Zinc Oxide Nanoparticles Cause Hepatotoxicity in Rare Minnow (Gobiocypris Rarus) Via Ros-Mediated Oxidative Stress and Apoptosis Activation and Inhibition of Lipid Peroxidation DOI
Liangxia Su, Huanhuan Li, Jiahuan Wang

et al.

Published: Jan. 1, 2024

Zinc oxide nanoparticles (diameters 30 ± 10 nm, ZnO NPs) is used in a variety of applications, such as batteries, plastics, ceramics, cosmetics, flame retardants and food. However, the potential influence risk NPs on aquatic ecosystems are not fully clearly. In this study, effect dietary supplementation hepatotoxicity rare minnow was investigated. Three hundred minnows were fed with diets containing 0 mg/kg, 20 mg/kg 60 for d. And then, fishes randomly subjected to assess at an interval every 15 days. The histological data showed that severely damage liver tissues, following cytoplasmic vacuolization, irregular missing nuclei. Additionally, accumulated zinc level supplement groups significantly higher controls (P < 0.05). As feed supplements, also reduced body weight HSI minnow. enzyme activity results demonstrated elevated levels reactive oxygen species (ROS), total cholesterol (T-CHO), triglyceride (TG), acetyl Coa carboxylase (ACC), fatty acid synthase (FAS) antioxidant enzymes observed groups. Further investigation found accumulation tissues up-regulated expression genes related (mn-sod, cat nf-κb), pro-apoptotic (bax) lipogenesis (gpat3, dgat1a dgat1b), down-regulated lipid catabolism (cpt1 tpi1). indicated caused induced by via ROS-mediated activation oxidative stress, apoptosis, inhibition peroxidation. Overall, our analysis suggested may pose serious threat animals, even ecosystem.

Language: Английский

The impact of biocorrosion and titanium ions release on peri-implantitis DOI
Chonghao Ji, Yaqian Chen, Misi Si

et al.

Clinical Oral Investigations, Journal Year: 2025, Volume and Issue: 29(3)

Published: Feb. 25, 2025

Language: Английский

Citations

2
Titanium dioxide-induced fibrotic liver model and the therapeutic effect of resveratrol by modulation of α-SMA and 8-oHdG expressions, oxidative stress, and inflammation DOI
Fatih Başak, Tansu Kuşat, Yusuf Ersan

et al.

Tissue and Cell, Journal Year: 2025, Volume and Issue: 93, P. 102748 - 102748

Published: Jan. 18, 2025

Language: Английский

Citations

1
Natural Slab Photonic Crystals as Biogenic, Customizable Nanomaterial for Label-Free Detection DOI Creative Commons
Johannes W. Goessling, Paula Martínez-Pérez, Laura Rodríguez‐Lorenzo

et al.

ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: 8(16), P. 7911 - 7919

Published: April 11, 2025

Photonic band gap-based sensors can detect small variations in the refractive index of surrounding media, facilitating precise detection changes their environment. In this proof-of-concept study, we demonstrate that biosilica produced by single-cell microalgae called diatoms work as a photonic crystal slab sensor. We exploited pseudo bandgap (pseudo-PBG) highly periodic nanoscale morphology to presence relevant chemical elements solutions. pseudo-PBG natural system be calibrated for environment using standard liquids. Subsequently, platform enables minute variations, accurate second decimal place, caused concentration induced analytes, such magnesium chloride and d-glucose. This underscores potential nanostructured an advanced sensing. addition, show it is possible customize working spectral region surface functionalization titanium dioxide nanoparticles modify effective therefore change properties pseudo-PBG. The results highlight precision natural, biogenic nanomaterial propose sustainable alternatives developing nanomaterials tailored sensing applications beyond.

Language: Английский

Citations

0
Toxicity and transcriptome sequencing analyses of Acipenser schrenckii under titanium dioxide nanoparticles stress DOI Creative Commons

Zhou Zhou,

Ting Liu, Jie Kong

et al.

Aquaculture Reports, Journal Year: 2024, Volume and Issue: 36, P. 102091 - 102091

Published: April 17, 2024

Increasing utilization of titanium dioxide nanoparticles (TiO2-NPs), with a wide range applications, has resulted in the increased release material into environment. In this study, we combined Illumina short-line RNA sequencing (RNA-Seq) and PacBio Iso-sequencing methods to obtain transcriptome Acipenser schrenckii livers treated 5.27 (TH), 0.527 (TM), 0.0527 mg/L (TL) TiO2-NPs for 14 days elucidate mechanisms underlying effects on sturgeons. total, 39.67G subread bases 31092 de-redundant transcripts (8929 unigenes) were obtained from A. livers, mean length 2289 bp. Moreover, 293 differentially expressed genes (DEGs) related TiO2-NP stress identified using DESeq; 175, 174, 62 DEGs TH vs. TC, TM TL TC groups. The Kyoto Encyclopedia Genes Genomes pathways immunity (neuroactive ligand-receptor interaction, rheumatoid arthritis, NF-kappa B signaling pathway, graft-versus-host disease) significantly altered by exposure, expression interleukin-8, possible biomarker environmental pollution, was upregulated. alpha-linolenic acid metabolism, glycerolipid arachidonic metabolism associated defense against oxidative also influenced exposure. activity carboxyl ester lipase involved rapidly downregulated groups which may play major role regulation. patterns eight selected generally consistent quantitative real-time PCR analysis results.

