Biocompatible ionized air alleviates rat osteoarthritis by modulating polarization from M1 to M2 macrophages DOI Creative Commons
Haoran Yu, Chengbiao Ding,

Zhongyao Hu

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Dec. 30, 2024

Abstract The imbalance in the proportion of M1/M2 macrophage polarization is a crucial contributor to persistent progression osteoarthritis (OA). This study aimed evaluate effects low-dose biocompatible ionized air (BIA) on and its subsequent chondroprotective effects, thereby validating potential BIA slowing OA. In vitro experiments demonstrated that modulates M1 macrophages toward M2 phenotype via ROS-mediated STAT6 pathway. shift reduces expression pro-inflammatory mediators while increasing anti-inflammatory pro-chondrogenic factors, leading an improved microenvironment surrounding chondrocytes. direct benefits this include enhanced chondrocyte viability, inhibition apoptosis, reduced degradation extracellular matrix. vivo studies rats showed inhibited infiltration synovium, upregulated macrophages, alleviated cartilage degeneration, delayed OA progression. gas-based regulatory strategy may open new avenues for treatment

Language: Английский

Iron homeostasis and ferroptosis in human diseases: mechanisms and therapeutic prospects DOI Creative Commons

Qin Ru,

Yusheng Li,

Lin Chen

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Oct. 14, 2024

Iron, an essential mineral in the body, is involved numerous physiological processes, making maintenance of iron homeostasis crucial for overall health. Both overload and deficiency can cause various disorders human diseases. Ferroptosis, a form cell death dependent on iron, characterized by extensive peroxidation lipids. Unlike other kinds classical unprogrammed death, ferroptosis primarily linked to disruptions metabolism, lipid peroxidation, antioxidant system imbalance. Ferroptosis regulated through transcription, translation, post-translational modifications, which affect cellular sensitivity ferroptosis. Over past decade or so, diseases have been as part their etiology, including cancers, metabolic disorders, autoimmune diseases, central nervous cardiovascular musculoskeletal Ferroptosis-related proteins become attractive targets many major that are currently incurable, some regulators shown therapeutic effects clinical trials although further validation potential needed. Therefore, in-depth analysis its molecular mechanisms may offer additional strategies prevention treatment. In this review, we discuss significance contribution etiology development along with evidence supporting targeting approach. Importantly, evaluate recent promising interventions, providing guidance future targeted treatment therapies against

Language: Английский

Citations

56
Advances in osteoarthritis research: From diagnosis, treatment to mechanism studies DOI Creative Commons

Zhongyang Lv,

Ziling Wang, Di Chen

et al.

Journal of Orthopaedic Translation, Journal Year: 2024, Volume and Issue: 44, P. A4 - A6

Published: Jan. 1, 2024

Language: Английский

Citations

8
The Role of Ferroptosis in Osteoarthritis: Progress and Prospects DOI
Weibei Sheng,

Shuai Liao,

Deli Wang

et al.

Biochemical and Biophysical Research Communications, Journal Year: 2024, Volume and Issue: 733, P. 150683 - 150683

Published: Sept. 10, 2024

Language: Английский

Citations

4
Disease-Associated Signatures Persist in Extracellular Vesicles from Reprogrammed Cells of Osteoarthritis Patients DOI Open Access
María Piñeiro-Ramil,

Iván Gómez-Seoane,

Ana Isabel Rodríguez-Cendal

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 870 - 870

Published: Jan. 21, 2025

Osteoarthritis (OA) is a prevalent joint disorder that lacks effective therapies to halt cartilage degeneration. Mesenchymal stromal cell (MSC)-derived small extracellular vesicles (sEVs) are being investigated as promising chondroprotective agents. Compared primary MSCs, induced pluripotent stem (iPSC)-derived MSCs (MLCs) offer superior scalability and enhanced paracrine activity. The aim of this study was explore the feasibility using autologous MLC-derived sEVs potential therapeutic strategy for OA through analysis their protein cargo. iPSCs from an patient healthy donor were differentiated into MLCs. isolated these MLCs characterized, with particular focus on Both iPSC lines successfully MLCs, which secreted comparable size distributions yields. differentially expressed proteins revealed high abundance associated pathology degradation in compared those persistence OA-associated signatures may limit efficacy. These findings underscore importance carefully evaluating disease-specific profiles regenerative applications.

