Long COVID and the cardiovascular system—elucidating causes and cellular mechanisms in order to develop targeted diagnostic and therapeutic strategies: a joint Scientific Statement of the ESC Working Groups on Cellular Biology of the Heart and Myocardial and Pericardial Diseases DOI Creative Commons
Mariann Gyöngyösi, Pilar Alcaide, Folkert W. Asselbergs

et al.

Cardiovascular Research, Journal Year: 2022, Volume and Issue: 119(2), P. 336 - 356

Published: July 25, 2022

Abstract Long COVID has become a world-wide, non-communicable epidemic, caused by long-lasting multiorgan symptoms that endure for weeks or months after SARS-CoV-2 infection already subsided. This scientific document aims to provide insight into the possible causes and therapeutic options available cardiovascular manifestations of long COVID. In addition chronic fatigue, which is common symptom COVID, patients may present with chest pain, ECG abnormalities, postural orthostatic tachycardia, newly developed supraventricular ventricular arrhythmias. Imaging heart vessels provided evidence chronic, post-infectious perimyocarditis consequent left right failure, arterial wall inflammation, microthrombosis in certain patient populations. Better understanding underlying cellular molecular mechanisms will aid development effective treatment strategies its manifestations. A number have been proposed, including those involving direct effects on myocardium, microthrombotic damage endothelium, persistent inflammation. Unfortunately, existing circulating biomarkers, coagulation, inflammatory markers, are not highly predictive either presence outcome when measured 3 infection. Further studies needed understand mechanisms, identify specific guide future preventive treatments address sequelae.

Language: Английский

Long COVID: major findings, mechanisms and recommendations DOI Open Access
Hannah Davis, Lisa McCorkell, Julia Moore Vogel

et al.

Nature Reviews Microbiology, Journal Year: 2023, Volume and Issue: 21(3), P. 133 - 146

Published: Jan. 13, 2023

Language: Английский

Citations

2794
Fatigue and cognitive impairment in Post-COVID-19 Syndrome: A systematic review and meta-analysis DOI Open Access
Felicia Ceban, Susan Ling, Leanna M.W. Lui

et al.

Brain Behavior and Immunity, Journal Year: 2021, Volume and Issue: 101, P. 93 - 135

Published: Dec. 29, 2021

Language: Английский

Citations

1251
Global Prevalence of Post-Coronavirus Disease 2019 (COVID-19) Condition or Long COVID: A Meta-Analysis and Systematic Review DOI Open Access
Chen Chen, Spencer R. Haupert, Lauren Zimmermann

et al.

The Journal of Infectious Diseases, Journal Year: 2022, Volume and Issue: 226(9), P. 1593 - 1607

Published: April 14, 2022

Abstract Background This study aims to examine the worldwide prevalence of post-coronavirus disease 2019 (COVID-19) condition, through a systematic review and meta-analysis. Methods PubMed, Embase, iSearch were searched on July 5, 2021 with verification extending March 13, 2022. Using random-effects framework DerSimonian-Laird estimator, we meta-analyzed post-COVID-19 condition at 28+ days from infection. Results Fifty studies included, 41 meta-analyzed. Global estimated pooled was 0.43 (95% confidence interval [CI], .39–.46). Hospitalized nonhospitalized patients had estimates 0.54 CI, .44–.63) 0.34 .25–.46), respectively. Regional Asia (0.51; 95% .37–.65), Europe (0.44; .32–.56), United States America (0.31; .21–.43). for 30, 60, 90, 120 after infection be 0.37 .26–.49), 0.25 .15–.38), 0.32 .14–.57), 0.49 .40–.59), Fatigue most common symptom reported 0.23 .17–.30), followed by memory problems (0.14; .10–.19). Conclusions finds is substantial; health effects COVID-19 seem prolonged can exert stress healthcare system.

