Examining the dietary contributions of lipids to pancreatic cancer burden (1990–2021): incidence trends and future projections

Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)

Published: Feb. 21, 2025

Pancreatic cancer (PC) ranks sixth globally among deaths, imposing a significant burden on healthcare systems worldwide. Although diet is known to be major risk factor, well-established factor for PC, the precise dietary components linked disease remain inconclusive, with studies showing varying results across different populations and regions. This study addresses this gap through comprehensive analysis of PC incidence trends from 1990 2021, specific focus associations age, patterns, socio-demographic determinants. The data utilized in were obtained 2021 Global Burden Disease (GBD) database, updated May 16, 2024. Unlike traditional single-variable correlation analyses, Bayesian generalized linear model was applied assess association between food intake during period 1990–2021. To account variations related year region, these variables incorporated as covariates model, allowing more nuanced background factors. Finally, "BAPC" package employed project age-standardized rates 2051. global increased 3.90 per 100,000 people (95% CI: 3.69, 4.08) 6.44 5.86, 6.93) 2021. revealed nuts, omega-3 fatty acids, polyunsaturated acids (PUFA), trans fats, sodium, calcium. In typical countries, higher nuts PUFA associated reduced while fats positively correlated incidence. Age-Period-Cohort (BAPC) prediction indicates that will show downward trend after From exhibited rapid upward trend, suggesting an increasing burden. findings suggest lipid significantly at level. finding underscores importance fat composition, particularly context pancreatic prevention, individuals should pay attention types sources their diets mitigate risk.

Language: Английский

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Nutrients Lowering Obesity-Linked Chemokines Blamable for Metastasis

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2275 - 2275

Published: March 4, 2025

Food intake is an essential contributor to both health and disease. Nutrients contribute a beneficial metabolic equilibrium at the cellular level, preventing or delaying disease onset. Dietary contributes obesity, obesity supports further cancer metastasis. Metastasis, multifactorial multistep process, supported by systemic inflammation of obesity. Spreading cells requires presence plethora recruiter regulator molecules. Molecules such as chemokines are provided high levels obesity-associated fat depots. Chemokine up-regulation in adipose tissue obese individuals has been associated with different types cancers breast, prostate, colon, liver, stomach. Chemokines support all metastasis steps from invasion/migration intravasation, circulation, extravasation, ending colonization. The pool supporting these processes includes CCL2, CCL3, CCL4, CCL5, CCL7, CCL8, CCL11, CCL18, CCL19, CCL20, CXCL1, CXCL5, CXCL 8, CXCL10, CXCL12. Keeping under control can be reducing pro-inflammatory risk poor outcome. help, support, boost treatment effects jeopardize treatment. Constituents anti-inflammatory anti-obesity properties polyphenols, organosulfur components, fatty acids, curcumin, vitamin E have proven effect lowering its contribution

Language: Английский

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Dietary omega-3 (ω-3) fatty acids mitigate intestinal barrier integrity alterations in mice fed a high-fat diet: Implications for pancreatic carcinogenesis

Journal of Nutrition, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Although body fatness is a recognized risk factor for pancreatic ductal adenocarcinoma (PDAC), the underlying mechanisms of how fat composition affects carcinogenesis are poorly understood. High-fat diets (HFDs) can disrupt intestinal barrier function, potentially accelerating carcinogenesis. Omega-3 (ω-3) polyunsaturated fatty acids (FAs) have anti-inflammatory properties and help preserve integrity.

Language: Английский

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The Impact of a Ketogenic Diet on Late-Stage Pancreatic Carcinogenesis in Mice: Efficacy and Safety Studies

Nutrients, Journal Year: 2024, Volume and Issue: 16(22), P. 3919 - 3919

Published: Nov. 16, 2024

High-fat diets (HFDs) have been associated with an increased risk of pancreatic cancer. In contrast, ketogenic (KDs) shown to display anti-tumor characteristics. The objective this work was evaluate the efficacy a KD on late-stage carcinogenesis in genetically modified mouse model cancer [LSL-

Language: Английский

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