Psychoneuroendocrinology, Journal Year: 2020, Volume and Issue: 122, P. 104899 - 104899
Published: Oct. 6, 2020
Language: Английский
Frontiers in Neuroendocrinology, Journal Year: 2022, Volume and Issue: 65, P. 100994 - 100994
Published: March 21, 2022
Adverse childhood experiences (ACEs) may leave long-lasting neurobiological scars, increasing the risk of developing mental disorders in later life. However, no review has comprehensively integrated existing evidence across fields: hypothalamic-pituitary-adrenal axis, immune/inflammatory system, neuroimaging, and genetics/epigenetics. We thus systematically reviewed previous meta-analyses towards an integrative account ACE-related alterations. Following Preferred Reporting Items for Systematic Reviews Meta-Analyses (PRISMA) guideline, a total 27 until October 2021 were identified. This found that individuals with ACEs possess blunted cortisol response to psychosocial stressors, low-grade inflammation evinced by increased C-reactive protein levels, exaggerated amygdalar emotionally negative information, diminished hippocampal gray matter volume. Importantly, these alterations consistently observed those without psychiatric diagnosis. These findings discussed schematic model Future longitudinal research based on multidisciplinary approach is imperative disorders' prevention treatment.
Language: Английский
Citations
80
Health Sciences Review, Journal Year: 2023, Volume and Issue: 6, P. 100079 - 100079
Published: Feb. 6, 2023
Everyday responsibilities and lifestyle issues are the main cause of physical psychological stress, which deteriorates individual's health. Prolonged exposure to stress triggers adrenocorticotrophic hormonal (ACTH) system causes release cortisol hormones from adrenal cortex. Many other biomarkers affected by but is considered most vital potentially clinically useful biomarker for estimation monitoring. Accurate timely detection increased levels might improve diagnosis, treatment, prevention stress-related diseases such as anxiety disorders, metabolic dysregulation, cardiovascular diseases. Unfortunately, assessments currently performed only in laboratories there no point-of-care solution ambulatory/real-time assessment. This review aims provide an overview promising techniques, used challenges associated with them. The also provides a feasibility report about measuring different bio-fluids (for example, urine), correlation perceived levels, methods/devices laboratory well ambulatory environment detection. overall conclusion suggests that significant research efforts investments required development accurate, rapid, repeatable device can be connected health applications.
Language: Английский
Citations
24
Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 15
Published: Feb. 14, 2025
Introduction Infertility is characterized by the failure to conceive after 12 months of unprotected sexual intercourse. In assisted reproduction technologies (ARTs), in-vitro fertilization and embryo transfer (IVF-ET) are pivotal, with quality essential for successful implantation. Objective This systematic review meta-analysis aimed explore prevalence embryonic factors involved in implantation process, concentrating on following research inquiries: 1) rates euploid versus untested transfers; 2) efficiency transferring good embryos different age groups; 3) impact transfers gestational carriers; 4) donated gametes/embryos. The goal identify critical points improve therapies. Methods A comprehensive literature search identified 1474 relevant papers, 11 which met inclusion criteria. information was gathered using a standardized form, risk bias evaluated. subgroups determine conducted synthesize results. Furthermore, data extracted from registries document persistent secondary role extraembryonic determinants Results demonstrated that preimplantation genetic testing aneuploidy (PGT-A) significantly increased odds Age found influence factors, older women experiencing reduced as carriers. However, overall incidence low. highlights need focus PGT-A, diagnostic hysteroscopy, endometrial receptivity improving rates. Conclusion Implantation success ARTs largely depends euploidy. While achieving three greatly increases rates, it challenging women. Extraembryonic although present, have marginal impact. Subsequent studies ought concentrate modulating responses immunologically developing algorithms precision predicting success; well timing occurrence dormant phenomena also warrants further investigation.
