Cancer Nanotechnology,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Aug. 21, 2024
Triple-negative
breast
cancer
(TNBC)
is
an
aggressive
subtype
of
cancer.
Radiation
therapy
(RT)
a
modality
for
TNBC
management.
Radiosensitizers
can
mitigate
the
adverse
effects
RT.
Applying
green-synthesized
silver
nanoparticles
(Ag-NPs)
from
biological
sources
such
as
plants
potential
strategy
to
sensitize
cells
radiotherapy
due
low
toxicity.
Therefore,
identifying
novel
natural
synthesizing
stable
and
broadly
applicable
green-Ag-NPs
has
gained
more
attention
in
therapy.
In
present
study,
we
synthesized
green-
Ag-NPs
pumpkin
peel
extract
elucidated
impact
radiosensitizer
MDA-MB
231
(a
model
TNBC).
The
prepared
had
spherical
shape
with
average
size
81
nm
zeta
−
9.96
mV.
Combination
RT
exhibited
synergistic
anticancer
optimum
combination
index
(CI)
0.49
MDA-MB-231
cells.
Green-synthesized
synergistically
potentiated
RT-induced
apoptosis
compared
corresponding
monotherapies.
Morphological
features
were
further
confirmed
by
DAPI–TUNEL
staining
assay.
HIF-1α
expression
was
decreased
subjected
Bax
p53
increased,
whereas
Bcl-2
genes
decreased.
significantly
increased
protein
level
PERK
CHOP
while
decreasing
cyclin
D1
p-ERK/total
ERK
levels
These
findings
indicate
effect
treatment.
ACS Omega,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 18, 2025
Silver
nanoparticles
(AgNPs)
are
widely
recognized
for
their
unique
optical,
electronic,
and
antibacterial
properties,
enabling
use
in
biosensing,
photonics,
electronics,
drug
delivery,
antimicrobial
treatments.
Green
chemistry-based
biological
synthesis
methods
offer
an
eco-friendly
alternative
to
traditional
chemical
techniques.
Among
metallic
(NPs)
metal
oxides,
those
derived
from
plant
extracts
exhibit
notable
medicinal
properties.
Due
exceptional
stability
low
reactivity,
AgNPs
particularly
well-suited
various
applications.
can
be
synthesized
through
chemical,
physical,
or
methods,
each
with
distinct
benefits
challenges.
Chemical
physical
approaches
often
involve
complex
purification,
reactive
reagents,
high
energy
demands,
while
though
slower,
provide
sustainable
solutions.
The
chosen
method
strongly
influences
the
stability,
size,
purity
of
resulting
NPs.
This
review
emphasizes
importance
selecting
appropriate
optimize
characteristics
functionality
silver
It
consolidates
research
spanning
past
two
decades,
including
most
recent
findings
2024.
A
comprehensive
electronic
search
databases
such
as
PubMed,
Scopus,
ScienceDirect,
Cochrane,
Google
Scholar
was
conducted
up-to-date
overview
advances
applications
nanoparticles.
Nanomaterials,
Journal Year:
2025,
Volume and Issue:
15(5), P. 328 - 328
Published: Feb. 20, 2025
This
study
explores
the
green
synthesis
of
silver
nanoparticles
(AgNPs)
using
Cymbopogon
citratus
(lemongrass)
extract
as
a
reducing
agent.
Synthesis
was
confirmed
by
color
change
(light
yellow
to
dark
brown)
under
optimal
conditions:
1.50
mM
nitrate,
3.5%
v/v
extract,
at
100
°C,
with
pH
9,
and
for
60
min.
The
AgNPs
exhibited
spherical
morphology,
hydrodynamic
diameter
135.41
±
49.30
nm,
zeta
potential
-29.9
1.4
mV,
crystalline
structure,
minimal
aggregation.
showed
significant
antibacterial
activity,
particularly
>20
µg/well,
zones
inhibition
varying
bacterial
strain.
In
vitro
studies
demonstrated
anti-inflammatory,
antidiabetic
(α-glucosidase
α-amylase
inhibition),
antioxidant
activities,
outperforming
plant
nearing
standard
efficacy
higher
concentrations.
Cyto-toxicity
indicated
that
were
less
toxic
than
doxorubicin
but
concentration-dependent
effects
on
cancerous
non-cancerous
cells.
