Chronic inflammation in the etiology of disease across the life span

Nature Medicine, Journal Year: 2019, Volume and Issue: 25(12), P. 1822 - 1832

Published: Dec. 1, 2019

Language: Английский

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Physical activity, sedentary behaviour, diet, and cancer: an update and emerging new evidence

The Lancet Oncology, Journal Year: 2017, Volume and Issue: 18(8), P. e457 - e471

Published: July 26, 2017

Language: Английский

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Systematic review of light exposure impact on human circadian rhythm

Chronobiology International, Journal Year: 2018, Volume and Issue: 36(2), P. 151 - 170

Published: Oct. 12, 2018

Light is necessary for life, and artificial light improves visual performance safety, but there an increasing concern of the potential health environmental impacts light. Findings from a number studies suggest that mistimed exposure disrupts circadian rhythm in humans, potentially causing further impacts. However, variety methods has been applied individual experimental light-induced impacts, including definition outcomes. Thus, systematic review needed to synthesize results. In addition, scientific evidence on developing evaluation method pollution, i.e., negative light, life cycle assessment (LCA). The current LCA practice does not have evaluate neither terms human nor ecological literature survey was conducted by searching two concepts: rhythm. searched with additional melatonin rapid-eye-movement (REM) sleep. search resulted 128 articles which were subjected data collection analysis. Melatonin secretion studied 122 REM sleep 13 articles. reports divided into specific (101 reports), usually controlled laboratory environment, prevailing conditions typical at home or work environments (21 studies). Studies generally adults their twenties thirties, only very few experimented children elderly adults. Surprisingly many small sample size: 39 out 10 less subjects. quality criteria more profound synthesis minimum size 20 subjects providing details (spectrum wavelength; illuminance, irradiance photon density). This qualified 2 Further analysis these 15 indicated two-hour blue (460 nm) evening suppresses melatonin, maximum melatonin-suppressing effect being achieved shortest wavelengths (424 nm, violet). concentration recovered rather rapidly, within min cessation exposure, suggesting short-term simultaneous impact secretion. suppression reduced age, phase advance impaired age. evening, night morning affected levels. even longest (631 red) intermittent exposures induced resetting responses, low levels (5-10 lux) when sleeping eyes closed response. enables development pollution regarding system.

Language: Английский

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Disruption of adolescents’ circadian clock: The vicious circle of media use, exposure to light at night, sleep loss and risk behaviors

Journal of Physiology-Paris, Journal Year: 2016, Volume and Issue: 110(4), P. 467 - 479

Published: Nov. 1, 2016

Language: Английский

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The Fourth Industrial Revolution and Its Impact on Occupational Health and Safety, Worker's Compensation and Labor Conditions

Safety and Health at Work, Journal Year: 2019, Volume and Issue: 10(4), P. 400 - 408

Published: Sept. 27, 2019

The "fourth industrial revolution" (FIR) is an age of advanced technology based on information and communication. FIR has a more powerful impact the economy than in past. However, prospects for labor environment are uncertain. purpose this study to anticipate prepare occupational health safety (OHS) issues. In FIR, nonstandard employment will be common. As result, it difficult receive OHS services compensation. Excessive trust new technologies can lead large-scale or forms accidents. Global business networks cause destruction workers' biorhythms, some cancers, overwork, task complexity. social disconnection because independent work risk worker's mental health. union bonds weaken, apply standardized regulations multinational enterprises. To cope with issues, we need establish concepts "decent work" standardize regulations, which enterprises each country, develop public as service, monitor emerging events among workers, nurture experts who responsible

Language: Английский

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Melatonin and Cancer Hallmarks

Molecules, Journal Year: 2018, Volume and Issue: 23(3), P. 518 - 518

Published: Feb. 26, 2018

Melatonin is a natural indoleamine produced by the pineal gland that has many functions, including regulation of circadian rhythm. Many studies have reported anticancer effect melatonin against myriad cancer types. Cancer hallmarks include sustained proliferation, evading growth suppressors, metastasis, replicative immortality, angiogenesis, resisting cell death, altered cellular energetics, and immune evasion. activity mediated interfering with various hallmarks. This review summarizes role in each hallmark. The discussed this should serve as solid foundation for researchers physicians to support basic clinical on promising agent.

