Exploring the therapeutic implications of natural compounds modulating apoptosis in vascular dementia DOI
Guangcheng Zhong,

Xinyue Wang,

Qian Zhang

et al.

Phytotherapy Research, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 2, 2024

Abstract Vascular dementia (VaD) is a prevalent form of stemming from cerebrovascular disease, manifesting in memory impairment and executive dysfunction, thereby imposing substantial societal burden. Unfortunately, no drugs have been approved for the treatment VaD due to its intricate pathogenesis, development innovative efficacious medications urgently needed. Apoptosis, programmed cell death process crucial eliminating damaged or unwanted cells within an organism, assumes pivotal roles embryonic tissue homeostasis maintenance. An increasing body evidence indicates that apoptosis may significantly influence onset progression VaD, numerous natural compounds demonstrated significant therapeutic potential. Here, we discuss molecular mechanisms underlying correlation with VaD. We also provide reference developing pharmaceuticals by systematically reviewing latest research progress concerning neuroprotective effects on regulating apoptosis. Further high‐quality clinical studies are imperative firmly ascertain these compounds' efficacy safety profiles

Language: Английский

Ginsenoside Rg2, a principal effective ingredient of Panax ginseng, attenuates DSS-induced ulcerative colitis through NF-κB/NLRP3 pathway DOI Creative Commons
Ji Zhang, Jing Xie,

Zhiqiang Niu

et al.

Journal of Ginseng Research, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

2
CircHIPK3 targets DRP1 to mediate hydrogen peroxide-induced necroptosis of vascular smooth muscle cells and atherosclerotic vulnerable plaque formation DOI Creative Commons
Xiaolu Li, Yanyan Yang, Zhibin Wang

et al.

Journal of Advanced Research, Journal Year: 2024, Volume and Issue: unknown

Published: April 1, 2024

Necroptosis triggered by H2O2 is hypothesized to be a critical factor in the rupture of atherosclerotic plaques, which may precipitate acute cardiovascular events. Nevertheless, specific regulatory molecules this development remain unclear. We aims elucidate mechanism from perspective circular RNA. There are few studies on circRNA VSMCs necroptosis. The objective our research shed light intricate roles that circHIPK3 plays process necroptosis and plaques prone rupture. Our study elucidates molecular mechanisms regulates vulnerable plaque formation through targeted proteins. Identifying at cellular level offers framework for understanding progression stability regulation, as well potential biomarker prognosis susceptible plaques. collected clinical vascular tissue HE staining Masson determine presence Then, NCBI database was used screen out with elevated expression tissue, up-regulated circRNA, circHIPK3, verified qRT-PCR FISH. Further, we synthesized circHIPK3′s small interference sequence overexpressed plasmid vitro, its regulation effect under physiological pathological conditions WB, PI staining. Through RNA pull down, mass spectrometry immunoprecipitation, DRP1 identified binding protein positively regulated circHIPK3. Meanwhile, basis silencing DRP1, mediated DRP1. Finally, validated ApoE-/- mice. investigated highly expressed increase promoted induced VSMCs. CircHIPK3 leading an elevation mitochondrial division rate, resulting increased reactive oxygen species impaired function, ultimately formation. interact involve Mitochondrial damage VSMCs, Silencing vivo can reduce findings have applications providing diagnostic biomarkers

Language: Английский

Citations

9
Advancements in enzymatic biotransformation and bioactivities of rare ginsenosides：A Review DOI

Hu Yanbo,

Yiming Li,

Yi Cao

et al.

Journal of Biotechnology, Journal Year: 2024, Volume and Issue: 392, P. 78 - 89

Published: June 28, 2024

Language: Английский

Citations

9
piRNA-823 is a novel potential therapeutic target in aortic dissection DOI Creative Commons
Min Li, Gang Li, Yanyan Yang

et al.

