Journal of Orthopaedic Translation, Journal Year: 2024, Volume and Issue: 45, P. A1 - A2
Published: March 1, 2024
Language: Английский
Journal of Orthopaedic Translation, Journal Year: 2025, Volume and Issue: 50, P. 44 - 55
Published: Jan. 1, 2025
Language: Английский
Citations
1
Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: 106, P. 106696 - 106696
Published: Feb. 6, 2025
Language: Английский
Citations
1
Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101613 - 101613
Published: Feb. 25, 2025
Language: Английский
Citations
1
Nutrients, Journal Year: 2024, Volume and Issue: 16(19), P. 3271 - 3271
Published: Sept. 27, 2024
Sarcopenia is characterized by the progressive loss of skeletal muscle mass, strength, and function, significantly impacting overall health quality life in older adults. This narrative review explores emerging targets potential treatments for sarcopenia, aiming to provide a comprehensive overview current prospective interventions.
Language: Английский
Citations
8
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2154 - 2154
Published: Feb. 27, 2025
The use of autologous biological preparations (ABPs) and their combinations fills the void in healthcare treatment options that exists between surgical procedures, like plastic reconstructive, cosmetic, orthopedic surgeries; non-surgical musculoskeletal procedures; current pharmaceutical treatments. ABPs, including high-density platelet-rich plasma (HD-PRP), bone marrow aspirate concentrates (BMACs), adipose tissue preparations, with unique stromal vascular fractions (SVFs), can play important roles regeneration repair processes. They be easily safely prepared at point care. Healthcare professionals employ ABPs to mimic classical wound healing cascade, initiate angiogenesis induce regenerative pathways, aiming restore integrity function damaged tissues. In this review, we will address combining HD-PRP tissue, particular fraction (t-SVF), as believe biocellular combination demonstrates a synergistic effect, where constituents enhance potential t-SVF its adipose-derived mesenchymal stem cells (AD-MSCs) pericytes, leading improved functional repair, regeneration, variety clinical applications. We some relevant platelet bio-physiological aspects, since these properties contribute effects t-SVF, promoting overall better outcomes chronic inflammatory conditions, soft rejuvenation.
Language: Английский
Citations
0
Future Pharmacology, Journal Year: 2025, Volume and Issue: 5(1), P. 11 - 11
Published: March 6, 2025
Exosomes can transport regulatory biomolecules and are mediators of cellular signaling among metabolic tissues through endocrine mechanisms. Understanding the pathways processes underlying exosome-mediated inter-tissue communication is critical for elucidating molecular pathophysiology diseases such as obesity, type 2 diabetes mellitus (T2DM), cardiovascular disorders. Consequently, these mechanisms represent novel promising targets pharmacological regulation. We examined current knowledge regarding exosome physiology, interaction with target tissues, its role in tissue communication. also analyzed secretory profiles exosomes emphasizing their roles adipose tissue, liver, pancreas, skeletal muscle, small intestine, while discussing association diseases. In this sense, we propose exosomal pentad a framework highlighting inter-organ communication, where may regulate axis involving tissues. This model aligns ominous octet but emphasizes key regulators homeostasis potential therapeutic targets. The treatment emerges area pharmacologic exploration. For instance, strategies that prevent binding or expression cargo molecules miRNAs could be designed, using antagomiRs nanoparticles. Additionally, integrins like αvβ5 on membrane blocked monoclonal antibodies engineered targeted delivery molecules. Exosomes, regulation, hold to design precise molecular-level therapies minimizing systemic side effects.
Language: Английский
Citations
0
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: April 2, 2025
The intricate interaction between skeletal muscle biomechanics, the tumor microenvironment, and immunotherapy constitutes a pivotal research focus oncology. This work provides comprehensive review of methodologies for evaluating including handheld dynamometry, advanced imaging techniques, electrical impedance myography, elastography, single-fiber experiments to assess quality performance. Furthermore, it elucidates mechanisms, applications, limitations various modalities, immune checkpoint inhibitors, adoptive cell therapy, cancer vaccines, combined chemoimmunotherapy, while examining their effects on function systemic responses. Key findings indicate that although is effective in augmenting antitumor immunity, frequently induces muscle-related adverse such as weakness, fatigue, or damage, primarily mediated by cytokine release activation. underscores significance niches within microenvironment influencing treatment outcomes proposes strategies optimize therapy through personalized regimens combinatorial approaches. highlights need further formation interactions muscle-tumor. Our crucial advancing efficacy immunotherapy, reducing effects, ultimately improving survival rates life patients with cancer.
Language: Английский
Citations
0
Journal of Orthopaedic Translation, Journal Year: 2025, Volume and Issue: 52, P. 70 - 84
Published: April 10, 2025
Language: Английский
Citations
0
Cells, Journal Year: 2025, Volume and Issue: 14(10), P. 683 - 683
Published: May 9, 2025
Extracellular vesicles (EVs) are membrane-bound structures released by cells carrying diverse biomolecules involved in intercellular communication. Small EVs abundant body fluids, playing a key role cell signaling. Their natural occurrence and therapeutic potential, especially the context of muscular disorders, make them significant area research. Sarcopenia, characterized progressive muscle fiber loss, represents pathological state which could offer benefits, reducing morbidity mortality. Recent studies have proposed an interplay between adipose tissue (AT) skeletal regarding sarcopenia pathology. AT dysregulation, as seen obesity, contributes to loss multifactorial way. While AT-derived stem (ATDSC) small been implicated musculoskeletal homeostasis, their precise action regeneration remains incompletely understood. In this context, ATDSC-derived can stimulate through improved proliferation migration cells, enhancement perfusion, improvement tendon nerve regeneration, stimulation angiogenesis, promotion myogenic differentiation. However, they also increase loss. Notably, is first comprehensive review systematically examine sarcopenia.
Language: Английский
Citations
0
Published: July 2, 2024
Caveolin is a structural protein within caveolae, which may be involved in transmembrane molecular transport and/or various intercellular interactions cells. Specific mutations of caveolin-3 muscle cells are well-known to cause limb-girdle muscular dystrophy. Altered expression the has been also detected Duchenne's dystrophy, part pathological process leading weakness. Interestingly, it shown that renovation nitric oxide synthase (NOS) sarcolemma with dystrophy could improve health, suggesting NOS pathology Here, we summarize notable function caveolin skeletal cells, and would like discuss about their involvement as well possible tactics for innovative treatment dystrophies.
Language: Английский
Citations
3