Language: Английский

Citations

3
Bioaccumulation and human risk assessment of inorganic nanoparticles in aquaculture species DOI Creative Commons
Cristian Suárez-Oubiña, Paloma Herbello-Hermelo, Natalia Mallo

et al.

Environmental Science Nano, Journal Year: 2024, Volume and Issue: 11(7), P. 2937 - 2947

Published: Jan. 1, 2024

Potential bioaccumulation and human oral bioavailability of TiO 2 NPs Ag in aquaculture products.

Language: Английский

Citations

2
UV-aging process of titanium dioxide nanoparticles aggravates enterohepatic toxicity of bis(2-ethylhexyl)-2,3,4,5-tetrabromophthalate to zebrafish DOI
Yuxi Zhou,

Kaiyu Fu,

Fan Li

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 958, P. 178074 - 178074

Published: Dec. 13, 2024

Language: Английский

Citations

2
Harnessing Plasmonic Membranes for nanostructured TiO2 Activity Profiling DOI Creative Commons
Ecem Tiryaki, Ana Sousa‐Castillo, Laura Rodríguez‐Lorenzo

et al.

ChemCatChem, Journal Year: 2024, Volume and Issue: 16(22)

Published: Aug. 9, 2024

Abstract Titanium dioxide nanoparticles (TiO 2 NPs) are widely manufactured semiconductors, but their release into aquatic environments poses significant threats to ecosystems and human health. The environmental hazard associated with TiO NPs in surface water primarily results from photocatalytic activity, which generates reactive oxygen species (ROS). Addressing this challenge is crucial for ensuring the safe utilization of preserving environment. In study, we developed a novel plasmonic membrane comprising titanate nanowires (TiNWs) functionalized silica‐coated gold nanostars (AuNSts) probe, situ, capture measurement activity complex media such as seawater. This method represents unique precise approach real‐time monitoring presence NPs, thereby laying foundation establishing an risk parameter these particles.

Language: Английский

Citations

1
Diving into the metabolic interactions of titanium dioxide nanoparticles in “Sparus aurata” and “Ruditapes philippinarum” DOI Creative Commons
Mário Jorge Araújo, María Vázquez, Laura Rodríguez‐Lorenzo

et al.

Environmental Pollution, Journal Year: 2024, Volume and Issue: 360, P. 124665 - 124665

Published: Aug. 6, 2024

The biological response to nanomaterials exposure depends on their properties, route of exposure, or model organism. Titanium dioxide nanoparticles (TiO2 NPs) are among the most used nanomaterials; however, concerns related oxidative stress and metabolic effects resulting from ingestion rising. Therefore, in present work, we addressed citrate-coated 45 nm TiO2 NPs combining bioaccumulation, tissue ultrastructure, proteomics approaches gilthead seabream, Sparus aurata Japanese carpet shell, Ruditapes philippinarum. was exposed through artificially contaminated feeds, while R. philippinarum using NPs-doped microalgae solutions. accumulation titanium fish liver is associated with alterations hepatic structure, alteration expression proteins lipid fatty acid metabolism, breakdown for energy, transport, homeostasis. While cellular structure were less affected than atypical gill cilia microvilli metabolic-related also observed bivalve. Overall, feeding appear stem various interactions cells, involving key proteins, changes cell membranes, structures, organelles. possible appearance disorders environmental risks aquatic organisms posed by deserve further study.

Language: Английский

Citations

1
Zinc oxide nanoparticles cause hepatotoxicity in rare minnow (Gobiocypris rarus) via ROS-mediated oxidative stress and apoptosis activation and inhibition of lipid peroxidation DOI Creative Commons
Liangxia Su, Huanhuan Li, Jiahuan Wang

et al.

Aquaculture Reports, Journal Year: 2024, Volume and Issue: 38, P. 102317 - 102317

Published: Aug. 27, 2024

Language: Английский

Citations

1
Dietary intervention in enhancing immunity of cancer patients DOI Open Access
Rui Han, Yuqian Wang

Journal of Vaccines and Immunology, Journal Year: 2023, Volume and Issue: 9(1), P. 024 - 029

Published: Aug. 9, 2023

The compromised function and environment of the immune system in individuals with cancer create a scenario which fails to effectively identify eliminate cells. As result, tumors can thrive avoid detection by system, leading progression disease. Gaining comprehensive understanding these immune-related challenges is essential for development effective treatments, including immunotherapies, aim enhance response against cancer. In addition conventional dietary interventions have shown potential supporting patients improving their through nutritional support, influencing gut microbiome, boosting other means. It crucial note that should be tailored each individual patient, considering specific requirements, preferences, tolerances. This review seeks underscore significance implementing well-adapted appropriate approaches anticancer immunity patients.

Language: Английский

Citations

1