All Life,
Journal Year:
2024,
Volume and Issue:
17(1)
Published: July 4, 2024
The
present
study
investigated
the
effect
of
Gastrodia
elata
extracts
(GE)
on
chronic
electric
foot-shock
stress
(cEFS)-induce
anxiety-like
behaviors
in
male
C57BL/6
mice.
Mice
were
administered
GE
(200
or
400
mg/kg/day,
oral),
and
then
exposed
to
cEFS
(0.6
mA
intensity,
1
s
every
5
interval,
3
min
duration)
for
seven
days.
treatment
ameliorates
behavior
induced
by
cEFS,
which
determined
with
elevated
plus
maze
test
open
field
test.
decreased
dopamine
serotonin
levels
brain
both
reversed
treatment.
increased
corticosterone
serum
number
c-fos
positive
cells
brain,
downregulated
These
results
suggested
that
regulating
serotonin,
serum.
Journal of Agricultural and Food Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 21, 2025
This
study
evaluated
the
antidepressant
effects
of
arecoline,
a
bioactive
alkaloid
derived
from
areca
nuts,
using
mouse
model
depression
induced
by
chronic
unpredictable
mild
stress.
Arecoline
treatment
significantly
alleviated
depression-like
behaviors,
including
anxiety,
anhedonia,
and
despair,
as
evidenced
behavioral
tests.
Mechanistically,
arecoline
restored
serotonin
norepinephrine
levels
in
brain
serum,
reduced
pro-inflammatory
markers
such
IL-1β
LPS
both
serum
colon,
enhanced
hippocampal
neuroplasticity
through
increased
BDNF
PSD-95
expression.
Moreover,
modulated
gut
microbiota
composition,
particularly
enriching
beneficial
species
like
Bifidobacterium
pseudolongum
Ligilactobacillus
murinus,
regulated
metabolites
associated
with
tryptophan
metabolism,
neurotransmitter
synthesis,
oxidative
These
findings
demonstrate
that
exerts
its
via
multitargeted
approach
involving
gut-brain
axis,
modulation,
enhancement.
highlights
promising
therapeutic
candidate
for
depression,
emphasizing
potential
to
address
central
peripheral
mechanisms.
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
16
Published: May 6, 2025
The
emergence
of
the
microbiota-gut-brain
axis
has
opened
new
avenues
for
improving
sleep
quality.
Recent
studies
have
revealed
a
close
relationship
between
insomnia
and
gut
microbiome.
Chinese
herbal
medicines
their
active
components
can
alter
relative
abundance
sleep-related
microbiota
by
reversing
dysbiosis
in
Improving
quality
through
regulation
using
medicine
its
become
highly
promising
therapeutic
strategy.
This
article
elucidates
how
modulates
via
intricate
communication
network
gut-brain
axis.
It
also
reviews
latest
research
on
utilizing
to
regulate
enhancing
Additionally,
it
provides
insights
into
potential
modulation
microbiota.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: May 28, 2024
Abstract
Multi-generational
asexual
reproduction
of
Gastrodia
elata
Bl.
will
cause
seedling
species
degeneration.
Sexual
seed
is
an
effective
method
to
solve
the
problem
The
development
seeds
cannot
be
separated
from
germination
fungus.
However,
there
are
few
strains
fungus
in
production,
and
also
degradation
application
for
many
years.
It
very
important
sexual
isolate
more
new
excellent
origin.
This
study
used
f.
glauca
S.
chow
vegetative
propagation
corms
capture
its
symbiotic
fungus,
comprehensively
identified
by
colony
morphology,
ITS,
sporocarps
regeneration
function,
compared
growth
characteristics
ability
with
other
(
Mycena
purpureofusca
,
dendrobii
osmundicola
).
was
isolated
named
GYGL-1.
After
comprehensive
identification,
GYGL-1
Mycetinis
scorodonius
.
Compared
has
fast
speed,
vigorous
growth,
high
seeds.
Innovated
isolation
obtained
regenerated
discovered
that
a
function
germinating
seeds,
enriching
resource
library
Critical Reviews in Analytical Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 30
Published: Sept. 27, 2024
Bl.
still
widely
known
as
a
medicinal
plant
due
to
its
anti-inflammatory,
neuroprotection,
cardiovascular
protection
etc.
Additionally,
these
medical
applications
cannot
be
separated
from
antioxidant,
anti-aging,
regulating
cell
apoptosis
ability,
which
make
it
have
potential
functional
food
well
has
been
eaten
for
more
than
2,000
years
in
China.
At
present,
although
Journal of Agricultural and Food Chemistry,
Journal Year:
2024,
Volume and Issue:
72(43), P. 23875 - 23892
Published: Oct. 21, 2024
Obesity-related
cognitive
dysfunction
poses
a
significant
threat
to
public
health.
The
present
study
demonstrated
mitigating
effects
of
intermittent
fasting
(IF)
and
its
combination
with
isomalto-oligosaccharides
IF
(IF
+
IMO)
on
impairments
induced
by
high-fat-high-fructose
(HFHF)
diet
in
mice,
IMO
exhibiting
superior
effects.
Transcriptomic
analysis
the
hippocampus
revealed
that
protective
cognition
might
be
attributed
suppression
toll-like
receptor
4
(TLR4)/NFκB
signaling,
oxidative
phosphorylation,
neuroinflammation.
Moreover,
both
modulated
gut
microbiome
promoted
production
short-chain
fatty
acids,
displaying
more
pronounced
IMO-modulated
microbiota,
metabolites,
molecular
targets
associated
were
further
corroborated
using
human
data
from
databases
Gmrepo
gutMgene.
Furthermore,
fecal
transplantation
confirmed
direct
impacts
IMO-derived
microbiota
improving
functions
suppressing
TLR4/NFκB
signaling
increasing
BDNF
levels.
Notably,
prior
exposure
prevented
weight-regain-induced
decline,
suppressed
inflammatory
cytokines
hippocampus,
mitigated
weight
regain-caused
dysbacteriosis
without
altering
body
weight.
Our
underscores
IMO-augmented
alleviating
obesity-related
impairment
particularly
during
weight-loss
weight-regain
periods,
presenting
novel
nutritional
strategy
tackle
neurodegenerative
disorders.
