Ruthenium (II) polypyridyl complexes as two-photon absorbers and sensitizers: Design, structure-properties relationships and applications

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 518, P. 216050 - 216050

Published: July 7, 2024

This review addresses recent advancements in understanding multiphoton excitation of ruthenium polypyridyl complexes, highlighting their relevance the fields molecular materials and bio-medical applications. Emphasis is placed on two-photon absorption excited photoluminescence for which these complexes meet several requirements as sensitizers. Alongside appealing one-photon properties, are photostable under can exhibit noticeable cross-sections near-infrared (NIR) region. Moreover, presence atom favors spin–orbit coupling, facilitating rapid efficient population triplet states, thereby extending emission lifetimes, or uncaging reactions, according to structural characteristics. Indeed, offer great versatility terms functionalization, enabling property fine-tuning. also outlines forthcoming challenges prospects field through representative examples area materials, bio-imaging phototherapies.

Language: Английский

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Covalent organic frameworks: Advancing antimicrobial photodynamic therapy for next-generation treatments

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 528, P. 216424 - 216424

Published: Jan. 11, 2025

Language: Английский

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Acentric Order–Disorder Zn₃Sb₄CO₆F₆: Crystal Structure, Dye Degradation, Cr(VI) Removal, Antibacterial Activity, and Catalytic C–C Bond Formation

Inorganic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

Acentric Zn3Sb4CO6F6 has been synthesized by a hydrothermal technique. Single crystal X-ray diffraction study reveals that it crystallizes in cubic symmetry with = 8.1480 (5) Å and Z 2 (I4̅3 m). The carbon atom tetrahedral coordination Sb, either as an ordered structure at the center of tetrahedron or disordered displaced toward three Sb atoms; latter model leads to more acceptable Sb-C interatomic distances. established first multifunctional [M-L-C-O-F] compound, exceptional properties, i.e., photocatalyst, adsorbent, catalyst for organic reactions, antibacterial agent. This compound successfully degraded 89.5% 50 mg/L methylene blue dye under solar illumination. It was also proved be proficient adsorbent Cr(VI) removal qmax 47.18 mg/g. activity investigated "agar cup assay" against both Gram-positive Gram-negative bacterial strains. functions excellent solvent-free Knoevenagel condensation reaction, than 90% yield. Theoretical investigations further exhibits direct band gap energy 1.76 eV, which is consistent experimental findings. characterized through fourier transform infrared spectroscopy, powder diffraction, field emission scanning electron microscopy, transmission selected area study.

Language: Английский

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Molecular engineering and electrolyte optimization strategies for enhanced performance of Ru(ii) polypyridyl-sensitized DSSCs

RSC Advances, Journal Year: 2025, Volume and Issue: 15(13), P. 9763 - 9786

Published: Jan. 1, 2025

This review highlights the advantages of optimizing various DSSC components, such as Ru( ii )-polypyridyl photosensitizers, co-adsorbents, electrolytes, electrolyte additives, and counter electrodes, to improve overall performance DSSCs.

Language: Английский

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Application of Mono and Trinuclear Cyclometalated Iridium (III) Complexes in Differential Bacterial Imaging and Antimicrobial Photodynamic Therapy

Chemistry - A European Journal, Journal Year: 2024, Volume and Issue: 30(36)

Published: April 23, 2024

The application of transition metal complexes for antimicrobial photodynamic therapy (PDT) has emerged as an attractive alternative in mitigating a broad range bacterial pathogens, including multidrug-resistant pathogens. In view their photostability, long excited-state lifetimes, and tunable emission properties, also contribute bioimaging agents. the present work, we designed mono trinuclear cyclometalated iridium (III) to explore imaging antibacterial potential. For this, used Methicillin-resistant S. aureus (MRSA), most prevalent community-associated (CA) (MDR) bacteria (CA MDR) Lactococcus lactis (L. lactis) Gram-positive while Campylobacter jejuni (C. jejuni) E. coli Gram-negative bacteria. addition differential these bacteria, assessed effects both Ir(III) under exposure 427 nm LED light. data presented herein strongly suggest better efficacy complex over mononuclear imparting photoinduced cell death MRSA. Based on safety profile complexes, propose that iridium(III) holds great promise selective recognition targeting MDR with minimal off-target effect.

