International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(15), P. 8225 - 8225
Published: July 27, 2024
A
total
hip
arthroplasty
(THA)
can
improve
quality
of
life,
but
loosening
the
prosthesis
is
a
complex
problem
in
which
vitamin
D
may
also
play
role.
The
Vitamin
Receptor
(VDR)
involved
response
cells
to
action
D,
and
its
genetic
variability
raises
question
whether
individual
differences
could
influence
risk
loosening.
aim
this
study
was
investigate
relationship
between
VDR
single
nucleotide
polymorphisms
(SNPs)
(ApaI,
BsmI,
FokI
TaqI)
serum
25(OH)D
levels
three
groups
patients:
(1)
arthroscopy
patients
after
THA
without
(CA—Control
Arthroplasty),
(2)
with
loosened
prostheses
(L—Loosening)
(3)
control
group
(C—Control).
Our
results
suggest
that
genotypes
tt
TaqI,
BB
FF
effect
protheses.
showed
ACAC
haplotype
(AtBF)
over
two
times
more
frequent
L
than
CA
+
C:
OR
=2.35
[95%
CI
1.44–3.83;
p
=
0.001].
There
no
significant
correlation
levels,
there
were
studied
groups.
Cancers,
Journal Year:
2024,
Volume and Issue:
16(12), P. 2262 - 2262
Published: June 18, 2024
Melanoma,
originating
through
malignant
transformation
of
melanin-producing
melanocytes,
is
a
formidable
malignancy,
characterized
by
local
invasiveness,
recurrence,
early
metastasis,
resistance
to
therapy,
and
high
mortality
rate.
This
review
discusses
etiologic
risk
factors
for
melanoma,
diagnostic
prognostic
tools,
including
recent
advances
in
molecular
biology,
omics,
bioinformatics,
provides
an
overview
its
therapy.
Since
the
incidence
melanoma
rising
remains
unacceptably
high,
we
discuss
inherent
properties,
melanogenesis,
that
make
this
disease
resilient
treatment
propose
use
AI
solve
above
complex
multidimensional
problems.
We
provide
on
vitamin
D
anticancerogenic
report
field
can
solutions
prevention
and/or
therapy
melanoma.
Experimental
papers
clinicopathological
studies
role
status
signaling
pathways
initiated
active
metabolites
prognosis
are
reviewed.
conclude
signaling,
defined
specific
nuclear
receptors
selective
activation
hydroxyderivatives,
benefit
new
or
existing
therapeutic
approaches.
target
with
computational
biology
tools
solution
problem.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(15), P. 8224 - 8224
Published: July 27, 2024
Polynucleotides,
complex
molecules
composed
of
nucleotides,
have
gained
attention
in
aesthetic
medicine
for
their
potential
to
regulate
gene
expression
and
promote
tissue
regeneration.
This
review
aims
provide
an
overview
the
current
practices
perceived
effectiveness
polynucleotides
medicine.
A
comprehensive
search
literature
was
conducted
using
keywords
related
polynucleotides,
cosmetic
application,
application.
Studies
were
selected
based
on
relevance
inclusion
human
subjects.
The
found
that
been
used
improve
skin
texture,
reduce
wrinkle
depth,
enhance
facial
appearance.
studies
reported
varying
degrees
efficacy
safety,
with
some
demonstrating
significant
improvements
elasticity
hydration.
However,
others
limited
or
no
benefits.
also
highlighted
need
further
research
establish
optimal
use
While
existing
suggests
may
benefits
medicine,
more
is
needed
fully
understand
mechanisms
action
use.
Clinicians
should
be
aware
limitations
risks
associated
Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(8), P. 996 - 996
Published: Aug. 17, 2024
Evidence
is
increasing
that
vitamin
D
and
CYP11A1-derived
D,
tachysterol,
lumisterol
metabolites
play
a
significant
antioxidant
role
beyond
its
classical
functions
in
bone
health
calcium
metabolism.
Several
recent
studies
have
linked
these
elements
to
reduced
oxidative
stress
as
well
improved
immune,
cardiovascular,
neurological
result
of
chronic
kidney
disease
cancer.
Additionally,
supplementation
with
this
has
been
shown
be
one
the
most
cost-effective
micronutrient
interventions
worldwide,
highlighting
potential
therapeutic
approach.
The
underlying
mechanisms
implications
function
or
are
not
understood.
This
comprehensive
narrative
review
aimed
at
summarizing
current
evidence
regarding
molecular
implicated
provide
general
overview
identify
key
research
areas
for
future,
offering
an
extensive
perspective
can
guide
both
researchers
clinicians
management
diseases
associated
and/or
insufficient
status.
International Journal of Oncology,
Journal Year:
2024,
Volume and Issue:
65(6)
Published: Oct. 22, 2024
Significant
advancements
have
been
made
in
cancer
therapy;
however,
limitations
remain
with
some
conventional
approaches.
Adjuvants
are
agents
used
alongside
primary
treatments
to
enhance
their
efficacy
and
the
treatment
outcomes
of
patients.
Modern
lifestyles
contribute
deficiencies
melatonin
vitamin
D.
Limited
sun
exposure
affects
D
synthesis,
artificial
light
at
night
suppresses
production.
Both
possess
anti‑inflammatory,
immune‑boosting
anticancer
properties,
rendering
them
potential
adjuvants
interest.
Studies
suggest
supplementation
may
address
antioxidant
imbalances
lip,
oral
pharyngeal
cancers.
Moreover,
promising
results
from
breast,
head
neck,
brain,
osteosarcoma
research
indicate
for
tumor
growth
inhibition,
improved
survival,
a
better
quality
life
patients
cancer.
