International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(23), P. 12738 - 12738
Published: Nov. 27, 2024
Cannabis
sativa
L.
contains
numerous
compounds
with
antioxidant
and
anti-inflammatory
properties,
including
the
flavonoids
cannabinoids,
particularly
Δ-9-tetrahydrocannabinol
(THC)
cannabidiol
(CBD).
Cannabinoids
have
an
effect
on
endocannabinoid
system
(ECS),
a
cellular
communication
network,
are,
hence,
widely
studied
for
medical
applications.
Epidiolex®,
99%
pure
oral
CBD
extract,
has
been
approved
by
FDA
treatment
of
epilepsy.
Nabiximols
(Sativex)
is
oromucosal
spray
containing
equal
volume
THC
CBD,
it
commonly
used
as
add-on
unresponsive
spasticity
in
multiple
sclerosis
(MS)
patients.
Several
vitro
vivo
studies
also
shown
that
cannabinoids
can
be
to
treat
various
types
cancer,
such
melanoma
brain
glioblastoma;
first
positive
clinical
trials
anticancer
THC:CBD
blend
temozolomide
(TMZ)
highly
invasive
cancer
are
very
promising.
The
exert
their
properties
investigations
induction
cell
death,
mainly
apoptosis
cytotoxic
autophagy,
inhibition
proliferation.
In
several
studies,
found
induce
tumor
regression
inhibit
angiogenic
mechanisms
vivo,
well
two
low-numbered
epidemiological
studies.
They
exhibit
antiviral
effects
inhibiting
ACE2
transcription,
blocking
viral
replication
fusion,
acting
agents;
indeed,
prior
consumption
(a
study
93,565
persons
Chicago)
associated
much
lower
incidence
SARS-CoV-2
infections.
It
postulated
cannabis
extracts
many
other
diseases
systemic
lupus
erythematosus,
type
1
diabetes,
or
neurological
disorders,
e.g.,
Alzheimer’s
disease.
aim
this
review
outline
current
state
knowledge
regarding
currently
medicinal
preparations
derived
from
C.
selected
diseases,
present
latest
research
potential
applications
its
secondary
metabolites.
Journal of Cellular and Molecular Medicine,
Journal Year:
2022,
Volume and Issue:
26(11), P. 3083 - 3119
Published: May 2, 2022
Piper
betle
L.
(synonym:
betel
Blanco),
or
vine,
an
economically
and
medicinally
important
cash
crop,
belongs
to
the
family
Piperaceae,
often
known
as
green
gold.
The
plant
can
be
found
all
over
world
is
cultivatedprimarily
in
South
East
Asian
countries
for
its
beautiful
glossy
heart-shaped
leaves,
which
are
chewed
consumed
betelquidand
widely
used
Chinese
Indian
folk
medicine,
carminative,
stimulant,astringent,
against
parasitic
worms,
conjunctivitis,
rheumatism,
wound,
etc.,
andis
also
religious
purposes.
Hydroxychavicol
most
bioactive
compound
among
wide
range
of
phytoconstituents
essential
oil
extracts.
pharmacological
attributes
P.
antiproliferation,
anticancer,
neuropharmacological,
analgesic,
antioxidant,
antiulcerogenic,
hepatoprotective,
antifertility,
antibacterial,
antifungal
many
more.
Immense
attention
has
been
paid
nanoformulations
their
applications.
application
did
not
show
cytotoxicity
preclinical
experiments,
suggesting
that
it
could
serve
a
promising
therapeutic
candidate
different
diseases.
present
review
comprehensively
summarizes
botanical
description,
geographical
distribution,
economic
value
cultivation,
ethnobotanical
uses,
properties
with
insights
toxicological,
clinical
efficacy,
safety
betle.
findings
suggest
represents
orally
active
safe
natural
agent
exhibits
great
potential
managing
various
human
medical
conditions.
However,
further
research
needed
elucidate
underlying
molecular
mechanisms
action,
aspects,
structure-activity
relationships,
bioavailability
synergistic
interactions
other
drugs.
International Journal of Molecular Sciences,
Journal Year:
2020,
Volume and Issue:
21(18), P. 6740 - 6740
Published: Sept. 14, 2020
Cannabidiol
(CBD)
is
a
non-intoxicating
and
generally
well-tolerated
constituent
of
cannabis
which
exhibits
potential
beneficial
properties
in
wide
range
diseases,
including
cardiovascular
disorders.
