The 2020 Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for mood disorders

Australian & New Zealand Journal of Psychiatry, Journal Year: 2020, Volume and Issue: 55(1), P. 7 - 117

Published: Dec. 22, 2020

Objectives: To provide advice and guidance regarding the management of mood disorders, derived from scientific evidence supplemented by expert clinical consensus to formulate s that maximise utility. Methods: Articles information sourced search engines including PubMed, EMBASE, MEDLINE, PsycINFO Google Scholar were literature known disorders committee (e.g. books, book chapters government reports) published depression bipolar disorder guidelines. Relevant was appraised discussed in detail members committee, with a view formulating developing consensus-based recommendations guidance. The guidelines subjected rigorous consultation external review involving: advisors, key stakeholders, professional bodies specialist groups interest disorders. Results: Royal Australian New Zealand College Psychiatrists practice 2020 (MDcpg ) up-to-date is informed experience. guideline intended for use psychiatrists, psychologists, primary care physicians others an mental health care. Conclusion: MDcpg builds on previous 2015 maintains its joint focus both depressive It provides within evidence-based framework, consensus. Mood committee: Gin S Malhi (Chair), Erica Bell, Darryl Bassett, Philip Boyce, Richard Bryant, Hazell, Malcolm Hopwood, Bill Lyndon, Roger Mulder, Porter, Ajeet B Singh Greg Murray.

Language: Английский

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Biosynthesis and metabolic actions of simple phenolic acids in plants

Phytochemistry Reviews, Journal Year: 2020, Volume and Issue: 19(4), P. 865 - 906

Published: June 7, 2020

Language: Английский

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Trends in use, pharmacology, and clinical applications of emerging herbal nutraceuticals

British Journal of Pharmacology, Journal Year: 2019, Volume and Issue: 177(6), P. 1227 - 1240

Published: Dec. 4, 2019

The nutraceuticals market is vast, encompassing many different products with inconsistent levels of evidence available to support their use. This overview represents a Western perspective the market, brief comparison that in China, as an illustration how individual health supplements increase and decrease popularity regional terms. Recent changes sales patterns, mainly taken from US are summarized selection five newer products, which have not been subject extensive recent review profiled: astaxanthin, carotenoid found red algae, seafood, salmon trout, antioxidant; cannabidiol, non-euphoric marijuana ingredient used mood enhancer for painful/inflammatory conditions; modified extracts ginseng new indications including dementia space travel; monk fruit, non-sugar high intensity sweetener nigella seed, popular food Asian medicine, has experienced extraordinary rise recently. LINKED ARTICLES: article part themed section on Pharmacology Nutraceuticals. To view other articles this visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.6/issuetoc.

Language: Английский

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Industrial Hemp (Cannabis sativa subsp. sativa) as an Emerging Source for Value-Added Functional Food Ingredients and Nutraceuticals

Molecules, Journal Year: 2020, Volume and Issue: 25(18), P. 4078 - 4078

Published: Sept. 7, 2020

Industrial hemp (

Language: Английский

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Cannabidiol and Other Non-Psychoactive Cannabinoids for Prevention and Treatment of Gastrointestinal Disorders: Useful Nutraceuticals?

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(9), P. 3067 - 3067

Published: April 26, 2020

Cannabis sativa is an aromatic annual flowering plant with several botanical varieties, used for different purposes, like the production of fibers, oil from seeds, and especially recreational or medical purposes. Phytocannabinoids (terpenophenolic compounds derived plant), include well-known psychoactive cannabinoid Δ9-tetrahydrocannabinol, many non-psychoactive cannabinoids, cannabidiol. The endocannabinoid system (ECS) comprises ligands, enzymes synthesis degradation such receptors. This widely distributed in gastrointestinal tract, where phytocannabinoids exert potent effects, particularly under pathological (i.e., inflammatory) conditions. Herein, we will first look at hemp as a possible source new functional food ingredients nutraceuticals that might be eventually useful to treat even prevent Subsequently, briefly describe ECS general pharmacology phytocannabinoids. Finally, revise available data showing phytocannabinoids, cannabidiol, may disorders diseases tract. With increasing interest development foods healthy life, are hoped find place also tract function.

