Iron homeostasis and ferroptosis in human diseases: mechanisms and therapeutic prospects

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Oct. 14, 2024

Iron, an essential mineral in the body, is involved numerous physiological processes, making maintenance of iron homeostasis crucial for overall health. Both overload and deficiency can cause various disorders human diseases. Ferroptosis, a form cell death dependent on iron, characterized by extensive peroxidation lipids. Unlike other kinds classical unprogrammed death, ferroptosis primarily linked to disruptions metabolism, lipid peroxidation, antioxidant system imbalance. Ferroptosis regulated through transcription, translation, post-translational modifications, which affect cellular sensitivity ferroptosis. Over past decade or so, diseases have been as part their etiology, including cancers, metabolic disorders, autoimmune diseases, central nervous cardiovascular musculoskeletal Ferroptosis-related proteins become attractive targets many major that are currently incurable, some regulators shown therapeutic effects clinical trials although further validation potential needed. Therefore, in-depth analysis its molecular mechanisms may offer additional strategies prevention treatment. In this review, we discuss significance contribution etiology development along with evidence supporting targeting approach. Importantly, evaluate recent promising interventions, providing guidance future targeted treatment therapies against

Language: Английский

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Cynaroside improved depressive-like behavior in CUMS mice by suppressing microglial inflammation and ferroptosis

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 173, P. 116425 - 116425

Published: March 14, 2024

Depression is a common mental health disorder, and in recent years, the incidence of various forms depression has been on rise. Most medications for are highly dependency-inducing can lead to relapse upon discontinuation. Therefore, novel treatment modalities therapeutic targets urgently required. Traditional Chinese medicine (TCM) offers advantages owing its multi-target, multi-dimensional approach that addresses root cause by regulating organ functions balancing Yin Yang, with minimal side effects. Cynaroside (CNS), an extract from traditional herb honeysuckle, flavonoid compound antioxidant properties. In this study, network pharmacology identified 44 potential CNS associated several correlated inflammatory signaling pathways. alleviated LPS-induced M1 polarization release factors BV-2 cells. Transcriptomic analysis validation revealed reduced polarization, lipid peroxidation, ferroptosis via IRF1/SLC7A11/GPX4 pathway. vivo experiments showed had effects similar those fluoxetine (FLX). It effectively ameliorated anxiety-, despair-, anhedonia-like states chronic unpredictable mild stress (CUMS)-induced mice microglial activation hippocampus. Thus, we conclude exerts effect inhibiting cells polarizing into phenotype reducing inflammation levels. This study provides further evidence antidepressant, offering new avenues depression.

Language: Английский

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The Interplay between Ferroptosis and Neuroinflammation in Central Neurological Disorders

Antioxidants, Journal Year: 2024, Volume and Issue: 13(4), P. 395 - 395

Published: March 26, 2024

Central neurological disorders are significant contributors to morbidity, mortality, and long-term disability globally in modern society. These encompass neurodegenerative diseases, ischemic brain traumatic injury, epilepsy, depression, more. The involved pathogenesis is notably intricate diverse. Ferroptosis neuroinflammation play pivotal roles elucidating the causes of cognitive impairment stemming from these diseases. Given concurrent occurrence ferroptosis due metabolic shifts such as iron ROS, well their critical central nervous disorders, investigation into co-regulatory mechanism has emerged a prominent area research. This paper delves mechanisms along with interrelationship. It specifically emphasizes core molecules within shared pathways governing neuroinflammation, including SIRT1, Nrf2, NF-κB, Cox-2, iNOS/NO·, how different immune cells structures contribute dysfunction through mechanisms. Researchers’ findings suggest that mutually promote each other may represent key factors progression disorders. A deeper comprehension common pathway between cellular holds promise for improving symptoms prognosis related

Language: Английский

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Stress, pain, anxiety, and depression in endometriosis–Targeting glial activation and inflammation

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 132, P. 111942 - 111942

Published: April 2, 2024

Language: Английский

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The therapeutic effects of saikosaponins on depression through the modulation of neuroplasticity: From molecular mechanisms to potential clinical applications

Pharmacological Research, Journal Year: 2024, Volume and Issue: 201, P. 107090 - 107090

Published: Feb. 2, 2024

Depression is a major global health issue that urgently requires innovative and precise treatment options. In this context, saikosaponin has emerged as promising candidate, offering variety of therapeutic benefits may be effective in combating depression. This review delves into the multifaceted potential saikosaponins alleviating depressive symptoms. We summarized effects on structural functional neuroplasticity, elaborated regulatory mechanism modulating key factors affect such inflammation, hypothalamic-pituitary-adrenal (HPA) axis, oxidative stress, brain-gut axis. Moreover, paper highlights existing gaps current researches outlines directions for future studies. A detailed plan provided clinical application saikosaponins, advocating more targeted to speed up its transition from preclinical trials practice.

Language: Английский

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Ferroptosis: a new antidepressant pharmacological mechanism

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 8, 2024

The incidence rate of depression, a mental disorder, is steadily increasing and has the potential to become major global disability factor. Given complex pathological mechanisms involved in use conventional antidepressants may lead severe complications due their side effects. Hence, there critical need explore development novel antidepressants. Ferroptosis, newly recognized form cell death, been found be closely linked onset depression. Several studies have indicated that certain active ingredients can ameliorate depression by modulating ferroptosis signaling pathway. Notably, traditional Chinese medicine (TCM) TCM prescriptions demonstrated promising antidepressant effects previous investigations owing unique advantages therapy. Building upon these findings, our objective was review recent relevant research provide new insights directions for application innovative strategies.

Language: Английский

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Arginine Methylation of β-Catenin Induced by PRMT2 Aggravates LPS-Induced Cognitive Dysfunction and Depression-Like Behaviors by Promoting Ferroptosis

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: 61(10), P. 7796 - 7813

Published: March 2, 2024

Language: Английский

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Lycopene alleviates chronic stress-induced hippocampal microglia ferroptosis by inhibiting the ASK1/JNK signaling pathway

Food Bioscience, Journal Year: 2025, Volume and Issue: 64, P. 105859 - 105859

Published: Jan. 7, 2025

Language: Английский

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The Interplay Between Endoplasmic Reticulum Stress and Ferroptosis in Neurological Diseases

Neurochemical Research, Journal Year: 2025, Volume and Issue: 50(2)

Published: Feb. 10, 2025

Language: Английский

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Hippocampal GPR35 is involved in the depression-like behaviors induced by inflammation and mediates the antidepressant effects of fluoxetine in mice

Brain Behavior and Immunity, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

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