A Systematic Review and Meta‐Analysis of the Association Between Childhood Maltreatment and Adult Depression

Acta Psychiatrica Scandinavica, Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

ABSTRACT Introduction Childhood maltreatment (CM) and depression are serious global issues with high prevalence lifelong impacts on physical mental health. CM has been proposed as a modifiable risk factor for that, if prevented, may contribute to reduction in the incidence of depressive disorders. Despite this, there is paucity reviews examining strength association between these variables. The aim this systematic review meta‐analysis was evaluate empirical evidence determine supported preventable depression. Methods A search performed July 2024 all peer‐reviewed journal articles written English relationship adult electronic databases EBSCOhost , Proquest Embase . Studies were included they measured before 18 years age independent variable dependent variable. excluded outcome grouped comorbidity did not report primary quantitative data. total 77 studies 516,302 participants met inclusion criteria review. Results random‐effects used generate pooled odds ratio from 87 effect estimates demonstrated that individuals history any 2.5 times more likely experience ( OR = 2.49 [95% CI: 2.25–2.76]). This increase remained regardless how screened Conclusions These findings confirmed strong High heterogeneity meta‐analytic results also suggested further research required applies consistent adjustments comorbidities confounding factors examines temporal variables establish causality.

Language: Английский

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Childhood Maltreatment and Amygdala Response to Interpersonal Threat in a Transdiagnostic Adult Sample: The Role of Trait Dissociation

Biological Psychiatry Cognitive Neuroscience and Neuroimaging, Journal Year: 2024, Volume and Issue: 9(6), P. 626 - 634

Published: Jan. 26, 2024

Language: Английский

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Effects of expanded adverse childhood experiences including school bullying, childhood poverty, and natural disasters on mental health in adulthood

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: May 26, 2024

Abstract The study aimed to examine the association of expanded adverse childhood experiences (ACEs) with psychological distress in adulthood. data from nation-wide online cohort was used for analysis. Community dwelling adults Japan were included. ACEs assessed by 15 items ACE-J, including poverty and school bullying. Severe determined as score Kessler 6 over 13. Multivariable logistic regression analysis conducted, using sample weighting. A total 28,617 participants analyzed. About 75% Japanese people had one or more ACEs. prevalence those 4 14.7%. Those showed adjusted odds ratio = 8.18 [95% CI 7.14–9.38] severe distress. 29% 50–64 year old 40% 65 older participants. impact on less than other these age cohorts. Bullying experienced 21–27% young generations, but 10% However, adulthood relatively high all groups. have impacted mental health a long time. Future research practice reduce are encouraged.

Language: Английский

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Brain insulin signaling as a potential mediator of early life adversity effects on physical and mental health

Neuroscience & Biobehavioral Reviews, Journal Year: 2023, Volume and Issue: 153, P. 105350 - 105350

Published: Aug. 6, 2023

In numerous brain structures, insulin signaling modulates the homeostatic processes, sensitivity to reward pathways, executive function, memory, and cognition. Through human studies animal models, mounting evidence implicates central in metabolic, physiological, psychological consequences of early life adversity. this review, we describe adversity where is a key factor how may moderate effects on psychiatric cardio-metabolic health outcomes. Further understanding impact specific regions mental physical outcomes will assist prevention, diagnosis, potential intervention following

Language: Английский

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Heart rate variability: Evaluating a potential biomarker of anxiety disorders

Psychophysiology, Journal Year: 2023, Volume and Issue: 61(2)

Published: Nov. 21, 2023

Abstract Establishing quantifiable biological markers associated with anxiety will increase the objectivity of phenotyping and enhance genetic research disorders. Heart rate variability (HRV) is a physiological measure reflecting dynamic relationship between sympathetic parasympathetic nervous systems, promising target for further investigation. This review summarizes evidence evaluating HRV as potential biomarker disorders by highlighting literature related to combined investigations endophenotypes, neuroimaging, treatment response, genetics. Deficient shows promise an endophenotype pathological may serve noninvasive index prefrontal cortical control over amygdala, potentially aid outcome prediction. We propose that genetics can be used understanding etiological Given anxiety–HRV link, strategies are offered advance analytical approaches, including use polygenic methods, wearable devices, pharmacogenetic study designs. Overall, support anxiety, in transdiagnostic manner, heart–brain entwinement providing novel approach development.

Language: Английский

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Childhood abuse and neglect and profiles of adult emotion dynamics

Development and Psychopathology, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 19

Published: Jan. 10, 2024

Abstract Childhood maltreatment (CM) is experienced by ∼40% of all children at major personal and societal costs. The divergent associations between emotional, physical, sexual abuse or neglect in childhood differences adult emotional functioning regulation were examined terms daily emotion intensity, variability, instability, inertia, diversity, reported over 30 days 290 Dutch aged 19-73. Participants described their abuse/neglect experiences retrospectively using the Trauma Questionnaire (CTQ). Dissecting CM effects on dynamics may inform theories ontogenesis emotions, neglect, to better understand (dys)functional development, prevent adverse sequelae. Structural equation models (SEM) showed that most types associated with specific patterns dynamics, only had no unique dynamic indices. Emotional was measures (i.e., less intense, variable, unstable, diverse emotions). Sexual increases physical decreases negative affect variability instability. Physical inertia but a small effect size. Social contact frequency did not mediate much relationship dynamics.

