Processed foods, nitrosamines, and increased risk of colorectal cancer DOI Creative Commons

Maiara Leticia Libâneo Do Nascimento,

Nátalie Christine de Carvalho Ruivo,

Mércia Tancredo

et al.

OBSERVATÓRIO DE LA ECONOMÍA LATINOAMERICANA, Journal Year: 2024, Volume and Issue: 22(2), P. e3137 - e3137

Published: Feb. 8, 2024

Cancer, the second leading cause of death in Brazil, results from uncontrolled cell growth due to dietary choices or organic alterations affecting nutrition. Colorectal cancer affects large intestine, manifesting as polyps that slowly develop on intestinal wall, often associated with diets rich red meats, processed foods, and saturated fats. A healthy diet, exercise, a balanced lifestyle are fundamental preventive measures against cancer, emphasizing importance adopting habits. This study aims conduct literature review assess relationship between consumption foods nitrosamines development colorectal cancer. research involves bibliographic searches scientific databases such Bireme, Lilacs, SciELO, PubMed, Google Scholar covering years 2007 2017 updates 2018 2023. Predominantly, articles focusing antioxidants were highlighted review. From this review, it can be concluded convenience significantly contribute various health complications their excessive amounts salt chemical additives. However, simple modifications, adequate avoiding readily prepared products, along regular physical activity, improve overall quality life health.

Language: Английский

N-nitrosamines in processed meats: Exposure, formation and mitigation strategies DOI Creative Commons
Yingfeng Xie, Yaqian Geng,

Jinbo Yao

et al.

Journal of Agriculture and Food Research, Journal Year: 2023, Volume and Issue: 13, P. 100645 - 100645

Published: May 24, 2023

Nitrite and nitrate have been widely used in the preservation of meat products for effective antimicrobial action against several pathogenic bacteria such as Clostridium botulinum, Salmonella mesophilic bacteria. However, they can further react with secondary amines produce noxious compounds called nitrosamines during thermal processing. N-nitrosamines are divided into volatile non-volatile N-nitrosamines, among which a group highly hazardous chemical carcinogens whose carcinogenicity teratogenicity led to widespread concern. Owing their occurrence daily diet, it is great significance suppress formation toxicity on human health without causing adverse effects food flavors. In this paper, mechanism provided. Potential mitigations be carried out from perspectives precursors raw materials, processing conditions well exogenous additives. Moreover, promoting degradation an approach. The potential risks associated described. Different intervention substances, polyphenols, vitamins various plant extracts summarized, discussing impact nitrosamines. purpose review provide theoretical guidance control generation deleterious effects, so promote development practical production.

Language: Английский

Citations

43
Quantum Chemical Evaluation and QSAR Modeling of N-Nitrosamine Carcinogenicity DOI
Sebastian Schieferdecker,

Esther Vock

Chemical Research in Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

N-Nitrosamine compounds in pharmaceuticals are a major concern due to their carcinogenic potential. However, not all nitrosamines strong carcinogens, and understanding the structure-activity relationships of this compound group is challenge. The determination acceptable intake limits for determined by applying either simple potency categorization approach (CPCA) or read-across analysis from where experimental data exist. emergence structurally complex makes quantitative models desirable. Here, we present two-step modeling based on linear discriminant set quantum mechanical classical descriptors followed 3D-QSAR PLS regression model predict logTD50 nitrosamine compounds.

Language: Английский

Citations

2
Developing a novel continuous-flow cascade photocatalytic system for effective sulfamethoxazole elimination from hospital wastewater DOI
Adam Kubiak, Michał Cegłowski

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 495, P. 153518 - 153518

Published: June 27, 2024

Language: Английский

Citations

9
Food contaminants: Impact of food processing, challenges and mitigation strategies for food security DOI
Arumugam Vignesh,

Thomas Cheeran Amal,

Krishnan Vasanth

et al.

Food Research International, Journal Year: 2024, Volume and Issue: 191, P. 114739 - 114739

Published: July 6, 2024

Language: Английский

Citations

9
LC-MS/MS Investigation of nitrosamine impurities in certain Sartan group medicinal products available in Istanbul, Türkiye DOI

Tuna Öncü,

Bayram Yüksel, Emrullah BİNAY

et al.

