Effects of different antiviral mouthwashes on the surface roughness, hardness, and color stability of composite CAD/CAM materials

Journal of Applied Biomaterials & Functional Materials, Journal Year: 2024, Volume and Issue: 22

Published: Jan. 1, 2024

Objective: To evaluate the effect of COVID-19 preventive mouthwashes on surface hardness, roughness (Ra), and color change (ΔE) three different polymer-based composite CAD/CAM materials (Vita Enamic (ENA), Grandio Block (GB), Lava Ultimate (LU)). Methods: A total 100 rectangular-shaped specimens with dimensions 2 mm × 7 12 were obtained by sectioning blocks randomly divided into five subgroups according to 30 days mouthwash immersion protocol as follows: Control: artificial saliva, PVP-I: 1% povidone-iodine, HP: 1.5% hydrogen peroxide, CPC: containing 0.075% cetylpyridinium chloride, EO: essential oils. Microhardness, Ra, ΔE values measured at baseline after protocols. Data analyzed using Wald Chi-square, two-way ANOVA, post hoc Tukey tests. Results: The independent factors (materials solutions) significantly influenced microhardness ( p < 0.001). Ra was not affected any > 0.05). each material varied in PvP-I HP highest percentage microhardness, found LU immersed mouthwashes, while lowest ENA groups Conclusion: Within limitations this study, it that hardness tested are susceptible degradation mouthwashes.

Language: Английский

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Could mouth rinses be an adjuvant in the treatment of SARS‐CoV‐2 patients? An appraisal with a systematic review

International Journal of Dental Hygiene, Journal Year: 2021, Volume and Issue: 20(1), P. 136 - 144

Published: Oct. 10, 2021

A wide variety of mouth rinses are available to combat micro-organisms in the oral cavity. At present global pandemic, need hour is control viral infection due novel corona virus SARS-COV-2, as its port entry through receptors located and pharyngeal mucosa. This systematic literature review focuses on vivo studies [randomized trials (RCTs)] done efficacy existing which have been used reducing loads.The electronic database includes PubMed-MEDLINE, Google scholar, Scopus, Web Science, EMBASE, ProQuest CINAHL was searched from December 2019 June 2021 with appropriate Medical Subject Headings (MeSH) terms Boolean operators. Two reviewers independently reviewed abstracts.Of 2438 retrieved titles, 905 remained after removing duplicates. Twelve articles were eligible be included this seven randomized adequate sample size.Mouth washes containing povidone iodine chlorhexidine decrease load transiently. Large amount paramount importance, especially RCTs, prove these rinses.

Language: Английский

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Virucidal Activity of Different Mouthwashes Using a Novel Biochemical Assay

Healthcare, Journal Year: 2021, Volume and Issue: 10(1), P. 63 - 63

Published: Dec. 30, 2021

Saliva of patients with COVID-19 has a high SARS-CoV-2 viral load. The risk spreading the virus is not insignificant, and procedures for reducing loads in oral cavity have been proposed. Little research to date performed on effect mouthwashes virus, some their mechanisms action remain unknown. positive nasopharyngeal swabs measured by RT-PCR were used virucidal activity 1:1 ratio, an incubation time 1 min. solutions this study were: iodopovidone (8 mg); * D-limonene, terpene extracted from citrus peels (0.3%); † cetylpyridinium chloride (0.1%) (CPC); ‡ chlorhexidine gluconate (10%) (CHX); § CPC (0.12%) CHX (0.05%) containing formula; ** formula essential oils; †† (0.07%); ‡‡ D-limonene (0.2%) §§ solution sodium fluoride (0.075%); *** and; ††† formula. ‡‡‡ As control reaction, saline or excipient (water, glycerin, citric acid, colorant, citrate) was used. Within limitations study, we can conclude that mouthwash both reduced about 6 logs (>99.999% reduction). Hence, establishing clinical protocol dentists suggested, where all be treated rinse pre-operatively reduce likelihood infection dentists. This relatively inexpensive way transmission infected individuals within community. It also simple decrease infections asymptomatic pre-symptomatic patients.

