Green Synthesis of Silver Nanoparticles: A Comprehensive Review of Methods, Influencing Factors, and Applications

JCIS Open, Journal Year: 2024, Volume and Issue: 16, P. 100125 - 100125

Published: Oct. 11, 2024

Language: Английский

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Green-synthesized silver nanoparticles from peel extract of pumpkin as a potent radiosensitizer against triple-negative breast cancer (TNBC)

Cancer Nanotechnology, Journal Year: 2024, Volume and Issue: 15(1)

Published: Aug. 21, 2024

Triple-negative breast cancer (TNBC) is an aggressive subtype of cancer. Radiation therapy (RT) a modality for TNBC management. Radiosensitizers can mitigate the adverse effects RT. Applying green-synthesized silver nanoparticles (Ag-NPs) from biological sources such as plants potential strategy to sensitize cells radiotherapy due low toxicity. Therefore, identifying novel natural synthesizing stable and broadly applicable green-Ag-NPs has gained more attention in therapy. In present study, we synthesized green- Ag-NPs pumpkin peel extract elucidated impact radiosensitizer MDA-MB 231 (a model TNBC). The prepared had spherical shape with average size 81 nm zeta − 9.96 mV. Combination RT exhibited synergistic anticancer optimum combination index (CI) 0.49 MDA-MB-231 cells. Green-synthesized synergistically potentiated RT-induced apoptosis compared corresponding monotherapies. Morphological features were further confirmed by DAPI–TUNEL staining assay. HIF-1α expression was decreased subjected Bax p53 increased, whereas Bcl-2 genes decreased. significantly increased protein level PERK CHOP while decreasing cyclin D1 p-ERK/total ERK levels These findings indicate effect treatment.

Language: Английский

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Antioxidant and anti-diabetic potential of the green synthesized silver nanoparticles using Martynia annua L. root extract

Nano TransMed, Journal Year: 2025, Volume and Issue: unknown, P. 100070 - 100070

Published: Jan. 1, 2025

Language: Английский

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Silver Nanoparticles (AgNPs): Comprehensive Insights into Bio/Synthesis, Key Influencing Factors, Multifaceted Applications, and Toxicity─A 2024 Update

ACS Omega, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

Silver nanoparticles (AgNPs) are widely recognized for their unique optical, electronic, and antibacterial properties, enabling use in biosensing, photonics, electronics, drug delivery, antimicrobial treatments. Green chemistry-based biological synthesis methods offer an eco-friendly alternative to traditional chemical techniques. Among metallic (NPs) metal oxides, those derived from plant extracts exhibit notable medicinal properties. Due exceptional stability low reactivity, AgNPs particularly well-suited various applications. can be synthesized through chemical, physical, or methods, each with distinct benefits challenges. Chemical physical approaches often involve complex purification, reactive reagents, high energy demands, while though slower, provide sustainable solutions. The chosen method strongly influences the stability, size, purity of resulting NPs. This review emphasizes importance selecting appropriate optimize characteristics functionality silver It consolidates research spanning past two decades, including most recent findings 2024. A comprehensive electronic search databases such as PubMed, Scopus, ScienceDirect, Cochrane, Google Scholar was conducted up-to-date overview advances applications nanoparticles.

Language: Английский

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Aqueous Cymbopogon citratus Extract Mediated Silver Nanoparticles: Part I. Influence of Synthesis Parameters, Characterization, and Biomedical Studies

Nanomaterials, Journal Year: 2025, Volume and Issue: 15(5), P. 328 - 328

Published: Feb. 20, 2025

This study explores the green synthesis of silver nanoparticles (AgNPs) using Cymbopogon citratus (lemongrass) extract as a reducing agent. Synthesis was confirmed by color change (light yellow to dark brown) under optimal conditions: 1.50 mM nitrate, 3.5% v/v extract, at 100 °C, with pH 9, and for 60 min. The AgNPs exhibited spherical morphology, hydrodynamic diameter 135.41 ± 49.30 nm, zeta potential -29.9 1.4 mV, crystalline structure, minimal aggregation. showed significant antibacterial activity, particularly >20 µg/well, zones inhibition varying bacterial strain. In vitro studies demonstrated anti-inflammatory, antidiabetic (α-glucosidase α-amylase inhibition), antioxidant activities, outperforming plant nearing standard efficacy higher concentrations. Cyto-toxicity indicated that were less toxic than doxorubicin but concentration-dependent effects on cancerous non-cancerous cells. Eco-toxicity assays revealed acutely controls posed risks prolonged exposure. work highlights eco-friendly their in biomedical applications, demonstrating activities.

