Polymers,
Journal Year:
2024,
Volume and Issue:
16(15), P. 2161 - 2161
Published: July 30, 2024
Glioblastoma
(GBM)
conventional
treatment
is
not
curative,
and
it
associated
with
severe
toxicity.
Thus,
natural
compounds
anti-cancer
properties
lower
systemic
toxicity,
such
as
gallic
acid
(GA),
have
been
explored
alternatives.
However,
GA’s
therapeutic
effects
are
limited
due
to
its
rapid
metabolism,
low
bioavailability,
permeability
across
the
blood–brain
barrier
(BBB).
This
work
aimed
develop
poly
(lactic-co-glycolic
acid)
(PLGA)
nanoparticles
(NPs)
modified
folic
(FA),
receptor
overexpressed
in
BBB
GBM
cells,
for
GA
delivery
enhance
efficacy.
The
preparation
of
NPs
was
optimized
by
a
central
composite
design
(CCD).
obtained
showed
physicochemical
features
suitable
drug
internalization
tumor
cells
(sizes
below
200
nm,
monodispersity,
negative
surface
charge)
ability
maintain
slow
sustained
release
40
days.
In
vitro
studies
using
human
cell
line
(U215)
revealed
NPs’
accumulate
target
further
promoting
antiproliferative
activity
inducing
production
intracellular
reactive
oxygen
species
(ROS).
Furthermore,
encapsulation
developed
nanosystems
conferred
higher
protection
healthy
cells.
AAPS PharmSciTech,
Journal Year:
2022,
Volume and Issue:
23(7)
Published: Sept. 26, 2022
Abstract
Tissue
engineering
has
emerged
as
an
interesting
field
nowadays;
it
focuses
on
accelerating
the
auto-healing
mechanism
of
tissues
rather
than
organ
transplantation.
It
involves
implanting
In
Vitro
cultured
initiative
tissue
or
a
scaffold
loaded
with
regenerating
ingredients
at
damaged
area.
Both
techniques
are
based
use
biodegradable
,
biocompatible
polymers
scaffolding
materials
which
either
derived
from
natural
(e.g.
alginates,
celluloses,
and
zein)
synthetic
sources
PLGA,
PCL,
PLA).
This
review
discusses
in
detail
recent
applications
different
biomaterials
highlighting
targeted
besides
vitro
vivo
key
findings.
As
well,
smart
chitosan)
fascinating
candidates
they
capable
elucidating
chemical
physical
transformation
response
to
external
stimuli
temperature,
pH,
magnetic
electric
fields).
Recent
trends
summarized
this
stem
cells,
3D
printing
techniques,
most
4D
approach
relies
produce
dynamic
resembling
tissue.
Furthermore,
application
advanced
provides
hope
for
researchers
recognize
COVID-19/host
interaction,
also,
presents
promising
solution
rejuvenate
destroyed
lung
tissues.
Graphical
abstract
Expert Opinion on Drug Delivery,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 20
Published: Jan. 7, 2025
Introduction
The
pursuit
of
linear
dosage
in
pharmacy
is
essential
for
achieving
consistent
therapeutic
release
and
enhancing
patient
compliance.
This
review
provides
a
comprehensive
summary
zero-order
drug
delivery
systems,
with
particular
focus
on
reservoir-based
systems
emanated
from
different
microfabrication
technologies.
International Journal of Nanomedicine,
Journal Year:
2022,
Volume and Issue:
Volume 17, P. 1203 - 1225
Published: March 1, 2022
Purpose:
Gentiopicroside
(GPS),
an
adequate
bioactive
candidate,
has
a
promising
approach
for
enhancing
wound
healing
due
to
its
antioxidant
and
antimicrobial
properties.
Its
poor
aqueous
solubility
negatively
affects
oral
absorption
accompanied
by
low
bioavailability
intestinal/hepatic
first-pass
metabolism.
Our
aim
in
this
study
is
fabricate
GPS
into
appropriate
nanocarriers
(PLGA
nanospheres,
NSs)
enhance
hence
would
be
improved.
Methods:
Normal
ODS
silica
gel
together
with
Sephadex
LH20
column
used
isolation
of
from
Gentiana
lutea
roots.
Crude
further
processed
nanospheres
fabrication
using
single
o/w
emulsion
solvent
evaporation
technique
followed
vitro
optimization
examine
the
effect
two
formulation
variables:
polymer
(PLGA)
stabilizer
(PVA)
concentrations
on
physical
characterizations
prepared
NSs.
