One Health Bulletin,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 23, 2024
Antimicrobial
resistance
(AMR)
has
become
a
serious
threat
to
global
public
health.
By
2050,
AMR
is
estimated
cause
1.91
million
deaths
annually,
with
related
mortality
reaching
8.22
million.
The
challenges
posed
by
extend
beyond
the
healthcare
system
include
animal
health
and
environmental
factors
such
as
livestock
farming,
urbanization,
climate
change.
“One
Health”
approach,
an
interdisciplinary
cross-regional
collaborative
strategy,
integrates
management
of
human,
animal,
It
considered
crucial
framework
for
addressing
complex
providing
both
scientific
preventive
strategies
combat
AMR.
From
October
12
13,
2024,
Second
One
Health
Conference
Resistance
Containment
was
successfully
held
in
Hangzhou,
Zhejiang
Province,
China,
under
theme
“Hand
Hand
Contain
AMR”.
conference
brought
together
experts
from
various
fields
engage
in-depth
discussions
on
control,
consensus
take
action
towards
advancing
community.
This
strengthened
multi-sectoral
collaboration,
promoted
cross-departmental
cross-national
cooperation,
enhanced
awareness
AMR,
explored
control
mechanisms,
provided
theoretical
practical
guidance
mitigating
also
called
increased
investment
research
development
efforts
containment.
Foods,
Journal Year:
2024,
Volume and Issue:
13(11), P. 1629 - 1629
Published: May 23, 2024
Veterinary
medications
are
necessary
for
both
contemporary
animal
husbandry
and
food
production,
but
their
residues
can
linger
in
foods
obtained
from
animals
pose
a
dangerous
human
risk.
In
this
review,
we
aim
to
highlight
the
sources,
occurrence,
exposure
pathways,
health
effects
of
drug
food-animal
products.
Following
usage
veterinary
medications,
pharmacologically
active
compounds
known
as
be
found
food,
environment,
or
animals.
They
cause
major
concerns
people,
including
antibiotic
resistance
development,
development
cancer,
teratogenic
effects,
hypersensitivity,
disruption
normal
intestinal
flora.
Drug
products
originate
variety
water
contamination,
extra-label
use,
ignoring
withdrawal
periods.
This
review
also
examines
how
humans
exposed
through
drinking
water,
air,
dust,
discusses
various
analytical
techniques
identifying
these
food.
Furthermore,
suggest
some
potential
solutions
prevent
reduce
such
implementing
periods,
monitoring
programs,
education
campaigns,
new
technologies
that
crucial
safeguarding
public
health.
underscores
urgency
addressing
significant
emerging
threat,
calling
collaborative
efforts
researchers,
policymakers,
industry
stakeholders
develop
sustainable
ensure
safety
global
supply
chain.
Foods,
Journal Year:
2025,
Volume and Issue:
14(2), P. 253 - 253
Published: Jan. 15, 2025
Infections
caused
by
human
pathogenic
bacteria
in
food
sources
pose
significant
and
widespread
concerns,
leading
to
substantial
economic
losses
adverse
impacts
on
public
health.
This
review
seeks
shed
light
the
recent
literature
addressing
prevalence
of
Salmonella
supply
chains
North
African
countries.
Additionally,
it
aims
provide
an
overview
available
information
regarding
health-related
such
as
virulence
genes,
presence
antibiotic
resistance
Salmonella.
highlights
a
gap
our
comprehensive
understanding
nations,
with
limited
molecular
characterization
efforts
identify
its
sources.
Studies
at
level
across
region
have
shown
diversity
strains
their
profiles,
thus,
these
results
show
difficulty
controlling
infections
region.
In
addition,
discussion
makes
clear
that
there
is
need
for
development
strategies
fight
potential
threat
antimicrobial
strains.
Despite
common
reports
animal-derived
foods
this
region,
underscores
persistent
challenges
may
safety
health
Journal of Antimicrobial Chemotherapy,
Journal Year:
2024,
Volume and Issue:
79(7), P. 1473 - 1483
Published: May 14, 2024
Abstract
Antimicrobial
resistance
is
a
pressing
concern
that
poses
significant
threat
to
global
public
health,
necessitating
the
exploration
of
alternative
strategies
combat
drug-resistant
microbial
infections.
Recently,
antimicrobial
peptides
(AMPs)
have
gained
substantial
attention
as
possible
replacements
for
conventional
antibiotics.
Because
their
pharmacodynamics
and
killing
mechanisms,
AMPs
display
lower
risk
bacterial
evolution
compared
with
most
However,
bacteria
different
mechanisms
resist
AMPs,
role
metabolic
pathways
in
mechanism
not
fully
understood.