The
radioprotective
properties
another
exciting
area
exploration,
potentially
enhancing
radiotherapy
effectiveness
while
reducing
side
effects.
For
its
part,
sleep‑promoting
effects
indirectly
benefit
by
influencing
immune
system.
Thus,
prevalence
highlights
importance
supplementation,
as
lower
levels
can
worsen
side‑effects
treatments.
present
review
explores
combining
synergistic
therapy.
These
shown
promise
individually
prevention
treatment,
combined
warrant
investigation.
Therefore,
large‑scale
controlled
trials
crucial
definitively
determine
optimal
dosage,
safety
this
combination
improving
lives
F1000Research,
Journal Year:
2025,
Volume and Issue:
14, P. 17 - 17
Published: Jan. 3, 2025
Background
Honey,
a
natural
product
with
diverse
bioactive
compounds,
has
been
increasingly
explored
for
its
potential
anticancer
properties.
This
study
aims
to
comprehensively
analyze
the
scientific
literature
on
relationship
between
honey
and
breast
cancer.
Methods
A
bibliometric
analysis
was
conducted
using
ScienceDirect
database
identify
publications
from
2014
2024.
Data
publication
trends,
author
collaboration,
keyword
were
extracted
gain
insight
into
research
landscape.
Keyword
identified
nine
distinct
clusters,
indicating
directions
regarding
role
of
in
cancer
treatment.
Results
Key
journals
such
as
Journal
Ethnopharmacology
Food
Chemistry
have
at
forefront
disseminating
findings
this
domain,
demonstrating
strong
interdisciplinary
approach
that
bridges
traditional
medicine
modern
inquiry.
The
increasing
interest
properties
honey,
evidenced
by
growing
number
studies,
underlines
promising
agent
prevention
Recent
advances
synthesis
theranostic
paradigms
cerium
oxide
nanoparticles
(CeONPs)
highlighted,
well
selenium
nanoconstructs.
toxicity
quality
control
Perillae
Fructus
also
highlighted.
Conclusions
provides
comprehensive
overview
current
state
knowledge
uncovers
emerging
issues
require
further
investigation.
Health Science Reports,
Journal Year:
2025,
Volume and Issue:
8(1)
Published: Jan. 1, 2025
ABSTRACT
Background
and
Aims
This
study
investigates
the
global
impact
of
ambient
ultraviolet
radiation
(UVR)
on
dementia
incidence,
addressing
its
controversial
association
with
risk.
UVR,
through
both
vitamin
D‐dependent
independent
mechanisms,
influences
physiological
processes
essential
for
brain
health,
such
as
reducing
neuroinflammation,
improving
sleep
regulation,
enhancing
neuroplasticity.
aims
to
clarify
relationship
between
UVR
incidence
evaluate
role
in
public
health
strategies
prevention.
Methods
An
ecological
analysis
across
204
countries
was
conducted
using
country‐specific
data
levels
rates.
Bivariate
analysis,
partial
correlation,
multiple
linear
regression
models
were
employed
assess
incidence.
Confounding
factors,
including
aging,
economic
affluence,
genetic
predisposition,
urbanization,
controlled
ensure
robust
results.
Subgroup
analyses
performed
explore
differences
income
classifications,
regional
groupings,
developmental
statuses,
based
World
Bank
United
Nations
criteria.
Results
A
significant
inverse
correlation
identified
(
r
=
−0.764,
p
<
0.001),
which
persisted
after
adjusting
confounding
factors.
emerged
strongest
predictor
explaining
a
substantial
portion
variance,
followed
by
aging
second
predictor.
revealed
that
protective
effects
particularly
pronounced
developing
countries,
where
limited
access
D
supplementation,
combined
greater
exposure
natural
sunlight
may
enhance
influence.
Conclusion
Lower
are
associated
higher
rates
worldwide,
suggesting
critical
mitigating
Public
should
consider
environmental
factors
like
regions
sunlight.
Incorporating
interventions
optimize
could
offer
cost‐effective
approach
burden
outcomes.
F1000Research,
Journal Year:
2025,
Volume and Issue:
14, P. 17 - 17
Published: Jan. 20, 2025
Background
Honey,
a
natural
product
with
diverse
bioactive
compounds,
has
been
increasingly
explored
for
its
potential
anticancer
properties.
This
study
aims
to
comprehensively
analyze
the
scientific
literature
on
relationship
between
honey
and
breast
cancer.
Methods
A
bibliometric
analysis
was
conducted
using
ScienceDirect
database
identify
publications
from
2014
2024.
Data
publication
trends,
author
collaboration,
keyword
were
extracted
gain
insight
into
research
landscape.
Keyword
identified
nine
distinct
clusters,
indicating
directions
regarding
role
of
in
cancer
treatment.
Results
Key
journals
such
as
Journal
Ethnopharmacology
Food
Chemistry
have
at
forefront
disseminating
findings
this
domain,
demonstrating
strong
interdisciplinary
approach
that
bridges
traditional
medicine
modern
inquiry.
The
increasing
interest
properties
honey,
evidenced
by
growing
number
studies,
underlines
promising
agent
prevention
Recent
advances
synthesis
theranostic
paradigms
cerium
oxide
nanoparticles
(CeONPs)
highlighted,
well
selenium
nanoconstructs.
toxicity
quality
control
Perillae
Fructus
also
highlighted.
Conclusions
provides
comprehensive
overview
current
state
knowledge
uncovers
emerging
issues
require
further
investigation.