Language: Английский

Citations

1053
Mid and long-term neurological and neuropsychiatric manifestations of post-COVID-19 syndrome: A meta-analysis DOI
Lavienraj Premraj, Nivedha Kannapadi,

Jack Briggs

et al.

Journal of the Neurological Sciences, Journal Year: 2022, Volume and Issue: 434, P. 120162 - 120162

Published: Jan. 28, 2022

Language: Английский

Citations

619
Long COVID: post-acute sequelae of COVID-19 with a cardiovascular focus DOI Creative Commons
Betty Raman, David A. Bluemke,

Thomas F. Lüscher

et al.

European Heart Journal, Journal Year: 2022, Volume and Issue: 43(11), P. 1157 - 1172

Published: Feb. 7, 2022

Abstract Emerging as a new epidemic, long COVID or post-acute sequelae of coronavirus disease 2019 (COVID-19), condition characterized by the persistence COVID-19 symptoms beyond 3 months, is anticipated to substantially alter lives millions people globally. Cardiopulmonary including chest pain, shortness breath, fatigue, and autonomic manifestations such postural orthostatic tachycardia are common associated with significant disability, heightened anxiety, public awareness. A range cardiovascular (CV) abnormalities has been reported among patients acute phase include myocardial inflammation, infarction, right ventricular dysfunction, arrhythmias. Pathophysiological mechanisms for delayed complications still poorly understood, dissociation seen between ongoing objective measures cardiopulmonary health. long-term trajectory many chronic cardiac diseases which abundant in those at risk severe disease. In this review, we discuss definition its epidemiology, an emphasis on symptoms. We further review pathophysiological underlying CV injury, sequelae, impact multiorgan propose possible model referral post-COVID-19 services future directions research priorities clinical trials that currently underway evaluate efficacy treatment strategies sequelae.

Language: Английский

Citations

540
Prevalence of post-acute COVID-19 syndrome symptoms at different follow-up periods: a systematic review and meta-analysis DOI Creative Commons

Mohamad Salim Alkodaymi,

Osama Omrani, Nader A. Fawzy

et al.

Clinical Microbiology and Infection, Journal Year: 2022, Volume and Issue: 28(5), P. 657 - 666

Published: Feb. 3, 2022

Language: Английский

Citations

449
Long COVID burden and risk factors in 10 UK longitudinal studies and electronic health records DOI Creative Commons
Ellen J. Thompson, Dylan M. Williams, Alex J Walker

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: June 28, 2022

Abstract The frequency of, and risk factors for, long COVID are unclear among community-based individuals with a history of COVID-19. To elucidate the burden possible causes in community, we coordinated analyses survey data from 6907 self-reported COVID-19 10 UK longitudinal study (LS) samples 1.1 million diagnostic codes electronic healthcare records (EHR) collected by spring 2021. Proportions presumed cases LS reporting any symptoms for 12+ weeks ranged 7.8% 17% (with 1.2 to 4.8% debilitating symptoms). Increasing age, female sex, white ethnicity, poor pre-pandemic general mental health, overweight/obesity, asthma were associated prolonged both EHR data, but findings other factors, such as cardio-metabolic parameters, inconclusive.

Language: Английский

Citations

428
Psychiatric and neuropsychiatric sequelae of COVID-19 – A systematic review DOI Creative Commons

Thor Mertz Schou,

Sâmia R.L. Joca, Gregers Wegener

et al.

