[Erratum] Brain Imaging and neurostimulation in health and disorders: status report DOI Creative Commons
Abrahão Fontes Baptista, Adenauer G. Casali, Adriana Leico Oda

et al.

Brain Imaging and Stimulation, Journal Year: 2024, Volume and Issue: 3, P. e5952 - e5952

Published: Oct. 15, 2024

INTRODUCTION: Despite being considered least important for clinical practice in the pyramid of evidence recommendations, sometimes scientists' expert opinions could help to better understand summarization updated publications. OBJECTIVE: To provide a major summarized update about brain imaging and stimulation nervous system health disease. METHODS: Comprehensive review developed by experts each subarea knowledge neuroimaging non-invasive system. A team researchers clinic was invited present an on their area expertise. RESULTS: In basics techniques, we approach general quantitative electroencephalography, functional magnetic resonance imaging, near-infrared spectroscopy, experimental paradigms studies. Were included associations between transcranial electromyography, evaluate activity. Furthermore, showed several actualized central peripheral neuromodulation techniques. And finally, presented different performance uses neuromodulation. CONCLUSION: our knowledge, this is concentrated that can benefit neuroscience clinicians from levels experience.

Language: Английский

Clinical diagnostic utility of transcranial magnetic stimulation in neurological disorders. Updated report of an IFCN committee DOI Creative Commons
Steve Vucic, Kai‐Hsiang Chen, Matthew C. Kiernan

et al.

Clinical Neurophysiology, Journal Year: 2023, Volume and Issue: 150, P. 131 - 175

Published: March 30, 2023

The review provides a comprehensive update (previous report: Chen R, Cros D, Curra A, Di Lazzaro V, Lefaucheur JP, Magistris MR, et al. clinical diagnostic utility of transcranial magnetic stimulation: report an IFCN committee. Clin Neurophysiol 2008;119(3):504-32) on stimulation (TMS) in neurological diseases. Most TMS measures rely motor cortex and recording evoked potentials. Paired-pulse techniques, incorporating conventional amplitude-based threshold tracking, have established neurodegenerative, movement, episodic (epilepsy, migraines), chronic pain functional Cortical hyperexcitability has emerged as aid amyotrophic lateral sclerosis. Single-pulse are stroke, myelopathy even the absence radiological changes. Short-latency afferent inhibition, related to central cholinergic transmission, is reduced Alzheimer's disease. triple technique (TST) may enhance detect upper neuron involvement. potentials can be used perform mapping or preoperative assessment eloquent brain regions before surgical resection tumors. exhibits assessing lumbosacral/cervical nerve root function, especially demyelinating neuropathies, localizing site facial palsies. also high sensitivity detecting subclinical corticospinal lesions multiple Abnormalities conduction time TST correlate with impairment disability MS. Cerebellar cerebellum cerebello-dentato-thalamo-motor cortical pathways. Combining electroencephalography, novel method measure parameters altered disorders, including excitability, effective connectivity, response complexity.

Language: Английский

Citations

111
Resting-state electroencephalography (EEG) biomarkers of chronic neuropathic pain. A systematic review DOI Creative Commons
Thibaut Mussigmann, Benjamin Bardel, Jean‐Pascal Lefaucheur

et al.

NeuroImage, Journal Year: 2022, Volume and Issue: 258, P. 119351 - 119351

Published: June 2, 2022

Diagnosis and management of chronic neuropathic pain are challenging, leading to current efforts characterize 'objective' biomarkers using imaging or neurophysiological techniques, such as electroencephalography (EEG). A systematic literature review was conducted in PubMed-Medline Web-of-Science until October 2021 identify EEG humans. The risk bias assessed by the Newcastle-Ottawa-Scale. Experimental, provoked, non-neuropathic studies were excluded. We identified 14 studies, which resting-state spectral analysis compared between patients with related a neurological disease same but without healthy controls. From these heterogeneous exploratory some conclusions can be drawn, even if they must weighted fact that confounding factors, medication association anxio-depressive disorders, generally not taken into account. Overall, signal power increased θ band (4-7Hz) possibly high-β (20-30Hz), decreased high-α−low-β (10-20Hz) presence ongoing pain, while γ oscillations evidenced, unlike experimental pain. Consequently, dominant peak frequency θ-α whole-β patients. Disappointingly, intensity correlated various changes across no consistent trend. This also discusses location regional pain-related connectome, perspectives offered advanced techniques (source location, connectivity, classification methods based on artificial intelligence). provided particular interest for optimizing treatment neuromodulation transcranial alternating stimulation neurofeedback procedures.