Language: Английский

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A prospective, randomized, open-label trial of early versus late povidone-iodine gargling in patients with COVID-19

Scientific Reports, Journal Year: 2022, Volume and Issue: 12(1)

Published: Nov. 28, 2022

Abstract Povidone-iodine (PVP–I) is a broad-spectrum antiseptic reagent that has been used for over 50 years. The purpose of this study to look into the effect gargling with PVP–I on virus clearance and saliva infectivity in COVID-19. A prospective, randomized, open-label trial intervention was conducted at three quarantine facilities Osaka, Japan, enrolling adolescents adults asymptomatic-to-mild Patients were randomly allocated early late group 1:1 ratio. gargled from days 2 day 6; water first, then 5 after sampling till 6. primary secondary endpoints viral SARS-CoV-2 using RT-qPCR 6, respectively, investigational endpoint day5. We enrolled 430 participants, 215 assigned each group, 139 140 had positive test 2. On 5, significantly higher negative rate than (p = 0.015), 0.025). During intervention, one participant reported oropharyngeal discomfort. Gargling may hasten reduce transmission via salivary droplets aerosols patients (Clinical registration numbers: jRCT1051200078 dateof registration: 24/11/2020).

Language: Английский

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The use of antiviral Phthalocyanine mouthwash as a preventive measure against COVID-19.

GMS. Hygiene and infection control, Journal Year: 2021, Volume and Issue: 16, P. Doc24 - Doc24

Published: Jan. 1, 2021

Language: Английский

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Effect of Mouthwashes for COVID-19 Prevention on Surface Changes of Resin Composites

International Dental Journal, Journal Year: 2022, Volume and Issue: 73(4), P. 511 - 517

Published: Oct. 20, 2022

The aim of this research was to investigate the effect various mouthwashes for COVID-19 prevention on surface hardness, roughness, and colour changes bulk-fill conventional resin composites determine pH titratable acidity mouthwashes. Four hundred eighty specimens were fabricated in cylindrical moulds (10 mm diameter 2 thickness). Before immersion, baseline data values recorded. Each product (Filtek Z350XT, Premise, Filtek One Bulk Fill Restorative, SonicFil 2) divided into 4 groups 0.2% povidone iodine, 1% hydrogen peroxide, 0.12% chlorhexidine, deionised water (serving as a control). immersed 1 minute then stored artificial saliva until 24 hours. This process repeated 14 days. After measured at 7 statistically analysed by 2-way analysis variance, Tukey honestly significant difference, t test (P < .05). all caused significantly lower hardness greater roughness .05) tested. Mouthwashes had an evaluated leading decreased increased

Language: Английский

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Comparative evaluation of two cetylpyridinium chloride-based mouthwashes on the mechanical properties and strength loss of elastomeric chains used in dentistry: An vitro study

Heliyon, Journal Year: 2024, Volume and Issue: 10(6), P. e27721 - e27721

Published: March 1, 2024

ObjectivesEvaluate the strength degradation of polymeric ligature chains after their immersion in cetylpyridinium chloride-based mouthwashes.Methods240 elastomeric samples from four different manufacturers (Rocky Mountain®, Ormco®, Morelli® and Dentaurum®) two types configurations (with without intermodular links) divided 3 groups (distilled water, Vitis CPC Protect® PERIO·AID® 0.05%) at 5 follow-up periods (0–24 h, 7–14 -21 days) were immersed twice a day for 60 s, following manufacturers' protocols. A universal traction machine was used to perform measurements post hoc multiple comparisons based on Bonferroni test extended 3-way ANOVA (α = 0.05).ResultsThere drop up 35.9% 24 h. After week, short (52%) degraded less than long ones (57.3%) with significant differences (p < 0.001) same pattern observed until 21 days 0.001). At exposed distilled water 25.8%, VITIS 28.6% PERIO· AID® 0.05%, 27% days, group obtained much greater loss strength, being this statistically The Ormco® RMO® experienced least force when control or PERIO 0 0.05% (48% 51%), while Dentaurum's lost more 75%.ConclusionsThe orthodontic suffer sharp during first treatment. When comparing mouthwashes, there terms degradation.Clinical significanceBased results, some chains, such as links showed better properties throughout study. PERIO·AID®0.05%, all significantly results over time. Thus, PERIO·AID®0.05% can be recommended complementary oral hygiene element dental treatments are used.

