The Metabolic Syndrome, a Human Disease
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(4), P. 2251 - 2251
Published: Feb. 13, 2024
This
review
focuses
on
the
question
of
metabolic
syndrome
(MS)
being
a
complex,
but
essentially
monophyletic,
galaxy
associated
diseases/disorders,
or
just
related
rather
independent
pathologies.
The
human
nature
MS
(its
exceptionality
in
Nature
and
its
close
interdependence
with
action
evolution)
is
presented
discussed.
text
also
describes
components,
special
emphasis
description
their
interrelations
(including
syndromic
development
recruitment),
as
well
consequences
upon
energy
handling
partition.
main
theories
MS’s
origin
are
relation
to
hepatic
steatosis,
type
2
diabetes,
obesity,
encompass
most
components
described
so
far.
differential
effects
sex
biological
considered
under
light
social
needs
evolution,
which
directly
epidemiology,
severity,
relations
senescence.
triggering
maintenance
factors
discussed,
especial
inflammation,
complex
process
affecting
different
levels
organization
critical
element
for
development.
Inflammation
operation
connective
tissue
adipose
organ)
widely
studied
acknowledged
influence
diet.
role
diet
composition,
including
transcendence
anaplerotic
Krebs
cycle
from
dietary
amino
acid
supply
(and
timing),
developed
context
testosterone
β-estradiol
control
insulin-glycaemia
core
system
carbohydrate-triacylglycerol
handling.
high
probability
acting
unique
(essentially
monophyletic)
presented,
together
additional
perspectives/considerations
treatment
this
‘very’
disease.
Language: Английский
Inhibition of Pancreatic Lipase by Flavonoid Derivatives: In Vitro and In Silico Investigations
Advances in Pharmacological and Pharmaceutical Sciences,
Journal Year:
2024,
Volume and Issue:
2024, P. 1 - 10
Published: Jan. 24, 2024
Obesity,
characterized
by
excessive
adipose
tissue
accumulation,
has
emerged
as
a
crucial
determinant
for
wide
range
of
chronic
medical
conditions.
The
identification
effective
interventions
obesity
is
utmost
importance.
Widely
researched
antiobesity
agents
focus
on
pancreatic
lipase,
significant
therapeutic
target.
This
study
presented
the
evaluation
ten
flavonoid
compounds
in
terms
their
inhibitory
activities
against
utilizing
both
vitro
and
silico
approaches.
results
indicated
that
all
tested
demonstrated
modest
weaker
compared
to
reference
compound,
orlistat.
Among
investigated,
F01
exhibited
highest
potency,
with
an
IC50
value
17.68
±
1.43
µM.
enzymatic
inhibition
kinetic
analysis
revealed
operated
through
competitive
mechanism
determined
7.16
μM.
suggested
moderate
binding
affinity
lipase
enzyme.
Furthermore,
associated
id="M2">Vmax
was
quantified
at
0.03272
ΔA·min−1.
In
studies
displayed
mode
similar
orlistat,
despite
lacking
active
functional
group
capable
forming
covalent
bond
Ser152
catalytic
triad.
However,
formed
hydrogen
this
amino
acid.
interacted
other
residues
enzyme’s
site,
particularly
those
within
lid
domain.
Based
these
findings,
demonstrates
substantial
potential
candidate
further
investigations.
Language: Английский
Obesity Aggravates the Clinical Profile of COVID-19 Patients Hospitalized in the North of Mato Grosso, Brazil: A Cohort Study
Obesities,
Journal Year:
2025,
Volume and Issue:
5(1), P. 4 - 4
Published: Jan. 15, 2025
COVID-19,
caused
by
the
SARS-CoV-2
coronavirus,
has
significantly
impacted
global
health,
particularly
among
patients
with
obesity.
This
study
evaluates
prevalence
and
effects
of
overweight
obesity
on
clinical
profiles
complications
COVID-19
admitted
to
a
hospital
in
Northern
Mato
Grosso.
We
conducted
retrospective
cohort
analyzing
medical
records
hospitalized
from
March
2020
2021.
Patients
were
classified
into
normal
body
weight,
overweight,
groups.
Data
statistically
analyzed
using
Kruskal–Wallis’s
test
Dunn’s
post-test
(continuous
variables)
or
chi-square
(χ2)
(categorical
variables).
Among
145
ward
records,
24.1%
46.2%
29.7%
obese.
In
intensive
care
unit,
data
243
indicated
that
17.3%
37.9%
44.9%
obese,
highlighting
concerning
overweight/obesity.
Chest
computed
tomography
revealed
moderate
pulmonary
involvement
(25–50%)
was
most
frequent
group,
while
severe
(>50%)
predominant
group.
