Heliyon, Journal Year: 2024, Volume and Issue: 11(1), P. e41298 - e41298
Published: Dec. 18, 2024
Language: Английский
Applied Sciences, Journal Year: 2024, Volume and Issue: 14(16), P. 7280 - 7280
Published: Aug. 19, 2024
Nanoplastics (NPs) represent an escalating hazard to both humans and the ecosystem due their pervasive presence. This review delves into (i) widespread occurrence of NPs across different environmental matrices, including food; (ii) routes estimates for human exposure; (iii) mechanisms blood–brain barrier (BBB) crossing; (iv) implications health, with a specific focus on molecular features associated neurotoxicity neurodegenerative processes. The impact central nervous system, ability cross BBB underpinning mechanisms, potential initiate by fostering β-amyloid aggregation, interactions metallo-enzymes (such as superoxide dismutase) are elucidated. analysis transcriptomics epigenomic results, microRNA dysregulation, unveil how could contribute neurological disorders. need considering overlaps among diverse pathogenetic when probing effects is discussed. Additional urgent needs development reliable in vitro models studies able mimic complexity system exposure such more environmentally relevant NPs. Finally, extremely sensitive detection methodologies quantify biological matrices pressing priority.
Language: Английский
Citations
3
Life Sciences, Journal Year: 2024, Volume and Issue: 357, P. 123107 - 123107
Published: Oct. 5, 2024
Language: Английский
Citations
3
Toxics, Journal Year: 2024, Volume and Issue: 12(8), P. 617 - 617
Published: Aug. 21, 2024
Nanoplastics, as emerging environmental pollutants, can transport contaminants across marine environments, polluting pristine ecosystems and being ingested by organisms. This transfer poses a severe threat to global aquatic potentially impacts human health through the food chain. Neurobehavioral reproductive toxicity are critical areas of concern because they directly affect survival, health, population dynamics species, which have cascading effects on entire ecosystem. Using zebrafish model organism, we investigated toxic concentrations polystyrene nanoplastics (PS-NPs). Behavioral assessments, including novel tank test open field test, demonstrated significant neurobehavioral changes, indicating increased anxiety depressive behaviors. A pathological analysis brain gonadal tissues, along with evaluations biomarkers, revealed that exposure PS-NPs leads tissue lesions, inflammatory responses, oxidative stress activation, hormone level disruptions, damage. Real-time quantitative PCR studies gene expression further showed disrupt endocrine regulation pathways brain-pituitary-gonadal (BPG) axis, causing sex-specific differences. These findings provide crucial insights into organisms their ecological risks, offering theoretical support for future protection pollutant management efforts.
Language: Английский
Citations
2
Advances in medical technologies and clinical practice book series, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 23
Published: June 28, 2024
Alzheimer's disease (AD) is a progressive neurodegenerative that results in steady decline cognitive ability and memory function. As society ages, the need for an optimum AD management strategy becomes more important. This chapter analyzes stage-construction etiology escalating symptoms of discovered throughout this review, as well identification barrier to precise diagnosis. The artificial intelligence achieve quicker detection through machine learning, data analytics, predictive modeling also being considered. Therefore, employing AI AD-related studies novel approach enhancing patient outcomes. Proper diagnosis parallel increased probability many parameters one most difficult moments identify. However, use evaluation sensor network technologies big analysis has advanced, preventive instruments can be used. Thus, technology gives humanity hope stop or, at very least, slow down tragedy.
Language: Английский
Citations
1
Archives of Toxicology, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 6, 2024
Language: Английский
Citations
1
The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 954, P. 176898 - 176898
Published: Oct. 12, 2024
Language: Английский
Citations
1
Advanced Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 11, 2024
Biomolecule isolation is a crucial process in diverse biomedical and biochemical applications, including diagnostics, therapeutics, research, manufacturing. Recently, MXenes, novel class of two-dimensional nanomaterials, have emerged as promising adsorbents for this purpose due to their unique physicochemical properties. These biocompatible antibacterial nanomaterials feature high aspect ratio, excellent conductivity, versatile surface chemistry. This timely review explores the potential MXenes isolating wide range biomolecules, such proteins, nucleic acids, small molecules, while highlighting key future research trends innovative applications poised transform field. provides an in-depth discussion various synthesis methods functionalization techniques that enhance specificity efficiency biomolecule isolation. In addition, mechanisms by which interact with biomolecules are elucidated, offering insights into selective adsorption customized separation capabilities. also addresses recent advancements, identifies existing challenges, examines emerging may drive next wave innovation rapidly evolving area.
Language: Английский
Citations
1
Eurasian Journal of Toxicology, Journal Year: 2024, Volume and Issue: 6(1), P. 17 - 18
Published: April 14, 2024
The impact of microplastics on mental health is an emerging area research, and the medical literature points to potential neurobehavioral effects. Studies have shown that exposure can lead changes in behavior, neurotoxicity, cognitive impairments animal models. Although these findings from studies suggest a possible link between microplastic outcomes, it important note research this still limited more are needed understand mechanisms consequences for human health.
Language: Английский
Citations
0
Advances in medical diagnosis, treatment, and care (AMDTC) book series, Journal Year: 2024, Volume and Issue: unknown, P. 27 - 64
Published: Oct. 11, 2024
Nanomaterials possess different properties that make them suitable for application in numerous fields. Nonetheless, their toxicity, especially neurotoxic propensity, is a considerable area of investigation. In this chapter, nanomaterial neurotoxicity reviewed detail, with an emphasis on assessing levels exposure or routes entry to brain cells, mechanisms by which they cause damage, and specific types damage. addition, vitro, ex vivo, vivo models used measure are described. This chapter provides discussion matter considering challenges terms characterization, risk assessment, regulatory aspects. concludes underscoring the importance toxicological prediction safe-by-design solutions. Future research should address long-term effects using nanomaterials means preventing neurotoxicity.
Language: Английский
Citations
0
Molecules, Journal Year: 2024, Volume and Issue: 29(23), P. 5776 - 5776
Published: Dec. 6, 2024
Increasing evidence on the adverse health impacts of microplastics (MPs) is available, but their associated risks to well-being humans and long-term are poorly understood. An indicator remote effects MPs may be influence rate aging. To assess aging process, we used accelerated senescence OXYS rats that develop a complex geriatric diseases. We prepared polyethylene terephthalate (2-6 microns in size) Wistar (maternal strain) assessed chronic administration (10 or 100 mg/kg per day from age 1.5 3.5 months,) hematological biochemical blood parameters, spatial learning, memory. In addition, development cataracts retinopathy, similar age-related macular degeneration (AMD), were assessed. found absence significant changes standard clinical MP negatively affected cognitive functions both rats. Additionally, dose contributed cataract AMD progression Our results suggest increase and, long term, lifespan.
Language: Английский
Citations
0