Annales Pharmaceutiques Françaises, Journal Year: 2023, Volume and Issue: 82(1), P. 72 - 83

Published: Aug. 9, 2023

Citations

21
Optimizing the detection of N-nitrosamine mutagenicity in the Ames test DOI
Robert H. Heflich,

Michelle E. Bishop,

Roberta A. Mittelstaedt

et al.

Regulatory Toxicology and Pharmacology, Journal Year: 2024, Volume and Issue: 153, P. 105709 - 105709

Published: Sept. 28, 2024

Language: Английский

Citations

8
A systematic review on multipotent carcinogenic agent, N‐nitrosodiethylamine (NDEA), its major risk assessment, and precautions DOI
Pracheta Janmeda, Divya Jain, Priya Chaudhary

et al.

Journal of Applied Toxicology, Journal Year: 2024, Volume and Issue: 44(8), P. 1108 - 1128

Published: Jan. 11, 2024

The International Agency for Research on Cancer has classified N-nitrosodiethylamine (NDEA) as a possible carcinogen and mutagenic substances, placing it in category 2A of compounds that are probably harmful to humans. It is found nature tobacco smoke, along with its precursors, also synthesized endogenously the human body. oral or parenteral administration minimal quantity NDEA results severe liver kidney organ damage. required bioactivation by CYP450 enzyme form DNA adduct alkylation mechanism. Thus, this directs oxidative stress injury cells due higher formation reactive oxygen species alters antioxidant system tissues, whereas free radical scavengers guard membranes from NDEA-directed many enzymes. This might be one reasons etiology cancer not limited certain target but can affect various organs systems. Although there approaches treatment NDEA-induced cancer, their therapeutic outcomes still very dismal. However, several precautions were considered taken during handling working NDEA, being best way lower down occurrence cancers. present review was designed enlighten general guidelines mechanism, alter line cause malignancy different parts animal body protective agents. revelation constant, unpredictable situations even common life may remarkably augment toxic potential through rise damage DNA.

Language: Английский

Citations

7
Ecological risk assessment methods for oxidative by–products in the oxidation degradation process of emerging pollutants: A review DOI
Yufei Yang, Zhihui Xie, Hao Wang

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 950, P. 175401 - 175401

Published: Aug. 9, 2024

Language: Английский

Citations

6
N-Nitrosodimethylamine investigations in Muta™Mouse define point-of-departure values and demonstrate less-than-additive somatic mutant frequency accumulations DOI Creative Commons
Anthony M Lynch,

Jonathan Howe,

Deon Hildebrand

et al.

Mutagenesis, Journal Year: 2024, Volume and Issue: 39(2), P. 96 - 118

Published: Jan. 6, 2024

Abstract The N-nitrosamine, N-nitrosodimethylamine (NDMA), is an environmental mutagen and rodent carcinogen. Small levels of NDMA have been identified as impurity in some commonly used drugs, resulting several product recalls. In this study, was evaluated OECD TG-488 compliant Muta™Mouse gene mutation assay (28-day oral dosing across seven daily doses 0.02-4 mg/kg/day) using integrated design that assessed at the transgenic lacZ locus various tissues endogenous Pig-a gene-locus, along with micronucleus frequencies peripheral blood. Liver pathology determined together exposure blood liver. additivity induction by including two acute single-dose treatment groups (i.e. 5 10 mg/kg dose on Day 1), which represented same total repeat groups. did not induce statistically significant increases mean mutant frequency (MF) bone marrow, spleen, bladder, or stomach, nor (Pig-a induction) when tested up to 4 mg/kg/day. There were dose-dependent MF liver, lung, kidney following 28-day liver after a single (10 mg/kg). No observed genotoxic effect (NOGEL) for positive dose–response relationships. Mutagenicity exhibit simple since there reduction compared dose. Benchmark modelling estimate point departure mutagenicity rank order target organ tissue sensitivity (liver > lung). BMD50 value 0.32 mg/kg/day (confidence interval 0.21–0.46 mg/kg/day). addition, toxicity ≥ 1.1 correlated systemic exposure. integration these results their implications risk assessment are discussed.

Language: Английский

Citations

5
Bumetanide as a Model NDSRI Substrate: N-nitrosobumetanide Impurity Formation and its Inhibition in Bumetanide Tablets DOI
Diaá M. Shakleya,

Bethel Asmelash,

Alaadin Alayoubi

et al.

Journal of Pharmaceutical Sciences, Journal Year: 2023, Volume and Issue: 112(12), P. 3075 - 3087

Published: June 24, 2023

Language: Английский

Citations

12