Alginate/chitosan-based hemostatic microspheres loaded with doxorubicin liposomes for postoperative local drug delivery in solid tumor DOI
Xin Chen,

Fulin Luo,

Mengting Yuan

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 282, P. 137090 - 137090

Published: Oct. 31, 2024

Language: Английский

Polysaccharides from Lonicera japonica Thunb.: Extraction, purification, structural features and biological activities—A review DOI
Shiyong Gao,

Y. Shan,

Yue Wang

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 281, P. 136472 - 136472

Published: Oct. 15, 2024

Language: Английский

Citations

26
Unveiling polysaccharides of Houttuynia cordata Thunb.: Extraction, purification, structure, bioactivities, and structure–activity relationships DOI
Shiyong Gao,

Weiya Wang,

Jianwen Li

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156436 - 156436

Published: Jan. 1, 2025

Language: Английский

Citations

4
Rabdosia rubescens (Hemsl.) H. Hara: A Potent Anti-Tumor Herbal Remedy - Botany, Phytochemistry, and Clinical Breakthroughs DOI
Shiyong Gao,

Li JianWen,

Weiya Wang

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 340, P. 119200 - 119200

Published: Dec. 3, 2024

Language: Английский

Citations

11
A highly sensitive electrochemical sensing platform to detect rutin in pharmaceutical and serum samples DOI
Rui Liu, Xin Zhang,

Rijia Liu

et al.

Microchemical Journal, Journal Year: 2024, Volume and Issue: 201, P. 110646 - 110646

Published: April 28, 2024

Language: Английский

Citations

8
Maackiain induces apoptosis and autophagy via ROS-mediated endoplasmic reticulum stress in endometrial cancer DOI
Yijuan Xing, Xiao Lv, Xi Chen

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 147, P. 113935 - 113935

Published: Jan. 5, 2025

Language: Английский

Citations

1
Artificial intelligence-driven identification and mechanistic exploration of synergistic anti-breast cancer compound combinations from Prunella vulgaris L.-Taraxacum mongolicum Hand.-Mazz. herb pair DOI Creative Commons
Chunlai Feng,

Jiaxi Cheng,

Mengqiu Sun

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 7, 2025

The Prunella vulgaris L. (PVL) and Taraxacum mongolicum Hand.-Mazz. (TH) herb pair, which is commonly used in traditional Chinese medicine (TCM), has been applied for the treatment of breast cancer. Although its efficacy validated, synergistic anti-breast cancer compound combinations within this pair their underlying mechanisms action remain unclear. This study aimed to identify validate PVL-TH using large-scale biomedical data, artificial intelligence experimental methods. first step was investigate effects various PVL TH extracts vitro cellular assays most effective superior extracts. These were subjected liquid chromatography-mass spectrometry (LC-MS) analysis constituent compounds. A deep learning-based prediction model, DeepMDS, predict multi-compound combinations. predicted experimentally validated at actual content ratios found Preliminary bioinformatics analyses conducted explore these We also compared from different geographical origins analyzed contents compounds assess representation anti-tumor effect corresponding TCM. results revealed that LC-MS identified 27 21 (50% ethanol extracts) TH, respectively. Based on compounds, DeepMDS model such as F973 (caffeic acid, rosmarinic p-coumaric esculetin), T271 (chlorogenic cichoric caffeic acid), T1685 scopoletin) single PVL, combinations, concentrations extracts, demonstrated activity could regulate tumor-related pathways synergistically, inhibiting tumor cell growth, inducing apoptosis, blocking cycle progression. Furthermore, concentration ratio total closely associated with origins. combination represent pair. provides insights into exploring representative complex

Language: Английский

Citations

1
A bioactive fraction from the leaves of Ceiba pentandra (L.) Gaertn. exhibits antiproliferative activity via cell cycle arrest at the G1/S checkpoint and initiation of apoptosis via poly [ADP-ribose] polymerase 1 (PARP1) cleavage in HeLa cells. DOI
Bright Selorm Addy, Caleb Kesse Firempong, Gustav Komlaga

et al.

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119363 - 119363

Published: Jan. 1, 2025

Language: Английский

Citations

1
Regulation of 5-fluorouracil-induced intestinal damage by the interleukin-23/interleukin-22 axis in chemotherapy DOI

Yunning Han,

Jingping Xu,

Yuxuan Zhang

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 147, P. 114044 - 114044

Published: Jan. 9, 2025

Language: Английский

Citations

0
Pseudostellaria heterophylla (Miq.) Pax, a Traditional Folk Medicine, Ameliorates Colorectal Cancer by Remodeling the Tumor Immune Microenvironment DOI
Gui Yang, Hui Wu, Heng Fan

et al.

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: 342, P. 119362 - 119362

Published: Jan. 17, 2025

Language: Английский

Citations

0
Hepato-specific activity of Andrographolide, a major constituent of Andrographis paniculata (Burm. f.) Wall. ex Nees for targeting liver diseases DOI

Kallol Roy,

Pankaj Barman, Saikat Haldar

et al.

Pharmacological Research - Natural Products, Journal Year: 2025, Volume and Issue: 6, P. 100155 - 100155

Published: Jan. 31, 2025

Language: Английский

Citations

0