Language: Английский

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Identification of receptors and factors associated with human coronaviruses in the oral cavity using single-cell RNA sequencing

Heliyon, Journal Year: 2024, Volume and Issue: 10(7), P. e28280 - e28280

Published: March 16, 2024

Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) ravaged the world, and Coronavirus Disease 2019 (COVID-19) exhibited highly prevalent oral symptoms that had significantly impacted lives of affected patients. However, involvement four human coronavirus (HCoVs), namely SARS-CoV-2, SARS-CoV, MERS-CoV, HCoV-229E, in cavity infections remained poorly understood. We integrated single-cell RNA sequencing (scRNA-seq) data seven tissues through consistent normalization procedure, including minor salivary gland (MSG), parotid (PG), tongue, gingiva, buccal, periodontium pulp. The Seurat, scDblFinder, Harmony, SingleR, Ucell scCancer packages were comprehensively used for analysis. identified specific cell clusters generated expression profiles SARS-CoV-2 coronavirus-associated receptors factors (SCARFs) regions, providing direction predicting tropism HCoVs tissues, as well dental clinical treatment. Based on our analysis, it appears various SCARFs, ACE2, ASGR1, KREMEN1, DPP4, ANPEP, CD209, CLEC4G/M, TMPRSS family proteins (including TMPRSS2, TMPRSS4, TMPRSS11A), FURIN, are expressed at low levels cavity. Conversely, BSG, CTSB, CTSL exhibit enrichment tissues. Our study also demonstrates widespread restriction factors, particularly IFITM1-3 LY6E, cells. Additionally, some replication, assembly, trafficking appear to broad patterns. Overall, could potentially serve a high-risk site infection, while displaying comparatively lower degree susceptibility towards other MERS-CoV HCoV-229E). Specifically, MSG, gingiva represent potential sites vulnerability with MSG exhibiting high susceptibility. patterns SCARFs demonstrate relatively intricate may only be specifically associated infection. sheds light mechanisms infection gains insight into characteristics distribution possible target cells therapeutic targets

Language: Английский

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Evaluation of the dynamics of oral pathogenic microbiota in COVID-19 patients by genomic sequencing after application of foam with antimicrobial action

Medical alphabet, Journal Year: 2024, Volume and Issue: 11, P. 7 - 13

Published: May 11, 2024

Relevance. The COVID-19 pandemic caused by the SARS-CoV-2 virus has demonstrated critical importance of understanding mechanisms transmission and finding effective methods prevention. Particular attention been paid to role oral hygiene, as cavity serves a major route transmission. Studies show that composition microbiota can influence course outcome disease. Therefore, there is need study effects antiseptics on microbiome, which may offer new opportunities for prevention treatment this Objective. aim evaluate effectiveness cleansing foam «Parodontol PROF» in reducing pathogenic microflora patients with assess its effect risk secondary infections. Materials methods. was conducted basis Clinical Medical Centre «Kuskovo» Russian University Medicine. It included 450 confirmed diagnosis COVID-19. participants were divided into two groups: test group used foam, while control no additional hygiene. Comparative analyses taxonomic oropharyngeal dental plaque before after use performed. Results . showed who regularly had significant decrease representation pathogens, including Mycoplasma, an increase number beneficial commensals such Lactococcus Lactobacillus. These changes indicate potential efficacy product improve hygiene reduce Conclusion. supports hypothesis improving specialised antiseptic agents, help This, turn, pathogen migration lower respiratory tract development findings emphasise further research area comprehensive approaches management context infectious diseases.

Language: Английский

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Antiviral effect of oral antiseptic solutions commonly used in dentistry practice: A scoping review

Dentistry Review, Journal Year: 2023, Volume and Issue: 3(1), P. 100064 - 100064

Published: Jan. 29, 2023

The purpose of this scoping review is to show the evidence available in literature and provide an overview antimicrobial-containing mouthwashes for reducing viral load order group most up-to-date information make it more accessible dentists. A structured electronic search PubMed (Medline), LILACS, EMBASE EBSCO without temporal restriction was performed. studies were selected based on their title, abstract full reading following a pre-established inclusion exclusion criteria. included those that analyzed effect reduction by mouthwashes, primary studies, no reviews Spanish, English or Portuguese. resulted 1881 articles, at end duplicates selection, 71 articles review. substances commonly found chlorhexidine (CHX), povidone-iodine (PVP-I), essential oils (EO), cetylpyridinium chloride (CPC), hydrogen peroxide (H2O2) other (OTHERS). Of all analyzed, Essential oils, Cetylpyridinium Chloride Povidone-iodine, showed antiviral potential against common viruses present oral cavity, with significant side effects short-term use, are viable options use as pre-procedure clinical routine SARS-CoV-2 types viruses. solutions need further determine confirm use.

Language: Английский

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