Animal nutrition,
Journal Year:
2024,
Volume and Issue:
20, P. 95 - 109
Published: Nov. 2, 2024
Weaning
stress
causes
substantial
economic
loss
in
the
swine
industry.
Moreover,
weaning-induced
intestinal
barrier
damage
and
dysfunction
of
gut-liver
axis
are
associated
with
reduced
growth
performance
piglets.
Metasilicate-based
alkaline
mineral
water
(AMW)
has
shown
potential
therapeutic
effects
on
gastrointestinal
disorders;
however,
mechanisms
involved
their
overall
have
not
been
explored.
Here,
sodium
metasilicate
(SMS)
was
used
to
prepare
metasilicate-based
AMW
(basal
+
500
mg/L
SMS).
A
total
240
newly
weaned
piglets
were
allocated
Control
SMS
groups
(6
replicate
pens
per
group
20
pen)
for
a
15-day
trial
period.
Histopathological
evaluations
conducted
using
hematoxylin
eosin
staining.
To
analyze
composition
gut
microbiota,
16S
rRNA
PacBio
SMRT
Gene
Full-Length
Sequencing
performed.
Western
blotting
immunofluorescence
employed
assess
protein
expression
levels.
Our
results
indicated
that
effectively
alleviated
colonic
or
liver
morphological
injury
inflammatory
response,
as
well
cholesterol
metabolism
disorders.
Further
analysis
showed
promoted
deoxycholic
acid
(DCA)
biosynthesis
by
increasing
abundance
Lactobacillus_delbrueckii
colon
(P
<
0.001).
This
consequently
improved
through
DCA-secondary
bile
(SBA)
receptors
(SBAR)-nuclear
factor-kappaB
(NF-κB)/NOD-like
receptor
family
pyrin
domain-containing
3
(NLRP3)
pathways.
Growth
parameters,
including
final
body
weight
=
0.034)
average
daily
gain
0.001),
significantly
higher
than
those
group.
Therefore,
maintains
homeostasis
regulating
microbiota-mediated
SBA-SBAR
pathway
under
weaning
stress.
research
provides
new
strategy
mitigating
stress-induced
Journal of Agricultural and Food Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 11, 2025
Mycotoxin
contamination
is
a
universal
agricultural
problem
and
critical
health
issue.
Fumonisin
B1
(FB1)
one
of
the
most
toxic
extensive
fumonisins
that
exist
in
various
agro-products
foods.
Lycopene
(LYC),
as
natural
carotenoid,
becoming
increasingly
favored
owing
to
its
oxidation
resistance.
Here,
we
aim
explore
mechanism
FB1-induced
hepatotoxicity
antagonism
LYC.
In
this
study,
our
findings
indicated
FB1
induced
mitochondrial
structure
damage
loss
function
chicken
hepatocytes.
Furthermore,
upregulated
expression
PANoptosis-related
signal
molecules.
also
reduced
levels
SIRT1
Ac-FOXO1
protein
expression,
which
then
inhibited
mitophagy.
However,
LYC
relieved
these
alterations.
Most
importantly,
knockdown
protective
effects
PANoptosis.
Our
study
provides
evidence
for
role
mycotoxin-induced
hepatocyte
injury
points
potential
target
liver
protection.
Journal of Agricultural and Food Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 27, 2025
T-2
toxin
is
a
highly
toxic
fungal
that
threatens
humans
and
animals'
health.
As
major
detoxifying
metabolic
organ,
the
kidney
also
target
of
toxin.
This
article
reviews
nephrotoxicity
research
progress,
covering
renal
structure
function
damage,
mechanisms,
detoxification
methods
to
future
directions.
damages
structure,
causing
dysfunction.
The
mechanism
involves
multiple
factors
including
oxidative
stress,
endoplasmic
reticulum
mitophagy,
inflammatory
responses,
apoptosis,
which
are
intertwined
interdependent.
Current
strategies
mainly
involve
reducing
in
feedstuff
using
antioxidant
substances,
but
both
have
limits.
Future
should
focus
on
cells
sensitivity
toxin,
exploring
key
molecules
toxin's
nephrotoxicity,
injury's
impact
other
organs,
better
methods.
review
aims
guide
underpin
toxin-induced
prevention
treatment.
Journal of Agricultural and Food Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 25, 2025
Di(2-ethylhexyl)
phthalate
(DEHP),
which
is
widely
used
in
agricultural
plastics,
accumulates
humans
and
animals
through
the
food
chain
over
time,
resulting
liver
toxicity.
Recent
studies
have
reported
that
pyroptosis
mitochondrial
damage
are
closely
related
to
a
variety
of
diseases,
but
specific
mechanism
still
unclear.
To
address
this
issue,
vitro
vivo
hepatotoxicity
models
were
established.
The
results
demonstrated
exposure
DEHP
caused
buildup
MEHP
livers,
altered
metabolite
composition,
pyroptosis-like
changes
hepatocytes.
After
treatment,
REDOX
homeostasis
was
unbalanced,
reactive
oxygen
species
(mtROS)
overproduced.
activates
mediated
by
TNF/TNFR1
signaling
upregulates
perforating
protein
GSDMD-N
destroy
membrane
Above
all,
study
elucidates
potential
involvement
signaling-mediated
confirms
regulation
helpful
maintaining
normal
function.
Atrazine
(AT),
a
widely
utilized
chemical
herbicide,
causes
widespread
contamination
of
agricultural
water
bodies.
Recently,
exposure
to
AT
has
been
linked
the
development
age-related
neurodegenerative
diseases
(NDs),
suggesting
its
neurotoxicity
potential.
As
an
endocrine
disruptor,
targets
hypothalamus,
crucial
part
neuroendocrine
system.
However,
toxicological
mechanism
hypothalamus
and
correlation
with
ND
remain
unexplored.
Our
results
indicated
that
caused
significant
morphological
structural
damage
leading
loss
mature
intact
neurons
microglial
activation.
Furthermore,
hypothalamic
neural
stem
cells
(HtNSCs)
were
recruited
areas
neuronal
by
AT.
Through
in
vivo
vitro
experiments,
we
clarified
outcomes
AT-induced
HtNSC
recruitment
alongside
mature/intact
neurons.
Mechanistically,
induces
senescence
these
HtNSCs
activating
integrated
stress
response
signaling.
This
consequently
hinders
repair
damaged
inhibiting
proliferation
differentiation.
Overall,
our
findings
underscore
pivotal
role
pathway
damage.
Additionally,
present
study
offers
novel
perspectives
understand
mechanisms
provides
preliminary
evidence
linking
NDs.
