An Overview of the Recent Advances in Antimicrobial Resistance

Microorganisms, Journal Year: 2024, Volume and Issue: 12(9), P. 1920 - 1920

Published: Sept. 21, 2024

Antimicrobial resistance (AMR), frequently considered a major global public health threat, requires comprehensive understanding of its emergence, mechanisms, advances, and implications. AMR’s epidemiological landscape is characterized by widespread prevalence constantly evolving patterns, with multidrug-resistant organisms (MDROs) creating new challenges every day. The most common mechanisms underlying AMR (i.e., genetic mutations, horizontal gene transfer, selective pressure) contribute to the emergence dissemination resistant strains. Therefore, mitigation strategies (e.g., antibiotic stewardship programs—ASPs—and infection prevention control strategies—IPCs) emphasize importance responsible antimicrobial use surveillance. A One Health approach interconnectedness human, animal, environmental health) highlights necessity for interdisciplinary collaboration holistic in combating AMR. Advancements novel therapeutics alternative agents vaccines) offer promising avenues addressing challenges. Policy interventions at international national levels also promote ASPs aiming regulate use. Despite all observed progress, remains pressing concern, demanding sustained efforts address emerging threats sustainability. Future research must prioritize innovative approaches complex socioecological dynamics This manuscript resource researchers, policymakers, healthcare professionals seeking navigate develop effective mitigation.

Language: Английский

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Microbial Therapy and Breast Cancer Management: Exploring Mechanisms, Clinical Efficacy, and Integration within the One Health Approach

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(2), P. 1110 - 1110

Published: Jan. 16, 2024

This comprehensive review elucidates the profound relationship between human microbiome and breast cancer management. Recent findings highlight significance of microbial alterations in tissue, such as gut breast, their role influencing risk, development, progression, treatment outcomes. We delve into how can modulate systemic inflammatory responses estrogen levels, thereby impacting initiation therapeutic drug efficacy. Furthermore, we explore unique diversity within indicating potential imbalances brought about by highlighting specific microbes promising targets. Emphasizing a holistic One Health approach, this underscores importance integrating insights from human, animal, environmental health to gain deeper understanding complex microbe-cancer interplay. As field advances, strategic manipulation its metabolites presents innovative prospects for enhancement diagnostics therapeutics. However, rigorous clinical trials remain essential confirm microbiota-based interventions

Language: Английский

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Synergistic design of CuO/CoFe₂O₄/MWCNTs ternary nanocomposite for enhanced photocatalytic degradation of tetracycline under visible light

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 2, 2025

Language: Английский

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Environmental Antimicrobial Resistance: Implications for Food Safety and Public Health

Antibiotics, Journal Year: 2024, Volume and Issue: 13(11), P. 1087 - 1087

Published: Nov. 14, 2024

Antimicrobial resistance (AMR) is a serious global health issue, aggravated by antibiotic overuse and misuse in human medicine, animal care, agriculture. This study looks at the different mechanisms that drive AMR, such as environmental contamination, horizontal gene transfer, selective pressure, well severe implications of AMR for health. demonstrates need concerted efforts across scientific, healthcare, agricultural, policy sectors to control emergence AMR. Some crucial strategies discussed include developing antimicrobial stewardship (AMS) programs, encouraging targeted narrow-spectrum use, emphasizing significance strict regulatory frameworks surveillance systems, like Global Resistance Use Surveillance System (GLASS) Access, Watch, Reserve (AWaRe) classification. also emphasizes national international action plans combating promotes One Health strategy, which unifies environmental, animal, concludes preventing spread maintaining effectiveness antibiotics future generations requires comprehensive, multidisciplinary, internationally coordinated strategy.

Language: Английский

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Synthesis of novel 6-aminocoumarin derivatives as potential –biocompatible antimicrobial and anticancer agents

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1320, P. 139658 - 139658

Published: Aug. 15, 2024

Language: Английский

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Effect of copper doping on the photocatalytic performance of Ni₂O₃@PC membrane composites in norfloxacin degradation

RSC Advances, Journal Year: 2024, Volume and Issue: 14(7), P. 4424 - 4435

Published: Jan. 1, 2024

Cu@PC, Ni 2 O 3 @PC as well Cu/Ni mixed composite track-etched membranes were synthesized using an electroless deposition technique and demonstrated enhanced photocatalytic degradation capacity for norfloxacin.

