Polystyrene nanoplastics trigger ferroptosis in Nrf2-deficient gut via ether phospholipid accumulation DOI Creative Commons

Boxuan Liang,

Xiyun Huang,

Zhiming Li

et al.

Environment International, Journal Year: 2025, Volume and Issue: 197, P. 109367 - 109367

Published: March 1, 2025

The widespread environmental presence of nanoplastics (NPs) raises significant concerns about their health impacts, particularly on the gastrointestinal system, as NPs are primarily ingested. While previous studies have linked NP-induced intestinal toxicity to oxidative stress and reactive oxygen species (ROS) accumulation, specific mechanisms cell death remain unclear. Here, we showed that environmentally relevant concentrations polystyrene (PS-NPs) induced ferroptosis, a form lipid peroxidation-driven death, in epithelial cells. Using epithelial-specific Nrf2-deficient mice (Nrf2fl/fl-VilCre+) human Caco-2 cells, demonstrated Nrf2, key regulator, play protective role against PS-NP-induced ferroptosis. PS-NP exposure disrupted ether phospholipid metabolism, leading accumulation polyunsaturated fatty acid-ether phospholipids heightened peroxidation intestines Nrf2fl/fl-VilCre+ mice. This increased susceptibility cells Additionally, high-fat diet further exacerbated this effect, suggesting individuals with reduced NRF2 activity poor dietary habits may be especially vulnerable damage. Our findings offered new insights into molecular underscored risks posed by exposure, populations compromised antioxidant defenses.

Language: Английский

Brain single-nucleus transcriptomics highlights that polystyrene nanoplastics potentially induce Parkinson’s disease-like neurodegeneration by causing energy metabolism disorders in mice DOI

Boxuan Liang,

Yuji Huang,

Yizhou Zhong

et al.

Journal of Hazardous Materials, Journal Year: 2022, Volume and Issue: 430, P. 128459 - 128459

Published: Feb. 11, 2022

Language: Английский

Citations

125
Polystyrene micro- and nano-particle coexposure injures fetal thalamus by inducing ROS-mediated cell apoptosis DOI Creative Commons
Diqi Yang,

Jiandi Zhu,

Xiaoshu Zhou

et al.

Environment International, Journal Year: 2022, Volume and Issue: 166, P. 107362 - 107362

Published: June 18, 2022

The adverse effects of plastic on adult animal and human health have been receiving increasing attention. However, its potential toxicity to fetuses has not fully elucidated. Herein, biodistribution polystyrene (PS) particles was determined after the maternal mice were orally given PS micro- and/or nano-particles with without surface modifications during gestational days 1 17. results showed that microplastics (MPs) nanoparticles (NPs) mainly emerged in alimentary tract, brain, uterus, placenta mice, only latter infiltrated into fetal thalamus. NPs carboxyl-modified induced differentially expressed genes enriched oxidative phosphorylation GABAergic synapse. Maternal administration gestation led anxiety-like behavior progenies their γ-aminobutyric acid (GABA) reduction prefrontal cortex amygdala at Week 8. N-Acetylcysteine (NAC), an antioxidant, alleviated particles-induced injury brain rescued progenies. Additionally, caused excessive ROS apoptosis neuronal cell lines, which prevented by glutathione supplementation. These suggested produced a negative effect inducing suppressing GABA synthesis brain. findings contribute estimating risk for health.

Language: Английский

Citations

122
Nanoplastic occurrence, transformation and toxicity: a review DOI

Thilakshani Atugoda,

Hansika Piyumali,

Hasintha Wijesekara

et al.

Environmental Chemistry Letters, Journal Year: 2022, Volume and Issue: 21(1), P. 363 - 381

Published: Aug. 28, 2022

Language: Английский

Citations

99
Nanoplastics are bioaccumulated in fish liver and muscle and cause DNA damage after a chronic exposure DOI Creative Commons
I. Brandts,

M. Cánovas,

Asta Tvarijonaviciute

et al.

Environmental Research, Journal Year: 2022, Volume and Issue: 212, P. 113433 - 113433

Published: May 14, 2022

The extent of the widespread, planetary contamination by plastic waste is difficult to fully capture. Nanoplastics (NPs) are currently in center research concerning litter, both for analytical challenges they pose and their potential provoke hazardous effects organisms. However, there still many unanswered questions this multidisciplinary field, with a crucial missing piece being quantification NPs fish tissues after vivo exposures. Another relevant question that greatly unexplored how chronic exposure will affect health. This study aims provide answers these knowledge gaps. To end, goldfish (Carassius auratus) were exposed 44 nm polystyrene (PS)-NPs via water 30 days. Following exposure, gastrointestinal tract, liver muscle sampled PS-NPs analysis means size exclusion chromatography coupled high resolution mass spectrometry. detected all samples fish, higher concentrations than muscle, whereas no tract. Nevertheless, did not induce changes hematology parameters nor cortisol glucose levels plasma. On other hand, even relatively low concentration was able cause DNA damage, measured an increase erythrocyte nuclear abnormalities, suggesting can reach cell nucleus genotoxicity. These results show first time find way where bioaccumulate, but do alter survival hematological or physiological stress indicators. accumulation represent threat human health as possible route small-sized plastics. present model species open windows future studies edible species.