Language: Английский

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The Role of Glutamate Receptors in Epilepsy

Biomedicines, Journal Year: 2023, Volume and Issue: 11(3), P. 783 - 783

Published: March 4, 2023

Glutamate is an essential excitatory neurotransmitter in the central nervous system, playing indispensable role neuronal development and memory formation. The dysregulation of glutamate receptors glutamatergic system involved numerous neurological psychiatric disorders, especially epilepsy. There are two main classes receptor, namely ionotropic metabotropic (mGluRs) receptors. former stimulate fast neurotransmission, N-methyl-d-aspartate (NMDA), α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA), kainate; while latter G-protein-coupled that mediate activity via intracellular messenger systems. Glutamate, receptors, regulation astrocytes significantly pathogenesis acute seizure chronic Some receptor antagonists have been shown to be effective for treatment epilepsy, research clinical trials ongoing.

Language: Английский

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Cannabidiol (CBD) use in psychiatric disorders: A systematic review

NeuroToxicology, Journal Year: 2019, Volume and Issue: 74, P. 282 - 298

Published: Aug. 11, 2019

Language: Английский

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Zeolite Clinoptilolite: Therapeutic Virtues of an Ancient Mineral

Molecules, Journal Year: 2019, Volume and Issue: 24(8), P. 1517 - 1517

Published: April 17, 2019

Zeolites are porous minerals with high absorbency and ion-exchange capacity. Their molecular structure is a dense network of AlO4 SiO4 that generates cavities where water other polar molecules or ions inserted/exchanged. Even though there several synthetic natural occurring species zeolites, the most widespread studied naturally zeolite clinoptilolite (ZC). ZC an excellent detoxifying, antioxidant anti-inflammatory agent. As result, it been used in many industrial applications ranging from environmental remediation to oral applications/supplementation vivo humans as food supplements medical devices. Moreover, modification micronization (M-ZC) tribomechanically activated (TMAZ) furthermore double (PMA-ZC) allows improving its benefits preclinical clinical models. Despite extensive use, underlying action mechanisms modified forms still unclear, especially humans. The main aim this review shed light on geochemical aspects therapeutic potentials vision endorsing further research specific potential agent for promoting human brain health overall well-being.

Language: Английский

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The Effects of Cannabidiol, a Non-Intoxicating Compound of Cannabis, on the Cardiovascular System in Health and Disease

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(18), P. 6740 - 6740

Published: Sept. 14, 2020

Cannabidiol (CBD) is a non-intoxicating and generally well-tolerated constituent of cannabis which exhibits potential beneficial properties in wide range diseases, including cardiovascular disorders. Due to its complex mechanism action, CBD may affect the system different ways. Thus, we reviewed influence on this health disease determine risk side effects during use for medical wellness purposes elucidate therapeutic diseases. Administration healthy volunteers or animals usually does not markedly hemodynamic parameters. Although has been found exhibit vasodilatory antioxidant hypertension, it affected blood pressure hypertensive animals. Hypotensive action mainly revealed under stress conditions. Many positive have observed experimental models heart diseases (myocardial infarction, cardiomyopathy, myocarditis), stroke, neonatal hypoxic ischemic encephalopathy, sepsis-related encephalitis, complications diabetes, ischemia/reperfusion injures liver kidneys. In these pathological conditions decreased organ damage dysfunction, oxidative nitrative stress, inflammatory processes apoptosis, among others. Nevertheless, further clinical research needed recommend treatment

Language: Английский

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Variation in Terpene Profiles of Thymus vulgaris in Water Deficit Stress Response

Molecules, Journal Year: 2020, Volume and Issue: 25(5), P. 1091 - 1091

Published: Feb. 28, 2020

Thyme (Thymus spp.) volatiles predominantly consisting of monoterpenes and sesquiterpenes, serve as antimicrobial, antiseptic antioxidant in phytomedicine. They also play a key role plants secondary metabolites via their potential against herbivores, attracting pollinators abiotic stress tolerance. Plant are affected by different environmental factors including drought. Here, the effect prolonged water deficit on volatile composition was studied sensitive tolerant thyme plant cultivars (T. vulgaris Var. Wagner T. Varico3, respectively). Volatile sampling along with morpho–physiological parameters such soil moisture, potential, shoot dry weight, photosynthetic rate content measurements were performed one-month-old subsequent to withholding at 4-day intervals until wilted. The had clearly responses physiological levels. most stress-induced changes plants’ traits occurred rates, where maintained photosynthesis similar control ones 8th day drought period. While analysis compounds (VOCs) displayed same pattern for almost all them, plants, comparison revealed that could be classified into three separate groups. Our experimental theoretical studies totally determinant involved adaptation included α-phellandrene, O-cymene, γ-terpinene β-caryophyelene. Overall, it can concluded trade-off between growth defense, simultaneously activate response mechanism continue growth.

Language: Английский

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