PLGA Core-Shell Nano/Microparticle Delivery System for Biomedical Application

Polymers, Journal Year: 2021, Volume and Issue: 13(20), P. 3471 - 3471

Published: Oct. 10, 2021

Core–shell particles are very well known for their unique features. Their distinctive inner core and outer shell structure allowed promising biomedical applications at both nanometer micrometer scales. The primary role of core–shell is to deliver the loaded drugs as they capable sequence-controlled release provide protection drugs. Among other polymers, poly (lactic-co-glycolic acid) (PLGA), a food drug administration (FDA)-approved polymer, has been recognized vehicle material. This review introduces PLGA nano/microparticles summarizes various drug-delivery systems based on these cancer therapy tissue regeneration. Tissue regeneration mainly includes bone, cartilage, periodontal

Language: Английский

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An overview of the production methods for core–shell microspheres for parenteral controlled drug delivery

European Journal of Pharmaceutics and Biopharmaceutics, Journal Year: 2021, Volume and Issue: 170, P. 24 - 42

Published: Nov. 30, 2021

Core-shell microspheres hold great promise as a drug delivery system because they offer several benefits over monolithic in terms of release kinetics, for instance reduced initial burst release, the possibility delayed (pulsatile) and dual-drug release. Also, encapsulation efficiency can significantly be improved. Various methods have proven to successful producing these core-shell microspheres, both conventional bulk emulsion solvent evaporation method which are produced drop by drop. The latter become increasingly popular provide improved control particle characteristics. This review assesses various production summarizes characteristics formulations prepared different methods, with focus on their kinetics.

Language: Английский

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Biopolymer‐Based Multilayer Microparticles for Probiotic Delivery to Colon

Advanced Healthcare Materials, Journal Year: 2022, Volume and Issue: 11(11)

Published: Feb. 21, 2022

The potential health benefits of probiotics may not be realized because the substantial reduction in their viability during food storage and gastrointestinal transit. Microencapsulation has been successfully utilized to improve resistance critical conditions. Owing unique properties biopolymers, they have prevalently used for microencapsulation probiotics. However, majority microencapsulated products only contain a single layer protection around probiotics, which is likely inferior more sophisticated approaches. This review discusses emerging methods multilayer encapsulation probiotic using biopolymers. Correlations are drawn between fabrication techniques resultant microparticle properties. Subsequently, microparticles categorized based on designs. Recent reports specific biopolymeric formulations examined regarding physical biological In particular, animal models transit disease highlighted, with respect trials To conclude, novel materials approaches structures highlighted.

Language: Английский

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Potential Application of Plant-Based Derivatives as Green Components in Functional Coatings: A Review

Cleaner Materials, Journal Year: 2022, Volume and Issue: 4, P. 100097 - 100097

Published: May 27, 2022

The conventional coatings are generally unsustainable in harsh environments and offer limited protection to the intended infrastructures. Recently, emergence of plant-based components enhance has attracted significant attention due their characteristics anticorrosion, antifouling, antimicrobial, self-healing, ultraviolet (UV) shielding. Almost all plant parts can be utilized as a potential material interest, including leaves, flowers, oils, seeds, fruits. reason is that extract from these possesses many phytochemicals contribute properties stated above. In coating industry, introduced green additive said share similar functions synthetic additives, which ability coating. Moreover, they non-toxic, safe use, abundant, environmentally- friendly.

Language: Английский

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Efficient strategies for controlled release of nanoencapsulated phytohormones to improve plant stress tolerance

Plant Methods, Journal Year: 2023, Volume and Issue: 19(1)

Published: May 15, 2023

Abstract Climate change due to different human activities is causing adverse environmental conditions and uncontrolled extreme weather events. These harsh are directly affecting the crop areas, consequently, their yield (both in quantity quality) often impaired. It essential seek new advanced technologies allow plants tolerate stresses maintain normal growth development. Treatments performed with exogenous phytohormones stand out because they mitigate negative effects of stress promote rate plants. However, technical limitations field application, putative side effects, difficulty determining correct dose, limit widespread use. Nanoencapsulated systems have attracted attention a controlled delivery active compounds for protection eco-friendly shell biomaterials. Encapsulation continuous evolution development improvement techniques economically affordable environmentally friendly, as well biomaterials high affinity carry coat bioactive compounds. Despite potential an efficient alternative phytohormone treatments, encapsulation remain relatively unexplored date. This review aims emphasize treatments means enhancing plant tolerance, specific focus on benefits that can be gained through improved application these using techniques. Moreover, main techniques, materials recent work treated encapsulated been compiled.

Language: Английский

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