Journal of Global Health,
Journal Year:
2023,
Volume and Issue:
13
Published: Dec. 1, 2023
The
coronavirus
disease
2019
(COVID-19)
pandemic
has
presented
numerous
challenges
to
public
health,
including
the
emergence
of
subjective
dry
eye
symptoms
among
individuals.
However,
there
is
currently
a
dearth
comprehensive
knowledge
regarding
associated
factors
with
in
general
population.A
nationwide
survey
China
was
carried
out
from
20
June
31
August
2022,
involving
21
916
participants.
Subjective
were
assessed
using
Ocular
Surface
Disease
Index-6.
We
employed
random
forest
classification
select
potential
based
on
socioecological
model.
also
conducted
univariate
and
multivariable
logistic
regression
analyses
explore
symptoms.
Network
network
structure
factors.The
item
"watching
TV
(or
similar
task)"
displayed
highest
node
strength
exhibited
predictability
within
network.
results
multivariate
analysis
demonstrated
significant
associations
between
several
factors,
loneliness
(odds
ratio
(OR)
=
1.29;
95%
confidence
interval
(CI)
1.26
1.32),
problematic
Internet
use
(OR
1.08;
CI
1.08
1.09),
family
communication
1.01;
1.00
1.01),
presence
depression
1.53;
1.39
1.68)
anxiety
1.31;
1.17
1.47)
symptoms,
older
age
1.01
self-rated
health
status
0.99;
0.98
0.99),
0.97;
0.96
0.97),
literacy
0.98;
0.97
0.99)
agreeableness
personality
trait
0.95
0.99).These
findings
have
important
implications
for
interventions
targeting
prevention
management
population.
Strategies
addressing
individual
risk
supporting
psychological
well-being
may
prove
beneficial
mitigating
burden
ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(24), P. 25118 - 25135
Published: Dec. 5, 2023
Dry
eye
(DE)
disease,
which
is
primarily
linked
to
aqueous
deficiency,
an
escalating
health
issue
worldwide,
mainly
due
the
widespread
use
of
electronic
devices.
The
major
obstacles
in
DE
pharmacotherapy
include
insufficient
therapeutic
efficacy
and
low
ocular
bioavailability.
This
study
presents
development
a
ceria-based
nanosystem
carry
gabapentin
(GBT),
aiming
offer
comprehensive
relief
from
symptoms.
We
prepared
multifunctional
nanoceria
capped
with
thiolated
gelatin
followed
by
cross-linking
glutaraldehyde,
yielding
nanocarrier
desirable
biocompatibility
antioxidant,
anti-inflammatory,
antiangiogenic,
antiapoptotic,
neuronal
protective
activities.
Specifically,
highly
abundant
thiol
groups
on
increased
cellular
uptake
2.3-fold
its
mucin-binding
efficiency
10-fold,
thereby
extending
retention
amplifying
activity.
Moderate
not
only
enhanced
bioavailability
but
also
provided
slow,
degradation-controlled
release
GBT
promote
lacrimal
stimulation
restore
tear
film.
In
rabbit
model
DE,
topical
administration
our
GBT/nanoceria
nanoformulation
resulted
alleviation
symptoms,
including
repairing
corneal
epithelial
damage,
preserving
nerve
density,
stimulating
secretion,
demonstrating
superior
performance
comparison
free
drug.
These
results
underscore
safety
potential
this
innovative
for
pharmacotherapy.
Contact Lens and Anterior Eye,
Journal Year:
2024,
Volume and Issue:
47(4), P. 102158 - 102158
Published: April 16, 2024
This
paper
seeks
to
outline
the
history,
market
situation,
clinical
management
and
product
performance
related
correction
of
presbyopia
with
both
contact
lenses
spectacles.
The
history
development
various
optical
forms
presbyopic
are
reviewed,
an
overview
is
presented
current
status
Clinical
considerations
in
fitting
aftercare
lens
spectacle
wearers
presented,
general
recommendations
for
best
practice.
Current
options
include
soft
simultaneous,
rigid
translating
simultaneous
designs,
addition
monovision.
Spectacle
single
vision
lenses,
bifocal
a
range
progressive
lenses.
comparative
presented.
With
significant
proportion
global
population
now
being
presbyopic,
this
particularly
timely
designed
act
as
guide
researchers,
industry
eyecare
practitioners
alike.
Pharmacology Research & Perspectives,
Journal Year:
2024,
Volume and Issue:
12(1)
Published: Jan. 8, 2024
Abstract
Oxidative
stress
is
an
important
mechanism
of
aging,
and
in
turn,
aging
can
also
aggravate
oxidative
stress,
which
leads
to
a
vicious
cycle.
In
the
process
brain
converting
light
into
visual
signals,
eye
stimulated
by
harmful
blue‐light
radiation
directly.
Thus,
especially
vulnerable
becomes
one
organs
most
seriously
involved
during
process.
