Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113680 - 113680
Published: April 1, 2025
Language: Английский
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(16)
Published: Jan. 9, 2024
During liver fibrogenesis, the reciprocal crosstalk among capillarized sinusoidal endothelial cells (LSECs), activated hepatic stellate (HSCs), and dysfunctional hepatocytes constructs a self-amplifying vicious cycle, greatly exacerbating disease condition weakening therapeutic effect. Limited by malignant cellular interactions, previous single-cell centric treatment approaches show unsatisfactory efficacy fail to meet clinical demand. Herein, cycle-breaking strategy is proposed target repair pathological separately terminate progression of fibrosis. Chondroitin sulfate-modified vismodegib-loaded nanoparticles (CS-NPs/VDG) are designed efficiently normalize fenestrae phenotype LSECs restore HSCs quiescent state inhibiting Hedgehog signaling pathway. In addition, glycyrrhetinic acid-modified silybin-loaded (GA-NPs/SIB) prepared function relieving oxidative stress. The results successful interruption cycle as well distinct fibrosis resolution in two animal models through multiregulation cells. This work not only highlights significance modulating but also provides promising avenue for developing antifibrotic regimens.
Language: Английский
Citations
17
Radiology, Journal Year: 2025, Volume and Issue: 314(1)
Published: Jan. 1, 2025
Photoacoustic microscopy imaging could be used to evaluate the severity of liver fibrosis by means an analysis structural and functional characteristics lobules.
Language: Английский
Citations
3
Science Advances, Journal Year: 2023, Volume and Issue: 9(29)
Published: July 19, 2023
Pulmonary fibrosis (PF) is an age-related interstitial lung disease that results in notable morbidity and mortality. The Food Drug Administration-approved drugs can decelerate the progression of PF; however, curing aged patients with severe ineffective because insufficient accumulation these wide necrocytosis type II alveolar epithelial cells (AEC IIs). Here, we constructed a mesenchymal stem cell (MSC)-based nanoengineered platform via bioconjugation MSCs I collagenase-modified liposomes loaded nintedanib (MSCs-Lip@NCAF) for treating fibrosis. Specifically, MSCs-Lip@NCAF migrated to fibrotic lungs homing characteristic then Lip@NCAF was sensitively released. Subsequently, ablated collagen fibers, delivered into fibroblasts, inhibited fibroblast overactivation. differentiated AEC IIs repair structure ultimately promote regeneration damaged mice. Our findings indicated could be used as promising therapeutic candidate PF therapy, especially patients.
Language: Английский
Citations
39
Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 368, P. 219 - 232
Published: Feb. 28, 2024
Language: Английский
Citations
15
Small Methods, Journal Year: 2024, Volume and Issue: unknown
Published: July 23, 2024
Abstract Hyaluronic acid (HA) is a naturally occurring polysaccharide found in the extracellular matrix with broad applications disease treatment. HA possesses good biocompatibility, biodegradability, and ability to interact various cell surface receptors. Its wide range of molecular weights modifiable chemical groups make it an effective drug carrier for delivery. Additionally, overexpression specific receptors on surfaces many states enhances accumulation drugs at pathological sites through receptor binding. In this review, modification drugs, major proteins, latest advances receptor‐targeted nano delivery systems (DDS) treatment tumors inflammatory diseases are summarized. Furthermore, functions varying vivo selection methods different discussed.
Language: Английский
Citations
14
ACS Nano, Journal Year: 2024, Volume and Issue: 18(32), P. 20861 - 20885
Published: July 31, 2024
Liver fibrosis (LF) is a pathological repair reaction caused by chronic liver injury that affects the health of millions people worldwide, progressing to life-threatening cirrhosis and cancer without timely intervention. Due complexity LF pathology, multiple etiological characteristics, deposited extracellular matrix, traditional drugs cannot reach appropriate targets in time-space matching way, thus decreasing therapeutic effect. Nanoparticle drug delivery systems (NDDS) enable multidrug co-therapy develop multifactor strategies targeting processes, showing great potential therapy. Based on pathogenesis current clinical treatment status LF, we systematically elucidate mechanism NDDS used LF. Subsequently, focus progress applications for including combined fibrotic environment, overcoming biological barriers, precise intracellular regulation, intelligent responsive microenvironment. We hope this review will inspire rational design future order provide ideas methods promoting regression cure.
Language: Английский
Citations
14
Molecular Medicine Reports, Journal Year: 2024, Volume and Issue: 29(3)
Published: Jan. 16, 2024
Liver fibrosis due to viral or metabolic chronic liver diseases is a major challenge of global health. It critical pre‑stage condition severe hepatopathy, characterized by excessive accumulation extracellular matrix components and ongoing inflammation. To date, early prevention remains challenging. As the most abundant non‑parenchymal hepatic cell population, sinusoidal endothelial cells (LSECs) are stabilizers that maintain intrahepatic environment. Notably, LSECs dysfunction appears be implicated in progression via numerous mechanisms. Following sustained injury, they lose their fenestrae (cytoplasmic pores) change crosstalk with other cellular interactions blood LSEC‑targeted therapy has shown promising effects on resolution, opening up new opportunities for anti‑fibrotic therapy. In light this, present study summarized changes during milieu, as well possible therapeutic approaches specially target LSECs.
Language: Английский
Citations
11
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(23)
Published: Feb. 14, 2024
Abstract Idiopathic pulmonary fibrosis (IPF) is an age‐related interstitial disease with unclear etiology that poses a serious threat to human health. IPF interventions in clinical settings mainly involve oral medications, such as nintedanib (NIN), which exhibit limited accumulation the lungs and neglect epithelial micro‐environment. Inhalation efficient route for treatment of diseases. However, mucus barrier trachea extracellular matrix (ECM) interstitium are two main obstacles inhaled therapeutic agent delivery. Therefore, this study, dual barrier‐penetrating liposomes (AN‐TR) constructed utilizing tris‐(2‐carboxyethyl)‐phosphine (TCEP) l ‐arginine penetrate ECM barriers, respectively. This approach facilitates thorough uniform distribution NIN navitoclax (ABT‐263) across all five lung lobes. Furthermore, ABT‐263 can remove senescent cells alveoli, thereby improving efficiency treatment. study suggests noninvasive vehicles first‐line medications improve efficacy
Language: Английский
Citations
11
Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)
Published: April 7, 2023
Abstract Liver fibrosis could be the last hope for treating liver cancer and remodeling of hepatic microenvironment has emerged as a strategy to promote ablation fibrosis. In recent years, especially with rapid development nanomedicine, therapy been widely researched in studies concerning this comprehensive review, we summarized advances nano therapy-based microenvironment. Firstly, discussed novel strategies regulatory immune suppression caused by capillarization sinusoidal endothelial cells (LSECs) macrophage polarization. Furthermore, metabolic reprogramming extracellular matrix (ECM) deposition are activation stellate (HSCs). addition, ROS, hypoxia, impaired vascular fibrotic due ECM have also summarized. Finally, emerging nanotherapeutic approaches based on correlated signals were review. We proposed such engineered nanotherapeutics targeting antigen-presenting (APCs) or direct T immunotherapy used preventing summary, review illustrated opportunities drug current challenges addressed. Graphical
Language: Английский
Citations
18
Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 200, P. 115051 - 115051
Published: Aug. 6, 2023
Language: Английский
Citations
17