This
review
examines
intricate
relationship
between
genes
AMP
resistance,
focusing
on
impact
various
aspects
resistance.
Metabolic
related
guanosine
pentaphosphate
(pppGpp)
tetraphosphate
(ppGpp)
[collectively
(p)ppGpp],
tricarboxylic
acid
(TCA)
cycle,
haem
biosynthesis,
purine
pyrimidine
amino
lipid
metabolism
influence
ways
adjustments,
biofilm
formation
energy
production
could
be
involved
By
targeting
associated
genes,
it
enhance
efficacy
existing
therapies
overcome
challenges
exhibited
by
phenotypic
(recalcitrance)
genetic
toward
AMPs.
Further
research
this
area
needed
provide
valuable
insights
into
specific
uncover
novel
therapeutic
targets,
aid
fight
against
Communications Chemistry,
Journal Year:
2025,
Volume and Issue:
8(1)
Published: March 8, 2025
A
μSPEed
microextraction
combined
with
ultra-performance
liquid
chromatography
(UHPLC)
UV
detection
was
developed
for
analysing
six
veterinary
antibiotics
(tetracycline,
chlortetracycline,
oxytetracycline,
doxycycline,
sulfamethoxazole,
and
trimethoprim)
in
environmental
samples.
To
optimise
extraction,
12
sorbent
cartridges,
sample
loading
cycles,
volumes,
pH
were
assayed.
The
PS/DVB-RP
cartridge,
three
250
μL
two
50-µL
elutions
acidified
methanol
yielded
maximum
efficiency.
method
validated
optimised
fast
chromatographic
separation,
showing
good
linearity
(R2
>
0.99),
precision
(RSD
<
20%),
recoveries
between
46-86%.
Detection
quantification
limits
ranged
from
0.30-1.23
μg
L−1
0.92-3.73
L−1,
respectively.
μSPEed/UPLC-PDA
efficiently
analysed
water
samples,
requiring
only
6
min
analysis,
500
sample,
surpassing
alternative
methods
speed,
workloads
reproducibility.
cost-effective,
commercially
available
equipment
facilitates
accessibility
laboratories
adaptability
selected
diverse
matrices,
including
food
Convenient
the
of
are
paramount
to
quality
control.
Here,
authors
report
optimization
an
extraction
procedure
followed
by
simultaneous
analysis
several
Microorganisms,
Journal Year:
2023,
Volume and Issue:
11(12), P. 2939 - 2939
Published: Dec. 7, 2023
Avian
colibacillosis,
caused
by
avian
Escherichia
coli
(E.
coli),
has
historically
been
one
of
the
most
prevalent
infectious
diseases
in
large-scale
poultry
production,
causing
growth
delays
and
mortality
chickens,
resulting
huge
economic
losses.
In
recent
years,
widespread
use
antibiotics
led
to
emergence
multidrug
resistance
E.
as
a
significant
global
problem
long-term
challenge.
Resistant
can
be
transmitted
humans
through
animal
products
or
environment,
which
presents
public
health
concerns
food
safety
issues.
this
study,
we
analyzed
features
135
strains
obtained
from
white
feather
broiler
farm
Shandong,
China,
including
antimicrobial
susceptibility
tests,
detection
class
1
integrons,
drug
genes,
virulence
phylogenetic
subgroups.
It
is
particularly
worrying
that
all
were
resistant
at
least
five
antibiotic
agents,
100%
them
multidrug-resistant
(MDR).
Notably,
genes
blaTEM,
blaCTX-M,
qnrS,
aaC4,
tetA,
tetB
exhibited
high
prevalence
carriage
among
tested
genes.
However,
mcr-2~mcr-9
not
detected,
while
mcr-1
was
found
2.96%.
The
common
detected
EAST1
(14.07%,
encoding
enterotoxins)
fyuA
(14.81%,
biofilm
formation).
Phylogenetic
subgroup
analysis
revealed
belonging
groups
B2
D,
are
commonly
associated
with
virulence,
constituted
2.22%
11.11%,
respectively.
positive
rate
integrons
31.1%.
Whole-genome
sequencing
(WGS)
experiments
performed
on
unique
isolated
strain
called
21EC78
an
extremely
strong
membrane-forming
capacity.
WGS
results
showed
carried
11
16
Animal
intraperitoneal
injection
2
×
105
CFU
could
cause
death
one-day-old
SPF
chickens
3
days.
Luhua
comparatively
lower
than
chickens.
This
study
reports
isolation
poultry,
may
pose
potential
threat
human
via
chain.
Furthermore,
findings
enhance
our
comprehension
frequency
characteristics
farms,
emphasizing
urgent
need
for
improved
effective
continuous
surveillance
control
its
dissemination.