Language: Английский

Citations

80
Measuring Consciousness in the Intensive Care Unit DOI Open Access
Brian L. Edlow, Matteo Fecchio, Yelena G. Bodien

et al.

Neurocritical Care, Journal Year: 2023, Volume and Issue: 38(3), P. 584 - 590

Published: April 7, 2023

Language: Английский

Citations

32
The role of neuronavigation in TMS–EEG studies: Current applications and future perspectives DOI Creative Commons
Pantelis Lioumis, Mario Rosanova

Journal of Neuroscience Methods, Journal Year: 2022, Volume and Issue: 380, P. 109677 - 109677

Published: July 21, 2022

Transcranial magnetic stimulation combined with electroencephalography (TMS-EEG) allows measuring non-invasively the electrical response of human cerebral cortex to a direct perturbation. Complementing TMS-EEG structural neuronavigation tool (nTMS-EEG) is key for accurately selecting cortical areas, targeting them, and adjusting parameters based on some relevant anatomical priors. This step, together employment visualization tools designed perform quality check TMS-evoked potentials (TEPs) in real-time during data acquisition, pivotal maximizing impact TMS pulse ensuring highly reproducible measurements within sessions across subjects. Moreover, storing system can help replicating experimental sharing them research centers. Finally, systematic studies also critical standardize clinical populations search reliable diagnostic prognostic TMS-EEG-based biomarkers neurological psychiatric disorders.

Language: Английский

Citations

34
Pursuing personalized medicine for depression by targeting the lateral or medial prefrontal cortex with Deep TMS DOI Creative Commons
Abraham Zangen, Samuel Zibman, Aron Tendler

et al.

JCI Insight, Journal Year: 2023, Volume and Issue: 8(4)

Published: Jan. 24, 2023

BACKGROUND. Major depressive disorder (MDD) can benefit from novel interventions and personalization. Deep transcranial magnetic stimulation (Deep TMS) targeting the lateral prefrontal cortex (LPFC) using H1 coil was FDA cleared for treatment of MDD. However, recent preliminary data indicate that medial (MPFC) H7 might induce outcomes are as good or even better. Here, we explored whether TMS MPFC is noninferior to LPFC electrophysiological clinical markers patient selection be identified.

Language: Английский

Citations

21
Fronto-central resting-state 15-29 Hz transient beta events change with therapeutic transcranial magnetic stimulation for posttraumatic stress disorder and major depressive disorder DOI Creative Commons

Alexander Morris,

Simona Temereanca, Amin Zandvakili

et al.

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: April 19, 2023

Abstract Repetitive transcranial magnetic stimulation (rTMS) is an established treatment for major depressive disorder (MDD) and shows promise posttraumatic stress (PTSD), yet effectiveness varies. Electroencephalography (EEG) can identify rTMS-associated brain changes. EEG oscillations are often examined using averaging approaches that mask finer time-scale dynamics. Recent advances show some emerge as transient increases in power, a phenomenon termed “Spectral Events,” event characteristics correspond with cognitive functions. We applied Spectral Event analyses to potential biomarkers of effective rTMS treatment. Resting 8-electrode was collected from 23 patients MDD PTSD before after 5 Hz targeting the left dorsolateral prefrontal cortex. Using open-source toolbox ( https://github.com/jonescompneurolab/SpectralEvents ), we quantified features tested associated Events delta/theta (1–6 Hz), alpha (7–14 beta (15–29 Hz) bands occurred all patients. rTMS-induced improvement comorbid were pre- post-treatment changes fronto-central electrode features, including frontal frequency spans durations, central maxima power. Furthermore, pre-treatment duration correlated negatively symptom improvement. Beta events may provide new clinical response advance understanding rTMS.

Language: Английский

Citations

14
Effects of transcranial magnetic stimulation (TMS) current direction and pulse waveform on cortico‐cortical connectivity: A registered report TMS‐EEG study DOI Creative Commons
Giacomo Guidali, Agnese Zazio, Delia Lucarelli

et al.

