Quercetin as a protective agent for liver diseases: A comprehensive descriptive review of the molecular mechanism

Phytotherapy Research, Journal Year: 2021, Volume and Issue: 35(9), P. 4727 - 4747

Published: June 22, 2021

Quercetin is the major representative of flavonoid subgroup flavones, with good pharmacological activities for treatment liver diseases, including steatosis, fatty hepatitis, fibrosis, and cancer. It can significantly influence development diseases via multiple targets pathways antifat accumulation, anti‐inflammatory, antioxidant activity, as well inhibition cellular apoptosis proliferation. Despite extensive research on understanding mechanism quercetin in there are still no targeted therapies available. Thus, we have comprehensively searched summarized different stages concluded that inhibited inflammation mainly through NF‐κB/TLR/NLRP3, reduced PI3K/Nrf2‐mediated oxidative stress, mTOR activation autophagy, expression apoptotic factors associated diseases. In addition, showed mechanisms action at regulation PPAR, UCP, PLIN2‐related brown fat steatosis. The compound stromal ECM deposition fibrosis stage, affecting TGF1β, endoplasmic reticulum stress (ERs), apoptosis. While final cancer inhibiting cell proliferation spread hTERT, MEK1/ERK1/2, Notch, Wnt/β‐catenin‐related signaling pathways. conclusion, an effective protectant. We hope to explore pathogenesis review, so provide more accurate theoretical basis further

Language: Английский

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Associations between urinary phthalate metabolite concentrations and markers of liver injury in the US adult population

Environment International, Journal Year: 2021, Volume and Issue: 155, P. 106608 - 106608

Published: May 6, 2021

Phthalates have been largely used for years in varieties of products worldwide. However, research on the joint toxic effect various phthalates exposure liver is lacking. We aimed to assess function tests (LFTs). This analysis included data 6046 adults (≥20 old) who participated a National Health and Nutrition Examination Survey (NHANES) 2007–2016. employed linear regression Bayesian kernel machine (BKMR), explore associations urinary phthalate metabolites with 8 indicators LFTs. Di(2-ethylhexyl) (ΣDEHP) was found be positively associated serum alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT) alkaline phosphatase (ALP) (all P FDR < 0.05). significant positive ∑DEHP, mono-ethyl (MEP) mono-(carboxyisononyl) (MCNP) total bilirubin (TBIL) ΣDEHP, mono-n-butyl (MBP), mono-(3-carboxypropyl) (MCPP) mono-benzyl (MBzP) were negatively ALB The BKMR analyses showed significantly overall ALT, AST, ALP TBIL levels high concentrations negative TP, when all chemicals at low concentrations. Our results add novel evidence that exposures might adversely LTFs, indicating potential human liver.

Language: Английский

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Pharmacological properties of baicalin on liver diseases: a narrative review

Pharmacological Reports, Journal Year: 2021, Volume and Issue: 73(5), P. 1230 - 1239

Published: Feb. 17, 2021

Abstract Baicalin is the main active component of Scutellaria baicalensis, widely used in traditional Chinese medicine thanks to its various pharmacological effects, such as anti-tumor, anti-inflammatory, and antibacterial properties, well cardiovascular, hepatic, renal protective effect. Recently, effects baicalin on liver disease have received much more attention. Several studies showed that protects against several types diseases including viral hepatitis, fatty disease, xenobiotic induced injury, cholestatic hepatocellular carcinoma, with a variety mechanisms. A comprehensive understanding mechanism can provide valuable reference for clinical use, but up now, no narrative review available summarizes clarify potential use treatment diseases. Therefore, this progress research underlying diseases, promote further application.

Language: Английский

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Exploration of nitrogen-doped grape peels carbon dots for baicalin detection

Materials Today Physics, Journal Year: 2021, Volume and Issue: 22, P. 100576 - 100576

Published: Dec. 8, 2021

Language: Английский

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Scoparone as a therapeutic drug in liver diseases: Pharmacology, pharmacokinetics and molecular mechanisms of action

Pharmacological Research, Journal Year: 2020, Volume and Issue: 160, P. 105170 - 105170

Published: Aug. 30, 2020

Language: Английский

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Inhibition of Oxidative Stress and ALOX12 and NF-κB Pathways Contribute to the Protective Effect of Baicalein on Carbon Tetrachloride-Induced Acute Liver Injury

Antioxidants, Journal Year: 2021, Volume and Issue: 10(6), P. 976 - 976

Published: June 18, 2021

This study investigates the protective effect of baicalein on carbon tetrachloride (CCl4)-induced acute liver injury and underlying molecular mechanisms. Mice were orally administrated at 25 100 mg/kg/day for 7 consecutive days or ferrostatin-1 (Fer-1) 10 mg/kg was i.p. injected in mice 2 24 h prior to CCl4 injection vehicle. Our results showed that Fer-1 supplementation significantly attenuated exposure-induced elevations serum alanine aminotransferase aspartate aminotransferase, malondialdehyde levels tissues unregulated glutathione levels. Baicalein treatment inhibited nuclear factor kappa-B (NF-κB) pathway, activated erythroid 2-related (Nrf2)/heme oxygenase 1 (HO-1) pathway tissues, markedly improved CCl4-induced apoptosis, inflammation ferroptosis exposed with CCl4. In vitro, -induced decreases cell viabilities knockdown Nrf2 arachidonate 12-lipoxygenase (ALOX12) genes partly abolished cytotoxicity HepG2 cells. conclusion, our reveal ameliorates by upregulating antioxidant defense pathways downregulating oxidative stress, ferroptosis, which involved activation inhibition ALOX12 NF-κB pathways.

