Amphotericin B-conjugated Silica-Capped Gold Nanoparticles as Antifungal Agents with improved Cellular Uptake

Applied Biochemistry and Microbiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 20, 2025

Language: Английский

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Development of genistein-loaded gold nanoparticles and their antitumor potential against prostate cancer cell lines

Materials Science and Engineering C, Journal Year: 2021, Volume and Issue: 124, P. 112078 - 112078

Published: March 27, 2021

Language: Английский

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Copper Oxide Nanoparticle-Decorated Carbon Nanoparticle Composite Colloidal Preparation through Laser Ablation for Antimicrobial and Antiproliferative Actions against Breast Cancer Cell Line, MCF-7

BioMed Research International, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 13

Published: March 8, 2022

Copper oxide (CuO) nanoparticle- (NP-) decorated carbon NPs (CNPs) were produced as colloidal suspension through pulsed laser ablation technique in liquid (PLAL) medium. The antimicrobial activity of the was tested against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli), anticancer breast cancer cell line, MCF-7, together with biocompatibility assessment these NPs. X-ray diffraction (XRD) patterns obtained CNPs showed peaks at 26.58° 43.78° (2θ) identical to (002) (111) planes, respectively, phases. It also displayed new 38.5° 48.64° after doping CuO Transmission electron microscope (TEM) images revealed crystalline nature spherical shape prepared 5-40 nm diameter ranges. In addition, NP effects on bacterial walls nucleic acid confirmed using a scanning (SEM) microscopic fluorescence analysis. antibacterial SEM examinations pathogenic microbial species, S. E. coli. cellular material release assay, optical density cells, treated NPs, significant increase time exposure cytotoxicity reached more than 80% level for morphology MCF-7 cells decreased numbers, loss contact surrounding observed. These results that have no observable side can be safely used therapeutic applications. is noteworthy it first report preparation (CuO NPs-CNPs) by PLAL, antiproliferative activities lines, MCF-7. main advantage PLAL synthesizing NPs-CNPs provided two-step, cost-effective, eco-friendly method.

Language: Английский

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Microbial L-asparaginase as a promising enzyme for treatment of various cancers

Applied Microbiology and Biotechnology, Journal Year: 2022, Volume and Issue: 106(17), P. 5335 - 5347

Published: July 25, 2022

Language: Английский

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Bioengineering, characterization, and biological activities of C@CuO@Cu nanocomposite based-mediated the Vicia faba seeds aqueous extract

Journal of Materials Research and Technology, Journal Year: 2021, Volume and Issue: 14, P. 1998 - 2016

Published: July 27, 2021

Vicia faba seeds are a rich source of polyphenolic, and flavonoid compounds that have high antioxidant activity. The aqueous extract V. has been used for the biosynthesis nanocomposite (NC) consisting three different types nanoparticles deposited onto each other as [email protected]2[email protected]. Physicochemical, optical, electrical, morphological properties as-biofabricated protected] NC were characterized using analytical techniques X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FT-IR), Ultraviolet–visible (UV–Vis), Photoluminescence (PL), Transmission Electron Microscopy (TEM), Scanning (SEM), Energy Dispersive X-Ray (EDX), Raman, Zeta-potential, water/moisture content). Results confirmed mediated fabrication at pure crystalline nature. nano-formulation had face center cubic crystallographic system nano-scale range Debye–Scherrer's equation (13.8 nm) in XRD analysis (20.9 ± 6.2 TEM analysis. crystallinity index (1.6) with large surface area polycrystalline nature being investigated. In addition, biological activity synthesized was analyzed. showed anti-inflammatory compared diclofenac potassium IC50 = 213.3 μg/mL. Moreover, potent antibacterial activity, particularly against Gram-negative bacteria. Cytotoxicity MCF7, HCT116, HepG2 cell lines efficient cytotoxic impact 84.8, 116.1, 120.5 μg/mL, respectively. So, may provide promising platform effective treatment cancer.

Language: Английский

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Synthesis of environmentally benign antimicrobial dressing nanofibers based on polycaprolactone blended with gold nanoparticles and spearmint oil nanoemulsion

Journal of Materials Research and Technology, Journal Year: 2021, Volume and Issue: 15, P. 3447 - 3460

Published: Oct. 6, 2021

Electrospun nanofibers incorporated with functional additives can be used to produce antimicrobial wound dressings. Thus, the current research work was aimed obtain highly efficient dressing based on high mechanical and biocompatible polymer; polycaprolactone (PCL) blended gold nanoparticles (AuNPs) spearmint oil nanoemulsion (SNE). The nanofibrous obtained through electrospinning method for PCL solution different concentrations of AuNPs, SNE both them. With assistance advanced techniques, as-synthesized were systematically characterized in terms their morphological structure, contact angle properties. resultant depicted preparation smooth surface when AuNPs. Meanwhile, developed changed rough addition SNE. In addition, size fiber diameter loaded greater than that pure nanofiber or Their activities prepared them tested against four species; Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus Candida albicans illustrated have ability prevent growth microbes.

