Stem Cell Research & Therapy,
Journal Year:
2022,
Volume and Issue:
13(1)
Published: July 28, 2022
Abstract
Parkinson's
disease
(PD)
is
the
second
most
predominant
neurodegenerative
worldwide.
It
recognized
clinically
by
severe
complications
in
motor
function
caused
progressive
degeneration
of
dopaminergic
neurons
(DAn)
and
dopamine
depletion.
As
current
standard
treatment
focused
on
alleviating
symptoms
through
Levodopa,
developing
neuroprotective
techniques
critical
for
adopting
a
more
pathology-oriented
therapeutic
approach.
Regenerative
cell
therapy
has
provided
us
with
an
unrivalled
platform
evaluating
potentially
effective
novel
methods
treating
illnesses
over
last
two
decades.
Mesenchymal
stem
cells
(MSCs)
are
promising,
as
they
can
differentiate
into
produce
neurotrophic
substances.
The
precise
process
which
repair
neuronal
injury
unknown,
MSC-derived
exosomes
suggested
to
be
responsible
significant
portion
such
effects.
present
review
discusses
application
mesenchymal
PD
treatment.
International Journal of Molecular Sciences,
Journal Year:
2019,
Volume and Issue:
20(18), P. 4472 - 4472
Published: Sept. 10, 2019
It
has
been
proposed
that
a
chronic
state
of
inflammation
correlated
with
aging
known
as
inflammaging,
is
implicated
in
multiple
disease
states
commonly
observed
the
elderly
population.
Inflammaging
associated
over-abundance
reactive
oxygen
species
cell,
which
can
lead
to
oxidation
and
damage
cellular
components,
increased
inflammation,
activation
cell
death
pathways.
This
review
focuses
on
inflammaging
its
contribution
various
age-related
diseases
such
cardiovascular
disease,
cancer,
neurodegenerative
diseases,
obstructive
pulmonary
diabetes,
rheumatoid
arthritis.
Recently
published
mechanistic
details
roles
will
also
be
discussed.
Advancements
potential
treatments
ameliorate
oxidative
stress,
consequently,
reduce
morbidity
explored.
Cell Death and Disease,
Journal Year:
2020,
Volume and Issue:
11(4)
Published: April 27, 2020
Abstract
Parkinson’s
disease
(PD)
is
a
progressively
debilitating
neurodegenerative
condition
that
leads
to
motor
and
cognitive
dysfunction.
At
present,
clinical
treatment
can
only
improve
symptoms,
but
cannot
effectively
protect
dopaminergic
neurons.
Several
reports
have
demonstrated
human
umbilical
cord
mesenchymal
stem
cells
(hucMSCs)
afford
neuroprotection,
while
their
application
limited
because
of
uncontrollable
differentiation
other
reasons.
Stem
communicate
with
through
secreted
exosomes
(Exos),
the
present
study
aimed
explore
whether
Exos
by
hucMSCs
could
function
instead
hucMSCs.
were
successfully
isolated
characterized,
shown
contribute
6-hydroxydopamine
(6-OHDA)-stimulated
SH-SY5Y
cell
proliferation;
hucMSC-derived
also
involved
in
this
process.
The
purified
identified,
then
labeled
PKH
26,
it
was
found
be
efficiently
taken
up
after
12
h
incubation.
Pretreatment
promoted
6-OHDA-stimulated
proliferate
inhibited
apoptosis
inducing
autophagy.
Furthermore,
reached
substantia
nigra
blood–brain
barrier
(BBB)
vivo,
relieved
apomorphine-induced
asymmetric
rotation,
reduced
neuron
loss
apoptosis,
upregulated
level
dopamine
striatum.
These
results
demonstrate
hucMSCs-Exos
capability
for
PD
traverse
BBB,
indicating
potential
effective
PD.
International Journal of Molecular Sciences,
Journal Year:
2021,
Volume and Issue:
22(4), P. 2153 - 2153
Published: Feb. 22, 2021
Neurodegenerative
diseases
resulting
from
the
progressive
loss
of
structure
and/or
function
neurons
contribute
to
different
paralysis
degrees
and
cognition
sensation.
The
lack
successful
curative
therapies
for
neurodegenerative
disorders
leads
a
considerable
burden
on
society
high
economic
impact.
Over
past
20
years,
regenerative
cell
therapy,
also
known
as
stem
has
provided
an
excellent
opportunity
investigate
potentially
powerful
innovative
strategies
treating
diseases.