Due
to
its
complex
mechanism
action,
CBD
may
affect
the
system
different
ways.
Thus,
we
reviewed
influence
on
this
health
disease
determine
risk
side
effects
during
use
for
medical
wellness
purposes
elucidate
therapeutic
diseases.
Administration
healthy
volunteers
or
animals
usually
does
not
markedly
hemodynamic
parameters.
Although
has
been
found
exhibit
vasodilatory
antioxidant
hypertension,
it
affected
blood
pressure
hypertensive
animals.
Hypotensive
action
mainly
revealed
under
stress
conditions.
Many
positive
have
observed
experimental
models
heart
diseases
(myocardial
infarction,
cardiomyopathy,
myocarditis),
stroke,
neonatal
hypoxic
ischemic
encephalopathy,
sepsis-related
encephalitis,
complications
diabetes,
ischemia/reperfusion
injures
liver
kidneys.
In
these
pathological
conditions
decreased
organ
damage
dysfunction,
oxidative
nitrative
stress,
inflammatory
processes
apoptosis,
among
others.
Nevertheless,
further
clinical
research
needed
recommend
treatment
International Journal of Molecular Sciences,
Journal Year:
2020,
Volume and Issue:
21(12), P. 4448 - 4448
Published: June 23, 2020
The
Cannabis
plant
contains
numerous
components,
including
cannabinoids
and
other
active
molecules.
phyto-cannabinoid
activity
is
mediated
by
the
endocannabinoid
system.
Cannabinoids
affect
nervous
system
play
significant
roles
in
regulation
of
immune
While
not
yet
registered
as
a
drug,
potential
cannabinoid-based
medicines
for
treatment
various
conditions
has
led
many
countries
to
authorize
their
clinical
use.
However,
data
from
basic
medical
research
dedicated
currently
limited.
A
variety
pathological
involve
dysregulation
For
example,
cancer,
surveillance
cancer
immuno-editing
result
tolerance.
On
hand,
autoimmune
diseases
increased
causes
tissue
damage.
Immuno-modulating
therapies
can
regulate
therefore
immune-regulatory
properties
cannabinoids,
suggest
use
therapy
related
disorders.
In
this
contemporary
review,
we
discuss
immunity
explore
emerging
about
effects
on
response
different
pathologies.
addition,
complexities
using
treatments
each
these
conditions.
Food Science & Nutrition,
Journal Year:
2022,
Volume and Issue:
10(6), P. 1789 - 1819
Published: March 4, 2022
Abstract
The
genus
Syzygium
comprises
1200–1800
species
that
belong
to
the
family
of
Myrtaceae.
Moreover,
plants
are
belonged
this
being
used
in
traditional
system
medicine
Asian
countries,
especially
China,
India,
and
Bangladesh.
aim
review
is
describe
scientific
works
provide
organized
information
on
available
uses,
phytochemical
constituents,
pharmacological
activities
mostly
related
was
analytically
composed
from
databases,
including
PubMed,
Google
Scholar,
Science
Direct,
Web
Science,
Wiley
Online
Library,
Springer,
Research
Gate
link,
published
books,
conference
proceedings.
Bioactive
compounds
such
as
flavanone
derivatives,
ellagic
acid
derivatives
other
polyphenolics,
terpenoids
reported
several
.
However,
many
members
need
further
comprehensive
studies
regarding
constituents
mechanism‐based
activities.
Molecules,
Journal Year:
2022,
Volume and Issue:
28(1), P. 106 - 106
Published: Dec. 23, 2022
The
management
of
orofacial
pain
to
alleviate
the
quality
life
affected
patients
is
becoming
increasingly
challenging
for
scientific
research
and
healthcare
professionals.
From
this
perspective,
in
addition
conventional
therapies,
new
alternatives
are
being
sought,
looking
at
use
both
natural
synthetic
products.
Cannabis
sativa
L.
represents
an
interesting
source
bioactive
compounds,
including
non-psychoactive
cannabinoids,
flavonoids,
terpenes,
many
which
effective
improving
intensity.
Here,
we
aim
analyze
possible
mechanisms
action
hemp-derived
compounds
responsible
modulatory
effects
on
pain-related
pathways.
ability
these
act
multiple
through
a
synergistic
effect,
reducing
release
inflammatory
mediators
regulating
response
endocannabinoid
system,
makes
them
agents
alternative
formulations
be
used
pain.
