Vaccine effectiveness of two-dose BNT162b2 against symptomatic and severe COVID-19 among adolescents in Brazil and Scotland over time: a test-negative case-control study

The Lancet Infectious Diseases, Journal Year: 2022, Volume and Issue: 22(11), P. 1577 - 1586

Published: Aug. 9, 2022

Summary

Background

Little is known about vaccine effectiveness over time among adolescents, especially against the SARS-CoV-2 omicron (B.1.1.529) variant. This study assessed associations between since two-dose vaccination with BNT162b2 and occurrence of symptomatic infection severe COVID-19 adolescents in Brazil Scotland.

Methods

We did test-negative, case-control studies aged 12–17 years COVID-19-related symptoms linked records RT-PCR antigen tests to national clinical records. excluded from individuals who not have symptoms, were vaccinated before start programme, received vaccines other than or a booster dose any kind, had an interval their first second fewer 21 days. Additionally, we negative recorded within 14 days previous test, 7 after positive test done 90 missing sex location information. Cases (SARS-CoV-2 test-positive adolescents) controls (test-negative drawn sample whom collected 10 symptom onset. estimated adjusted odds ratio for both countries (hospitalisation death) across fortnightly periods.

Findings

analysed 503 776 2 948 538 Sept 2, 2021, April 19, 2022, 127 168 404 673 Scotland Aug 6, 2022. Vaccine peaked at 14–27 during waves, was significantly lower omicron-dominant period (64·7% [95% CI 63·0–66·3]) (82·6% [80·6–84·5]), it delta-dominant (80·7% 77·8–83·3] 92·8% [85·7–96·4] Scotland). efficacy started decline 27 countries, reducing 5·9% (95% 2·2–9·4) 50·6% (42·7–57·4) 98 more period. In Brazil, protection disease remained above 80% 28 82·7% 68·8–90·4) receiving dose.

Interpretation

found waning However, outcomes high Booster doses need be considered.

Funding

UK Research Innovation (Medical Council), Scottish Government, Health Data BREATHE Hub, Fiocruz, Fazer o Bem Faz Brazilian National Council, Wellcome Trust.

Translation

For Portuguese translation abstract see Supplementary Materials section.

Language: Английский

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Vaccination burnout impedes the compliance with multiple-dose administration of vaccines

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 17, 2025

Language: Английский

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Antibody responses to COVID‐19 vaccination in people with obesity: A systematic review and meta‐analysis

Influenza and Other Respiratory Viruses, Journal Year: 2022, Volume and Issue: 17(1)

Published: Dec. 19, 2022

COVID-19 vaccine is critical in preventing SARS-CoV-2 infection and transmission. However, obesity's effect on immune responses to vaccines still unknown. We performed a meta-analysis of the literature compared antibody with among persons without obesity. used Pubmed, Embase, Web Science, Cochrane Library identify all related studies up April 2022. The Stata.14 software was analyze selected data. Eleven were included present meta-analysis. Five them provided absolute values titers obese group non-obese group. Overall, we found that population significantly associated lower (standardized mean difference [SMD] = -0.228, 95% CI [-0.437, -0.019], P < 0.001) after vaccination. Significant heterogeneity most pooled analyses but reduced subgroup analyses. No publication bias observed analysis. Trim Fill method did not change results primary suggested obesity decreased vaccines. Future should be unravel mechanism response individuals.

Language: Английский

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Efficacy, immunogenicity and safety of COVID-19 vaccines in older adults: a systematic review and meta-analysis

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: Sept. 13, 2022

Older adults are more susceptible to severe health outcomes for coronavirus disease 2019 (COVID-19). Universal vaccination has become a trend, but there still doubts and research gaps regarding the COVID-19 in elderly. This study aimed investigate efficacy, immunogenicity, safety of vaccines older people aged ≥ 55 years their influencing factors.Randomized controlled trials from inception April 9, 2022, were systematically searched PubMed, EMBASE, Cochrane Library, Web Science. We estimated summary relative risk (RR), rates, or standardized mean difference (SMD) with 95% confidence interval (CI) using random-effects meta-analysis. was registered PROSPERO (CRD42022314456).Of 32 eligible studies, 21, 25 analyzed safety, respectively. In adults, efficacious against (79.49%, CI: 60.55-89.34), excellent seroconversion rate (92.64%, 86.77-96.91) geometric titer (GMT) (SMD 3.56, 2.80-4.31) neutralizing antibodies, provided significant protection (87.01%, 50.80-96.57). Subgroup meta-regression analyses consistently found vaccine types number doses be primary factors efficacy immunogenicity. Specifically, mRNA showed best (90.72%, 86.82-93.46), consistent its highest (98.52%, 93.45-99.98) GMT 6.20, 2.02-10.39). Compared control groups, significantly increased incidence total adverse events (AEs) (RR 1.59, 1.38-1.83), including most local systemic AEs, such as pain, fever, chill, etc. For inactivated DNA vaccines, any AEs similar between groups (p > 0.1), while had range 1.74 7.22).COVID-19 acceptable immunogenicity people, especially providing high disease. The efficacious, it is worth surveillance some caused. Increased booster coverage warranted, additional studies urgently required longer follow-up periods variant strains.