This
is
due
cells’
capability
repair
injured
neuronal
tissue
by
replacing
damaged
or
lost
cells
with
differentiated
cells,
providing
conducive
environment
that
in
favor
regeneration,
protecting
existing
healthy
glial
further
damage.
Thus,
this
review,
various
types
current
knowledge
stem-cell-based
diseases,
recent
advances
field
are
summarized.
Indeed,
better
understanding
studies
technologies
cause
progress
into
realistic
efficacious
treatments
disorders.
Journal of Parkinson s Disease,
Journal Year:
2021,
Volume and Issue:
12(2), P. 477 - 493
Published: Dec. 21, 2021
Monoamine
oxidase-B
(MAO-B)
inhibitors
are
commonly
used
for
the
symptomatic
treatment
of
Parkinson's
disease
(PD).
MAO-B
inhibitor
monotherapy
has
been
shown
to
be
effective
and
safe
early-stage
PD,
while
as
adjuvant
drugs
have
widely
applied
advanced
stages
illness.
can
effectively
improve
patients'
motor
non-motor
symptoms,
reduce
"OFF"
time,
may
potentially
prevent/delay
progression.
In
this
review,
we
discuss
effects
on
symptoms
in
PD
patients,
their
mechanism
action,
future
development
therapy.
Neural Regeneration Research,
Journal Year:
2021,
Volume and Issue:
16(9), P. 1702 - 1702
Published: Jan. 1, 2021
Astrocytes
play
multifaceted
and
vital
roles
in
maintaining
neurophysiological
function
of
the
central
nervous
system
by
regulating
homeostasis,
increasing
synaptic
plasticity,
sustaining
neuroprotective
effects.
become
activated
as
a
result
inflammatory
responses
during
progression
pathological
changes
associated
with
neurodegenerative
disorders.
Reactive
astrocytes
(neurotoxic
A1
A2)
are
triggered
disease
pathogenesis
due
to
neuroinflammation
ischemia.
However,
only
limited
body
literature
describes
morphological
functional
diseases.
The
present
review
investigated
detrimental
beneficial
diseases
reported
recent
studies,
these
cells
have
promising
therapeutic
potential
offer
new
approaches
for
treatment
Nutrients,
Journal Year:
2022,
Volume and Issue:
14(13), P. 2661 - 2661
Published: June 27, 2022
The
involvement
of
the
gut
microbiota
and
metabolites
colon-residing
bacteria
in
brain
disease
pathogenesis
has
been
covered
a
growing
number
studies,
but
comparative
literature
is
scarce.
To
fill
this
gap,
we
explored
contribution
microbiota-gut-brain
axis
to
pathophysiology
seven
brain-related
diseases
(attention
deficit
hyperactivity
disorder,
autism
spectrum
schizophrenia,
Alzheimer's
disease,
Parkinson's
major
depressive
bipolar
disorder).
In
article,
discussed
changes
bacterial
abundance
metabolic
implications
these
on
development
progression.
Our
central
findings
indicate
that,
mechanistically,
all
are
associated
with
leaky
gut,
neuroinflammation,
over-activated
microglial
cells,
which
gut-residing
their
important
contributors.
Patients
show
pro-inflammatory
shift
colon
microbiota,
harbouring
more
Gram-negative
containing
immune-triggering
lipopolysaccharides
(LPS)
cell
walls.
addition,
properties
(
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(3), P. 2136 - 2136
Published: Jan. 21, 2023
Flavonoids
have
been
shown
to
anti-oxidative
effects,
as
well
other
health
benefits
(e.g.,
anti-inflammatory
and
anti-tumor
functions).
Luteolin
(3′,
4′,
5,7-tetrahydroxyflavone)
is
a
flavonoid
found
in
vegetables,
fruits,
flowers,
herbs,
including
celery,
broccoli,
green
pepper,
navel
oranges,
dandelion,
peppermint,
rosemary.
has
multiple
useful
especially
regulating
inflammation-related
symptoms
diseases.
In
this
paper,
we
summarize
the
studies
about
immunopharmacological
activity
of
luteolin
on
anti-inflammatory,
anti-cardiovascular,
anti-cancerous,
anti-neurodegenerative
diseases
published
since
2018
available
PubMed
or
Google
Scholar.
review,
also
introduce
some
additional
formulations
improve
its
solubility
bioavailability.
