Published: Jan. 1, 2022
Language: Английский
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(1), P. 731 - 731
Published: Jan. 1, 2023
The research on new treatments for dry eye diseases (DED) has exponentially grown over the past decades. increased prevalence of conditions, particularly in younger population, received much attention. Therefore, it is utmost importance to identify novel therapeutical targets. Regulated cell death (RCD) an essential process control biological homeostasis tissues and organisms. identification different mechanisms RCD stimulated their involvement human pathologies. Whereas apoptosis been widely studied DED included vicious cycle, role still needs be completely elucidated. In this review, we will explore potential roles types ocular surface dysfunction. Starting from evidence oxidative stress inflammation pathology, analyse therapeutic applications following principal mechanisms: ferroptosis, necroptosis, pyroptosis.
Language: Английский
Citations
20
Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(2), P. 578 - 578
Published: Feb. 8, 2023
Dry eye disease (DED) is a common ocular disorder characterized by an inadequate lubrication of the tears leading to inflammation and alteration surface. Current treatments are often limited due their side effects ineffectiveness. Thymoquinone (TQ) natural compound present in essential oil Nigella sativa L., with anti-inflammatory antioxidant activities. In this study, conventional hyaluronic acid-coated liposomes were developed improve TQ activity at level. cytoprotective or assessed against oxidative inflammatory processes human corneal epithelial cells (HCE-2). Hyperosmolarity conditions (450 mOsm) used as model DED. Interleukin-1β (IL-1β), Interleukin-6 (IL-6) tumor necrosis factor (TNFα) quantified quantitative real-time polymerase chain reaction (RT-qPCR); COX-2 Phospho-NF-κB p65 (p-p65) Western blotting (WB). Moreover, mitochondrial reactive oxygen species (mtROS) levels measured MitoSOX assay. The hyperosmotic treatment induced significant increase proinflammatory genes proteins expression that significantly decreased liposomes-treated cells. coincubation reverted mtROS production, evidently stimulated stress. Our data suggest TQ-loaded have potential therapeutic agent dry disease, improving efficacy.
Language: Английский
Citations
16
Heliyon, Journal Year: 2024, Volume and Issue: 10(7), P. e28829 - e28829
Published: March 27, 2024
This review aims to evaluate the therapeutic potential of green tea (GT), scientifically named Camellia sinensis, in treating eye diseases. We provide an overview ingredients and traditional use followed by a detailed discussion its uses various diseases, including ocular surface diseases (allergic dry eye, pterygium, infections), cataract, glaucoma, uveitis, retinal optic nerve The pharmacologic activities related such as anti-vascular endothelial growth factor, aldose reductase inhibitor activity, anti-bacterial, anti-inflammatory, antioxidant effects are also explored this review. dose route administration GT studies discussed. Safety issues GT, side associated with high doses long-term use, addressed. highlights natural agent for variety Its make it promising treatment option. However, more well-designed needed determine optimal assess safety efficacy. Overall, appears be adjunct therapy
Language: Английский
Citations
4
Journal of Ophthalmology, Journal Year: 2025, Volume and Issue: 2025(1)
Published: Jan. 1, 2025
Severe dry eye disease (DED) is an inflammatory condition characterized by a lack of sufficient moisture or lubrication on the surface eye, significantly impacting quality life and visual function. Since detrimental immune response crucially responsible for development aggravation DED, therapeutic agents which modulate phenotype function eye-infiltrated cells could be used treatment severe DED. Due to their potent immunomodulatory properties, mesenchymal stem (MSCs) represent potentially new remedies diseases. The majority MSC-sourced bioactive factors are contained within MSC-derived exosomes (MSC-Exos), nano-sized extracellular vesicles which, due nanosize dimension lipid envelope, easily pass all biological barriers in body deliver cargo directly into target cells. MSC-Exos contain variety proteins (growth factors, immunoregulatory molecules, cytokines, chemokines) lipids, microRNAs (miRNAs) affect viability, proliferation, phenotype, Accordingly, may progression diseases, including Therefore, this review article, we summarized current knowledge regarding molecular cellular mechanisms were trophic, anti-inflammatory, immunoregulatory, regenerative properties For purpose, extensive literature was carried out February 2024 across several databases (Medline, Embase, Google Scholar), from 2000 present. Eligible studies delineated MSC-Exos-based modulation cell-driven inflammation findings analyzed review. Results obtained these demonstrated beneficial effects paving way future clinical use ophthalmology. Trial Registration: ClinicalTrials.gov identifier: NCT04213248, NCT06475027, NCT06543667, NCT05738629.