Possible
GPS-PLGA
chemical
interactions
have
been
analyzed
Fourier-transform
infrared
spectroscopy
(FTIR)
differential
scanning
calorimetry
(DSC).
The
optimum
NSs
chosen
investigate
inhibitory
action
Staphylococcus
aureus
compared
unloaded
Also,
well-designed
vivo
streptozotocin-induced
diabetic
rats
performed
histological
examination
incisions
at
different
day
intervals
throughout
study.
Results:
PLGA
(F5)
well-controlled
particle
size
(250.10±
07.86
nm),
relative
high
entrapment
efficiency
(83.35±
5.71),
highest
%
cumulative
release
(85.79±
8.74)
increased
activity
as
it
exhibited
higher
bacterial
growth
than
free
GPS.
F5
showed
greater
impact
significant
stimulating
synthesis
collagen
fibers
Conclusion:
These
findings
demonstrate
that
loading
considered
strategy
ensuring
delivery
potential
management
wounds.
Keywords:
core/shell
in-vitro
optimization,
sustained-release,
,
evaluation,
Biomaterials Science,
Journal Year:
2023,
Volume and Issue:
11(16), P. 5390 - 5409
Published: Jan. 1, 2023
Microneedles
(MNs)
have
recently
been
found
to
applications
in
drug,
vitamin,
protein
and
vaccine
delivery.
Polymeric
MN
arrays
continue
attract
increasing
attention
due
their
capability
bypass
the
skin's
stratum
corneum
(SC)
barrier
with
minimal
invasiveness.
These
carriers
can
achieve
targeted
intradermal
delivery
of
drugs
vaccines
improve
transdermal
level.
As
a
nontoxic
FDA-approved
copolymer,
polylactic
glycolic
acid
(PLGA)
has
good
biocompatibility
biodegradability.
Currently,
PLGA-based
MNs
noticeable
tendency
be
utilized
as
system.
This
study
focuses
on
most
recent
advances
MNs.
Both
PLGA
nanoparticle-based
matrix-based
MNs,
created
for
vaccines,
drugs,
proteins
other
therapeutic
agents,
are
discussed.
The
paper
also
discusses
various
types
potential
applications.
Finally,
prospects
challenges
reviewed.
Advanced NanoBiomed Research,
Journal Year:
2023,
Volume and Issue:
3(9)
Published: Aug. 3, 2023
Diverse
applications
of
nanoparticles
(NP)
have
been
revolutionary
for
various
industrial
sectors
worldwide.
In
particular,
magnetic
(MNP)
gained
great
interest
because
their
in
specialized
medical
areas.
This
review
starts
with
a
brief
overview
the
behavior
MNP
and
short
description
most
used
synthesis
methods.
The
second
part
is
dedicated
to
tissue
engineering,
emphasizing
calcium
phosphate‐based
NP
intrinsic
properties,
recently
highlighted
literature
as
alternative
viable
solutions
bone
regeneration.
challenges
associated
controversial
long‐term
toxicity
effects
can
be
overcome
using
this
new
generation
multifunctional
bone‐like
materials.
Furthermore,
influence
field
parameters,
such
modality
application,
intensity,
spatial
distribution,
on
biological
materials,
especially
repair,
shown.
last
presents
current
state
art
regarding
development
biomaterials
additive
manufacturing
(AM),
aiming
fabricate
scaffolds
by
AM
technologies,
focusing
engineering
applications.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2022,
Volume and Issue:
10
Published: Oct. 12, 2022
Surface
modification
of
biomaterial
can
improve
its
biocompatibility
and
add
new
biofunctions,
such
as
targeting
specific
tissues,
communication
with
cells,
modulation
intracellular
trafficking.
Here,
we
summarize
the
use
various
natural
materials,
namely,
cell
membrane,
exosomes,
proteins,
peptides,
lipids,
fatty
acids,
polysaccharides
coating
materials
on
micron-
nano-sized
particles
droplets
functions
imparted
by
different
materials.
We
discuss
applicability,
operational
parameters,
limitation
techniques,
from
more
conventional
approaches
extrusion
sonication
to
latest
innovation
seen
microfluidics
platform.
Methods
commonly
used
in
field
examine
coating,
including
composition,
physical
dimension,
stability,
fluidity,
permeability,
biological
functions,
are
reviewed.