Brain Behavior and Immunity, Journal Year: 2021, Volume and Issue: 97, P. 328 - 348

Published: July 30, 2021

It has become evident that coronavirus disease 2019 (COVID-19) a multi-organ pathology includes the brain and nervous system. Several studies have also reported acute psychiatric symptoms in COVID-19 patients. An increasing number of are suggesting deficits may persist after recovery from primary infection. In current systematic review, we provide an overview available evidence supply information on potential risk factors underlying biological mechanisms behind such sequelae. We performed search for sequelae patients using databases PubMed Embase. Included all contained follow-up period provided quantitative measures mental health. The was June 4th 2021. 1725 unique were identified. Of these, 66 met inclusion criteria included. Time to ranged immediately hospital discharge up 7 months discharge, participants spanned 3 266,586 participants. Forty anxiety and/or depression, 20 symptoms- or diagnoses post-traumatic stress disorder (PTSD), 27 cognitive deficits, 32 articles found fatigue at follow-up, sleep disturbances 23 studies. Highlighted severity, duration symptoms, female sex. One study showed abnormalities correlating with several inflammatory markers correlate symptoms. Overall, results this review suggest survivors but generally improve over time.

Language: Английский

Citations

371
Persistent COVID-19 symptoms in a community study of 606,434 people in England DOI Creative Commons
Matthew Whitaker, Joshua Elliott, Marc Chadeau‐Hyam

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: April 12, 2022

Long COVID remains a broadly defined syndrome, with estimates of prevalence and duration varying widely. We use data from rounds 3-5 the REACT-2 study (n = 508,707; September 2020 - February 2021), representative community survey adults in England, replication round 6 97,717; May 2021) to estimate identify predictors persistent symptoms lasting 12 weeks or more; unsupervised learning cluster individuals by reported symptoms. At 3-5, 37.7% experienced at least one symptom, falling 21.6% 6. Female sex, increasing age, obesity, smoking, vaping, hospitalisation COVID-19, deprivation, being healthcare worker are associated higher probability Asian ethnicity lower probability. Clustering analysis identifies subset participants predominantly respiratory Managing long-term sequelae COVID-19 will remain major challenge for affected their families health services.

Language: Английский

Citations

336
Long covid outcomes at one year after mild SARS-CoV-2 infection: nationwide cohort study DOI Creative Commons
Barak Mizrahi, Tamar Sudry, Natalie Flaks‐Manov

et al.

BMJ, Journal Year: 2023, Volume and Issue: unknown, P. e072529 - e072529

Published: Jan. 11, 2023

Abstract Objectives To determine the clinical sequelae of long covid for a year after infection in patients with mild disease and to evaluate its association age, sex, SARS-CoV-2 variants, vaccination status. Design Retrospective nationwide cohort study. Setting Electronic medical records from an Israeli healthcare organisation. Population 1 913 234 Maccabi Healthcare Services members all ages who did polymerase chain reaction test between March 2020 October 2021. Main outcome measures Risk evidence based list 70 reported outcomes unvaccinated infected matched uninfected people, adjusted age sex stratified by risk breakthrough compared controls. Risks were using hazard ratios differences per 10 000 measured during early (30-180 days) late (180-360 time periods infection. Results Covid-19 was significantly associated increased risks anosmia dysgeusia (hazard ratio 4.59 (95% confidence interval 3.63 5.80), difference 19.6 16.9 22.4) period; 2.96 (2.29 3.82), 11.0 (8.5 13.6) period), cognitive impairment (1.85 (1.58 2.17), 12.8, (9.6 16.1); 1.69 (1.45 1.96), 13.3 (9.4 17.3)), dyspnoea (1.79 (1.68 1.90), 85.7 (76.9 94.5); 1.30 (1.22 1.38), 35.4 (26.3 44.6)), weakness (1.78 (1.69 1.88), 108.5, 98.4 118.6; 1.37), 50.2 (39.4 61.1)), palpitations (1.49 (1.35 1.64), 22.1 (16.8 27.4); 1.16 (1.05 1.27), 8.3 (2.4 14.1)) significant but lower excess streptococcal tonsillitis dizziness. Hair loss, chest pain, cough, myalgia, respiratory disorders only phase. Male female showed minor differences, children had fewer than adults phase covid-19, which mostly resolved period. Findings remained consistent across variants. Vaccinated similar other patients. Conclusions This study suggests that covid-19 are at small number health outcomes, most within diagnosis.

Language: Английский

Citations

294