Pharmacological Research, Journal Year: 2023, Volume and Issue: 196, P. 106932 - 106932

Published: Sept. 20, 2023

Aortic dissection (AD) presents a medical challenge for clinicians. Here, to determine the role of novel small non-coding piRNA-823 (piR-823) in AD, murine and human aorta from patients with AD were used. A high expression levels piR-823 found AD. Using performed loss- gain-of-function assays vitro vivo, we explore regulatory effect on vascular smooth muscle cells (VSMCs) obviously facilitates proliferation, migration, phenotypic transformation VSMCs or without nicotine treatment. directly binds suppresses histone deacetylase 1 (HDAC1) expression, regulates acetylation 3 (H3) via H3K9ac H3K27ac, eventually, VSMC functions To consolidate our findings, model was performed, observed that antagomir strongly inhibited pathogenesis through regulating remodeling. Thus, study finds potential target prevention treatment strategy nicotine-induced

Language: Английский

Citations

20
Ginsenosides retard atherogenesis via remodelling host–microbiome metabolic homeostasis DOI
Yun Wang, Jiawei Wu,

Yu Hong

et al.

British Journal of Pharmacology, Journal Year: 2024, Volume and Issue: 181(12), P. 1768 - 1792

Published: Feb. 14, 2024

Abstract Background and Purpose Panax ginseng is widely applied in the adjuvant treatment of cardiometabolic diseases clinical practice without clear mechanisms. This study aims to clearly define efficacy underlying mechanism P. its active components protecting against atherosclerosis. Experimental Approach The anti‐atherogenic total saponin extract (TGS) was evaluated on Ldlr −/− mice. Gut microbial structure analysed by 16S rRNA sequencing PCR. Bile acid profiles were revealed using targeted metabolomics with LC–MS/MS analysis. contribution gut microbiota atherosclerosis assessed co‐housing experiments. Key Results Ginsenoside Rb1, representing protopanaxadiol (PPD)‐type saponins, increased intestinal Lactobacillus abundance, resulting enhanced bile salt hydrolase (BSH) activity promote conjugated hydrolysis excretion, followed suppression enterohepatic farnesoid X receptor (FXR)–fibroblast growth factor 15 (FGF15) signal, thereby cholesterol 7α‐hydroxylase (CYP7A1) transcriptional expression facilitated metabolic elimination cholesterol. Synergistically, protopanaxatriol (PPT)‐type represented ginsenoside Rg1, protected atherogenesis‐triggered leak endotoxaemia. Rg1 directly induced mucin production nutritionally maintain Akkermansia muciniphila , which reciprocally inhibited permeation. Rb1/Rg1 combination, rather than a single compound, can largely mimic holistic TGS mice from atherogenesis. Conclusion Implications Our provides strong evidence supporting combinations as effective therapies atherogenesis, via targeting different signal nodes may provide some elucidation mode herbal medicines.

Language: Английский

Citations

7
Chinese Herbal Medicines for Coronary Heart Disease: Clinical Evidence, Pharmacological Mechanisms, and the Interaction with Gut Microbiota DOI
Linhai Cao, Hongxia Ni, Xiaoxiao Gong

et al.

Drugs, Journal Year: 2024, Volume and Issue: 84(2), P. 179 - 202

Published: Jan. 24, 2024

Language: Английский

Citations

6
CircTMEM165 facilitates endothelial repair by modulating mitochondrial fission via miR-192/SCP2 in vitro and in vivo DOI Creative Commons
Yan Liu, Yanyan Yang, Min Li

et al.

iScience, Journal Year: 2024, Volume and Issue: 27(4), P. 109502 - 109502

Published: March 16, 2024

Constitutive explorations indicate a correlation between circular RNAs (circRNAs) and cardiovascular diseases. However, the involvement of circRNAs in endothelial recuperation in-stent restenosis (ISR) remains underexplored. CircTMEM165 has first been reported to be highly expressed hypoxic human umbilical vein cells (HUVECs). Here, we identified that circTMEM165 was downregulated ISR patients, inversely correlating with severity. Functionally, found abundant cells, inhibiting inflammation, adhesion. Particularly, observed could alleviate HUVECs apoptosis mitochondrial fission induced by lipopolysaccharide (LPS). Mechanistically, circTMEM165, as miR-192-3p sponge, enhancing SCP2 expression, which serves critical regulator biological functions. Moreover,

Language: Английский

Citations

6
Saponins as therapeutic candidates for atherosclerosis DOI

Nuan Lv,

Luming Wang, Miao Zeng

et al.