The
group
experienced
more
complications,
including
increased
use
mechanical
ventilation.
Notably,
both
settings,
mortality
rates
higher
concludes
worsen
outcomes.
Language: Английский
Distinct phenotypes of patients and healthcare resource utilization after hospitalization for COVID-19: an observational study
BMC Health Services Research,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: Jan. 27, 2025
Little
is
known
about
postdischarge
healthcare
resource
use
(HCU)
among
patients
hospitalized
for
coronavirus
disease
2019
(COVID-19).
The
objective
was
to
identify
distinct
profiles
of
based
on
cares.
This
a
retrospective
cohort
study
using
the
French
National
Health
System
claims
database.
We
followed
up
all
COVID-19
between
2020/02/01
and
2020/06/30
6
months;
discharge
date
index
date.
excluded
who
died
during
stay
or
within
30
days
after
discharge.
described
patients'
HCU
over
5
months
from
day
31
end
follow-up,
i.e.,
post-COVID-19
period.
sociodemographic
clinical
characteristics
participants
44
selected
types
HCU,
including
medical
emergency
room
visits,
medications,
biological
tests,
oxygen
therapy,
rehabilitation,
rehospitalization,
nurse
sick
leave.
performed
Ward's
ascendant
hierarchical
clustering
(AHC)
analysis
groups
with
similar
by
cluster.
population
included
68,822
(median
age:
64.8
years,
47%
women).
Eight
clusters
were
identified,
each
comprising
1,163
35,501
patients.
Four
characterized
older
high
proportions
comorbidities,
i.e.
cancer
(cluster
3),
mental
disorders
4),
cardiac
insufficiency
5)
respiratory
failure
6).
Cluster
8
younger
patients,
often
obese
low
mortality.
Another
cluster
complex
stays
7)
last
2)
specific
contacts
therapy.
main
1,
n
=
35,501)
overall
population.
duration
complexity
also
varied
across
clusters.
Based
data,
AHC
identified
clinically
relevant
surviving
acute
episode
hospitalization.
illustrate
many
impacts
COVID
health
status
infected
may
help
anticipate
future
needs
care
in
context.
Language: Английский
Nanotherapeutics in metabolic diseases–Associated infections
Elsevier eBooks,
Journal Year:
2025,
Volume and Issue:
unknown, P. 617 - 648
Published: Jan. 1, 2025
Language: Английский
A Systematic Review of Metabolic Syndrome: Key Correlated Pathologies and Non-Invasive Diagnostic Approaches
F. Giangregorio,
No information about this author
Emilio Mosconi,
No information about this author
Maria Grazia Debellis
No information about this author
et al.
Journal of Clinical Medicine,
Journal Year:
2024,
Volume and Issue:
13(19), P. 5880 - 5880
Published: Oct. 2, 2024
Background
and
Objectives:
Metabolic
syndrome
(MetS)
is
a
condition
marked
by
complex
array
of
physiological,
biochemical,
metabolic
abnormalities,
including
central
obesity,
insulin
resistance,
high
blood
pressure,
dyslipidemia
(characterized
elevated
triglycerides
reduced
levels
high-density
lipoproteins).
The
pathogenesis
develops
from
the
accumulation
lipid
droplets
in
hepatocyte
(steatosis).
This
accumulation,
genetically
predisposed
subjects
with
other
external
stimuli
(intestinal
dysbiosis,
caloric
diet,
physical
inactivity,
stress),
activates
production
pro-inflammatory
molecules,
alter
autophagy,
turn
on
activity
hepatic
stellate
cells
(HSCs),
provoking
low
grade
chronic
inflammation
fibrosis.
associated
significantly
increased
risk
developing
type
2
diabetes
mellitus
(T2D),
cardiovascular
diseases
(CVD),
vascular,
renal,
pneumologic,
rheumatological,
sexual,
cutaneous
syndromes
overall
mortality,
rising
five-
to
seven-fold
for
T2DM,
three-fold
CVD,
one
half–fold
all-cause
mortality.
purpose
this
narrative
review
examine
as
“systemic
disease”
its
interaction
major
internal
medicine
conditions
such
diabetes,
renal
failure,
respiratory
failure.
It
essential
practitioners
approach
widespread
“holistic”
rather
than
fragmented
manner,
particularly
Western
countries.
Additionally,
it
important
be
aware
non-invasive
tools
available
assessing
condition.
Materials
Methods:
We
conducted
an
exhaustive
search
PubMed
up
July
2024,
focusing
terms
related
pathologies
(heart,
Lung
(COPD,
asthma,
pulmonary
hypertension,
OSAS)
kidney
rheumatological
(osteoarthritis,
rheumatoid
arthritis),
endocrinological,
sexual
neoplastic
risks.
was
managed
accordance
PRISMA
statement.
