The Antimicrobial Activity and Resistance Evolution of Nanomaterials: A Review

ACS Materials Letters, Journal Year: 2025, Volume and Issue: unknown, P. 1085 - 1111

Published: Feb. 19, 2025

Language: Английский

---

Insight into using a novel ultraviolet/peracetic acid combination disinfection process to simultaneously remove antibiotics and antibiotic resistance genes in wastewater: Mechanism and comparison with conventional processes

Water Research, Journal Year: 2021, Volume and Issue: 210, P. 118019 - 118019

Published: Dec. 29, 2021

Language: Английский

---

The plant microbiota signature of the Anthropocene as a challenge for microbiome research

Microbiome, Journal Year: 2022, Volume and Issue: 10(1)

Published: March 26, 2022

Abstract Background One promise of the recently presented microbiome definition suggested that, in combination with unifying concepts and standards, research could be important for solving new challenges associated anthropogenic-driven changes various microbiota. With this commentary we want to further elaborate suggestion, because noticed specific signatures microbiota affected by Anthropocene. Results Here, discuss based on a review available literature our own targeting exemplarily plant microbiome. It is not only crucial plants themselves but also linked planetary health. We suggest that different human activities are commonly shift diversity evenness microbiota, which characterized decrease host specificity, an increase r-strategic microbes, pathogens, hypermutators. The resistome, anchored microbiome, follows antimicrobial resistance (AMR) mechanisms as well plasmid-associated genes. This typical signature Anthropocene often dysbiosis loss resilience, leads frequent pathogen outbreaks. Although several these observations already confirmed meta-studies, issue requires more attention upcoming studies. Conclusions Our aims inspire holistic studies development solutions restore save microbial ecosystem functioning closely connected

Language: Английский

---

Triclosan Promotes Conjugative Transfer of Antibiotic Resistance Genes to Opportunistic Pathogens in Environmental Microbiome

Environmental Science & Technology, Journal Year: 2022, Volume and Issue: 56(21), P. 15108 - 15119

Published: Oct. 17, 2022

Although triclosan, as a widely used antiseptic chemical, is known to promote the transmission of antibiotic resistance diverse hosts in pure culture, it still unclear whether and how triclosan could affect broad-host-range plasmids among complex microbial communities. Here, bacterial culturing, fluorescence-based cell sorting, high-throughput 16S rRNA gene amplicon sequencing were combined investigate contributions on transfer rate range an IncP-type plasmid from proteobacterial donor activated sludge microbiome. Our results demonstrate that significantly enhances conjugative RP4 communities at environmentally relevant concentrations. High-throughput sorted transconjugants demonstrates not only promoted intergenera but also intragenera Moreover, mediated opportunistic human pathogens, for example, Legionella spp. The mechanism triclosan-mediated primarily associated with excessive oxidative stress, followed by increased membrane permeability provoked SOS response. findings offer insights into impacts dissemination aquatic environmental

Language: Английский

---

Effects of trace PFOA on microbial community and metabolisms: Microbial selectivity, regulations and risks

Water Research, Journal Year: 2022, Volume and Issue: 226, P. 119273 - 119273

Published: Oct. 18, 2022

Language: Английский

---

Nitric Oxide: A Neglected Driver for the Conjugative Transfer of Antibiotic Resistance Genes among Wastewater Microbiota

Environmental Science & Technology, Journal Year: 2022, Volume and Issue: 56(10), P. 6466 - 6478

Published: May 5, 2022

The dissemination of plasmid-borne antibiotic resistance genes (ARGs) in wastewater is becoming an urgent concern. Previous studies mainly focused on the effects coexisting contaminants plasmid conjugation, but ignored potential contribution some byproducts inevitably released from treatment processes. Herein, we demonstrate for first time that nitric oxide (NO), intermediate nitrogen cycle, can significantly boost conjugative transfer RP4 Escherichia coli K12 to different recipients (E. HB101, Salmonella typhimurium, and microbiota). Phenotypic genotypic tests confirmed NO-induced promotion was not attributed SOS response, a well-recognized driver horizontal gene transfer. Instead, NO exposure increased outer membrane permeability both donor recipient by inhibiting expression key involved lipopolysaccharide biosynthesis (such as waaJ), thereby lowering barrier conjugation. On other hand, only resulted accumulation intracellular tryptophan also triggered deficiency methionine, which were validated play roles regulating global regulatory (korA, korB, trbA) RP4, activating its encoding apparatus (represented trfAp trbBp). Overall, our findings highlighted risks spreading ARGs among microbiota updated regulation mechanism

Language: Английский

---

Dormancy induced by oxidative damage during disinfection facilitates conjugation of ARGs through enhancing efflux and oxidative stress: A lagging response

Water Research, Journal Year: 2022, Volume and Issue: 221, P. 118798 - 118798

Published: June 26, 2022

Language: Английский

---

Transmission of antibiotic resistance genes through mobile genetic elements in Acinetobacter baumannii and gene-transfer prevention

The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 857, P. 159497 - 159497

Published: Oct. 17, 2022

Antibiotic resistance is a major global public health concern. Acinetobacter baumannii nosocomial pathogen that has emerged as threat because of its high levels to many antibiotics, particularly those considered last-resort such carbapenems. Mobile genetic elements (MGEs) play an important role in the dissemination and expression antibiotic genes (ARGs), including mobilization ARGs within between species. We conducted in-depth, systematic investigation occurrence associated with MGEs A. baumannii. focused on cross-sectoral approach integrates humans, animals, environments. Four strategies for prevention ARG through have been discussed: airborne transmission using semi-permeable membrane-covered thermophilic composting; application nanomaterials removal emerging pollutants (antibiotics) pathogens; tertiary treatment technologies controlling wastewater plants; by advanced oxidation techniques. This review contemplates evaluates drivers involved from perspective ARG-transfer processes.

Language: Английский

---

Insights into the role of extracellular polymeric substances (EPS) in the spread of antibiotic resistance genes

Environmental Pollution, Journal Year: 2023, Volume and Issue: 343, P. 123285 - 123285

Published: Dec. 31, 2023

Language: Английский

---

Antimicrobial and the Resistances in the Environment: Ecological and Health Risks, Influencing Factors, and Mitigation Strategies

Toxics, Journal Year: 2023, Volume and Issue: 11(2), P. 185 - 185

Published: Feb. 16, 2023

Antimicrobial contamination and antimicrobial resistance have become global environmental health problems. A large number of antimicrobials are used in medical animal husbandry, leading to the continuous release residual into environment. It not only causes ecological harm, but also promotes occurrence spread resistance. The role factors is often overlooked. There a antimicrobial-resistant bacteria genes human beings, which increases likelihood that pathogenic acquire resistance, adds opportunities for contact with pathogens. In this paper, we review fate environment, including occurrence, spread, impact on health. More importantly, emphasizes can exacerbate future, timely removal environment will be more effective alleviating

Language: Английский

---