Language: Английский

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Transition metal complexes: next-generation photosensitizers for combating Gram-positive bacteria

Future Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 18

Published: Jan. 29, 2025

The rise of antibiotic-resistant Gram-positive bacterial infections poses a significant threat to public health, necessitating the exploration alternative therapeutic strategies. A photosensitizer (PS) can convert energy from absorbed photon into reactive oxygen species (ROS) for damaging bacteria. This photoinactivation action bypassing conventional antibiotic mechanism is less prone resistance development, making antibacterial photodynamic therapy (aPDT) highly efficient in combating Photodynamic transition metal complexes leveraging unique properties metals enhance aPDT activity are next-generation PS. review provides an overview metal-based PS Based on structures, these metal-PS could be mainly classified as metal-tetrapyrrole derivatives, ruthenium complexes, iridium and zinc complexes. based other such silver, cobalt, rhenium also presented. Finally, we summarize advantages shortcomings metal- PS, conclude some critical aspects impacting their performances give perspective future development.

Language: Английский

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Discovery of Phototoxic Metal Complexes with Antibacterial Properties via a Combinatorial Approach

Inorganic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 28, 2025

Antimicrobial resistance is one of the biggest global healthcare challenges. Therefore, there an urgent need to develop new molecules that display distinct antibacterial properties overcome resistance. With this aim, we have developed a combinatorial and semiautomated platform synthesize screen library 78 compounds against Gram-positive Gram-negative bacteria. This based on octahedral iridium(III) complexes with general formula [Ir(CN)2(NN)]Cl (where CN are cyclometallating polyaromatic ligands NN phenanthroline-imidazole or dipyridophenazine derivatives) which known generate reactive oxygen species (ROS) upon light irradiation. From initial entire (in dark under irradiation) Escherichia coli Staphylococcus aureus, show scaffold highly effective at inhibiting growth bacteria intermediate dose (16 μg/mL), displaying hit rate >30% in rising 56% Six were selected for further studies panel five strains, allowing us identify two lead MICs as low 2 μg/mL. These studied more detail establish their mode action using time-kill study S. aureus USA300 strain.

Language: Английский

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On the In Silico Evaluation of the Emission Quantum Yield of Cyclometalated Ir(III) Complexes

Inorganic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 15, 2025

The in silico determination of the emission quantum yield (Φem) a cyclometalated Ir(III) complex requires evaluation all its possible radiative and nonradiative decays. task is challenging, particularly when more than one minimum present on potential energy surface emitting lowest-energy triplet T1, situation common what was previously thought. In contribution, we study paths for two complexes, [Ir(ppy)2(pyim)]+ [Ir(diFppy)2(dtb-bpy)]+, indeed characterized by T1 minima both metal-to-ligand charge transfer ligand-centered nature. Comparing computed yields accounting processes only those principle relevant, aimed at judging importance characterizing decays to provide an accurate estimation Φem. Evaluating barrier between 3MC states obtaining corresponding transition state or approximating latter using CI-NEB method, performing optimizations. task, due intrinsic complexity poor convergence behavior, bottleneck characterization photophysics consequently prevents efficient screening complexes technological applications.

Language: Английский

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Predicting Nonradiative Decay Rate Constants of Cyclometalated Ir(III) Complexes

Inorganic Chemistry, Journal Year: 2024, Volume and Issue: 63(36), P. 16600 - 16604

Published: Aug. 26, 2024

The theoretical calculation of the temperature-dependent nonradiative decay rate constant is fundamental for predicting usefulness transition-metal complexes technological applications. Such a computation implies determination barriers separating emitting triplet state from metal-centered states, which are key mediators this type radiationless relaxation. We here do so two green-emitting cyclometalated Ir(III) complexes, [Ir(ppy)

Language: Английский

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Attaching Metal-Containing Moieties to β-Lactam Antibiotics: The Case of Penicillin and Cephalosporin

Inorganic Chemistry, Journal Year: 2024, Volume and Issue: 63(27), P. 12593 - 12603

Published: June 26, 2024

Procedures for the preparation of transition metal complexes having intact bicyclic cepham or penam systems as ligands have been developed. Starting from readily available 4-azido-2-azetidinones, a synthetic approach has tuned using copper-catalyzed azide–alkyne cycloaddition between 3-azido-2-azetinones and alkynes, followed by methylation transmetalation to Au(I) Ir(III) mesoionic carbene Ag(I) complexes. This methodology was applied 6-azido 7-azido derivatives build 6-(1,2,3-triazolyl)penam 7-(1,2,3-triazolyl)cepham proligands, which upon metalation with yielded products derived coordination C6 C7 positions, preserving structure penicillin cephalosporin scaffolds. The crystal complex 28b, an Ir atom directly bonded bicycle, determined X-ray diffraction. is first structural report penicillin-transition-metal system these antibiotics intact. selectivity processes interpreted DFT calculations.

Language: Английский

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