Eco-toxicity
assays
revealed
acutely
controls
posed
risks
prolonged
exposure.
work
highlights
eco-friendly
their
in
biomedical
applications,
demonstrating
activities.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: March 11, 2024
Abstract
The
present
study
reports
the
green
synthesis
of
silver
nanoparticles
(AgNPs)
in
powder
form
using
leaf
extract
Azadirachta
indica
.
AgNPs
was
confirmed
by
UV–vis
spectroscopy,
FTIR,
XRD,
FESEM,
and
EDX.
synthesized
were
a
powdered
state
dispersed
completely
5%
polyethylene
glycol
(PEG)
demonstrated
prolonged
shelf
life
enhanced
bioavailability
over
year
without
any
aggregation.
resulting
nanoformulation
complete
inhibition
against
Sclerotinia
sclerotiorum
Colletotrichum
falcatum
68%
to
80%
gloeosporioides
Rhizoctonia
solani
respectively,
at
2000
ppm.
EC
50
values
determined
through
statistical
analysis
66.42,
157.7,
19.06,
33.30
ppm
for
S.
,
C.
R.
respectively.
also
established
significant
cytotoxicity,
with
74.96%
rate
human
glioblastoma
cell
line
U87MG
250
IC
value
cancerous
lines
be
56.87
analysis.
proposed
may
used
as
next-generation
fungicide
crop
improvement
find
application
anticancer
investigations.
To
best
our
knowledge,
this
is
first
report
demonstrating
economically
phytopathogen
Materials,
Journal Year:
2024,
Volume and Issue:
17(10), P. 2252 - 2252
Published: May 10, 2024
This
work
aims
to
analyze
the
influence
of
selected
plants
on
synthesis
silver
nanoparticles
(AgNPs).
Six
were
chosen
for
experiment,
from
which
extracts
prepared:
maclura
fruit,
spruce
and
ginkgo
needles,
green
algae
(Ch.
kessleri),
mushrooms,
namely
Collybia
nuda,
Macrolepiota
procera.
The
composition
colloids
after
preparation
was
analyzed
using
FTIR
analysis.
affected
not
only
rate
but
also
shape
nanoparticles.
TEM
analysis
confirmed
mainly
spherical
(size
range:
10-25
nm).
However,
triangular
prisms
polyhedral
synthesized
by
containing
flavonoids,
terpenes,
phenols
(the
main
compounds
resins)
confirmed.
EDS
used
It
proven
that
choosing
right
plant
extract
appropriate
technology
with
treatment,
it
is
possible
prepare
different
shapes.
European Journal of Medicinal Chemistry Reports,
Journal Year:
2024,
Volume and Issue:
11, P. 100168 - 100168
Published: May 10, 2024
The
emergence
of
metallic
nanoparticles
through
green
synthesis
has
garnered
significant
recognition,
shaping
global
research
efforts
towards
eco-friendly
practices,
often
termed
as
the
revolution.
Specifically,
silver
(AgNPs)
made
considerable
strides
in
past
decade,
becoming
a
prominent
fixture
realm
science
and
technology.
study
explores
characterization
using
Cassia
fistula
L.
flowers
extract
chemical
co-precipitation
(CM_AgNPs)
methods
(CFF_AgNPs).
Characterization
techniques,
including
scanning
electron
microscopy
(SEM),
transmission
(TEM),
attenuated
total
reflectance
fourier-transform
infrared
(FTIR),
X-ray
diffraction
(XRD),
revealed
irregular
morphologies
with
agglomeration,
polycrystalline
nature,
intrinsic
functional
groups
involved
capping
AgNPs.
Antioxidant
assessment
demonstrated
superior
antioxidative
activity
(84.48%)
green-synthesized
compared
to
chemically
synthesized
ones
(75.87%),
they
exhibited
dose-dependent
anti-inflammatory
effects
IC50
values
CFF_AgNPs_30.19
μg/mL
CM_AgNPs
_34.14
respectively.
lower
value
signifies
finer
better
due
presence
phytochemicals
present
it.
Whereas
for
is
34.14
which
solely
To
ensure
promising
therapeutic
aspects
AgNPs
careful
their
safety
profile,
cytotoxicity
on
HEP3B
cancer
cells
was
evaluated
MTT
assay,
lactate
dehydrogenase
(LDH)
release,
reactive
oxygen
species
(ROS)
level
measurement.
In
vitro
evaluation,
more
pronounced
adverse
upon
exposure
CFF_AgNPs
CM_AgNPs.
This
underscores
bioactive
potential
mediated
AgNPs,
suggesting
applications
biomedicine
environmental
sustainability.
findings
contribute
growing
interest
benefits
various
fields.
