Chemosphere, Journal Year: 2022, Volume and Issue: 305, P. 135324 - 135324
Published: June 11, 2022
Language: Английский
Experimental Eye Research, Journal Year: 2020, Volume and Issue: 197, P. 108115 - 108115
Published: June 16, 2020
Language: Английский
Citations
198
Experimental Eye Research, Journal Year: 2020, Volume and Issue: 201, P. 108294 - 108294
Published: Oct. 8, 2020
Most patients with chronic dry eye disease (DED) have episodic flares, which can be triggered by a variety of activities and environmental stresses. These flares are typically associated rapid exacerbation discomfort symptoms, followed prolonged elevation inflammation. In an acute flare, ocular surface inflammation begins nonspecific innate immune response, in some cases slower but more specific adaptive response. At the surface, epithelial cells central to we discuss their role DED alongside other core components. Epithelial response (neutrophils, monocytes, macrophages dendritic cells) trigger increased osmolarity, detected via pattern receptors on cell surface. Ultimately, downstream signaling pathways activate responses, consequent symptoms. DED, pathogenic T infiltrated tissues. The established is likely lead flare-ups at lower thresholds stress, maintained over longer period. Increased understanding inflammatory cascades activated during flare may guide management improve outcomes.
Language: Английский
Citations
117
Mucosal Immunology, Journal Year: 2022, Volume and Issue: 15(6), P. 1143 - 1157
Published: Aug. 24, 2022
Language: Английский
Citations
58
Allergy, Journal Year: 2024, Volume and Issue: 79(4), P. 937 - 948
Published: Feb. 5, 2024
Abstract Background Dupilumab is used for the treatment of atopic dermatitis (AD). Approximately one third AD patients develop a dupilumab‐associated ocular surface disease (DAOSD), which pathomechanism poorly understood. This study aimed at investigating inflammatory markers in tear fluids on dupilumab therapy. Methods Tear were collected from with DAOSD (ADwDAOSD), without (ADw/oDAOSD), and non‐AD before during therapy, analyzed using specialized proteomic approach quantifying markers. The microbiome was determined by next generation sequencing technology. Results Upon an upregulation 31 observed compared to baseline patients. While IL‐12B upregulated both ADwDAOSD ADw/oDAOSD groups, pattern significantly differed between groups over time. In group, shift mixed Th2/Th17 toward Th1/Th17 profile under observed. Furthermore, remodeling fibrosis seen DAOSD. Semantic map hierarchical cluster analyses marker expression revealed four clusters distinguishing as well patient groups. pilot study, therapy associated decrease richness microbiome. Conclusions characterized cytokine known promote fibrosis. might serve prognostic factor
Language: Английский
Citations
11
Pharmaceutics, Journal Year: 2021, Volume and Issue: 13(3), P. 308 - 308
Published: Feb. 26, 2021
Three-dimensional (3D) printing is a game changer technology that holds great promise for wide variety of biomedical applications, including ophthalmology. Through this emerging technique, specific eye tissues can be custom-fabricated in flexible and automated way, incorporating different cell types biomaterials precise anatomical 3D geometries. However, despite the progress possibilities generated recent years, there are still challenges to overcome jeopardize its clinical application regular practice. The main goal review provide an in-depth understanding current status implementation bioprinting ophthalmology field order manufacture relevant such as cornea, retina conjunctiva. Special attention paid description most commonly employed methods, tissue engineering studies performed by at preclinical level. In addition, other issues related use ocular drug delivery, well both ethical regulatory aspects, analyzed. review, we aim raise awareness among research community report advances future directions apply advanced therapy regeneration field.
Language: Английский
Citations
55
The Ocular Surface, Journal Year: 2021, Volume and Issue: 20, P. 139 - 162
Published: Feb. 21, 2021
Language: Английский
Citations
47
Experimental Eye Research, Journal Year: 2022, Volume and Issue: 218, P. 109007 - 109007
Published: March 4, 2022
Language: Английский
Citations
35
Mucosal Immunology, Journal Year: 2022, Volume and Issue: 15(4), P. 620 - 628
Published: March 31, 2022
Immune cells in the exposed conjunctiva mucosa defend against environmental and microbial stresses. Expression profiling by single-cell RNA sequencing was performed to identify conjunctival immune cell populations expressing homeostatic regulatory genes. Fourteen distinct clusters were identified, including myeloid (neutrophils, monocytes, macrophages), dendritic (DC), lymphoid (B, T, γδT, ILC2, NK) lineages. Novel neutrophil [lipocalin (Lcn2) high low), MHCII
Language: Английский
Citations
29
American Journal Of Pathology, Journal Year: 2020, Volume and Issue: 191(2), P. 294 - 308
Published: Nov. 5, 2020
Language: Английский
Citations
44
Frontiers in Medicine, Journal Year: 2022, Volume and Issue: 8
Published: Jan. 17, 2022
Dry eye is currently one of the most common ocular surface disease. It can lead to discomfort and even cause visual impairment, which greatly affects work quality life patients. With increasing incidence dry disease (DED) in recent years, receiving more attention, has become hot research fields ophthalmology research. Recently, with in-depth on etiology, pathogenesis treatment DED, it been shown that defects immune regulation main pathological mechanisms DED. Since non-specific specific response are jointly regulated, a variety cells inflammatory factors involved development The conventional DED application artificial tears for lubricating surface. However, moderate-to-severe anti-inflammatory drugs necessary. In this review, immunomodulatory latest progress its related treatments including Chinese medicine will be discussed.
Language: Английский
Citations
24