Understanding bacterial biofilms: From definition to treatment strategies

Frontiers in Cellular and Infection Microbiology, Journal Year: 2023, Volume and Issue: 13

Published: April 6, 2023

Bacterial biofilms are complex microbial communities encased in extracellular polymeric substances. Their formation is a multi-step process. Biofilms significant problem treating bacterial infections and one of the main reasons for persistence infections. They can exhibit increased resistance to classical antibiotics cause disease through device-related non-device (tissue) -associated infections, posing severe threat global health issues. Therefore, early detection search new alternative treatments essential suppressing biofilm-associated In this paper, we systematically reviewed biofilms, associated methods, potential treatment strategies, aiming provide researchers with latest progress biofilms.

Language: Английский

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Current Advances on the Single‐Atom Nanozyme and Its Bioapplications

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(10)

Published: Feb. 11, 2023

Nanozymes, a class of nanomaterials mimicking the function enzymes, have aroused much attention as candidate in diverse fields with arbitrarily tunable features owing to diversity crystalline nanostructures, composition, and surface configurations. However, uncertainty their active sites lower intrinsic deficiencies nanomaterial-initiated catalysis compared natural enzymes promote pursuing alternatives by imitating biological centers. Single-atom nanozymes (SAzymes) maximize atom utilization well-defined structure, providing an important bridge investigate mechanism relationship between structure catalytic activity. They risen new burgeoning alternative enzyme from vitro bioanalytical tool vivo therapy flexible atomic engineering structure. Here, focus is mainly on three parts. First, detailed overview single-atom catalyst synthesis strategies including bottom-up top-down approaches given. Then, according structural feature nanocatalysts, influence factors such central metal atom, coordination number, heteroatom doping, metal-support interaction are discussed representative applications (including antibacterial/antiviral performance, cancer therapy, biosensing) highlighted. In end, future perspective challenge facing demonstrated.

Language: Английский

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Antibacterial Carbon Dots: Mechanisms, Design, and Applications

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(23)

Published: May 13, 2023

Abstract The increase in antibiotic resistance promotes the situation of developing new antibiotics at forefront, while development non‐antibiotic pharmaceuticals is equally significant. In post‐antibiotic era, nanomaterials with high antibacterial efficiency and no drug make them attractive candidates for materials. Carbon dots (CDs), as a kind carbon‐based zero‐dimensional nanomaterial, are attracting much attention their multifunctional properties. abundant surface states, tunable photoexcited excellent photo‐electron transfer properties sterilization CDs feasible gradually emerging field. This review provides comprehensive insights into recent topics include mechanisms, design, optimization processes, potential practical applications also highlighted, such treatment bacterial infections, against biofilms, surfaces, food preservation, bacteria imaging detection. Meanwhile, challenges outlook field discussed proposed.

Language: Английский

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Engineering an Enzymatic Cascade Catalytic Smartphone-Based Sensor for Onsite Visual Ratiometric Fluorescence–Colorimetric Dual-Mode Detection of Methyl Mercaptan

Environmental Science & Technology, Journal Year: 2023, Volume and Issue: 57(4), P. 1680 - 1691

Published: Jan. 16, 2023

Precise and reliable onsite detection of methyl mercaptan (CH3SH) is great significance for environmental surveillance. Here, we synthesized a novel blue fluorescence nanozyme CeO2@TPE with high peroxidase-like activity by employing aggregation-induced emission (AIE) tetraphenylethene (TPE) to embed into hollow CeO2 nanospheres. In the presence ethanol oxidase (AOX) o-phenylenediamine (OPD), engineered an enzymatic cascade activation ratiometric fluorescence-colorimetric dual-mode system AOX/CeO2@TPE + OPD toward CH3SH. this design, CH3SH initiated AOX catalytic convert it H2O2 activating CeO2@TPE, producing •OH oxidizing naked-eye colorless deep yellow 2,3-diaminophenazine (DAP) absorption enhancement at ∼425 nm, companied new peak ∼550 nm match intrinsic ∼441 observing response, enabling analysis. Interestingly, both colorimetric signals could be gathered being converted hue parameter on smartphone-based sensor, achieving visual in real media acceptable results. This study gave insight designing target-responsive system-based efficient point-of-care sensors safeguarding health.

Language: Английский

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Polydopamine-based nanozyme with dual-recognition strategy-driven fluorescence-colorimetric dual-mode platform for Listeria monocytogenes detection

Journal of Hazardous Materials, Journal Year: 2022, Volume and Issue: 439, P. 129582 - 129582

Published: July 12, 2022

Language: Английский

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Antibacterial Carbon Dots‐Based Composites

Small, Journal Year: 2023, Volume and Issue: 19(31)

Published: Feb. 17, 2023

Abstract The emergence and global spread of bacterial resistance to conventionally used antibiotics have highlighted the urgent need for new antimicrobial agents that might replace antibiotics. Currently, nanomaterials hold considerable promise as in anti‐inflammatory therapy. Due their distinctive functional physicochemical characteristics exceptional biocompatibility, carbon dots (CDs)‐based composites attracted a lot attention context these nanomaterials. Here, thorough assessment current developments field CDs‐based is provided, starting with brief explanation general synthesis procedures, categorization, composites. many processes driving antibacterial action are then thoroughly described, including physical destruction, oxidative stress, incorporation agents. Finally, obstacles now suffer combating infectious diseases outlined investigated, along potential applications

Language: Английский

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Smartphone-assisted colorimetric sensing platform based on molybdenum-doped carbon dots nanozyme for visual monitoring of ampicillin

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 468, P. 143615 - 143615

Published: May 19, 2023

Language: Английский

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Nanozymes: Applications in clinical biomarker detection

Deleted Journal, Journal Year: 2023, Volume and Issue: 1(4)

Published: Sept. 19, 2023

Abstract Enzymes are highly efficient catalysts employed in the biomedical field. However, their use is limited by poor stability and high cost. To address this, there an imperative need for research on nanozymes. In last decade, introduction of nanozymes has led to exponential growth nanozyme‐based biosensors. The rapid precise detection clinical biomarkers crucial various disease diagnostics. recent years, researchers have developed different catalytic active nanomaterials combined them with colorimetric, fluorescent, electrochemical methods detect biomarkers. This review critically overviews progress, future prospects, challenges biomarker assays past few years.

Language: Английский

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Insight into nanozymes for their environmental applications as antimicrobial and antifouling agents: Progress, challenges and prospects

Nano Today, Journal Year: 2023, Volume and Issue: 48, P. 101755 - 101755

Published: Jan. 14, 2023

Language: Английский

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Recent design strategies for boosting chemodynamic therapy of bacterial infections

Exploration, Journal Year: 2023, Volume and Issue: 4(2)

Published: Oct. 17, 2023

Abstract The emergence of drug‐resistant bacteria poses a significant threat to people's lives and health as bacterial infections continue persist. Currently, antibiotic therapy remains the primary approach for tackling infections. However, escalating rates drug resistance coupled with lag in development novel drugs have led diminishing effectiveness conventional treatments. Therefore, nonantibiotic‐dependent therapeutic strategies has become imperative impede rise resistance. chemodynamic (CDT) opened up new possibility due CDT can convert H 2 O into •OH via Fenton/Fenton‐like reaction treatment. efficacy is limited by variety practical factors. To overcome this limitation, sterilization efficiency be enhanced introducing therapeutics inherent antimicrobial capability. In addition, researchers explored CDT‐based combined therapies augment its effects mitigate potential toxic side toward normal tissues. This review examines research progress field, explores various enhance presents synergistic combination other modalities. And last, current challenges faced future directions are discussed.

Language: Английский

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