Cataracts,
age‐related
macular
degeneration
(AMD),
glaucoma,
diabetic
retinopathy
(DR),
dry
are
inextricably
linked
stress.
Chlorogenic
acid
(CGA)
has
been
demonstrated
have
antioxidant
anti‐inflammatory
activities,
its
validity
established
experimentally
numerous
fields,
including
cardiovascular
disease,
metabolic
disorders,
cancers,
other
chronic
diseases.
There
previously
evidence
CGA's
therapeutic
effect
field
ophthalmopathy.
Considering
that
many
ophthalmic
drugs
lead
systemic
side
effects,
CGA
may
act
as
natural
exogenous
for
patients
take
regularly,
controlling
their
condition
while
minimizing
effects.
this
paper,
vitro
vivo
studies
treatment
diseases
reviewed,
prospects
application
discussed.
The
aim
review
summarize
relevant
knowledge
provide
theoretical
support
future
research.
Life,
Journal Year:
2023,
Volume and Issue:
13(3), P. 837 - 837
Published: March 20, 2023
Given
the
expanding
elderly
population
in
United
States
and
world,
it
is
important
to
understand
processes
underlying
both
natural
pathological
age-related
changes
eye.
Both
anterior
posterior
segment
of
eye
undergo
biological,
chemical,
physical
properties
driven
by
oxidative
stress.
With
advancing
age,
include
dermatochalasis,
blepharoptosis,
thickening
sclera,
loss
corneal
endothelial
cells,
stiffening
lens.
Changes
lowered
viscoelasticity
vitreous
body,
photoreceptor
cell
loss,
drusen
deposition
at
macula
fovea.
Age-related
ocular
pathologies
including
glaucoma,
cataracts,
macular
degeneration
are
largely
mediated
The
prevalence
these
diseases
expected
increase
coming
years,
highlighting
need
develop
new
therapies
that
address
stress
slow
progression
pathologies.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(5), P. 1484 - 1484
Published: May 12, 2023
Slow-release
delivery
systems
are
needed
to
ensure
long-term
sustained
treatments
for
retinal
diseases
such
as
age-related
macular
degeneration
and
diabetic
retinopathy,
which
currently
treated
with
anti-angiogenic
agents
that
require
frequent
intraocular
injections.
These
can
cause
serious
co-morbidities
the
patients
far
from
providing
adequate
drug/protein
release
rates
required
pharmacokinetics
sustain
prolonged
efficacy.
This
review
focuses
on
use
of
hydrogels,
particularly
temperature-responsive
hydrogels
vehicles
intravitreal
injection
therapies,
their
advantages
disadvantages
administration,
current
advances
in
treat
diseases.
Translational Vision Science & Technology,
Journal Year:
2024,
Volume and Issue:
13(5), P. 13 - 13
Published: May 20, 2024
The
purpose
of
this
study
was
to
conduct
a
large-scale
genome-wide
association
(GWAS)
and
construct
polygenic
risk
score
(PRS)
for
stratification
in
patients
with
dry
eye
disease
(DED)
using
the
Taiwan
Biobank
(TWB)
databases.
Investigative Ophthalmology & Visual Science,
Journal Year:
2024,
Volume and Issue:
65(13), P. 12 - 12
Published: Nov. 6, 2024
Purpose:
Aging
alters
the
function
of
lacrimal
gland
and
disrupts
balance
microenvironment
on
ocular
surface,
eventually
leading
to
aqueous-tear-deficient
dry
eye.
Mitophagy
has
been
reported
play
an
important
role
in
aging,
but
underlying
mechanism
remains
unclear.
Methods:
The
young
(6
weeks)
middle-aged
(12
months)
male
C57BL/6J
mice
were
used
this
study,
mitophagy
agonist
rapamycin
inhibitor
Mdivi-1
vivo
experiments.
Hematoxylin
eosin,
Masson,
Oil
Red
O,
reactive
oxygen
species
(ROS)
staining
detect
histological
changes
lipids
gland.
Changes
expression
proteins
identified
by
Western
blotting
lysates.
Transmission
electron
microscopy
immunofluorescence
assess
mitophagy.
single-cell
RNA
sequencing
(scRNA-seq)
bioinformatics
analyses
transcription
signature
during
aging.
Results:
In
we
discovered
that
aging
increased
oxidative
stress,
which
apoptosis,
generated
ROS
acinar
epithelial
cells.
Furthermore,
activation
PINK1/Parkin-mediated
reduced
concentrations
prevented
aging-induced
apoptosis
cells,
thereby
causing
alterations,
microstructural
degradation,
increasing
tear
secretion
associated
with
accumulation.
By
contrast,
aggregates
mitochondrial
thereafter
leads
impairment
inhibiting
fission
giving
rise
Conclusions:
Overall,
our
findings
suggested
could
impair
age-related
alterations
may
be
treated
therapeutic
approaches
enhance
while
maintaining
function.
