Exploring the Functional Mechanism of Action of Sanxiankaixin Powder in Preventing and Treating Reproductive Aging Based on Network Pharmacology and Molecular Docking DOI
Zhiming Liu, Zhong Li, Yuan Sun

et al.

Integrative Medicine in Nephrology and Andrology, Journal Year: 2024, Volume and Issue: 11(4)

Published: Dec. 1, 2024

Background: To explore the functional mechanism of Sanxiankaixin powder (SXKXP) in preventing and treating reproductive aging (RA) through network pharmacology molecular docking technology. Methods: The traditional Chinese medicine systems database analysis platform was utilized to identify major active components SXKXP. SwissTargetPrediction algorithm used potential SXKXP targets for RA prevention treatment. GeneCards OMIM were disease targets, whereas Venny 2.1.0 find common targets. Protein-protein interaction conducted with STRING, diagrams created Cytoscape. We performed a gene ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) pathway enrichment using DAVID database. compound-drug–component-core target-KEGG networks Cytoscape software. Finally, we PubChem, UniProt, PDB, PyMoL, AutoDock software docking. Results: It found that 93 effective directly acted on 56 core prevent treat multiple pathways, among which kaempferol, luteolin, 8-Prenylkaempferol, quercetin, Schisandrol B components, AKT1, estrogen receptor 1 (ESR1), glyceraldehyde-3-phosphate dehydrogenase (GAPDH), tumor necrosis factor (TNF), interleukin 6 (IL-6) important results GO showed apoptosis, cell proliferation, plasma membrane, ATP binding may be closely related RA. KEGG suggested AGE-RAGE signaling diabetic complications PI3K-Akt play roles. Molecular well bound Conclusion: interferes biological processes such as oxidation inflammatory reactions pathways This study provides research direction theoretical basis experimental

Language: Английский

Application of Network Pharmacology in the Treatment of Neurodegenerative Diseases with Traditional Chinese Medicine DOI Creative Commons
Qiang Chen, Guanghui Chen,

Qianyan Wang

et al.

Planta Medica, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 8, 2025

In recent years, the incidence of neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s Huntington’s and amyotrophic lateral sclerosis, has shown a steadily rising trend, which posed major challenge to global public health. Traditional Chinese Medicine (TCM), with its multi-component multi-target characteristics, offers promising approach for treatment diseases. However, it is difficult comprehensively elucidate complex mechanisms underlying TCM formulations. As an emerging systems biology approach, network pharmacology provided crucial tool uncovering through high-throughput technologies, molecular docking, analysis. This paper reviews advancements in application treating diseases TCM, analyzes current status relevant databases technological methods, discusses limitations research, proposes future directions promote modernization development precision medicine. Keywords: Neurodegenerative Medicine, Network pharmacology, Therapeutic targets

Language: Английский

Citations

0
Chemical Profiling and Quality Evaluation of Gualou‐Xiebai Herbal Pair by Liquid Chromatography‐Tandem Mass Spectrometry With Feature‐Based Molecular Network and High‐Performance Liquid Chromatography With Charged Aerosol Detector DOI
Lu Zhang, Xiaoqing Cai,

Yongzhe Cheng

et al.

Journal of Separation Science, Journal Year: 2025, Volume and Issue: 48(3)

Published: Feb. 28, 2025

ABSTRACT Gualou‐Xiebai (GX), a traditional Chinese herbal pair, is often used in the treatment of cardiovascular diseases. However, investigation into components GX not comprehensive enough. In order to obtain chemical profile GX, method that combined mass spectrometry with feature‐based molecular network was utilized for identification its complex constituents. total, 121 compounds were annotated and four potential new inferred. addition, an optimized fingerprint analysis using high‐performance liquid chromatography coupled charged aerosol detector established, which further validated implemented simultaneous quantification 17 ingredients including semi‐quantitative 13 allium saponins quantitative fatty acids. This achieved detection no ultraviolet absorption constituents GX. The results have important impact on revealing basis lay foundation quality assessment.

