Toxicity to the Male Reproductive System after Exposure to Polystyrene Nanoplastics: A Macrogenomic and Metabolomic Analysis DOI Creative Commons
Xue Zhang,

Yueping Wu,

Xufeng Fu

et al.

Toxics, Journal Year: 2024, Volume and Issue: 12(8), P. 531 - 531

Published: July 23, 2024

Nanoplastics (NPs) cause serious contamination of drinking water and potential damage to human health. This study aimed investigate the effects NPs with different particle sizes concentrations on reproductive function male mice. In this study, free exposure was used expose BALB/C mice PS-NPs (20 nm, 200 1000 nm) at 0.1 mg/L, 1 5 mg/L for 4 months. The assessed after exposure, fecal blood samples were collected macrogenomics metabolomics. results showed that resulted in reduced testicular organ coefficients, decreased sperm quality, altered tissue structure, disturbed sex hormone levels, abnormal levels inflammatory factors oxidative stress. Furthermore, found NP affected alteration gut communities metabolic pathways related reproduction, such as Clostridium glutathione metabolism. Importantly, we an effect size function. future, more attention should be paid smaller NPs.

Language: Английский

Polystyrene Nanoplastics Activate Autophagy and Suppress Trophoblast Cell Migration/Invasion and Migrasome Formation to Induce Miscarriage DOI

Shukun Wan,

Xiaoqing Wang, Weina Chen

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(4), P. 3733 - 3751

Published: Jan. 22, 2024

Nanoplastics (NPs), as emerging pollutants, have attracted global attention. Nevertheless, the adverse effects of NPs on female reproductive health, especially unexplained miscarriage, are poorly understood. Defects trophoblast cell migration and invasion associated with miscarriage. Migrasomes were identified cellular organelles largely unidentified functions. Whether might affect migration, invasion, migrasome formation induce miscarriage has been completely unexplored. In this study, we selected polystyrene nanoplastics (PS-NPs, 50 nm) a model plastic particles treated human cells pregnant mice PS-NPs at doses near actual environmental exposure in humans. We found that to induced mouse suppressed ROCK1-mediated migration/invasion formation. SOX2 was transcription factor ROCK1. activated autophagy promoted degradation SOX2, thus suppressing SOX2-mediated ROCK1 transcription. Supplementing murine or could efficiently rescue alleviate Analysis protein levels ROCK1, TSPAN4, NDST1, P62, LC-3BII/I PS-NP-exposed cells, villous tissues patients, placental gave consistent results. Collectively, study revealed toxicity their potential regulatory mechanism, indicating NP is risk for health.

Language: Английский

Citations

39
Microplastics in the human body: A comprehensive review of exposure, distribution, migration mechanisms, and toxicity DOI

Yue Li,

Liping Chen,

Nonglin Zhou

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 946, P. 174215 - 174215

Published: June 22, 2024

Language: Английский

Citations

39
Polylactic Acid Micro/Nanoplastic Exposure Induces Male Reproductive Toxicity by Disrupting Spermatogenesis and Mitochondrial Dysfunction in Mice DOI
Qiancheng Zhao, Zishui Fang, Pengcheng Wang

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

Although considered an "eco-friendly" biodegradable plastic, polylactic acid (PLA) microplastic (PLA-MP) poses a growing concern for human health, yet its effects on male reproductive function remain underexplored. This study investigated the toxicity of PLA in mice and potential mechanisms. To this end, our vivo vitro experiments demonstrated that after degradation digestive system, significant number PLA-MP-derived nanoparticles could penetrate blood–testis barrier (BTB) localize within spermatogenic microenvironment. Mice exposed to PLA-MPs long time exhibited toxicity, evidenced by decreased sperm concentration motility, increased deformity rates, disrupted sex hormone levels. Further analysis revealed impaired BTB, induced mitochondrial dysfunction testes, triggered oxidative stress through excessive ROS production from mitochondria, leading further testicular damage. Notably, nanoplastics internalized sheath structure sperm, causing dose-dependent impairments function. Transcriptome analyses indicated spermatogenesis inhibiting expression key mRNA involved process. Collectively, findings highlight toxic effect damaging BTB impairing function, which provides insights into toxicological implications microplastics mammalian fertility.

Language: Английский

Citations

3
Association of mixed exposure to microplastics with sperm dysfunction: a multi-site study in China DOI Creative Commons

Chen Zhang,

Guanghui Zhang, Kuan Sun

et al.