Phytotherapy Research, Journal Year: 2024, Volume and Issue: 38(3), P. 1651 - 1680

Published: Feb. 1, 2024

Abstract Drug development for atherosclerosis, the underlying pathological state of ischemic cardiovascular diseases, has posed a longstanding challenge. Saponins, classified as steroid or triterpenoid glycosides, have shown promising therapeutic potential in treatment atherosclerosis. Through an exhaustive examination scientific literature spanning from May 2013 to 2023, we identified 82 references evaluating 37 types saponins terms their prospective impacts on These studies suggest that ameliorate atherosclerosis by regulating lipid metabolism, inhibiting inflammation, suppressing apoptosis, reducing oxidative stress, and modulating smooth muscle cell proliferation migration, well gut microbiota, autophagy, endothelial senescence, angiogenesis. Notably, ginsenosides exhibit significant manifest essential pharmacological attributes, including lipid‐lowering, anti‐inflammatory, anti‐apoptotic, anti‐oxidative stress effects. This review provides comprehensive attributes with particular emphasis role regulation metabolism anti‐inflammatory Thus, may warrant further investigation therapy However, due various reasons such low oral bioavailability, clinical application still needs exploration.

Language: Английский

Citations

5
A systemic review of ginseng and its activity on coronary heart disease DOI Creative Commons
Shivam Alpeshkumar Parmar, Vinyas Mayasa, Vinod K. Nelson

et al.

Pharmacological Research - Modern Chinese Medicine, Journal Year: 2024, Volume and Issue: 12, P. 100480 - 100480

Published: July 14, 2024

Coronary heart disease (CHD) is a leading cause of mortality and morbidity globally, highlighting the need for effective therapeutic strategies. This systematic review evaluates cardioprotective mechanisms ginseng its potential as complementary or adjunctive therapy in prevention management CHD. A literature search was conducted major databases (SCOPUS, PubMed, Google Scholar) following PRISMA guidelines to identify relevant preclinical clinical studies investigating ginseng's effects on CHD associated cardiovascular conditions. Studies reporting positive outcomes related properties active compounds were included analysis. Ginseng bioactive constituents, especially ginsenosides, exhibit diverse CHD, including vasodilation, hypotensive, antioxidant, anti-hyperlipidemic effects, anti- atherosclerotic, antithrombotic, anti-inflammatory various other molecular mechanism proven by that demonstrates can mitigates myocardial ischemia, improves cardiac contractility, regulates blood pressure, lipid profiles, thrombus formation glycemic control. represents promising natural due well-established safety profile targeting multiple pathways involved pathophysiology. Although, more robust evidence needed. Integrating into conventional treatment regimens, guided scientific research, could enhance improve patient outcomes.

Language: Английский

Citations

5
Everolimus-encapsulation in Pluronic P123 self-assembled micelles as drug delivery systems for drug-coated balloons DOI Creative Commons
Mohammad Akrami-Hasan-Kohal, Adrien Chouchou, Sébastien Blanquer

et al.

International Journal of Pharmaceutics X, Journal Year: 2024, Volume and Issue: 7, P. 100230 - 100230

Published: Jan. 10, 2024

Drug-coated balloons (DCBs) are effective tools for cardiovascular interventions, ensuring uniform drug delivery to occluded arteries. This research investigates the potential of Pluronic P123 (P123), a micelle-forming polymer, solubilize and release Everolimus (EVE) from DCBs. Furthermore, it seeks understand how ratio EVE affects rates micelle formation under physiological conditions. We tested three ratios: 90:10, 75:25, 50:50. Microscopy revealed that increasing proportions resulted in more coatings. Fourier-transform infrared spectroscopy (FTIR) analysis confirmed successful incorporation into matrix without altering its chemical properties. Differential scanning calorimetry (DSC) studies showed affected crystalline structure P123, leading In vitro all formulations had <1% loss first minute (the tracking phase); furthermore, 90:10 exhibited optimal following 3 min, corresponding deployment phase DCB angioplasty. Analysis loading capacity (LC), encapsulation efficiency (EE), size, indicated an increase both LC EE with higher content enlargement size. Given these findings, optimized formula provided consistent coating on commercial balloons, highlighting using release.

Language: Английский

Citations

3