Burns & Trauma,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 21, 2025
Abstract
Background
Magnesium
ions
play
crucial
roles
in
maintaining
cellular
functions.
Research
has
shown
that
Mg2+
can
promote
angiogenesis,
indicating
its
potential
for
treating
cardiovascular
ischemic
diseases.
However,
conventional
intravenous
or
oral
administration
of
presents
several
challenges,
including
the
risk
systemic
side
effects,
diminished
bioavailability,
and
a
lack
targeted
delivery
mechanisms.
In
this
study,
we
designed
Mg2+-releasing
adhesive
tissue
patch
(MgAP)
enables
dural
release
ions.
Methods
A
novel
was
developed
on
basis
ionic
crosslinking.
Fourier
transform
infrared
spectroscopy
confirmed
chemical
structure,
whereas
rheological
analysis
demonstrated
stable
mechanical
properties
adaptability
to
dynamic
loads.
Sustained
quantified
over
7
days
by
inductively
coupled
plasma–mass
spectrometry.
rat
acute
myocardial
infarction
model,
performed
echocardiography
strain
assess
cardiac
function
histological
staining
evaluate
adverse
remodeling.
We
also
verified
proangiogenic
effect
through
vitro
tube
formation
vivo
immunofluorescence
assays.
Furthermore,
transcriptomics
Western
blotting
were
explore
underlying
mechanism.
Additional
assessments
carried
out
model
lower
limb
ischemia.
Results
Compared
with
magnesium
chloride,
MgAP
application
effectively
improved
reduced
remodeling
model.
The
left
ventricular
ejection
fraction
increased
20.3
±
6.6%,
radial
27.4
4.1%.
fibrosis
area
cell
apoptosis
rate
decreased
10.9
1.2%
32.1
5.5%,
respectively.
RNA
sequencing
highlighted
upregulation
genes
related
electrophysiological
properties,
structural
functional
intercellular
connections,
revascularization.
gap
junction
protein
expression
restored
local
blood
supply
could
contribute
repair
process
posttreatment.
observed
ischemia
Conclusions
above
results
revealed
convincing
vascular
regeneration
an
ion
therapy-based
hydrogel,
which
enabled
tissue,
aiding
repair.
This
study
strategy
highlights
use
across
various
conditions.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: April 1, 2024
Abstract
Background
Herbal
nanoparticles
are
made
from
natural
herbs/medicinal
plants,
their
extracts,
or
a
combination
with
other
nanoparticle
carriers.
Compared
to
traditional
herbs,
herbal
lead
improved
bioavailability,
enhanced
stability,
and
reduced
toxicity.
Previous
research
indicates
that
medicine
nanomaterials
rapidly
advancing
making
significant
progress;
however,
bibliometric
analysis
knowledge
mapping
for
currently
lacking.
We
performed
by
retrieving
publications
related
the
Web
of
Science
Core
Collection
(WoSCC)
database
spanning
2004
2023.
Data
processing
was
using
R
package
Bibliometrix,
VOSviewers,
CiteSpace.
Results
In
total,
1876
articles
were
identified,
originating
various
countries,
China
being
primary
contributing
country.
The
number
in
this
field
increases
annually.
Beijing
University
Chinese
Medicine,
Shanghai
Traditional
Saveetha
India
prominent
institutions
domain.
Journal
“International
Nanomedicine”
has
highest
publications.
authors
these
reached
8234,
Yan
Zhao,
Yue
Zhang,
Huihua
Qu
most
prolific
Zhao
frequently
cited
author.
“Traditional
medicine,”
“drug
delivery,”
“green
synthesis”
main
focal
points.
Themes
such
as
synthesis,”
“curcumin,”
“wound
healing,”
“carbon
dots”
may
represent
emerging
areas.
Conclusions
Our
study
findings
assist
identifying
latest
frontiers
hot
topics,
providing
valuable
references
scholars
investigating
role
nanotechnology
medicine.
Graphical
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 17, 2024
Abstract
Bacterial
infections,
especially
caused
by
multidrug‐resistant
bacteria,
pose
a
big
challenge
to
the
healthcare
system.
As
group
of
historic
agents,
metals
with
broad‐spectrum
antibacterial
activity
are
regarded
as
promising
alternatives
tackle
antibiotic
resistance.
Among
them,
gallium
ions
have
presented
encouraging
effects
in
research
and
preclinic
studies.
However,
utilization
has
difficulty
achieving
high
targeting
long‐term
effectiveness.
With
renaissance
liquid
metal,
here,
novel
facile
nanostructure
is
proposed
which
polydopamine‐modified
nanocore
serves
an
ion
reservoir
for
enhanced
metal
release
surface
also
permits
secondary
reaction,
allowing
situ
formation
Ag
nanoparticles
improve
property,
ROS
generation,
photothermal
performance.
Notably,
≈100%
bacterial
killing
efficacy
can
be
achieved
when
combined
NIR
laser
irradiation.
The
vivo
treatment
results
methicillin‐resistant
Staphylococcus
aureus
(MRSA)‐infected
mice
demonstrate
that
microneedle
patch
loaded
exhibits
outstanding
elimination
inflammation
alleviation,
promotes
angiogenesis
collagen
deposition,
further
accelerating
wound
healing.
This
gallium‐based
offers
effective
nanoplatform
treatments
combinatory
strategies,
holds
significant
promise
refractory
bacteria
related
infections.
Biomedical Materials,
Journal Year:
2024,
Volume and Issue:
19(5), P. 052009 - 052009
Published: Aug. 27, 2024
Abstract
Curcumin
is
a
natural
polyphenolic
compound
extracted
from
turmeric
with
antibacterial,
antioxidant,
antitumor,
preventive
and
therapeutic
neurological
disorders
variety
of
bioactivities,
which
widely
used
in
the
field
food
medicine.
However,
drawbacks
curcumin
such
as
poor
aqueous
solubility
stability
have
limited
practical
application
curcumin.
To
overcome
these
defects
enhance
its
functional
properties,
various
nanoscale
systems
(liposomes,
polymer
nanoparticles,
protein
solid
lipid
metal
etc)
been
extensively
employed
for
encapsulation
delivery.
Despite
rapid
development
nanoformulations,
there
lack
comprehensive
reviews
on
their
preparation
properties.
This
review
provides
an
overview
construction
nano-delivery
systems,
mechanisms
action,
nanocarrier
methods
applications
nanocarriers
pharmaceutical
fields
to
provide
theoretical
basis
technological
support
efficient
bio-utilization,
product
early
clinical