Language: Английский

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Association of sociodemographic, proximal, and distal clinical factors with current suicidal ideation: Findings from a nonclinical sample of young adults

European Psychiatry, Journal Year: 2023, Volume and Issue: 66(1)

Published: Jan. 1, 2023

Abstract Background Accumulating evidence indicates that a variety of distal and proximal factors might impact risk suicide. However, the association between both groups remains unknown. Therefore, in present study, we aimed to investigate interplay correlates current suicidal ideation. Methods A total 3,000 individuals (aged 18–35 years, 41.7% males), who had reported negative history psychiatric treatment, were enrolled through an online computer-assisted web interview. Self-reports administered measure: (a) factors: childhood trauma (CT), reading disabilities (RDs), symptoms attention-deficit/hyperactivity disorder (ADHD), lifetime non-suicidal self-injury (NSSI), problematic substance use as well family schizophrenia mood disorders; (b) depressive symptoms, psychotic-like experiences (PLEs), insomnia; (c) sociodemographic characteristics. Results Suicidal ideation was directly associated with unemployment, being single, higher level RD, NSSI severity PLEs, depression, insomnia. The fully (a CT ADHD) or partially RD) mediated by (PLEs, insomnia). Conclusions Main findings from this study posit role related neurodevelopmental disorders, shaping suicide risk. Their effects be

Language: Английский

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The impact of bullying in childhood and adolescence

Current Opinion in Psychiatry, Journal Year: 2023, Volume and Issue: 36(6), P. 461 - 465

Published: Aug. 24, 2023

Purpose of review Bullying is a common adversity affecting many children and adolescents. It has been shown to negatively impact the psychological well being not only targets bullying, but also that bullying perpetrators those witnessing bullying. linked depression poorer mental health functioning among Given high prevalence adolescents negative sequelae this an area urgent public concern. This narrative brings forth recent research findings in arena, which could help shape policies for addressing preventing Recent demonstrate association with depression, nonsuicidal self-injury, sleep loss, reduced health-related quality life, rates graduation from school later problems. A systematic showed peer-victimization activation amygdala, left parahippocampal gyrus fusiform gyrus, alterations other brain areas. Summary Evidence indicates childhood adolescence associated higher odds developing problems; therefore, early identification timely intervention crucial.

Language: Английский

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The association of adverse childhood experiences with long-term outcomes of psychosis: a 21-year prospective cohort study after a first episode of psychosis

Psychological Medicine, Journal Year: 2024, Volume and Issue: 54(11), P. 3099 - 3108

Published: May 30, 2024

Abstract Background Evidence suggests a possible relationship between exposure to childhood adversity (CA) and functional impairment in psychosis. However, the impact of CA on long-term outcomes psychotic disorders remains poorly understood. Methods Two hundred forty-three patients were assessed at their first episode psychosis for re-assessed after mean 21 years follow-up several outcome domains, including symptoms, functioning, quality life, cognitive performance, neurological dysfunction, comorbidity. The unique predictive ability was examined using linear regression analysis controlling relevant confounders, socioeconomic status, family risk schizophrenia, obstetric complications. Results There 54% with documented history mild or higher levels. experiences more prevalent severe schizophrenia than other ( p < 0.001). Large very large effect sizes observed predicting most role functioning variables negative symptoms (Δ R 2 0.105 0.181). Moderate positive personal impaired social cognition, immediate verbal learning, poor global internalized stigma, recovery, drug abuse severity 0.040 0.066). A dose–response levels domains. Conclusion Our results suggest strong widespread link early disorders. Awareness serious consequences should encourage better identification those development effective interventions.

Language: Английский

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Do coping strategies mediate the effects of childhood adversities and traumata on clinical high-risk of psychosis, depression, and social phobia? A cross-sectional study on patients of an early detection service

BMC Psychiatry, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 7, 2025

Abstract Background Childhood adversities and traumata (CAT) increase the risk for various mental disorders, including clinical high-risk of psychosis (CHR-P) state its main comorbidities, i.e., depression, social phobia. However, these relations are likely mediated by personal coping behaviors. This cross-sectional study investigates relationships between CAT domains, coping, CHR-P, Methods Using path analyses, we analyzed data 736 patients (mean age 24 years, 67% male) who presented at an early detection service 2002 2013, answered questionnaires on CAT, depressiveness, phobia, underwent examination CHR-P according to recommendations Guidance project European Psychiatric Association. Results All models (total sample, males females) showed good excellent fit data. In all models, higher scores maladaptive negative effect emotional abuse health outcomes. Additionally, in total sample males, lower adaptive neglect, physical neglect was associated with that, turn, were linked depression phobia but not CHR-P. Overall, effects than those although more diversely CAT. Furthermore, interrelated widely explained which significantly them. Conclusions Our findings underscore complex interplay domains their relevant mediators outcomes that reflect underlying sex-specific psychological, social, cultural neurobiological mechanisms. Supporting a broader view traditional focus sexual abuse, results indicate important role descriptively, is most strongly strategies A detailed understanding will future help develop multi-dimensional, holistic approach treatment have experienced Trial registration The registered German Clinical Register ( https://drks.de/ ) as DRKS00024469 02/24/2021.

Language: Английский

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