Impact of Micro- and Nanoplastics on Mitochondria

Metabolites, Journal Year: 2022, Volume and Issue: 12(10), P. 897 - 897

Published: Sept. 23, 2022

Mitochondria are highly dynamic cellular organelles that perform crucial functions such as respiration, energy production, metabolism, and cell fate decisions. Mitochondrial damage dysfunction critically lead to the pathogenesis of various diseases including cancer, diabetes, neurodegenerative cardiovascular disorders. in response environmental contaminant exposure its association with has also been reported. Recently, persistent pollutants, micro- nanoplastics, have become growing global threats potential health risks. In this review, we discuss impact nanoplastics on mitochondria review current knowledge field.

Language: Английский

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Polystyrene nanoplastic exposure induces excessive mitophagy by activating AMPK/ULK1 pathway in differentiated SH-SY5Y cells and dopaminergic neurons in vivo

Particle and Fibre Toxicology, Journal Year: 2023, Volume and Issue: 20(1)

Published: Nov. 22, 2023

Microplastics and nanoplastics (MNPs) are emerging environmental contaminants detected in human samples, have raised concerns regarding their potential risks to health, particularly neurotoxicity. This study aimed investigate the deleterious effects of polystyrene (PS-NPs, 50 nm) understand mechanisms inducing Parkinson's disease (PD)-like neurodegeneration, along with exploring preventive strategies.

Language: Английский

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Cellular Uptake, Transport, and Organelle Response After Exposure to Microplastics and Nanoplastics: Current Knowledge and Perspectives for Environmental and Health Risks

Reviews of Environmental Contamination and Toxicology, Journal Year: 2022, Volume and Issue: 260(1)

Published: Dec. 1, 2022

Language: Английский

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Nanoplastic-induced vascular endothelial injury and coagulation dysfunction in mice

The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 865, P. 161271 - 161271

Published: Dec. 30, 2022

Language: Английский

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Polystyrene micro- and nanoparticles exposure induced anxiety-like behaviors, gut microbiota dysbiosis and metabolism disorder in adult mice

Ecotoxicology and Environmental Safety, Journal Year: 2023, Volume and Issue: 259, P. 115000 - 115000

Published: May 19, 2023

Plastics have been proven to be a potential threat the ecosystem, and their toxicity mechanism is still uncertain. In ecological environment, plastics can degraded into microplastics (MPs) nanoplastics (NPs), which contaminated ingested through food chain. MPs NPs are associated with severe intestinal injury, microbiota disorder, neurotoxicity, but it unclear whether MPs- NPs-induced dysbiosis will affect brain gut-brain axis. current study, we determined effects of exposure polystyrene (PS)-MPs PS-NPs on anxiety-like behaviors explored underlying mechanisms. This study behavioral 30-day 60-day PS-MPs using open field test (OFT) elevated plus maze (EPM) test. Behavioral tests showed treatment remarkedly induced compared control group. Using 16 S rRNA gene sequencing untargeted metabolomics analyses, observed that reduced beneficial gut expression level, such as Lachnoclostridium Lactobacillus, increased conditionally pathogenic bacteria expressions Proteobacteria, Actinobacteria, Desulfovibrio. addition, reduce mucus secretion increase permeability. The results serum metabonomics suggested metabolic pathways, ABC transporter aminoacyl-tRNA biosynthesis, biosynthesis amino acids, bile were enriched after treatment. Besides, neurotransmitter metabolites also altered by PS-MPs. It noteworthy correlation analysis disorder was related disorder. regulation may promising strategy for PS-MPs- PS-NPs-induced anxiety

Language: Английский

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A global review on the abundance and threats of microplastics in soils to terrestrial ecosystem and human health

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 912, P. 169469 - 169469

Published: Dec. 27, 2023

Language: Английский

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Toxicological effects of micro/nano-plastics on mouse/rat models: a systematic review and meta-analysis

Frontiers in Public Health, Journal Year: 2023, Volume and Issue: 11

Published: May 18, 2023

Micro/nano-plastics (MNPs) are considered a heterogeneous class of environmental contaminants that cause multiple toxic effects on biological species. As the commonly used mammalian models to study MNPs with regard their effects, mouse and rat making great contribution disciplines toxicology medical health. However, have not been systematically summarized. Therefore, systematic review meta-analysis mouse/rat were conducted. A total seven main categories established in this review, 24 subcategories further divided according specific physiological significance endpoint or classification system, which covered all selected pieces literature. 1,762 endpoints found, 52.78% them significantly affected. This fact indicates there relative factors, including size, polymer type, concentration, exposure time different sexes could affect endpoints. These can be classified into various such as dose-response relationships between MNP concentration nervous growth, reproduction, digestive tract histopathology, inflammatory cytokine level, among others. negatively affected blood glucose metabolism, lipid reproductive function mice. The male mice is more sensitive MNPs. findings also provide insights directions for exploring evidence mechanisms human It clear research required pathological at molecular level long-term tissue accumulation.

Language: Английский

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Microplastic environmental behavior and health risk assessment: a review

Environmental Chemistry Letters, Journal Year: 2024, Volume and Issue: 22(6), P. 2913 - 2941

Published: Aug. 20, 2024

Language: Английский

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Combined Effects of Polystyrene Nanosphere and Homosolate Exposures on Estrogenic End Points in MCF-7 Cells and Zebrafish

Environmental Health Perspectives, Journal Year: 2024, Volume and Issue: 132(2)

Published: Feb. 1, 2024

Micro- and nanoplastics (MNPs) homosalate (HMS) are ubiquitous emerging environmental contaminants detected in human samples. Despite the well-established endocrine-disrupting effects (EDEs) of HMS, interaction between MNPs HMS its impact on HMS-induced EDEs remain unclear.

Language: Английский

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Gender-specific effects of polystyrene nanoplastic exposure on triclosan-induced reproductive toxicity in zebrafish (Danio rerio)

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 932, P. 172876 - 172876

Published: April 29, 2024

Language: Английский

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