Language: Английский

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Obesity and sleep disturbance: the chicken or the egg?

Critical Reviews in Food Science and Nutrition, Journal Year: 2018, Volume and Issue: 59(13), P. 2158 - 2165

Published: Oct. 18, 2018

Epidemiological studies suggested an association between obesity and sleep disturbances. Obstructive apnea is the most prevalent type of obesity-related disorder that lead to increased risk for numerous chronic health conditions. In addition visceral adipose tissue might be responsible secretion inflammatory cytokines could contribute alter sleep-wake rhythm. Unhealthy food characterized by high consumption fat carbohydrate seems negatively influence quality while diet rich fiber associated more restorative deeper sleep. Although cause through several pathogenetic mechanisms alteration sleep, it has been reported subjects suffering from disorders are prone develop obesity. Experimental laboratory have demonstrated decreasing either amount or increase developing restriction also causes physiological, hormonal behavioral changes promote a positive energy balance compensatory disproportionate in intake, decrease physical activity, weight gain. Thus, aim this review provide observational evidence on with disturbances viceversa emphasis possible pathophysiological (hormonal metabolic) link these two pathological

Language: Английский

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Melatonin and Hippo Pathway: Is There Existing Cross-Talk?

International Journal of Molecular Sciences, Journal Year: 2017, Volume and Issue: 18(9), P. 1913 - 1913

Published: Sept. 6, 2017

Melatonin is an indolic hormone that regulates a plethora of functions ranging from the regulation circadian rhythms and antioxidant properties to induction maintenance tumor suppressor pathways. It binds specific receptors as well some cytosolic proteins, leading several cellular signaling cascades. Recently, involvement melatonin in cancer insurgence progression has clearly been demonstrated. In this review, we will first describe structure its receptors, then discuss both molecular epidemiological evidence on anticancer effects. Finally, shed light potential cross-talk between Hippo pathway, along with possible implications for therapy.

Language: Английский

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Working Time Society consensus statements: Evidence-based effects of shift work on physical and mental health

Industrial Health, Journal Year: 2019, Volume and Issue: 57(2), P. 139 - 157

Published: Jan. 1, 2019

Potential effects of shift work on health are probably related to the misalignment between light-dark cycle and human activity-rest cycle. Light exposure at night mediates these effects, including social leads an inversion activity rest, which, in turn, is linked changes behaviours. This article reviews epidemiological evidence association health, possible mechanisms underlying this association. First, from findings meta-analyses systematic published last 10 yr presented. In addition, it reports larger single-occupation studies recent large population-based general workforce. Koch's postulates were used evaluate development disease as a result work. Finally, we discussed limitations multiple pathways that link with specific disorders methodological challenges facing research. We concluded clearest indications being cause given when there substantial body high quality field showing good laboratory supporting causal explanation link.

Language: Английский

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Can melatonin reduce the severity of COVID-19 pandemic?

International Reviews of Immunology, Journal Year: 2020, Volume and Issue: 39(4), P. 153 - 162

Published: April 29, 2020

The current COVID-19 pandemic is one of the most devastating events in recent history. virus causes relatively minor damage to young, healthy populations, imposing life-threatening danger elderly and people with diseases chronic inflammation. Therefore, if we could reduce risk for vulnerable it would make more similar other typical outbreaks. Children don't suffer from as much their grandparents have a higher melatonin level. Bats are nocturnal animals possessing high levels melatonin, which may contribute anti-viral resistance. Viruses induce an explosion inflammatory cytokines reactive oxygen species, best natural antioxidant that lost age. programmed cell death coronaviruses cause, can result significant lung damage, also inhibited by melatonin. Coronavirus inflammation lungs requires inflammasome activity. Melatonin blocks these inflammasomes. General immunity impaired anxiety sleep deprivation. improves habits, reduces stimulates immunity. Fibrosis be dangerous complication after COVID-19. known prevent fibrosis. Mechanical ventilation necessary but yet imposes risks due oxidative stress, reduced Thus, using safe over-the-counter drug immediately able development severe disease symptoms coronavirus patients, severity symptoms, and/or immuno-pathology infection on patients' health active phase over.

Language: Английский

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