Language: Английский

Citations

0
Recent advances in potential therapeutic targets of ferroptosis‑associated pathways for the treatment of stroke (Review) DOI
Hao Dong, Yaping Ma,

Mei-Mei Cui

et al.

Molecular Medicine Reports, Journal Year: 2024, Volume and Issue: 30(1)

Published: May 22, 2024

Stroke is a severe neurological disease that associated with high rates of morbidity and mortality, the underlying pathological processes are complex. Ferroptosis fulfills significant role in progression treatment stroke. It well established ferroptosis type programmed cell death distinct from other forms or types death. The process involves multiple signaling pathways regulatory mechanisms interact inherent to stroke development. Inducers inhibitors have been shown exert onset this process. Furthermore, it has interfering affects occurrence stroke, indicating targeting may offer promising therapeutic approach for treating patients Hence, present review aimed summarize latest progress made terms using interventions as targets cases provides an overview relevant molecular investigated recent years, highlighting roles inducers Additionally, intervention potential various Traditional Chinese Medicine also summarized. In conclusion, comprehensive afforded by ferroptosis‑associated offering new insights into how be exploited

Language: Английский

Citations

2
Vinpocetine protects against osteoarthritis by inhibiting ferroptosis and extracellular matrix degradation via activation of the Nrf2/GPX4 pathway DOI
Jinwu Wang,

Jin Yang,

Yuqin Fang

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 135, P. 156115 - 156115

Published: Sept. 30, 2024

Language: Английский

Citations

1
CD73 alleviates osteoarthritis by maintaining anabolism and suppressing catabolism of chondrocytes extracellular matrix DOI Creative Commons
Hu Guo,

Zhongyang Lv,

Maochun Wang

et al.

Journal of Orthopaedic Translation, Journal Year: 2024, Volume and Issue: 49, P. 96 - 106

Published: Oct. 5, 2024

Language: Английский

Citations

1
Semaglutide protects against diabetes‐associated cardiac inflammation via Sirt3‐dependent RKIP pathway DOI Open Access

Kaibin Lin,

Wang Ai,

Changlin Zhai

et al.

British Journal of Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 22, 2024

Glucagon-like peptide-1 receptor agonists (GLP-1RAs) exert cardiovascular benefits in diabetic patients, but the underlying mechanisms remain incompletely understood. Semaglutide, a novel long-acting GLP-1RA, has shown reduced risk of events. Based on these results, we investigated therapeutic potential semaglutide cardiomyopathy and sought to elucidate mechanisms.

Language: Английский

Citations

1
Biocompatible ionized air alleviates rat osteoarthritis by modulating polarization from M1 to M2 macrophages DOI Creative Commons
Haoran Yu, Chengbiao Ding,

Zhongyao Hu

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Dec. 30, 2024

Abstract The imbalance in the proportion of M1/M2 macrophage polarization is a crucial contributor to persistent progression osteoarthritis (OA). This study aimed evaluate effects low-dose biocompatible ionized air (BIA) on and its subsequent chondroprotective effects, thereby validating potential BIA slowing OA. In vitro experiments demonstrated that modulates M1 macrophages toward M2 phenotype via ROS-mediated STAT6 pathway. shift reduces expression pro-inflammatory mediators while increasing anti-inflammatory pro-chondrogenic factors, leading an improved microenvironment surrounding chondrocytes. direct benefits this include enhanced chondrocyte viability, inhibition apoptosis, reduced degradation extracellular matrix. vivo studies rats showed inhibited infiltration synovium, upregulated macrophages, alleviated cartilage degeneration, delayed OA progression. gas-based regulatory strategy may open new avenues for treatment

Language: Английский

Citations

0