Language: Английский
Citations
1
Neuroscience & Biobehavioral Reviews, Journal Year: 2023, Volume and Issue: 147, P. 105101 - 105101
Published: Feb. 17, 2023
Language: Английский
Citations
18
Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 159, P. 105595 - 105595
Published: Feb. 17, 2024
Trauma can shape the way an individual experiences world and interacts with other people. Touch is a key component of social interactions, but surprisingly little known how trauma exposure influences processing touch. In this review, we examine possible neurobiological pathways through which influence touch lead to aversion avoidance in trauma-exposed individuals. Emerging evidence indicates that may affect sensory thresholds by modulating activity primary cortex posterior insula. Disturbances multisensory integration oxytocin reactivity combined diminished reward-related anxiolytic responses induce bias towards negative appraisal contexts. Furthermore, hippocampus deactivation during reflect dissociative state. These changes depend not only on type severity also features We hypothesise disrupted impair interactions confer elevated risk for future stress-related disorders.
Language: Английский
Citations
7
Translational Psychiatry, Journal Year: 2022, Volume and Issue: 12(1)
Published: April 14, 2022
Alterations of the hypothalamus pituitary-axis on one hand and heightened rates somatic diseases mortality other are consistently found for PTSD MDD patients. A possible link between these factors might be immune system, in particular pro- anti-inflammatory cytokines. 'low-grade inflammation' patients was found, whereas influence acute stress role cytokines rarely examined. In this study, 17 female participated Trier social test while serum cytokine levels (IL-6, IL-10) were assessed. Cytokine compared with depressive (n = 18) healthy controls 18). Group differences assessed using a 3 (group) x 8 (time: -15, -1, +1, +10, +20, +30, +45, +60 min) ANCOVA repeated measures baseline values as covariates. There no group difference regarding IL-6 (p 0.920) but showed significantly higher IL-10 < 0.001, d 0.16) 0.38). Under stress, did not show widely elevated an increase IL-10. Therefore, seems to promote imbalance indicate hyperreactive response. This should considered future studies further understand system response diseases.
Language: Английский
Citations
25
European journal of psychotraumatology, Journal Year: 2022, Volume and Issue: 13(2)
Published: Nov. 2, 2022
Background: Neurophysiological models link dissociation (e.g. feeling detached during or after a traumatic event) to hypoarousal. It is currently assumed that the initial passive reaction threat may coincide with blunted autonomic response, which constitutes dissociative subtype of post-traumatic stress disorder (PTSD). Objective: Within this systematic review we summarize research evaluates nervous system activation heart rate, blood pressure) and in PTSD patients discern validity current neurophysiological trauma-related Method: Of 553 screened articles, 28 studies (N = 1300 subjects) investigating physiological response provocation interventions were included final analysis. Results: No clear trend exists across all measured markers dissociation. Extracted results are inconsistent, part due high heterogeneity experimental methodology. Conclusion: The unable provide robust evidence peri- associated hypoarousal, questioning distinct psychophysiological profiles PTSD.
Language: Английский
Citations
23
Neuroscience & Biobehavioral Reviews, Journal Year: 2023, Volume and Issue: 150, P. 105211 - 105211
Published: May 3, 2023
Language: Английский
Citations
13
Frontiers in Pain Research, Journal Year: 2023, Volume and Issue: 4
Published: June 21, 2023
Chronic pain is among the most common reasons adults in U.S. seek medical care. Despite chronic pain's substantial impact on individuals' physical, emotional, and financial wellness, biologic underpinnings of remain incompletely understood. Such deleterious an wellness also manifested co-occurrence stress with pain. However, whether adversity related alcohol substance misuse increases risk developing pain, and, if so, what overlapping psychobiological processes are, not well Individuals suffering find alleviation through prescription opioids as non-prescribed cannabis, alcohol, other drugs to control use these substances have grown significantly. Substance experience stress. Thus, given evidence showing a strong correlation between we aim review identify factors processes. We first explore predisposing psychologic features both conditions. This followed by examining neural circuitry order trace pathophysiologic for development its link use. Based previous literature our own findings, propose critical role ventromedial prefrontal cortex dysfunction, brain area associated regulation that affected use, key Finally, need future research exploring medial circuits pathology. Critically, alleviate enormous burden without exacerbating co-occurring crisis, emphasize better approaches treat prevent
Language: Английский
Citations
13
Clinical Psychological Science, Journal Year: 2023, Volume and Issue: 11(3), P. 490 - 508
Published: Jan. 10, 2023
An experimental paradigm with subjective and objective assessments was used to further explicate the role of positive emotion dysregulation on risky behavior. Participants were 151 community women currently experiencing intimate partner violence using substances (
Language: Английский
Citations
11