Language: Английский

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Metallic nanoparticles unveiled: Synthesis, characterization, and their environmental, medicinal, and agricultural applications

Talanta, Journal Year: 2024, Volume and Issue: 280, P. 126790 - 126790

Published: Aug. 29, 2024

Language: Английский

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Comprehensive antifungal investigation of green synthesized silver nanoformulation against four agriculturally significant fungi and its cytotoxic applications

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: March 11, 2024

Abstract The present study reports the green synthesis of silver nanoparticles (AgNPs) in powder form using leaf extract Azadirachta indica . AgNPs was confirmed by UV–vis spectroscopy, FTIR, XRD, FESEM, and EDX. synthesized were a powdered state dispersed completely 5% polyethylene glycol (PEG) demonstrated prolonged shelf life enhanced bioavailability over year without any aggregation. resulting nanoformulation complete inhibition against Sclerotinia sclerotiorum Colletotrichum falcatum 68% to 80% gloeosporioides Rhizoctonia solani respectively, at 2000 ppm. EC 50 values determined through statistical analysis 66.42, 157.7, 19.06, 33.30 ppm for S. , C. R. respectively. also established significant cytotoxicity, with 74.96% rate human glioblastoma cell line U87MG 250 IC value cancerous lines be 56.87 analysis. proposed may used as next-generation fungicide crop improvement find application anticancer investigations. To best our knowledge, this is first report demonstrating economically phytopathogen

Language: Английский

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Impact of Plant Extract Phytochemicals on the Synthesis of Silver Nanoparticles

Materials, Journal Year: 2024, Volume and Issue: 17(10), P. 2252 - 2252

Published: May 10, 2024

This work aims to analyze the influence of selected plants on synthesis silver nanoparticles (AgNPs). Six were chosen for experiment, from which extracts prepared: maclura fruit, spruce and ginkgo needles, green algae (Ch. kessleri), mushrooms, namely Collybia nuda, Macrolepiota procera. The composition colloids after preparation was analyzed using FTIR analysis. affected not only rate but also shape nanoparticles. TEM analysis confirmed mainly spherical (size range: 10-25 nm). However, triangular prisms polyhedral synthesized by containing flavonoids, terpenes, phenols (the main compounds resins) confirmed. EDS used It proven that choosing right plant extract appropriate technology with treatment, it is possible prepare different shapes.

Language: Английский

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Green and chemical syntheses of silver nanoparticles: Comparative and comprehensive study on characterization, therapeutic potential, and cytotoxicity

European Journal of Medicinal Chemistry Reports, Journal Year: 2024, Volume and Issue: 11, P. 100168 - 100168

Published: May 10, 2024

The emergence of metallic nanoparticles through green synthesis has garnered significant recognition, shaping global research efforts towards eco-friendly practices, often termed as the revolution. Specifically, silver (AgNPs) made considerable strides in past decade, becoming a prominent fixture realm science and technology. study explores characterization using Cassia fistula L. flowers extract chemical co-precipitation (CM_AgNPs) methods (CFF_AgNPs). Characterization techniques, including scanning electron microscopy (SEM), transmission (TEM), attenuated total reflectance fourier-transform infrared (FTIR), X-ray diffraction (XRD), revealed irregular morphologies with agglomeration, polycrystalline nature, intrinsic functional groups involved capping AgNPs. Antioxidant assessment demonstrated superior antioxidative activity (84.48%) green-synthesized compared to chemically synthesized ones (75.87%), they exhibited dose-dependent anti-inflammatory effects IC50 values CFF_AgNPs_30.19 μg/mL CM_AgNPs _34.14 respectively. lower value signifies finer better due presence phytochemicals present it. Whereas for is 34.14 which solely To ensure promising therapeutic aspects AgNPs careful their safety profile, cytotoxicity on HEP3B cancer cells was evaluated MTT assay, lactate dehydrogenase (LDH) release, reactive oxygen species (ROS) level measurement. In vitro evaluation, more pronounced adverse upon exposure CFF_AgNPs CM_AgNPs. This underscores bioactive potential mediated AgNPs, suggesting applications biomedicine environmental sustainability. findings contribute growing interest benefits various fields.

Language: Английский

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Identification and characterization of silver nanoparticles from Erythrina indica and its antioxidant and Uropathogenic antimicrobial properties

Microbial Pathogenesis, Journal Year: 2024, Volume and Issue: 190, P. 106635 - 106635

Published: April 4, 2024

Language: Английский

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