Language: Английский

Citations

81
An overview of the effects of nanoplastics on marine organisms DOI
Muhammad Rozaimi Mohd Zaki, Ahmad Zaharin Aris

The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 831, P. 154757 - 154757

Published: March 24, 2022

Language: Английский

Citations

80
Trophic transfer of nanoplastics through a microalgae–crustacean–small yellow croaker food chain: Inhibition of digestive enzyme activity in fish DOI
Lia Kim, Rongxue Cui, Jin Il Kwak

et al.

Journal of Hazardous Materials, Journal Year: 2022, Volume and Issue: 440, P. 129715 - 129715

Published: Aug. 4, 2022

Language: Английский

Citations

72
Long‐Chain Acyl Carnitines Aggravate Polystyrene Nanoplastics‐Induced Atherosclerosis by Upregulating MARCO DOI Creative Commons
Bo Wang,

Boxuan Liang,

Yuji Huang

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 10(19)

Published: May 5, 2023

Abstract Exposure to micro‐ and nanoplastics (MNPs) is common because of their omnipresence in environment. Recent studies have revealed that MNPs may cause atherosclerosis, but the underlying mechanism remains unclear. To address this bottleneck, ApoE −/− mice are exposed 2.5–250 mg kg −1 polystyrene (PS‐NPs, 50 nm) by oral gavage with a high‐fat diet for 19 weeks. It found PS‐NPs blood aorta mouse exacerbate artery stiffness promote atherosclerotic plaque formation. activate phagocytosis M1‐macrophage aorta, manifesting as upregulation macrophage receptor collagenous structure (MARCO). Moreover, disrupt lipid metabolism increase long‐chain acyl carnitines (LCACs). LCAC accumulation attributed PS‐NP‐inhibited hepatic carnitine palmitoyltransferase 2. PS‐NPs, well LCACs alone, aggravate via upregulating MARCO oxidized low‐density lipoprotein‐activated foam cells. Finally, synergistic effects on increasing total cholesterol cells found. Overall, study indicates PS‐NP‐induced atherosclerosis MARCO. This offers new insight into mechanisms MNP‐induced cardiovascular toxicity, highlights combined endogenous metabolites system, which warrant further study.

Language: Английский

Citations

49
Nanoplastic Exposure at Environmental Concentrations Disrupts Hepatic Lipid Metabolism through Oxidative Stress Induction and Endoplasmic Reticulum Homeostasis Perturbation DOI
Weiyu Wang,

Xuan Mao,

Rui Zhang

et al.

Environmental Science & Technology, Journal Year: 2023, Volume and Issue: 57(38), P. 14127 - 14137

Published: Sept. 8, 2023

In this study, we investigated the mechanism underlying perturbation of hepatic lipid metabolism in response to micro/nanoplastic (MP/NP) exposure at environmentally relevant concentrations. Polystyrene (PS) MPs/NPs with different sizes (0.1, 0.5, and 5.0 μm) were studied for their effects on homeostasis function Nile tilapia (Oreochromis niloticus) liver. Results showed that PS readily internalized accumulated various internal organs/tissues, especially fish liver muscle. Smaller-sized NPs caused more severe toxicity than larger MPs, including steatosis, inflammatory response, disturbed function. Mechanistically, a particle size 100 nm perturbed protein endoplasmic reticulum (ER) by inhibiting expression chaperone proteins genes involved ER-associated degradation. This led activation PERK-eIF2α pathway, which dysfunction metabolism. Induction oxidative stress Nrf2/Keap1 pathway also NP-induced accumulation. These findings highlight potential adverse environmental aquatic organisms, raising concerns about ecotoxicity food safety.

Language: Английский

Citations

47
Investigation of nephrotoxicity on mice exposed to polystyrene nanoplastics and the potential amelioration effects of DHA-enriched phosphatidylserine DOI Open Access

Yunping Tang,

Rui Zhao,

Qiuyan Pu

et al.

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 892, P. 164808 - 164808

Published: June 10, 2023

Language: Английский

Citations

46
Water quality in biofloc technology (BFT): an applied review for an evolving aquaculture DOI
Mohammad Hossein Khanjani,

Alireza Mohammadi,

Maurício Gustavo Coelho Emerenciano

et al.

Aquaculture International, Journal Year: 2024, Volume and Issue: 32(7), P. 9321 - 9374

Published: July 19, 2024

Language: Английский

Citations

27