Language: Английский
Citations
0
International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125355 - 125355
Published: Feb. 1, 2025
Language: Английский
Citations
0
Pharmacology Research & Perspectives, Journal Year: 2025, Volume and Issue: 13(2)
Published: Feb. 20, 2025
Dry eye disease (DED) is a chronically inflammatory ocular surface disorder of unknown pathogenesis. Anti-inflammatory medications, artificial tears, autologous serum, and LipiFlow have been shown to be highly beneficial in alleviating symptoms. Nevertheless, these interventions often provide only short-term results do not address the underlying problems disease. There growing evidence that risk DED associated with vicious cycle inflammation. This inflammation produced by interaction several factors, including tear film hyperosmolarity, instability, inflammation, apoptosis. Chinese medicine monomers, distinguished their multicomponent multitarget advantages, help treat modulating status, inhibiting responses, apoptosis, providing new way thinking management medicine.
Language: Английский
Citations
0
Clinical Rheumatology, Journal Year: 2024, Volume and Issue: 43(4), P. 1335 - 1352
Published: Feb. 20, 2024
Abstract Introduction Primary Sjögren’s syndrome (pSS) is an autoimmune disease characterized by inflammatory infiltration, and dysfunction of the salivary lacrimal glands. This research aimed to explore pathogenesis improve diagnosis treatment pSS mining inflammation-associated biomarkers. Methods Five pSS-related datasets were retrieved from Gene Expression Omnibus (GEO) database. Inflammation-associated biomarkers determined least absolute shrinkage selection operator (LASSO) support vector machines recursive feature elimination (SVM-RFE). Single sample gene set enrichment analysis (ssGSEA) was implemented profile infiltration levels immune cells. Real-time quantitative PCR (RT-qPCR) verified expression in clinical samples. Results Four genes (LY6E, EIF2AK2, IL15, CXCL10) screened as pSS, predictive performance which among three (AUC > 0.7). Functional results suggested that involved inflammation-related pathways. Immune revealed notably connected with type 2 T helper cells, regulatory cells significantly expressed between control. TESTOSTERONE CYCLOSPORINE predicted take effect targeting CXCL10 IL15 respectively. Conclusion explored, underlying mechanisms targeted drugs associated these preliminarily investigated according a series bioinformatics methods based on online provided reference for understanding pSS. Key Points• firstly identified LASSO SVM-RFE analyses. • CXCL10, EIF2AK2 LY6E prominently positively correlated immature B while negatively memory syndrome. LY6E, more highly samples compared healthy control samples, consistent GEO might be used
Language: Английский
Citations
3
International Ophthalmology, Journal Year: 2024, Volume and Issue: 44(1)
Published: Feb. 20, 2024
Gout is a common form of inflammatory arthritis that can cause number serious complications. Complications are in patients with gout and complicate their management disease outcome. The recent literature has reported an increasing presenting dry eye symptoms. However, until now, the link between not been clearly defined. (It unclear whether two conditions simply co-exist, there risk factors, or complication gout.) METHODS: A thorough search was conducted PubMed database to summarize most information on correlation explore potential relationship pathogenesis two. (Objective: Therefore, this paper, we review association both.) RESULTS: Studies last five years have shown eye, i.e., associated increased eye. NLRP3-IL-1β signaling pathway may be mechanism for combination disease; factors such as high blood uric acid xanthine oxidase activation aggravate development reducing use visual display terminals; abstaining from alcohol consumption; moderate coffee intake effectively prevent disease.
Language: Английский
Citations
2
Journal of Ophthalmology, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 11
Published: May 20, 2022
Astaxanthin (AST) is a naturally occurring carotenoid that has strong antioxidant, anti-inflammatory, and antiapoptosis effects used for the prevention of cancer. There growing evidence AST multiple protective against various eye diseases. This article reviews function potential mechanism in dry syndrome, keratitis, cataract, diabetic retinopathy, age-related macular degeneration, high intraocular pressure, other ocular It provides theoretical basis clinical application as nutraceutical.
Language: Английский
Citations
12
Ophthalmology and Therapy, Journal Year: 2024, Volume and Issue: 13(10), P. 2559 - 2573
Published: July 26, 2024
Patients with dry eye disease (DED) complain of a multitude symptoms that affect their visual function and quality life (QoL). This clinical investigation assessed the performance, tolerance, safety novel preservative-free ophthalmic solution containing xanthan gum 0.2% desonide sodium phosphate 0.025%.
Language: Английский
Citations
1