Finally,
we
selected
300
studies
(233
papers
first
strategy
67
second
one).
Our
included
that
provided
insights
into
techniques
evaluating
liver
fibrosis
steatosis.
Studies
were
not
humans,
published
languages
English,
or
did
assess
changes
heart
failure
excluded.
Results:
findings
revealed
clear
correlation
between
all
above
described,
indicating
assessments
steatosis
could
potentially
serve
markers
severity
progression
diseases.
Conclusions:
multisystem
disorder
impacts
organs
beyond
disrupts
functioning
various
organs.
Notably,
linked
higher
incidence
diseases,
independent
traditional
factors.
Non-invasive
allow
clinicians
evaluate
risk.
ability
may
open
new
diagnostic,
therapeutic,
prognostic
avenues
managing
complications,
disease,
which
leading
cause
death
these
patients.
Language: Английский
Transcriptomic and Proteomic Analysis Reveals the Potential Role of RBMS1 in Adipogenesis and Adipocyte Metabolism
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(14), P. 11300 - 11300
Published: July 11, 2023
Adipocytes
play
a
critical
role
in
maintaining
healthy
systemic
metabolism
by
storing
and
releasing
energy
the
form
of
fat
helping
to
regulate
glucose
lipid
levels
body.
Adipogenesis
is
process
through
which
pre-adipocytes
are
differentiated
into
mature
adipocytes.
It
complex
involving
various
transcription
factors
signaling
pathways.
The
dysregulation
adipogenesis
has
been
implicated
development
obesity
metabolic
disorders.
Therefore,
understanding
mechanisms
that
contribute
its
may
provide
insights
prevention
treatment
these
conditions.
RNA-binding
motif
single-stranded
interacting
protein
1
(RBMS1)
binds
RNA
plays
cellular
processes
such
as
alternative
splicing,
mRNA
stability,
translation.
RBMS1
polymorphism
shown
be
associated
with
type
2
diabetes,
but
adipose
not
known.
We
show
highly
expressed
during
early
phase
differentiation
murine
adipocyte
cell
line
3T3-L1
significantly
upregulated
tissue
depots
adipocytes
high-fat-fed
mice,
implying
possible
metabolism.
Knockdown
impacted
reduced
expression
some
key
adipogenic
markers.
Transcriptomic
proteomic
analysis
indicated
depletion
affected
several
genes
involved
major
processes,
including
carbohydrate
Our
findings
imply
an
important
offer
novel
therapeutic
opportunity
for
disorders
diabetes.
Language: Английский
Obesity Hypoventilation Syndrome is Associated with Worse In-Hospital Outcomes in Patients with Acute Myocardial Infarction: A Nationwide Study
Respiratory Medicine,
Journal Year:
2024,
Volume and Issue:
unknown, P. 107813 - 107813
Published: Sept. 1, 2024
Language: Английский
Transcriptomic and Proteomic Analysis Reveals the Potential Role of RBMS1 in Adipogenesis and Adipocyte Metabolism
Published: April 17, 2023
Adipocytes
play
a
critical
role
in
maintaining
healthy
systemic
metabolism
by
storing
and
releasing
energy
the
form
of
fat
helping
to
regulate
glucose
lipid
levels
body.
Adipogenesis
is
process
through
which
pre-adipocytes
are
differentiated
into
mature
adipocytes.
It
complex
involving
various
transcription
factors
signaling
pathways.
Dysregulation
adipogenesis
has
been
implicated
development
obesity
metabolic
disorders.
Therefore,
understanding
mechanisms
that
contribute
its
dysregulation
may
provide
insights
prevention
treatment
these
conditions.
RNA
Binding
Motif
Single
Stranded
Interacting
Protein
1
(RBMS1)
protein
binds
plays
cellular
processes
such
as
alternative
splicing,
mRNA
stability,
translation.
The
RBMS1
polymorphism
shown
be
associated
with
Type
2
diabetes,
but
adipose
not
known.
We
show
highly
expressed
during
early
phase
differentiation
murine
adipocyte
cell
line
3T3-L1
significantly
upregulated
tissue
depots
adipocytes
high-fat-fed
mice,
implying
possible
metabolism.
Knockdown
impacted
reduced
expression
some
key
adipogenic
markers.
Transcriptomic
proteomic
analysis
indicated
depletion
affected
several
genes
involved
major
processes,
including
carbohydrate
Our
findings
imply
an
important
offer
novel
therapeutic
opportunity
for
disorders
type
diabetes.
Language: Английский