European Journal of Neuroscience, Journal Year: 2023, Volume and Issue: 58(8), P. 3785 - 3809

Published: Aug. 31, 2023

Transcranial magnetic stimulation (TMS)-evoked potentials (TEPs) are a promising proxy for measuring effective connectivity, that is, the directed transmission of physiological signals along cortico-cortical tracts, and developing connectivity-based biomarkers. A crucial point is how parameters may affect TEPs, as they contribute to general variability findings across studies. Here, we manipulated two TMS (i.e. current direction pulse waveform) while (a) an early TEP component reflecting contralateral inhibition motor areas, namely, M1-P15, operative model interhemispheric (b) motor-evoked (MEP) corticospinal pathway. Our results showed these evoke influencing its amplitude, latency, replicability. Specifically, M1-P15 amplitude was strongly affected by in monophasic stimulation; latency significantly modulated biphasic pulses. The replicability substantial same condition. At time, it poor when were changed, suggesting factors must be controlled obtain stable single-subject measures. Finally, MEP direction, whereas non-statistically significant changes evident amplitude. Overall, our study highlights importance responses recording suggests controlling their impact connectivity biomarkers from TEPs. Moreover, out excitability tract, which commonly used reference set intensity, not correspond pathways.

Language: Английский

Citations

13
Transcranial magnetic stimulation‐evoked electroencephalography responses as biomarkers for epilepsy: A review of study design and outcomes DOI Creative Commons
Silvano R. Gefferie, Diego Jiménez‐Jiménez, Gerhard H. Visser

et al.

Human Brain Mapping, Journal Year: 2023, Volume and Issue: 44(8), P. 3446 - 3460

Published: March 10, 2023

Transcranial magnetic stimulation (TMS) with electroencephalography (EEG), that is TMS-EEG, may assist in managing epilepsy. We systematically reviewed the quality of reporting and findings TMS-EEG studies on people epilepsy healthy controls, individuals taking anti-seizure medication. searched Cochrane Library, Embase, PubMed Web Science databases for original comparing subjects before after Studies should involve quantitative analyses TMS-evoked EEG responses. evaluated study population characteristics protocols (TMS sessions equipment, TMS trials protocol), assessed variation between protocols, recorded main findings. identified 20 articles 14 unique populations methodologies. The median rate group parameters was 3.5/7 13/14 studies. varied Fifteen out 28 medication total were time-domain single-pulse data. Anti-seizure significantly increased N45, decreased N100 P180 component amplitudes but marginal numbers (N45: 8/15, N100: 7/15, P180: 6/15). Eight compared controls using different analyses, thus limiting comparability. methodological uniformity evaluating as an biomarker poor. inconsistent question validity biomarker. To demonstrate clinical applicability, methodology standards are required.

Language: Английский

Citations

11
Engineering and Technological Advancements in Repetitive Transcranial Magnetic Stimulation (rTMS): A Five-Year Review DOI Creative Commons

Abigail Tubbs,

Enrique Alvarez Vazquez

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(11), P. 1092 - 1092

Published: Oct. 30, 2024

In the past five years, repetitive transcranial magnetic stimulation (rTMS) has evolved significantly, driven by advancements in device design, treatment protocols, software integration, and brain-computer interfaces (BCIs). This review evaluates how these innovations enhance safety, efficacy, accessibility of rTMS while identifying key challenges such as protocol standardization ethical considerations. A structured peer-reviewed studies from 2019 to 2024 focused on technological clinical rTMS, including AI-driven personalized treatments, portable devices, integrated BCIs. AI algorithms have optimized patient-specific devices expanded access. Enhanced coil designs BCI integration offer more precise adaptive neuromodulation. However, remain standardizing addressing complexity, ensuring equitable While recent improve rTMS's utility, gaps long-term efficacy concerns persist. Future research must prioritize standardization, accessibility, robust frameworks ensure sustainable impact.

Language: Английский

Citations

4
Bridging the gap to clinical use: A systematic review on TMS–EEG test-retest reliability DOI Creative Commons
Giacomo Bertazzoli, Elisa Dognini, Peter J. Fried

et al.

Clinical Neurophysiology, Journal Year: 2025, Volume and Issue: 171, P. 133 - 145

Published: Jan. 24, 2025

Language: Английский

Citations

0