Language: Английский

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Anti-cancer activity of Hypnea valentiae seaweed loaded gold nanoparticles through EMT signaling pathway in A549 cells

Biochemical Systematics and Ecology, Journal Year: 2023, Volume and Issue: 107, P. 104606 - 104606

Published: Jan. 22, 2023

Language: Английский

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Unlocking the Potential of RGD-Conjugated Gold Nanoparticles: A New Frontier in Targeted Cancer Therapy, Imaging, and Metastasis Inhibition

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(42), P. 10786 - 10817

Published: Jan. 1, 2024

The review highlights the potential of RGD-conjugated AuNPs in cancer diagnosis and treatment, including breast cancer. It emphasizes need for further research to fully realize this technology’s inspire future investigations.

Language: Английский

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[Retracted] Preparation of Iron Oxide and Titania‐Based Composite, Core‐Shell Populated, Nanoparticulates Material by Two‐Step LASER Ablation in Aqueous Media as Antimicrobial and Anticancer Agents

Bioinorganic Chemistry and Applications, Journal Year: 2022, Volume and Issue: 2022(1)

Published: Jan. 1, 2022

Iron oxide and titania‐based composite nanoparticles (NPs) populated with core‐shell structures, as part of the mixture monometallic NPs, were prepared in water medium by two‐fluence LASER ablation technique applying 30 60 mJ/cm 2 energy irradiations. The monometallics, composite, NPs structures confirmed from XRD, TEM, EDX analyses, followed FE‐SEM UV absorptions. Optically, exhibited an increase gap 3.27 eV to 3.75 fluence increased . average core size distributions for material ranged at ∼70 nm shell thickness around 20 nm. biggest ∼170 which sparsely distributed. magnetization behaviors also investigated using vibrating sample magnetometer (VSM). showed antimicrobial activities against pathogenic species: Escherichia coli Staphylococcus aureus synthesized under influence magnetic fields, found be more potent than without presence any field. fields comparatively higher levels cytotoxicity lung cancer cell lines (A549) no field’s similar level effects fluence. flow cytometry analyses NPs’ cytotoxic impacts human A549 through initiation apoptosis promotion cycle arrest G1 phase division. To further confirm mechanism anticancer activity lines, several related parameters (cell viability, membrane permeability, nuclear intensity, cytochrome‐C release) analyzed high‐content screening (HCS) assay. study suggested that have potential anti‐lung‐cancer agents tested vitro These can combined chemotherapy different oncological interventions, well a sonosensitizer sonomagnetic heating‐based therapy, especially cancers.

Language: Английский

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Phytochemistry, Antioxidant Potential, and Antibacterial Activities of Anacyclus pyrethrum: Promising Bioactive Compounds

Horticulturae, Journal Year: 2023, Volume and Issue: 9(11), P. 1196 - 1196

Published: Nov. 2, 2023

Secondary metabolites derived from plants have demonstrated significant biological activity and hold both edible medicinal significance. These compounds play a crucial role in the development of pharmaceuticals, particularly context inflammatory disorders chronic diseases associated with oxidative stress. The objective this study was to investigate chemical characterization, antioxidant potential, antibacterial properties aqueous extract Anacyclus pyrethrum (AEAP). To achieve this, we employed various analytical techniques including HPLC–ESI–MS/MS, Fourier transform infrared, X-ray diffraction, scanning electron microscopy, energy-dispersive spectroscopy. AEAP assessed using DPPH (2,2-Diphenyl-1-picrylhydrazyl) reducing power assays, while evaluated against Gram-negative (Escherichia coli Pseudomonas aeruginosa) Gram-positive bacteria (Staphylococcus aureus Enterococcus faecium) broth microdilution assay. Our findings AEAP, as well broad-spectrum bacteria. HPLC analysis identified important bioactive compounds, notably pellitorine 3,4-dihydroxybenzoic acid, known for their properties. Overall, potent activities, suggesting its potential valuable natural source therapeutic applications.

Language: Английский

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