Frontiers in Bioscience-Landmark,
Journal Year:
2024,
Volume and Issue:
29(5)
Published: May 11, 2024
Choline
participates
in
three
major
metabolic
pathways:
oxidation,
phosphorylation,
and
acetylation.
Through
choline
is
converted
to
betaine
contributes
methyl
metabolism
epigenetic
regulation.
phospholipid
metabolism,
serves
as
the
precursor
of
phosphocholine,
phosphatidylcholine,
glycerophosphocholine,
other
essential
compounds,
thereby
modulating
lipid
transport.
acetylation,
transformed
into
acetylcholine
cholinergic
neurons,
playing
a
vital
role
neurotransmission.
Moreover,
gut
microbiota
can
metabolize
trimethylamine-N-oxide,
be
involved
pathogenesis
various
diseases
such
nonalcoholic
fatty
liver
disease
(NAFLD),
cancer,
cardiovascular
disease,
etc.
Since
implicated
development
NAFLD
diverse
cancers,
including
it
may
serve
therapeutic
target
for
these
future.
Currently,
there
are
numerous
agents
targeting
treat
but
most
them
ineffective
some
even
have
adverse
effects
that
lead
series
complications.
Therefore,
further
research
clinical
validation
required
obtain
safe
efficacious
drugs.
This
review
comprehensively
summarizes
pathway
its
regulatory
mechanisms,
elucidates
roles
mechanisms
aforementioned
diseases,
provides
discussion
current
advances
immense
potential
this
field.
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(14), P. 2372 - 2372
Published: July 22, 2024
Hepatobiliary
malignancies,
which
include
hepatocellular
carcinoma
(HCC)
and
cholangiocarcinoma
(CCA),
are
the
sixth
most
common
cancers
third
leading
cause
of
cancer-related
death
worldwide.
Hepatic
carcinogenesis
is
highly
stimulated
by
chronic
inflammation,
defined
as
fibrosis
deposition,
an
aberrant
imbalance
between
liver
necrosis
nodular
regeneration.
In
this
context,
gut-liver
axis
gut
microbiota
have
demonstrated
a
critical
role
in
pathogenesis
HCC,
dysbiosis
altered
intestinal
permeability
promote
bacterial
translocation,
to
inflammation
tumorigenesis
through
several
pathways.
A
few
data
exist
on
or
bacteria
resident
biliary
tract
CCA,
some
microbial
metabolites,
such
choline
bile
acids,
seem
show
association.
review,
we
analyze
impact
its
metabolites
HCC
CCA
development
biomarker
hepatobiliary
cancer
risk
response
during
anti-tumor
therapy.
We
also
discuss
future
application
management.
International Journal of Oncology,
Journal Year:
2024,
Volume and Issue:
65(1)
Published: June 6, 2024
Several
studies
have
indicated
that
the
gut
microbiome
and
tumor
microbiota
may
affect
tumors.
Emerging
metabolomics
research
illustrates
need
to
examine
variations
in
microbial
metabolite
composition
between
patients
with
cancer
healthy
individuals.
Microbial
metabolites
can
impact
progression
of
tumors
immune
response
by
influencing
a
number
mechanisms,
including
modulation
system,
or
immune‑related
signaling
pathways,
epigenetic
modification
proteins
DNA
damage.
also
alleviate
side
effects
drug
resistance
during
chemotherapy
immunotherapy,
while
effectively
activating
system
exert
immunotherapy.
Nevertheless,
on
immunity
be
both
beneficial
harmful,
potentially
influenced
concentration
specific
type.
The
present
review
summarizes
roles
various
different
solid
tumors,
alongside
their
influence
treatment.
Additionally,
clinical
trials
evaluating
therapeutic
related
microbes
been
listed.
In
summary,
studying
metabolites,
which
play
crucial
role
interaction
could
lead
identification
new
supplementary
treatments
for
cancer.
This
has
potential
improve
effectiveness
treatment
enhance
patient
prognosis.
Frontiers in Cellular and Infection Microbiology,
Journal Year:
2023,
Volume and Issue:
13
Published: Nov. 16, 2023
Background
Non-alcoholic
steatohepatitis
(NASH)
has
become
a
major
public
health
issue
as
one
of
the
leading
causes
liver
disease
and
transplantation
worldwide.
The
instrumental
role
gut
microbiota
is
emerging
but
still
under
investigation.
Endogenous
ethanol
(EtOH)
production
by
bacteria
yeasts
an
putative
mechanism.
Microbial
metagenomics
culture
studies
targeting
enterobacteria
or
have
been
reported,
no
culturomics
conducted
so
far.
Aim
To
assess
fecal
EtOH
other
biochemical
parameters,
characterize
NASH-associated
dysbiosis
identify
EtOH-producing
microbes
associated
with
disease,
samples
from
41
NASH
patients
24
controls
were
analyzed.
High-performance
liquid
chromatography
(HPLC)
was
used
for
EtOH,
glucose,
total
proteins,
triglyceride
cholesterol.
Viable
assessed
microbial
culturomics.
genetic
material
using
16S
hypervariable
V3V4
region.
Results
Fecal
glucose
elevated
in
stools
(p
<
0.05)
not
triglyceride,
cholesterol
proteins.
In
culturomics,
Enterocloster
bolteae
Limosilactobacillus
fermentum
enriched
NASH.
rRNA
amplicon
sequencing
confirmed
enrichment
including
L.
,
Mediterraneibacter
gnavus
Streptococcus
mutans
species
previously
dysbiosis-associated
diseases.
Strikingly,
E.
identified
only
well-known
Lacticaseibacillus
casei
never
isolated
0.05).
Conclusion
Elevated
feature
Several
different
may
play
disease.
Culturomics
metagenomics,
two
complementary
methods,
will
be
critical
to
future
diagnostic
markers
therapeutic
targets
Suppression
administration
are
options
tested
treatment.
Frontiers in Bioscience-Landmark,
Journal Year:
2024,
Volume and Issue:
29(5)
Published: May 11, 2024
Choline
participates
in
three
major
metabolic
pathways:
oxidation,
phosphorylation,
and
acetylation.
Through
choline
is
converted
to
betaine
contributes
methyl
metabolism
epigenetic
regulation.
phospholipid
metabolism,
serves
as
the
precursor
of
phosphocholine,
phosphatidylcholine,
glycerophosphocholine,
other
essential
compounds,
thereby
modulating
lipid
transport.
acetylation,
transformed
into
acetylcholine
cholinergic
neurons,
playing
a
vital
role
neurotransmission.
Moreover,
gut
microbiota
can
metabolize
trimethylamine-N-oxide,
be
involved
pathogenesis
various
diseases
such
nonalcoholic
fatty
liver
disease
(NAFLD),
cancer,
cardiovascular
disease,
etc.
Since
implicated
development
NAFLD
diverse
cancers,
including
it
may
serve
therapeutic
target
for
these
future.
Currently,
there
are
numerous
agents
targeting
treat
but
most
them
ineffective
some
even
have
adverse
effects
that
lead
series
complications.
Therefore,
further
research
clinical
validation
required
obtain
safe
efficacious
drugs.
This
review
comprehensively
summarizes
pathway
its
regulatory
mechanisms,
elucidates
roles
mechanisms
aforementioned
diseases,
provides
discussion
current
advances
immense
potential
this
field.
