Introduction of multilayered magnetic core–dual shell SERS tags into lateral flow immunoassay: A highly stable and sensitive method for the simultaneous detection of multiple veterinary drugs in complex samples

Journal of Hazardous Materials, Journal Year: 2023, Volume and Issue: 448, P. 130912 - 130912

Published: Feb. 2, 2023

Direct, convenient, and sensitive monitoring of the residues multiple drugs in complex environments is important but remains a challenge. Here, we report surface-enhanced Raman scattering (SERS)-based multiplexed lateral flow immunoassay (LFA) that supports simultaneous detection commonly used kanamycin, ractopamine, clenbuterol, chloramphenicol unprocessed samples through dual signal amplification strategy numerous efficient hotspots magnetic enrichment. Multilayered magnetic-core dual-shell nanoparticles (MDAu@Ag) with controllable subtle nanogaps were fabricated via polyethyleneimine-mediated layer-by-layer (LBL) assembly two layers Au@Ag satellites onto superparamagnetic Fe3O4 cores conjugated specific antibodies as multifunctional tags LFA system for rapid capture, separation, quantitative analysis. Two reporters embedded internal modified on surface MDAu@Ag ultrasensitive four targets test lines, which greatly simplified fabrication reading SERS-LFA. The proposed assay can rapidly detect drug 35 min limits down to pg/mL level. Moreover, MDAu@Ag-based SERS-LFA demonstrated better stability, higher throughput, superior sensitivity (at least 400 times) than traditional colloidal gold immunochromatography, showing its great potential field point-of-care testing.

Language: Английский

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Advances in surface‐enhanced Raman spectroscopy technology for detection of foodborne pathogens

Comprehensive Reviews in Food Science and Food Safety, Journal Year: 2023, Volume and Issue: 22(3), P. 1466 - 1494

Published: March 1, 2023

Abstract Rapid control and prevention of diseases caused by foodborne pathogens is one the existing food safety regulatory issues faced various countries has received wide attention from all sectors society. The development rapid reliable detection methods for remains a hot research area public health because limitations complex steps, time‐consuming, low sensitivity, or poor selectivity commonly used methods. Surface‐enhanced Raman spectroscopy (SERS), as novel spectroscopic technique, advantages high selectivity, nondestructive exhibited broad application prospects in determination pathogenic bacteria. In this study, enhancement mechanisms SERS are briefly introduced, then characteristics properties liquid‐phase, rigid solid‐phase, flexible solid‐phase categorized. Furthermore, comprehensive review advances label‐free label‐based strategies SERS‐compatible techniques provided, disadvantages these reviewed. Finally, current challenges technology applied practical applications listed, possible trends field future discussed.

Language: Английский

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SERS-based microdevices for use as in vitro diagnostic biosensors

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(11), P. 5394 - 5427

Published: Jan. 1, 2024

This review explores various microdevices developed for applying SERS technology to in vitro diagnostics and delves into their clinical applications.

Language: Английский

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Nanohybrid SERS substrates intended for food supply chain safety

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 494, P. 215349 - 215349

Published: July 28, 2023

Language: Английский

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Recent advances on emerging biosensing technologies and on-site analytical devices for detection of drug-resistant foodborne pathogens

TrAC Trends in Analytical Chemistry, Journal Year: 2023, Volume and Issue: 167, P. 117258 - 117258

Published: Aug. 26, 2023

Language: Английский

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Navigating the landscape of optical biosensors

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 490, P. 151661 - 151661

Published: April 26, 2024

Language: Английский

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A film-like SERS aptasensor for sensitive detection of patulin based on GO@Au nanosheets

Food Chemistry, Journal Year: 2024, Volume and Issue: 441, P. 138364 - 138364

Published: Jan. 7, 2024

Language: Английский

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Evaluation of the Multidimensional Enhanced Lateral Flow Immunoassay in Point-of-Care Nanosensors

ACS Nano, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 23, 2024

Point-of-care (POC) nanosensors with high screening efficiency show promise for user-friendly manipulation in the ever-increasing on-site analysis demand illness diagnosis, environmental monitoring, and food safety. Currently, inspired by merits of integrating advanced nanomaterials, molecular biology, machine learning, artificial intelligence, lateral flow immunoassay (LFIA)-based POC have been devoted to satisfying commercial demands terms sensitivity, specificity, practicality. Herein, we examine use multidimensional enhanced LFIA various fields over past two decades, focusing on introducing nanomaterials improve acquisition capability small order magnitude targets through engineering transformations emphasizing interdomain fusion collaboratively address inherent challenges current applications, such as multiplexing, development detectors quantitative analysis, more practical sensitivity enhancement. Specifically, this comprehensive review encompasses latest advances comprehending an alternative signal transduction pattern, aiming achieve rapid, ultrasensitive, "sample-to-answer" available options progressive applications nanosensors. In summary, cross-collaboration disciplines, has potential break barriers toward commercialization laboratory-level nanosensors, thus leading emergence next generation LFIA.

Language: Английский

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A Dual Fluorescence Turn‐On Sensor Array Formed by Poly(para‐aryleneethynylene) and Aggregation‐Induced Emission Fluorophores for Sensitive Multiplexed Bacterial Recognition

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(16)

Published: Feb. 26, 2024

Bacterial infections have emerged as the leading causes of mortality and morbidity worldwide. Herein, we developed a dual-channel fluorescence "turn-on" sensor array, comprising six electrostatic complexes formed from one negatively charged poly(para-aryleneethynylene) (PPE) positively aggregation-induced emission (AIE) fluorophores. The 6-element array enabled simultaneous identification 20 bacteria (OD

Language: Английский

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Unlocking the potential of 2D nanomaterials for sustainable intelligent packaging

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 490, P. 151711 - 151711

Published: April 26, 2024

The demand for high food safety standards, spoilage prevention, and the minimization of waste has spurred extensive investigation into intelligent packaging. Within this field, considerable attention been directed towards two-dimensional (2D) nanomaterials owing to their exceptionally thin layered configuration diverse physicochemical, electrical, optical, thermal properties. These attributes render 2D highly suitable enhancing sensing capabilities in packaging systems. This review delves forefront research concerning utilization applications. It provides a comprehensive survey concepts explores various materials, including graphene-based MXene, silicate clay, investigated potential Additionally, interprets structure, properties, materials biosensing systems encompassing gas, moisture, pH, bacteria sensors, indicators, or wireless tags. Moreover, it examines influence on mechanical, thermal, barrier, bioactive properties smart packaging, while also deliberating respective advantages limitations. By combining these foundational elements, study offers distinctive thorough contribution domain laying groundwork future development sustainable high-performance materials.

Language: Английский

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