Language: Английский

Citations

0
Crosstalk between lipid metabolism and macrophages in atherosclerosis: therapeutic potential of natural products DOI Creative Commons

Taoming Qian,

Dong Guo, Lu Sun

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 12

Published: March 3, 2025

Atherosclerosis is a highly prevalent cardiovascular condition that affects individuals worldwide. Despite ongoing research into its treatment and prevention, atherosclerotic disease continues to exhibit high morbidity mortality rates. The accumulation of low-density lipoprotein cholesterol considered major contributor the development atherosclerosis, with abnormalities in lipid metabolism playing significant role pathogenesis. Lipid macrophage function are intricately interconnected, being influenced by inflammatory responses, while activity regulated alterations metabolism. interaction between these two processes plays critical progression atherosclerosis. Natural products have shown considerable promise treating variety diseases, including Moreover, modulation crosstalk represents key mechanism through which natural may exert their effects. This aims provide new insights current state on regulating this pathway interplay macrophages context offering potential directions for future.

Language: Английский

Citations

0
Ginsenoside Rg1 targets TLR2 to inhibit the NF-κB signaling pathway and ameliorate hematopoietic support of mesenchymal stromal cells DOI
Wei Han, Yonggang Liu,

Caihong Huang

et al.

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119917 - 119917

Published: May 1, 2025

Language: Английский

Citations

0
Exploring the pharmacological mechanisms of the flower of Rhododendron molle in rheumatoid arthritis rats based on metabolomics integrated network pharmacology DOI
Xiaohong Guo, Wenhui Wu,

Qiang Ran

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 334, P. 118524 - 118524

Published: July 5, 2024

Language: Английский

Citations

2
Qingre Huoxue Decoction Alleviates Atherosclerosis by Regulating Macrophage Polarization Through Exosomal miR-26a-5p DOI Creative Commons
Weifeng He, Huanyi Zhao, Weiqi Xue

et al.

Drug Design Development and Therapy, Journal Year: 2024, Volume and Issue: Volume 18, P. 6389 - 6411

Published: Dec. 1, 2024

Qingre Huoxue Decoction (QRHX) is a classical Chinese herbal prescription widely used in clinical practice for the treatment of atherosclerosis (AS). Our previous study demonstrated its efficacy stabilizing plaque and improving prognosis, as well ability to regulate macrophage polarization. This aimed further investigate effects QRHX on AS explore underlying mechanisms.

Language: Английский

Citations

1
Citrus extraction provides neuroprotective effect in optic nerve crush injury mice through P53 signaling pathway DOI Creative Commons
Changming Yang, Jie Chen,

Yinjia He

et al.

Journal of Functional Foods, Journal Year: 2024, Volume and Issue: 122, P. 106517 - 106517

Published: Oct. 17, 2024

Language: Английский

Citations

0
Exploring the Functional Mechanism of Action of Sanxiankaixin Powder in Preventing and Treating Reproductive Aging Based on Network Pharmacology and Molecular Docking DOI
Zhiming Liu, Zhong Li, Yuan Sun

et al.

Integrative Medicine in Nephrology and Andrology, Journal Year: 2024, Volume and Issue: 11(4)

Published: Dec. 1, 2024

Background: To explore the functional mechanism of Sanxiankaixin powder (SXKXP) in preventing and treating reproductive aging (RA) through network pharmacology molecular docking technology. Methods: The traditional Chinese medicine systems database analysis platform was utilized to identify major active components SXKXP. SwissTargetPrediction algorithm used potential SXKXP targets for RA prevention treatment. GeneCards OMIM were disease targets, whereas Venny 2.1.0 find common targets. Protein-protein interaction conducted with STRING, diagrams created Cytoscape. We performed a gene ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) pathway enrichment using DAVID database. compound-drug–component-core target-KEGG networks Cytoscape software. Finally, we PubChem, UniProt, PDB, PyMoL, AutoDock software docking. Results: It found that 93 effective directly acted on 56 core prevent treat multiple pathways, among which kaempferol, luteolin, 8-Prenylkaempferol, quercetin, Schisandrol B components, AKT1, estrogen receptor 1 (ESR1), glyceraldehyde-3-phosphate dehydrogenase (GAPDH), tumor necrosis factor (TNF), interleukin 6 (IL-6) important results GO showed apoptosis, cell proliferation, plasma membrane, ATP binding may be closely related RA. KEGG suggested AGE-RAGE signaling diabetic complications PI3K-Akt play roles. Molecular well bound Conclusion: interferes biological processes such as oxidation inflammatory reactions pathways This study provides research direction theoretical basis experimental

Language: Английский

Citations

0