
that
combine
well
vascular
endothelial
growth
factor
A
(VEGFA),
free
binding
energies
calculated
to
be
−6.7
−7.9
kcal·mol–1,
Moreover,
anti-amyloid-β
ability
amorphous
or
has
studied.
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: March 8, 2025
Tinospora
cordifolia
has
been
used
for
thousands
of
years
to
treat
various
health
conditions,
including
neurodegenerative
diseases.
The
study
aimed
elucidate
the
mechanism
action
and
protein
targets
T.
in
context
Alzheimer's
disease
through
untargeted
metabolomics
network
pharmacology.
LC–MS/MS
analysis
resulted
1186
metabolites,
known
bioactive
compounds
such
as
liquiritin,
Plastoquinone
3,
Shoyuflavone
A,
name
a
few.
pharmacology
highlighted
metabolite-protein
interaction
with
enrichment
591
human
proteins,
neurotransmitter
receptors
other
regulatory
proteins.
Pathway
cAMP,
mTOR,
MAPK,
PI3K-Akt
signaling
pathways
along
cholinergic,
dopaminergic,
serotonergic,
glutamatergic
synapse,
apoptosis.
docking
results
suggest
that
metabolites
could
interact
key
BACE1
MAO-B,
suggesting
its
role
neuroprotection.
These
findings
provide
insights
into
biochemical
underlying
cordifolia's
therapeutic
effects
provides
foundation
future
exploration
translational
research.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(6), P. 2539 - 2539
Published: March 12, 2025
Licorice
(Glycyrrhiza
L.)
is
a
globally
popular
medicinal
and
edible
plant,
with
nearly
30
species
distributed
across
all
continents.
The
usable
part
primarily
the
root.
To
understand
metabolic
differences
among
different
Glycyrrhiza
species,
we
selected
four
performed
comprehensive
analyses
of
their
roots.
Metabolomic
profiling
was
conducted
using
UPLC-MS/MS
GC-MS,
while
transcriptomic
analysis
carried
out
RNA-sequencing.
A
total
2716
metabolites
were
identified,
including
flavonoids
(527
types)
terpenoids
(251
types),
various
other
components.
Subsequently,
network
pharmacology
employed
to
explore
value
potential
pharmacological
ingredients
these
metabolites.
Joint
metabolomic
data
revealed
significant
in
differentially
accumulated
(DAMs)
expressed
genes
(DEGs)
pairwise
comparisons
species.
These
enriched
isoflavone
pathway.
Further
investigation
into
regulatory
mechanisms
biosynthesis
identified
key
involved
biosynthesis.
Finally,
made
reasonable
predictions
suitable
habitats
for
aiming
provide
new
insights
development
utilization
licorice
resources.
results
this
study
can
serve
as
basis
in-depth
research
on
regulation
licorice.
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
16
Published: April 2, 2025
Cardiovascular
disease
poses
a
significant
risk
to
human
health
and
remains
the
leading
cause
of
illness
death
globally,
with
its
incidence
continuing
rise.
The
intricate
pathophysiological
mechanisms
CVDs
include
inflammation,
oxidative
stress,
autophagy,
myocardial
fibrosis.
In
light
these
underlying
mechanisms,
traditional
Chinese
medicine
(TCM)
constituents
have
demonstrated
distinct
advantages
in
managing
CVDs.
By
exerting
synergistic
effects
across
multiple
components
targets,
can
modulate
inflammatory
response,
mitigate
regulate
excessive
enhance
fibrosis
repair.
This
article
reviews
latest
advancements
understanding
how
TCM
compounds
signaling
pathways
involved
treatment
Journal of Separation Science,
Journal Year:
2025,
Volume and Issue:
48(4)
Published: April 1, 2025
ABSTRACT
Huangqin
Decoction
(HQD),
a
traditional
Chinese
medicine
prescription,
was
first
recorded
in
Treatise
on
Febrile
Diseases
2000
years
ago.
It
is
widely
used
the
treatment
of
ulcerative
colitis
(UC).
The
purpose
study
to
investigate
and
compare
pharmacokinetic
behaviors
main
bioactive
components
HQD
UC
normal
rats.
A
simple,
rapid,
sensitive
liquid
chromatography‐tandem
mass
spectrometry
method
developed
for
simultaneous
determination
eight
rat
plasma.
Analytes
were
separated
C18
column
under
gradient
elution
with
mobile
phase
consisting
0.1%
formic
acid
water
acetonitrile.
Multiple
reaction
monitoring
mode
acquire
transitions.
Method
validation
results
showed
good
specificity
linearity,
limit
quantification
ranging
from
2.5
5.0
ng/mL
which
sufficient
study.
accuracy
precision
within
12.1%
11.8%,
respectively.
Extraction
recovery
matrix
effect
81.8%
98.8%
83.6%
98.4%,
relative
error
values
stability
different
storage
conditions
12.8%.
successfully
applied
pharmacokinetics
plasma
after
oral
administration
HQD.
Pharmacokinetic
parameters
analytes
calculated.
Results
that
rats
significantly
different,
especially
time
peak
drug
concentration
(T
max
),
(C
area
curve
(AUC).
In
general,
C
all
AUCs
most
markedly
lower
than
rats,
might
be
related
pathological
state
influencing
exposure
levels
HQD,
reducing
absorption
them,
resulting
differences
behaviors.
This
could
provide
reference
future
clinical
application
this
classical
formula.