Language: Английский

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Evidence linking COVID-19 and the health/well-being of children and adolescents: an umbrella review

BMC Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: March 13, 2024

Abstract Background Experiences during childhood and adolescence have enduring impacts on physical mental well-being, overall quality of life, socioeconomic status throughout one’s lifetime. This underscores the importance prioritizing health children adolescents to establish an impactful healthcare system that benefits both individuals society. It is crucial for providers policymakers examine relationship between COVID-19 adolescents, as this understanding will guide creation interventions policies long-term management virus. Methods In umbrella review (PROSPERO ID: CRD42023401106), systematic reviews were identified from Cochrane Database Systematic Reviews; EMBASE (OvidSP); MEDLINE (OvidSP) December 2019 February 2023. Pairwise single-arm meta-analyses extracted included reviews. The methodological appraisal was completed using AMSTAR-2 tool. Single-arm re-presented under six domains associated with condition. classified into five according evidence classification criteria. Rosenberg’s FSN calculated binary continuous measures. Results We 1551 301 pairwise 124 met our predefined criteria inclusion. focus meta-analytical predominantly outcomes COVID-19, encompassing study designs. However, rigor suboptimal. Based gathered meta-analyses, we constructed illustrative representation disease severity, clinical manifestations, laboratory radiological findings, treatments, 2020 2022. Additionally, discovered 17 instances strong or highly suggestive concerning long-COVID, pediatric comorbidity, vaccines, health, depression. Conclusions findings advocate implementation surveillance systems track consequences establishment multidisciplinary collaborative rehabilitation programs affected younger populations. future research endeavors, it important prioritize investigation non-physical bridge gap application in field.

Language: Английский

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Effectiveness of COVID-19 vaccine in children and adolescents with the Omicron variant: A systematic review and meta-analysis

Journal of Infection, Journal Year: 2023, Volume and Issue: 86(3), P. e64 - e66

Published: Jan. 6, 2023

Language: Английский

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Adverse Events Following COVID-19 Vaccination in Adolescents: Insights From Pharmacovigilance Study of VigiBase

Journal of Korean Medical Science, Journal Year: 2024, Volume and Issue: 39

Published: Jan. 1, 2024

During coronavirus disease 2019 (COVID-19) pandemic, several COVID-19 vaccines were licensed with fast-track procedures. Although these have demonstrated high immunogenicity, there has been concerns on the serious adverse events (AEs) following vaccination among adolescents. We aimed to analyze comparative safety of in

Language: Английский

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Probable Vogt–Koyanagi–Harada Disease after COVID-19 Vaccination: Case Report and Literature Review

Vaccines, Journal Year: 2022, Volume and Issue: 10(5), P. 783 - 783

Published: May 16, 2022

COVID-19 vaccination is considered the most effective and promising approach for elimination of SARS-CoV-2 pandemic globally. Although vaccine has been proven to be safe, as evidenced by promotion mass vaccination, new side effects, including several ocular complications that were not described during experimental stage, are now emerging. In present study, we report a 33-year-old Chinese man who developed probable Vogt-Koyanagi-Harada (VKH) disease only one day after his first dose an inactivated vaccine, without any systemic symptoms. His medical history was unremarkable, except hypertension. successfully relieved oral prednisone, patient progressed chronic stage VKH with depigmentation 4 months onset. By reviewing similar cases previously reported, discuss summarize common characteristics associated vaccines against SARS-CoV-2, well possible mechanisms behind this phenomenon. causality unclear, ophthalmologists generalists should aware adverse effect vaccination.

Language: Английский

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Effectiveness of COVID-19 Pfizer-BioNTech (BNT162b2) mRNA vaccination in adolescents aged 12–17 years: A systematic review and meta-analysis

Human Vaccines & Immunotherapeutics, Journal Year: 2023, Volume and Issue: 19(1)

Published: Jan. 2, 2023

The rapid emergence of COVID-19 variants concern (VOCs) has hindered vaccine uptake. To inform policy, we investigated the effectiveness BNT162b2 vaccination among adolescents against symptomatic and severe diseases using mostly real-world data (15 studies). We searched international databases until May 2022 used Cochrane's risk bias tools for critical appraisal. Random effects models were to examine overall (VE) across studies (general inverse-variance) effect circulating VOCs on VE (log relative ratio VE). Meta-regression assessed age time (restricted-maximum likelihood). PCR-confirmed SARS-CoV-2 was 82.7% (95%CI: 78.37–87.31%). higher (88%) than non-severe (35%) outcomes declining over improved following booster dose in omicron era [73%(95%CI:65–81%)]. Fully vaccinated are protected from by especially need care or life support.

Language: Английский

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Safety of mRNA BNT162b2 COVID-19 (Pfizer-BioNtech) vaccine in children aged 5–11 years: Results from an active pharmacovigilance study in central Italy

Human Vaccines & Immunotherapeutics, Journal Year: 2022, Volume and Issue: 18(6)

Published: Oct. 31, 2022

This survey investigated on adverse events after vaccination with mRNA BNT162b2 (Comirnaty, Pfizer-BioNTech) vaccine in children aged 5-11 years central Italy through active surveillance reporting. During December 2021-January 2022, parents of who undergone were interviewed using a structured questionnaire. 197 out 208 contacted participated (94.7% response rate), whom 166 (84.3%) had one child. Of the 229 children, mean age was 8.9 years, 50.7% female. 193 at least event first dose (mean 9.1 years; 54.4% female), and 146 (73.4%) 199 second 54.8% which not administered to 30 due previous COVID-19 history. Local symptoms occurred 183 (94.8%) 141 (96.6%) recipients (p = .435), respectively, while systemic reactions 62 (32.1%) 34 (23.3%) .074). Mild reported by 81.7% 69.8% dose, followed moderate (3.9% 10.6%) severe (1.3% 0.5%). After each injection site (79.5% 68.8%) most frequent, headache (13.1%) lymphadenopathy (8.5%) respectively. The pediatricians only for 5.7% 3.9% treated 17.6% 15.8%. is report about safety profile among Italy, revealing temporary mild-to-moderate no serious dose.

Language: Английский

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