Language: Английский

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Validation of Baveno VII criteria for recompensation in entecavir-treated patients with hepatitis B-related decompensated cirrhosis

Journal of Hepatology, Journal Year: 2022, Volume and Issue: 77(6), P. 1564 - 1572

Published: Aug. 28, 2022

•This is the first prospective validation of Baveno VII recompensation definition in patients with HBV-related cirrhosis.•A stable improvement liver function tests was defined as MELD <10 and/or ALB & INR TBIL within Child-Pugh A.•On-treatment scores may be more predictive probability than baseline scores.•Prompt antiviral therapy effective for cirrhosis, even under severe conditions. Background AimsAntiviral improves clinical outcomes chronic hepatitis B (CHB), including those cirrhosis. In present study, we validated and explored criteria entecavir-treated CHB-related decompensated cirrhosis.MethodsIn this multicentre (ascites) cirrhosis were enrolled treated entecavir 120 weeks. Patients followed up events, viral biochemical tests, ultrasonography every 6 months. The rate per calculated. Multivariate regression models used to identify predictors recompensation. Finally, explored.ResultsOf 320 recruited patients, 283 completed 120-week 261/283 (92.2%) achieving HBV DNA levels <20 IU/ml 171/283 (60.4%) resolution ascites, encephalopathy, absence recurrent variceal bleeding at least 12 We identified model end-stage disease Class A (albumin >35 g/L, international normalised ratio <1.50 total bilirubin <34 μmol/L) tests. Accordingly, 56.2% (159/283) fulfilled a by current study.ConclusionsOur study required on therapy. derived from warrant further other aetiologies.Lay summaryDecompensation marks point which no longer able normally (and symptoms become apparent). Recently idea proposed individuals who experience an if underlying cause their addressed (e.g. antivirals cirrhosis). Herein, show that over 50% B-related could recompensate propose laboratory define Antiviral explored. Of study. Our aetiologies.

Language: Английский

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Organ-organ communication: The liver's perspective

Theranostics, Journal Year: 2021, Volume and Issue: 11(7), P. 3317 - 3330

Published: Jan. 1, 2021

Communication between organs participates in most physiological and pathological events. Owing to the importance of precise coordination among liver virtually all body for maintenance homeostasis, many hepatic disorders originate from impaired organ-organ communication, resulting concomitant phenotypes distant organs. Hepatokines are proteins that predominantly secreted liver, hepatokines several signaling have been linked diseases other organs, such as heart, muscle, bone, eyes. Although liver-centered interorgan communication has proposed both basic clinical studies, date, regulatory mechanisms hepatokine production, secretion, reciprocation with factors obscure. Whether hormones cytokines involved also warrants investigation. Herein, we summarize current knowledge a variety possible involvement and/or important factors. This provides novel insight into underlying roles liver-originated signal transduction and, more importantly, understanding disease an integrative view.

Language: Английский

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Sequential Nano-Penetrators of Capillarized Liver Sinusoids and Extracellular Matrix Barriers for Liver Fibrosis Therapy

ACS Nano, Journal Year: 2022, Volume and Issue: 16(9), P. 14029 - 14042

Published: Aug. 29, 2022

During liver fibrogenesis, sinusoidal capillarization and extracellular matrix (ECM) deposition construct dual pathological barriers to drug delivery. Upon capillarization, the vanished fenestrae in endothelial cells (LSECs) significantly hinder substance exchange between blood cells, while excessive ECM further hinders delivery of nanocarriers activated hepatic stellate (HSCs). Herein, an efficient nanodrug system was constructed sequentially break through capillarized LSEC barrier deposited barrier. For first barrier, LSEC-targeting fenestrae-repairing nanoparticles (named HA-NPs/SMV) were designed on basis modification with hyaluronic acid loading simvastatin (SMV). second collagenase I vitamin A codecorated collagen-ablating HSC-targeting functions CV-NPs/siCol1α1) prepared deliver siCol1α1 goal inhibiting collagen generation HSC activation. Our vivo results showed that upon encountering HA-NPs/SMV rapidly released SMV exerted a function, which allowed more CV-NPs/siCol1α1 enter space Disse degrade finally achieve higher accumulation HSCs. Scanning electronic microscopy images recovery sinusoids, analysis tissue sections demonstrated had synergetic effect. barrier-normalization strategy provides antifibrotic therapeutic regimen.

Language: Английский

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Diet and Risk of Non-Alcoholic Fatty Liver Disease, Cirrhosis, and Liver Cancer: A Large Prospective Cohort Study in UK Biobank

Nutrients, Journal Year: 2022, Volume and Issue: 14(24), P. 5335 - 5335

Published: Dec. 15, 2022

Background and Aims: Epidemiological evidence has shown the association between nutritional habits liver disease. However, results remain conflicting. This study investigated influence of dietary factors on risk incident non-alcoholic fatty disease (NAFLD), cirrhosis, cancer. Methods: Data from UK Biobank database were analyzed (n = 372,492). According to baseline data food frequency questionnaire, two main patterns (Western prudent) identified using principal component analysis. We used cox proportional hazards models explore associations individual groups with NAFLD, Results: During a median follow-up 12 years, 3527 hospitalized 1643 669 cancer cases recorded among 372,492 participants without prior history or chronic diseases at baseline. In multivariable adjusted analysis, in high tertile Western pattern score had an 18% (95%CI 1.09–1.29), 21% 1.07–1.37), 24% 1.02–1.50) higher cancer, respectively, compared low tertile. Participants prudent scores 15% 0.75–0.96) lower as those addition, consumption red meat fruit, cereal, tea, fiber significantly associated (ptrend < 0.05). Conclusions: large prospective cohort showed that increased intake could be correlated diseases, while was only reduced cirrhosis risk. These may provide new insights into lifestyle interventions for prevention chronical diseases.

Language: Английский

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