EBioMedicine, Journal Year: 2024, Volume and Issue: 108, P. 105369 - 105369

Published: Sept. 28, 2024

Language: Английский

Citations

9
Assessing the impact of sub-chronic polyethylene terephthalate nanoplastic exposure on male reproductive health in mice DOI

Oğuz Kaan Tombul,

Arife Dilşad Akdağ,

Pınar Buket Thomas

et al.

Toxicology and Applied Pharmacology, Journal Year: 2025, Volume and Issue: 495, P. 117235 - 117235

Published: Jan. 19, 2025

Language: Английский

Citations

1
Exposure to polystyrene nanoplastics impairs sperm metabolism and pre-implantation embryo development in mice DOI Creative Commons
Yingdong Liu,

Fengdan Hao,

Hao Liang

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 28, 2025

Introduction Microplastics and nanoplastics are prevalent environmental contaminants. Recent reports indicate that polystyrene nanoparticles may adversely impact male reproductive health. This study aims to examine the effects of exposure on sperm metabolism development pre-implantation embryos. Methods In this study, C57BL/6 mice were orally gavage-administered (60 nm, 20 mg/kg/day) for 35 days assess their reproduction early embryonic development. Experiments included testicular transcriptome analysis, metabolomics, motility fertilization assays, ROS detection, RNA sequencing 2-cell embryos, revealing adverse embryo Results The results revealed oral gavage induced a pronounced immune-inflammatory response in tissue, reduced motility, significantly lowered rate. Notably, from treated exhibited substantial metabolic disruptions, affecting key pathways, including glycerophospholipid biosynthesis DNA repair. After fertilization, embryos at stage suffered damage apoptotic repair subsequently impairing Discussion conclusion, demonstrated administration affects function, resulting abnormalities alterations associated gene expression profiles. These findings offer essential scientific insights future research into sperm-mediated transgenerational

Language: Английский

Citations

1
Adverse effects and potential mechanisms of polystyrene microplastics (PS-MPs) on the blood-testis barrier DOI
Jinchen Jiang,

Zhenhao Shu,

Lianglin Qiu

et al.

Environmental Geochemistry and Health, Journal Year: 2024, Volume and Issue: 46(7)

Published: June 7, 2024

Language: Английский

Citations

7
Reproductive and developmental implications of micro- and nanoplastic internalization: Recent advances and perspectives DOI Creative Commons
Zitong Zhang,

Jiahua Meng,

Jiaqi Tian

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 286, P. 117245 - 117245

Published: Oct. 25, 2024

Language: Английский

Citations

5
Review of New Approach Methodologies for Application in Risk Assessment of Nanoparticles in the Food and Feed Sector: Status and Challenges DOI Open Access

Shirin M. Usmani,

Susanne Bremer‐Hoffmann, Karlien Cheyns

et al.

EFSA Supporting Publications, Journal Year: 2024, Volume and Issue: 21(9)

Published: Sept. 1, 2024

Abstract New Approach Methodologies (NAMs), broadly understood to include in silico, chemico, vitro and ex vivo methods, show great potential advancing risk assessment albeit their regulatory implementation is lagging. The EFSA Guidance on of nanomaterials (EFSA Nano‐RA) suggests nano‐specific best achieved through Integrated Approaches Testing Assessment (IATAs) with NAMs as the first choice generate new information. Integrating promises several advantages such a better human focus, more detailed insights into molecular mechanisms higher efficacy. However, applying NMs also poses considerable challenges issues related dispersion stability, dosimetry, agglomeration, dissolution, transformations or assay interferences. Significant efforts are being undertaken by standardisation organisations research projects establish various for NMs. Here thorough review provided covering that will be potentially useful food feed sector. It follows structure Nano‐RA expands it, where needed, support decision‐making selection NM assessment. begins an overview NAM‐frameworks, followed description individual including those relevant physicochemical characterisation, exposure hazard toxicodynamics toxicokinetics. focus concerning degradation/dissolution, genotoxicity, cytotoxicity, oxidative stress, (pro‐)inflammation, barrier integrity important endpoints initial screening according framework. As result, total 267 nano‐relevant NAMs, mostly “not validated” (with few notable exceptions), were included this review. Validation notwithstanding, could already prove reliable NMs, especially integrated approaches.

Language: Английский

Citations

4
Research Progress in Reproductive Toxicity of Micro- and Nanoplastics on Males and Its Mechanisms DOI Creative Commons

昱 谭

Hans Journal of Food and Nutrition Science, Journal Year: 2025, Volume and Issue: 14(01), P. 23 - 29

Published: Jan. 1, 2025

Language: Английский

Citations

0