Language: Английский

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Hydroquinone Ecotoxicity: Unveiling Risks in Soil and River Ecosystems with Insights into Microbial Resilience

Toxics, Journal Year: 2024, Volume and Issue: 12(2), P. 115 - 115

Published: Jan. 29, 2024

Despite widespread industrial use, the environmental safety of hydroquinone (HQ), a benzene compound from plants used in processes like cosmetics, remains uncertain. This study evaluated ecotoxicological impact HQ on soil and river environments, utilizing non-target indicator organisms diverse trophic levels: Daphnia magna, Aliivibrio fischeri, Allium cepa, Eisenia fetida. For more environmentally realistic assessment, microbial communities untreated underwent 16S rRNA gene sequencing, with growth changes community-level physiological profiling assessed using Biolog EcoPlate™ assays. The water D. magna exhibited highest sensitivity to (EC50 = 0.142 µg/mL), followed by A. fischeri 1.446 cepa (LC50 7.631 while E. fetida showed resistance 234 mg/Kg). Remarkably, mitigated both aquatic terrestrial environments. River microorganisms displayed minimal inhibition, except for significant reduction polymer metabolism at concentration (100 µg/mL). Soil demonstrated resilience up 100 µg/mL, beyond which there was decrease population capacity metabolize carbohydrates polymers. mitigation, highly toxic various levels, emphasizing necessity regulations.

Language: Английский

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Intrinsic and Acquired Antimicrobial Resistomes in Plant Microbiomes: Implications for Agriculture and Public Health

Journal of Sustainable Agriculture and Environment, Journal Year: 2025, Volume and Issue: 4(1)

Published: March 1, 2025

ABSTRACT Antimicrobial resistance (AMR) poses a significant threat to both human and environmental health. Before intervention, the natural resistome existed in relatively balanced state, mainly regulated by microbial interactions factors. However, continuous use of antimicrobials other novel entities (chemicals or biological substances) agricultural production clinical settings has resulted huge release residual into environment. This may lead decrease diversity an increase selection pressure. The outcome is alteration with mobile clinically relevant antibiotic genes (ARGs), posing risk In sector, emergence AMR result multiple mechanisms. It involves intricate between activities, factors processes. Direct exposure antibiotic‐resistant bacteria ARGs produce particularly raw eaten vegetables, salad, herbs fruits facilitate spread humans review aims provide comprehensive overview fresh microbiomes. focuses on impact practices risks associated More importantly, this highlights several mitigation strategies future interventions for better understanding ARG transmission within food systems.

Language: Английский

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Green Synthesis of Metallic Nanoparticles by Acacia Tortilis Seed Powder to Mitigate Tylosin from Soil: A Strategy for Sustainable Soil Remediation

Published: Jan. 1, 2025

Abstract Metallic nanoparticles (MNPs), including Iron (FeONPs), have a significant role in environmental remediation. Their high surface area and reactivity make them excellent agents for transforming or degrading soil antibiotics. The production of biogenic MNPs using plant powder can mitigate the adverse impacts synthetic manufacturing processes. main objectives this work were to produce FeONPs Acacia tortilis seeds verify their removal efficiency tylosin (TYL) from industrial region (S.I.) stable (S.S.). UV–visible spectrophotometer (UV–Vis), dynamic light scattering (DLS), transmission electron microscopy (TEM) utilized characterize FeONPs. applied at 40 mg tylosin-contaminated soils. effectiveness TYL was evaluated 24 h Liquid Chromatography-Mass Spectrometry (LC–MS). UV–Vis absorption spectrum observed 405.015 nm. average ζ-potential −29.51 mV TEM image reveals that spherical shape with an size 57.29 S.I. significant, percentage 39.3%. However, S.S. soil, decrease rate 23.8% This research demonstrates promising eco-friendly approach mitigating antibiotic pollution negative potential. study underscores critical need further understand properties behavior remedial tailor effective cleanup strategies.

Language: Английский

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Reviving hope: Phage therapy application for antimicrobial resistance in farm animal production over the past decade

Animal Feed Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 116333 - 116333

Published: April 1, 2025

Language: Английский

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