Frontiers in Medicine,
Journal Year:
2024,
Volume and Issue:
11
Published: Aug. 29, 2024
Remarkable
progress
has
been
achieved
in
sepsis
treatment
recent
times,
the
mortality
rate
of
experienced
a
gradual
decline
as
result
prompt
administration
antibiotics,
fluid
resuscitation,
and
implementation
various
therapies
aimed
at
supporting
multiple
organ
functions.
However,
there
is
still
significant
room
for
improvement.
The
septic
patients,
22.5%,
unacceptably
high,
accounting
19.7%
all
global
deaths.
Therefore,
it
crucial
to
thoroughly
comprehend
pathogenesis
order
enhance
clinical
diagnosis
methods.
Here,
we
summarized
classic
mechanisms
progression,
activation
signal
pathways,
mitochondrial
quality
control,
imbalance
pro-and
anti-
inflammation
response,
diseminated
intravascular
coagulation
(DIC),
cell
death,
presented
latest
research
findings
each
mechanism
identify
potential
therapeutic
targets
within
mechanism.
Journal of Ginseng Research,
Journal Year:
2022,
Volume and Issue:
47(2), P. 169 - 172
Published: Aug. 11, 2022
The
coronavirus
disease
2019
(COVID)
pandemic
began
in
December
2019.
Many
countries
have
implemented
restrictions
such
as
mandatory
mask
wearing
and
social
distancing.
These
measures
caused
diverse
complex
health
problems,
particularly
women's
health,
anxiety,
depression.
This
review
examines
an
alternative
approach
to
the
treatment
of
endometriosis
during
COVID
pandemic.
efficacy
ginseng
with
anti-inflammatory
activity
ability
relieve
or
prevent
symptoms
is
discussed
reviewed.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(24), P. 5900 - 5900
Published: Dec. 13, 2024
Quercetin
is
a
natural
polyphenolic
flavonoid
widely
found
in
plants,
fruits,
and
vegetables,
has
been
reported
to
play
pharmacological
roles
numerous
pathogenic
conditions.
The
anti-inflammatory
effects
of
quercetin
various
inflammatory
conditions
diseases
have
well-documented.
However,
its
regulatory
role
noncanonical
inflammasome
activation
not
yet
demonstrated.
This
study
investigated
the
caspase-11
inflammasome-activated
responses
macrophages
mouse
model
acute
lethal
sepsis.
protected
J774A.1
from
lipopolysaccharide
(LPS)-induced
cell
death
inflammasome-induced
pyroptosis.
It
significantly
decreased
production
mRNA
expression
pro-inflammatory
cytokines,
such
as
interleukin
(IL)-1β,
IL-18,
IL-6,
but
tumor
necrosis
factor
(TNF)-α,
molecules,
nitric
oxide
(NO)
inducible
NO
synthase
cells.
Mechanistically,
strongly
suppressed
autoproteolysis
secretion
proteolysis
gasdermin
D
did
inhibit
direct
binding
LPS.
In
vivo,
revealed
that
increased
survival
rate
mice
with
sepsis
serum
levels
cytokines
without
causing
significant
toxicity.
conclusion,
this
highlights
quercetin-mediated
action
through
novel
mechanism
targets
macrophages,
suggesting
promising
agent
medicine.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
26(1), P. 27 - 27
Published: Dec. 24, 2024
The
inflammatory
response
consists
of
two
stages:
priming
and
triggering.
triggering
stage
is
marked
by
the
activation
inflammasomes,
which
are
cytosolic
protein
complexes
acting
as
platforms
for
inflammation.
Inflammasomes
divided
into
canonical
noncanonical
categories.
Inflammatory
lung
diseases
such
asthma,
chronic
obstructive
pulmonary
disease
(COPD),
acute
respiratory
distress
syndrome
(ARDS),
injury,
fibrosis
arise
from
inflammation
damage.
While
role
inflammasomes
in
these
well
demonstrated,
recent
findings
emphasize
critical
roles
regulating
various
conditions.
Particularly,
new
studies
highlight
their
involvement
diseases.
This
review
delves
research
on
regulatory
human
caspase-4
murine
caspase-11,
development
diseases,
potential
targeting
treatments.
Journal of Ginseng Research,
Journal Year:
2023,
Volume and Issue:
47(5), P. 638 - 644
Published: April 14, 2023
The
anti-platelet
activity
of
the
saponin
fraction
Korean
Red
Ginseng
has
been
widely
studied.
consists
panaxadiol
(PDF)
and
panaxatriol
(PTF);
however,
their
is
yet
to
be
compared.
Our
study
aimed
investigate
potency
PDF
PTF
elucidate
how
well
they
retain
via
different
administration
routes.
For
ex
vivo
studies,
Sprague-Dawley
rats
were
orally
administered
250
mg/kg
for
7
consecutive
days
before
blood
collection
cardiac
puncture.
Platelet
aggregation
was
conducted
after
isolation
washed
platelets.
in
vitro
platelets
obtained
from
rats.
Collagen
adenosine
diphosphate
(ADP)
used
induce
platelet
aggregation.
as
an
agonist
assaying
triphosphate
release,
thromboxane
B2,
serotonin,
cyclic
monophosphate,
guanosine
monophosphate
(cGMP)
release.
When
treated
vivo,
not
only
inhibited
ADP
collagen-induced
aggregation,
but
also
upregulated
cGMP
levels
reduced
adhesion
fibronectin.
Furthermore,
it
Akt
phosphorylation
induced
by
collagen
treatment.
Panaxadiol
did
exert
any
vitro,
whereas
exhibited
potent
activity,
inhibiting
ADP,
collagen,
thrombin-induced
significantly
elevated
cGMP.
showed
that
treatments
levels,
indicating
possible
metabolic
conversions
ginsenosides,
which
altered
content
ginsenosides
capable
preventing
Frontiers in Medicine,
Journal Year:
2024,
Volume and Issue:
11
Published: Aug. 29, 2024
Remarkable
progress
has
been
achieved
in
sepsis
treatment
recent
times,
the
mortality
rate
of
experienced
a
gradual
decline
as
result
prompt
administration
antibiotics,
fluid
resuscitation,
and
implementation
various
therapies
aimed
at
supporting
multiple
organ
functions.
However,
there
is
still
significant
room
for
improvement.
The
septic
patients,
22.5%,
unacceptably
high,
accounting
19.7%
all
global
deaths.
Therefore,
it
crucial
to
thoroughly
comprehend
pathogenesis
order
enhance
clinical
diagnosis
methods.
Here,
we
summarized
classic
mechanisms
progression,
activation
signal
pathways,
mitochondrial
quality
control,
imbalance
pro-and
anti-
inflammation
response,
diseminated
intravascular
coagulation
(DIC),
cell
death,
presented
latest
research
findings
each
mechanism
identify
potential
therapeutic
targets
within
mechanism.
